JP2015532654A5 - - Google Patents
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- Publication number
- JP2015532654A5 JP2015532654A5 JP2015530154A JP2015530154A JP2015532654A5 JP 2015532654 A5 JP2015532654 A5 JP 2015532654A5 JP 2015530154 A JP2015530154 A JP 2015530154A JP 2015530154 A JP2015530154 A JP 2015530154A JP 2015532654 A5 JP2015532654 A5 JP 2015532654A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- ntd
- muteins
- tale
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 239000012636 effector Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000002103 transcriptional effect Effects 0.000 claims 3
- 102000018120 Recombinases Human genes 0.000 claims 2
- 108010091086 Recombinases Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 1
- 241000232299 Ralstonia Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696689P | 2012-09-04 | 2012-09-04 | |
| US61/696,689 | 2012-09-04 | ||
| US201361753763P | 2013-01-17 | 2013-01-17 | |
| US61/753,763 | 2013-01-17 | ||
| US201361818364P | 2013-05-01 | 2013-05-01 | |
| US61/818,364 | 2013-05-01 | ||
| PCT/US2013/058100 WO2014039585A2 (en) | 2012-09-04 | 2013-09-04 | Chimeric polypeptides having targeted binding specificity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018146232A Division JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532654A JP2015532654A (ja) | 2015-11-12 |
| JP2015532654A5 true JP2015532654A5 (enExample) | 2016-10-13 |
| JP6442406B2 JP6442406B2 (ja) | 2018-12-19 |
Family
ID=50237752
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Active JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
| JP2018146232A Active JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018146232A Active JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9902962B2 (enExample) |
| EP (3) | EP2893022B1 (enExample) |
| JP (4) | JP6442406B2 (enExample) |
| KR (3) | KR102201867B1 (enExample) |
| CN (2) | CN104781404B (enExample) |
| AU (3) | AU2013312801B2 (enExample) |
| BR (1) | BR112015004696B1 (enExample) |
| CA (1) | CA2883511C (enExample) |
| DK (1) | DK2893022T3 (enExample) |
| IL (1) | IL237442B (enExample) |
| SG (2) | SG11201501525QA (enExample) |
| WO (1) | WO2014039585A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3059768A1 (en) | 2008-09-05 | 2010-03-11 | President And Fellows Of Harvard College | Continuous directed evolution of proteins and nucleic acids |
| JP6088438B2 (ja) | 2010-12-22 | 2017-03-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 連続的定向進化 |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9902962B2 (en) * | 2012-09-04 | 2018-02-27 | The Scripps Research Institute | Chimeric polypeptides having targeted binding specificity |
| US9708589B2 (en) * | 2012-12-18 | 2017-07-18 | Monsanto Technology Llc | Compositions and methods for custom site-specific DNA recombinases |
| US10793867B2 (en) | 2013-03-15 | 2020-10-06 | Monsanto Technology, Llc | Methods for targeted transgene-integration using custom site-specific DNA recombinases |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| WO2015134121A2 (en) | 2014-01-20 | 2015-09-11 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| US10507232B2 (en) | 2014-04-02 | 2019-12-17 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| JP6796773B2 (ja) | 2014-07-30 | 2020-12-09 | ツムトー バイオロジクス、インコーポレイテッド | 非フコシル化タンパク質および方法 |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2016077052A2 (en) | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
| US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) * | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| WO2017019895A1 (en) | 2015-07-30 | 2017-02-02 | President And Fellows Of Harvard College | Evolution of talens |
| US11339408B2 (en) | 2015-08-20 | 2022-05-24 | Applied Stemcell, Inc. | Nuclease with enhanced efficiency of genome editing |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CN109804066A (zh) * | 2016-08-09 | 2019-05-24 | 哈佛大学的校长及成员们 | 可编程cas9-重组酶融合蛋白及其用途 |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018187796A1 (en) * | 2017-04-07 | 2018-10-11 | Donald Danforth Plant Science Center | Methods for increasing resistance to cotton bacterial blight and plants produced thereby |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2019010164A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | Evolution of trna synthetases |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US12060553B2 (en) | 2017-08-25 | 2024-08-13 | President And Fellows Of Harvard College | Evolution of BoNT peptidases |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| WO2019056002A1 (en) | 2017-09-18 | 2019-03-21 | President And Fellows Of Harvard College | CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| EP3781193A4 (en) | 2018-04-18 | 2022-01-26 | Altius Institute For Biomedical Sciences | Animal pathogen-derived polypeptides and uses thereof for genetic engineering |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| US12264181B2 (en) | 2018-06-27 | 2025-04-01 | Altius Institute For Biomedical Sciences | Nucleic acid binding domains and methods of use thereof |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN109771403A (zh) * | 2019-01-24 | 2019-05-21 | 广州医科大学附属第一医院 | 一种大鼠造影剂肾病模型的构建方法 |
| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| TW202132565A (zh) * | 2019-11-01 | 2021-09-01 | 美商聖加莫治療股份有限公司 | Ｇｉｎ重組酶變異體 |
| US12012433B1 (en) * | 2020-02-27 | 2024-06-18 | Integrated Dna Technologies Inc. | Expression and purification of Cas enzymes |
| EP4143324A2 (en) | 2020-05-01 | 2023-03-08 | Integrated DNA Technologies, Inc. | Lachnospiraceae sp cas12a mutants with enhanced cleavage activity at non-canonical tttt protospacer adjacent motifs |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| WO2022016118A2 (en) * | 2020-07-17 | 2022-01-20 | Cb Therapeutics, Inc. | Prenyltransferase enzymes |
| KR102265501B1 (ko) * | 2020-12-17 | 2021-06-15 | 국립해양생물자원관 | 다중구리 산화효소 펩타이드를 포함하는 구리대사 관련 신경계 질환의 예방 또는 치료용 조성물 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0644936A1 (en) * | 1992-06-11 | 1995-03-29 | New York University | Chimeric receptor polypeptides, human h13 proteins and uses thereof |
| US20050084885A1 (en) | 1994-01-18 | 2005-04-21 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US7277941B2 (en) | 1998-03-11 | 2007-10-02 | Commvault Systems, Inc. | System and method for providing encryption in a storage network by storing a secured encryption key with encrypted archive data in an archive storage device |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| EP1181359A1 (en) | 1999-05-28 | 2002-02-27 | Sangamo Biosciences Inc. | Gene switches |
| AU776576B2 (en) | 1999-12-06 | 2004-09-16 | Sangamo Biosciences, Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
| US7026462B2 (en) | 2000-12-07 | 2006-04-11 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| CA2435394C (en) | 2001-01-22 | 2018-01-09 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
| US7067617B2 (en) | 2001-02-21 | 2006-06-27 | The Scripps Research Institute | Zinc finger binding domains for nucleotide sequence ANN |
| JP2005500061A (ja) | 2001-08-20 | 2005-01-06 | ザ スクリップス リサーチ インスティテュート | Ｃｎｎについての亜鉛フィンガー結合ドメイン |
| US20060078880A1 (en) | 2002-02-07 | 2006-04-13 | The Scripps Research Institute | Zinc finger libraries |
| US20060211846A1 (en) | 2002-02-13 | 2006-09-21 | Barbas Carlos F Iii | Zinc finger binding domains for nucleotide sequence ANN |
| KR20090031938A (ko) * | 2006-07-05 | 2009-03-30 | 더 스크립스 리서치 인스티튜트 | 방향성 진화로 촉매 작용을 최적화시킨 키메라 징크 핑거 리컴비나제 |
| CA2783351C (en) * | 2009-12-10 | 2021-09-07 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| CA2798988C (en) * | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
| AU2010360293B2 (en) * | 2010-09-06 | 2016-06-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between Xa10 and AvrXa10 |
| US9499592B2 (en) * | 2011-01-26 | 2016-11-22 | President And Fellows Of Harvard College | Transcription activator-like effectors |
| HK1200871A1 (en) * | 2011-11-16 | 2015-08-14 | Sangamo Therapeutics, Inc. | Modified dna-binding proteins and uses thereof |
| US9688997B2 (en) * | 2011-12-29 | 2017-06-27 | Iowa State University Research Foundation, Inc. | Genetically modified plants with resistance to Xanthomonas and other bacterial plant pathogens |
| US9902962B2 (en) * | 2012-09-04 | 2018-02-27 | The Scripps Research Institute | Chimeric polypeptides having targeted binding specificity |
-
2013
- 2013-09-04 US US14/425,944 patent/US9902962B2/en active Active
- 2013-09-04 SG SG11201501525QA patent/SG11201501525QA/en unknown
- 2013-09-04 EP EP13834893.3A patent/EP2893022B1/en active Active
- 2013-09-04 AU AU2013312801A patent/AU2013312801B2/en not_active Revoked
- 2013-09-04 CN CN201380057657.5A patent/CN104781404B/zh active Active
- 2013-09-04 DK DK13834893.3T patent/DK2893022T3/da active
- 2013-09-04 BR BR112015004696-7A patent/BR112015004696B1/pt active IP Right Grant
- 2013-09-04 KR KR1020157008001A patent/KR102201867B1/ko active Active
- 2013-09-04 EP EP22181257.1A patent/EP4148134A1/en active Pending
- 2013-09-04 WO PCT/US2013/058100 patent/WO2014039585A2/en not_active Ceased
- 2013-09-04 EP EP20167774.7A patent/EP3750999B1/en active Active
- 2013-09-04 CN CN201811108126.5A patent/CN109517068B/zh active Active
- 2013-09-04 CA CA2883511A patent/CA2883511C/en active Active
- 2013-09-04 KR KR1020217000390A patent/KR102357105B1/ko active Active
- 2013-09-04 JP JP2015530154A patent/JP6442406B2/ja active Active
- 2013-09-04 SG SG10201701675PA patent/SG10201701675PA/en unknown
- 2013-09-04 KR KR1020227002477A patent/KR102596125B1/ko active Active
-
2015
- 2015-02-26 IL IL23744215A patent/IL237442B/en active IP Right Grant
-
2018
- 2018-01-23 US US15/878,043 patent/US10829766B2/en active Active
- 2018-08-02 JP JP2018146232A patent/JP6728283B2/ja active Active
-
2019
- 2019-02-08 AU AU2019200922A patent/AU2019200922B2/en active Active
-
2020
- 2020-07-01 JP JP2020114229A patent/JP7100681B2/ja active Active
- 2020-09-24 US US17/031,149 patent/US11466277B2/en active Active
-
2021
- 2021-09-30 AU AU2021240252A patent/AU2021240252B2/en active Active
-
2022
- 2022-07-01 JP JP2022106801A patent/JP7459174B2/ja active Active
- 2022-09-23 US US17/951,849 patent/US20230304022A1/en active Pending
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