IL237442B - Chimeric polypeptides with targeted binding specificity - Google Patents
Chimeric polypeptides with targeted binding specificityInfo
- Publication number
- IL237442B IL237442B IL23744215A IL23744215A IL237442B IL 237442 B IL237442 B IL 237442B IL 23744215 A IL23744215 A IL 23744215A IL 23744215 A IL23744215 A IL 23744215A IL 237442 B IL237442 B IL 237442B
- Authority
- IL
- Israel
- Prior art keywords
- binding specificity
- chimeric polypeptides
- targeted binding
- targeted
- chimeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Environmental Sciences (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696689P | 2012-09-04 | 2012-09-04 | |
| US201361753763P | 2013-01-17 | 2013-01-17 | |
| US201361818364P | 2013-05-01 | 2013-05-01 | |
| PCT/US2013/058100 WO2014039585A2 (en) | 2012-09-04 | 2013-09-04 | Chimeric polypeptides having targeted binding specificity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL237442A0 IL237442A0 (en) | 2015-04-30 |
| IL237442B true IL237442B (en) | 2019-11-28 |
Family
ID=50237752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL23744215A IL237442B (en) | 2012-09-04 | 2015-02-26 | Chimeric polypeptides with targeted binding specificity |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9902962B2 (enExample) |
| EP (3) | EP2893022B1 (enExample) |
| JP (4) | JP6442406B2 (enExample) |
| KR (3) | KR102201867B1 (enExample) |
| CN (2) | CN104781404B (enExample) |
| AU (3) | AU2013312801B2 (enExample) |
| BR (1) | BR112015004696B1 (enExample) |
| CA (1) | CA2883511C (enExample) |
| DK (1) | DK2893022T3 (enExample) |
| IL (1) | IL237442B (enExample) |
| SG (2) | SG11201501525QA (enExample) |
| WO (1) | WO2014039585A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA3059768A1 (en) | 2008-09-05 | 2010-03-11 | President And Fellows Of Harvard College | Continuous directed evolution of proteins and nucleic acids |
| JP6088438B2 (ja) | 2010-12-22 | 2017-03-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 連続的定向進化 |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9902962B2 (en) * | 2012-09-04 | 2018-02-27 | The Scripps Research Institute | Chimeric polypeptides having targeted binding specificity |
| US9708589B2 (en) * | 2012-12-18 | 2017-07-18 | Monsanto Technology Llc | Compositions and methods for custom site-specific DNA recombinases |
| US10793867B2 (en) | 2013-03-15 | 2020-10-06 | Monsanto Technology, Llc | Methods for targeted transgene-integration using custom site-specific DNA recombinases |
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| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
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| JP6796773B2 (ja) | 2014-07-30 | 2020-12-09 | ツムトー バイオロジクス、インコーポレイテッド | 非フコシル化タンパク質および方法 |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
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| WO2017015545A1 (en) * | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
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| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
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| KR102265501B1 (ko) * | 2020-12-17 | 2021-06-15 | 국립해양생물자원관 | 다중구리 산화효소 펩타이드를 포함하는 구리대사 관련 신경계 질환의 예방 또는 치료용 조성물 |
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| EP0644936A1 (en) * | 1992-06-11 | 1995-03-29 | New York University | Chimeric receptor polypeptides, human h13 proteins and uses thereof |
| US20050084885A1 (en) | 1994-01-18 | 2005-04-21 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
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| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
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| US20060078880A1 (en) | 2002-02-07 | 2006-04-13 | The Scripps Research Institute | Zinc finger libraries |
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| CA2783351C (en) * | 2009-12-10 | 2021-09-07 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| CA2798988C (en) * | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
| AU2010360293B2 (en) * | 2010-09-06 | 2016-06-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between Xa10 and AvrXa10 |
| US9499592B2 (en) * | 2011-01-26 | 2016-11-22 | President And Fellows Of Harvard College | Transcription activator-like effectors |
| HK1200871A1 (en) * | 2011-11-16 | 2015-08-14 | Sangamo Therapeutics, Inc. | Modified dna-binding proteins and uses thereof |
| US9688997B2 (en) * | 2011-12-29 | 2017-06-27 | Iowa State University Research Foundation, Inc. | Genetically modified plants with resistance to Xanthomonas and other bacterial plant pathogens |
| US9902962B2 (en) * | 2012-09-04 | 2018-02-27 | The Scripps Research Institute | Chimeric polypeptides having targeted binding specificity |
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2013
- 2013-09-04 US US14/425,944 patent/US9902962B2/en active Active
- 2013-09-04 SG SG11201501525QA patent/SG11201501525QA/en unknown
- 2013-09-04 EP EP13834893.3A patent/EP2893022B1/en active Active
- 2013-09-04 AU AU2013312801A patent/AU2013312801B2/en not_active Revoked
- 2013-09-04 CN CN201380057657.5A patent/CN104781404B/zh active Active
- 2013-09-04 DK DK13834893.3T patent/DK2893022T3/da active
- 2013-09-04 BR BR112015004696-7A patent/BR112015004696B1/pt active IP Right Grant
- 2013-09-04 KR KR1020157008001A patent/KR102201867B1/ko active Active
- 2013-09-04 EP EP22181257.1A patent/EP4148134A1/en active Pending
- 2013-09-04 WO PCT/US2013/058100 patent/WO2014039585A2/en not_active Ceased
- 2013-09-04 EP EP20167774.7A patent/EP3750999B1/en active Active
- 2013-09-04 CN CN201811108126.5A patent/CN109517068B/zh active Active
- 2013-09-04 CA CA2883511A patent/CA2883511C/en active Active
- 2013-09-04 KR KR1020217000390A patent/KR102357105B1/ko active Active
- 2013-09-04 JP JP2015530154A patent/JP6442406B2/ja active Active
- 2013-09-04 SG SG10201701675PA patent/SG10201701675PA/en unknown
- 2013-09-04 KR KR1020227002477A patent/KR102596125B1/ko active Active
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2015
- 2015-02-26 IL IL23744215A patent/IL237442B/en active IP Right Grant
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2018
- 2018-01-23 US US15/878,043 patent/US10829766B2/en active Active
- 2018-08-02 JP JP2018146232A patent/JP6728283B2/ja active Active
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2019
- 2019-02-08 AU AU2019200922A patent/AU2019200922B2/en active Active
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2020
- 2020-07-01 JP JP2020114229A patent/JP7100681B2/ja active Active
- 2020-09-24 US US17/031,149 patent/US11466277B2/en active Active
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2021
- 2021-09-30 AU AU2021240252A patent/AU2021240252B2/en active Active
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2022
- 2022-07-01 JP JP2022106801A patent/JP7459174B2/ja active Active
- 2022-09-23 US US17/951,849 patent/US20230304022A1/en active Pending
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Legal Events
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|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |