CN102762591A - 结合il-23的基于纤连蛋白的支架结构域蛋白质 - Google Patents
结合il-23的基于纤连蛋白的支架结构域蛋白质 Download PDFInfo
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- CN102762591A CN102762591A CN2011800100540A CN201180010054A CN102762591A CN 102762591 A CN102762591 A CN 102762591A CN 2011800100540 A CN2011800100540 A CN 2011800100540A CN 201180010054 A CN201180010054 A CN 201180010054A CN 102762591 A CN102762591 A CN 102762591A
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
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- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- Proteomics, Peptides & Aminoacids (AREA)
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- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30556610P | 2010-02-18 | 2010-02-18 | |
| US61/305566 | 2010-02-18 | ||
| US33070610P | 2010-05-03 | 2010-05-03 | |
| US61/330706 | 2010-05-03 | ||
| PCT/US2011/024959 WO2011103105A1 (en) | 2010-02-18 | 2011-02-16 | Fibronectin based scaffold domain proteins that bind il-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102762591A true CN102762591A (zh) | 2012-10-31 |
Family
ID=43901183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800100540A Pending CN102762591A (zh) | 2010-02-18 | 2011-02-16 | 结合il-23的基于纤连蛋白的支架结构域蛋白质 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8927693B2 (enExample) |
| EP (1) | EP2536757B1 (enExample) |
| JP (1) | JP2013520426A (enExample) |
| KR (1) | KR20130010461A (enExample) |
| CN (1) | CN102762591A (enExample) |
| AR (1) | AR080229A1 (enExample) |
| AU (1) | AU2011218243A1 (enExample) |
| BR (1) | BR112012019881A2 (enExample) |
| CA (1) | CA2790329A1 (enExample) |
| CL (1) | CL2012002296A1 (enExample) |
| EA (1) | EA201270713A1 (enExample) |
| MX (1) | MX2012009050A (enExample) |
| PE (1) | PE20130041A1 (enExample) |
| SG (1) | SG183215A1 (enExample) |
| TN (1) | TN2012000372A1 (enExample) |
| TW (1) | TWI508736B (enExample) |
| WO (1) | WO2011103105A1 (enExample) |
| ZA (1) | ZA201206969B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110621302A (zh) * | 2017-05-03 | 2019-12-27 | 百时美施贵宝公司 | 结合肌生成抑制蛋白的纤连蛋白基支架结构域蛋白质的稳定制剂 |
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| BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| EP2247615B1 (en) | 2008-02-14 | 2014-07-30 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
| AR071874A1 (es) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| TW201138808A (en) * | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP3091028A1 (en) | 2010-05-26 | 2016-11-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| KR102049223B1 (ko) | 2010-11-04 | 2019-11-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 항-il-23 항체 |
| EP2655411A1 (en) * | 2010-12-22 | 2013-10-30 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind il-23 |
| EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
| US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| US9347058B2 (en) | 2011-05-17 | 2016-05-24 | Bristol-Myers Squibb Company | Methods for the selection of binding proteins |
| US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
| EP2773964A4 (en) * | 2011-11-03 | 2015-06-24 | Stc Biolog Inc | METHOD FOR DETERMINING THE PHARMACOLOGICAL PROPERTIES OF RECOMBINANT PROTEINS |
| CN109206516A (zh) | 2012-05-03 | 2019-01-15 | 勃林格殷格翰国际有限公司 | 抗IL-23p19抗体 |
| RS58801B1 (sr) | 2012-09-13 | 2019-07-31 | Bristol Myers Squibb Co | Skafold domenski proteini na bazi fibronektina koji se vezuju za miostatin |
| CZ2012829A3 (cs) | 2012-11-23 | 2014-06-11 | Biotechnologický Ústav Av Čr, V.V.I. | Polypeptidy pro léčbu autoimunitních chorob založenou na blokaci receptoru pro lidský cytokin IL-23 |
| US20150361159A1 (en) | 2013-02-01 | 2015-12-17 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
| WO2014124017A1 (en) * | 2013-02-06 | 2014-08-14 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
| US10065987B2 (en) | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
| KR20150062352A (ko) * | 2013-11-29 | 2015-06-08 | 일진엘이디(주) | 유전체층을 가진 발광 다이오드 |
| AU2015231170B2 (en) | 2014-03-20 | 2019-10-03 | Bristol-Myers Squibb Company | Serum albumin-binding fibronectin type III domains |
| EP3172339A1 (en) | 2014-07-24 | 2017-05-31 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| CA2959629C (en) | 2014-09-03 | 2023-10-31 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| KR20170120616A (ko) | 2015-02-04 | 2017-10-31 | 베링거 인겔하임 인터내셔날 게엠베하 | 염증성 질환의 치료 방법 |
| EP3353198B1 (en) | 2015-09-23 | 2020-06-17 | Bristol-Myers Squibb Company | Glypican-3binding fibronectin based scafflold molecules |
| US10766946B2 (en) | 2015-09-23 | 2020-09-08 | Bristol-Myers Squibb Company | Fast-off rate serum albumin binding fibronectin type III domains |
| WO2017115828A1 (ja) * | 2015-12-29 | 2017-07-06 | 国立大学法人東京工業大学 | 標的結合ペプチドの安定化方法 |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| EP3789049A1 (en) * | 2019-09-06 | 2021-03-10 | QGel SA | Method for obtaining healthy intestinal organoids |
| TW202535466A (zh) | 2019-09-09 | 2025-09-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗-il-23p19抗體調配物 |
Citations (4)
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| CN1651575A (zh) * | 2004-09-02 | 2005-08-10 | 中国人民解放军军事医学科学院放射医学研究所 | 抑制纤连蛋白表达的反义寡核苷酸的结构和用途 |
| WO2008103432A1 (en) * | 2007-02-23 | 2008-08-28 | Schering Corporation | Engineered anti-il-23p19 antibodies |
| WO2009083804A2 (en) * | 2007-12-27 | 2009-07-09 | Novartis Ag | Improved fibronectin-based binding molecules and their use |
| WO2009133208A1 (en) * | 2008-05-02 | 2009-11-05 | Novartis Ag | Improved fibronectin-based binding molecules and uses thereof |
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| US20070269422A1 (en) | 2006-05-17 | 2007-11-22 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
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| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
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| EP2247615B1 (en) * | 2008-02-14 | 2014-07-30 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
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| CA2759942A1 (en) * | 2009-04-27 | 2010-10-07 | Novartis Ag | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betai subunit |
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2011
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- 2011-02-16 JP JP2012553974A patent/JP2013520426A/ja active Pending
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- 2011-02-16 EP EP11708608.2A patent/EP2536757B1/en not_active Not-in-force
- 2011-02-16 CN CN2011800100540A patent/CN102762591A/zh active Pending
- 2011-02-16 WO PCT/US2011/024959 patent/WO2011103105A1/en not_active Ceased
- 2011-02-16 US US13/579,204 patent/US8927693B2/en active Active
- 2011-02-16 EA EA201270713A patent/EA201270713A1/ru unknown
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- 2011-02-16 MX MX2012009050A patent/MX2012009050A/es active IP Right Grant
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- 2011-02-16 BR BR112012019881A patent/BR112012019881A2/pt not_active IP Right Cessation
- 2011-02-16 CA CA2790329A patent/CA2790329A1/en not_active Abandoned
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2012
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- 2012-09-17 ZA ZA2012/06969A patent/ZA201206969B/en unknown
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- 2014-11-25 US US14/553,379 patent/US9714281B2/en active Active
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| CN1651575A (zh) * | 2004-09-02 | 2005-08-10 | 中国人民解放军军事医学科学院放射医学研究所 | 抑制纤连蛋白表达的反义寡核苷酸的结构和用途 |
| WO2008103432A1 (en) * | 2007-02-23 | 2008-08-28 | Schering Corporation | Engineered anti-il-23p19 antibodies |
| WO2009083804A2 (en) * | 2007-12-27 | 2009-07-09 | Novartis Ag | Improved fibronectin-based binding molecules and their use |
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| CN110621302A (zh) * | 2017-05-03 | 2019-12-27 | 百时美施贵宝公司 | 结合肌生成抑制蛋白的纤连蛋白基支架结构域蛋白质的稳定制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150274806A1 (en) | 2015-10-01 |
| MX2012009050A (es) | 2012-09-07 |
| ZA201206969B (en) | 2015-06-24 |
| JP2013520426A (ja) | 2013-06-06 |
| EP2536757A1 (en) | 2012-12-26 |
| TN2012000372A1 (en) | 2014-01-30 |
| KR20130010461A (ko) | 2013-01-28 |
| TWI508736B (zh) | 2015-11-21 |
| PE20130041A1 (es) | 2013-01-28 |
| CL2012002296A1 (es) | 2013-01-11 |
| WO2011103105A1 (en) | 2011-08-25 |
| US20130012436A1 (en) | 2013-01-10 |
| AU2011218243A1 (en) | 2012-10-04 |
| TW201130501A (en) | 2011-09-16 |
| US8927693B2 (en) | 2015-01-06 |
| HK1179276A1 (en) | 2013-09-27 |
| AR080229A1 (es) | 2012-03-21 |
| BR112012019881A2 (pt) | 2017-06-27 |
| SG183215A1 (en) | 2012-09-27 |
| US9714281B2 (en) | 2017-07-25 |
| EA201270713A1 (ru) | 2013-01-30 |
| EP2536757B1 (en) | 2015-03-25 |
| CA2790329A1 (en) | 2011-08-25 |
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Application publication date: 20121031 |