AU2013312801B2 - Chimeric polypeptides having targeted binding specificity - Google Patents

Chimeric polypeptides having targeted binding specificity Download PDF

Info

Publication number
AU2013312801B2
AU2013312801B2 AU2013312801A AU2013312801A AU2013312801B2 AU 2013312801 B2 AU2013312801 B2 AU 2013312801B2 AU 2013312801 A AU2013312801 A AU 2013312801A AU 2013312801 A AU2013312801 A AU 2013312801A AU 2013312801 B2 AU2013312801 B2 AU 2013312801B2
Authority
AU
Australia
Prior art keywords
leu
ala
val
gly
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
AU2013312801A
Other languages
English (en)
Other versions
AU2013312801A1 (en
Inventor
Carlos F. Barbas Iii
Thomas GAJ
Brian M. Lamb
Andrew Mercer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of AU2013312801A1 publication Critical patent/AU2013312801A1/en
Application granted granted Critical
Publication of AU2013312801B2 publication Critical patent/AU2013312801B2/en
Priority to AU2019200922A priority Critical patent/AU2019200922B2/en
Priority to AU2021240252A priority patent/AU2021240252B2/en
Revoked legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013312801A 2012-09-04 2013-09-04 Chimeric polypeptides having targeted binding specificity Revoked AU2013312801B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2019200922A AU2019200922B2 (en) 2012-09-04 2019-02-08 Chimeric polypeptides having targeted binding specificity
AU2021240252A AU2021240252B2 (en) 2012-09-04 2021-09-30 Chimeric polypeptides having targeted binding specificity

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261696689P 2012-09-04 2012-09-04
US61/696,689 2012-09-04
US201361753763P 2013-01-17 2013-01-17
US61/753,763 2013-01-17
US201361818364P 2013-05-01 2013-05-01
US61/818,364 2013-05-01
PCT/US2013/058100 WO2014039585A2 (en) 2012-09-04 2013-09-04 Chimeric polypeptides having targeted binding specificity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019200922A Division AU2019200922B2 (en) 2012-09-04 2019-02-08 Chimeric polypeptides having targeted binding specificity

Publications (2)

Publication Number Publication Date
AU2013312801A1 AU2013312801A1 (en) 2015-03-26
AU2013312801B2 true AU2013312801B2 (en) 2018-11-15

Family

ID=50237752

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2013312801A Revoked AU2013312801B2 (en) 2012-09-04 2013-09-04 Chimeric polypeptides having targeted binding specificity
AU2019200922A Active AU2019200922B2 (en) 2012-09-04 2019-02-08 Chimeric polypeptides having targeted binding specificity
AU2021240252A Active AU2021240252B2 (en) 2012-09-04 2021-09-30 Chimeric polypeptides having targeted binding specificity

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2019200922A Active AU2019200922B2 (en) 2012-09-04 2019-02-08 Chimeric polypeptides having targeted binding specificity
AU2021240252A Active AU2021240252B2 (en) 2012-09-04 2021-09-30 Chimeric polypeptides having targeted binding specificity

Country Status (12)

Country Link
US (4) US9902962B2 (enExample)
EP (3) EP2893022B1 (enExample)
JP (4) JP6442406B2 (enExample)
KR (3) KR102201867B1 (enExample)
CN (2) CN109517068B (enExample)
AU (3) AU2013312801B2 (enExample)
BR (1) BR112015004696B1 (enExample)
CA (1) CA2883511C (enExample)
DK (1) DK2893022T3 (enExample)
IL (1) IL237442B (enExample)
SG (2) SG10201701675PA (enExample)
WO (1) WO2014039585A2 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5723774B2 (ja) 2008-09-05 2015-05-27 プレジデント アンド フェローズ オブ ハーバード カレッジ タンパク質および核酸の連続的指向性進化
CA2825370A1 (en) 2010-12-22 2012-06-28 President And Fellows Of Harvard College Continuous directed evolution
WO2013066438A2 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
KR102201867B1 (ko) 2012-09-04 2021-01-12 더 스크립스 리서치 인스티튜트 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들
US9708589B2 (en) 2012-12-18 2017-07-18 Monsanto Technology Llc Compositions and methods for custom site-specific DNA recombinases
US10793867B2 (en) 2013-03-15 2020-10-06 Monsanto Technology, Llc Methods for targeted transgene-integration using custom site-specific DNA recombinases
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
US20150166984A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting alpha-antitrypsin point mutations
EP3097196B1 (en) 2014-01-20 2019-09-11 President and Fellows of Harvard College Negative selection and stringency modulation in continuous evolution systems
WO2015153889A2 (en) 2014-04-02 2015-10-08 University Of Florida Research Foundation, Incorporated Materials and methods for the treatment of latent viral infection
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
JP6796773B2 (ja) * 2014-07-30 2020-12-09 ツムトー バイオロジクス、インコーポレイテッド 非フコシル化タンパク質および方法
WO2016077052A2 (en) 2014-10-22 2016-05-19 President And Fellows Of Harvard College Evolution of proteases
US11299729B2 (en) 2015-04-17 2022-04-12 President And Fellows Of Harvard College Vector-based mutagenesis system
WO2017015545A1 (en) 2015-07-22 2017-01-26 President And Fellows Of Harvard College Evolution of site-specific recombinases
WO2017015559A2 (en) 2015-07-23 2017-01-26 President And Fellows Of Harvard College Evolution of bt toxins
WO2017019895A1 (en) 2015-07-30 2017-02-02 President And Fellows Of Harvard College Evolution of talens
CN107922953B (zh) * 2015-08-20 2022-03-04 应用干细胞有限公司 提高基因编辑效率的核酸酶
SG10202104041PA (en) 2015-10-23 2021-06-29 Harvard College Nucleobase editors and uses thereof
KR20250103795A (ko) 2016-08-03 2025-07-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
SG11201903089RA (en) 2016-10-14 2019-05-30 Harvard College Aav delivery of nucleobase editors
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
EP3592381A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Cancer vaccine
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
WO2018165629A1 (en) 2017-03-10 2018-09-13 President And Fellows Of Harvard College Cytosine to guanine base editor
WO2018176009A1 (en) 2017-03-23 2018-09-27 President And Fellows Of Harvard College Nucleobase editors comprising nucleic acid programmable dna binding proteins
WO2018187796A1 (en) * 2017-04-07 2018-10-11 Donald Danforth Plant Science Center Methods for increasing resistance to cotton bacterial blight and plants produced thereby
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
WO2019010164A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College Evolution of trna synthetases
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
WO2019040935A1 (en) 2017-08-25 2019-02-28 President And Fellows Of Harvard College EVOLUTION OF PEPTIDASES BONT
EP3676376B1 (en) 2017-08-30 2025-01-15 President and Fellows of Harvard College High efficiency base editors comprising gam
WO2019056002A1 (en) 2017-09-18 2019-03-21 President And Fellows Of Harvard College CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS
US11795443B2 (en) 2017-10-16 2023-10-24 The Broad Institute, Inc. Uses of adenosine base editors
WO2019118949A1 (en) 2017-12-15 2019-06-20 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
US12312383B2 (en) 2018-04-18 2025-05-27 Altius Institute For Biomedical Sciences Animal pathogen-derived polypeptides and uses thereof for genetic engineering
US12157760B2 (en) 2018-05-23 2024-12-03 The Broad Institute, Inc. Base editors and uses thereof
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
WO2020006126A1 (en) 2018-06-27 2020-01-02 Altius Institute For Biomedical Sciences Nucleic acid binding domains and methods of use thereof
EP3820495A4 (en) 2018-07-09 2022-07-20 The Broad Institute Inc. RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
CN109771403A (zh) * 2019-01-24 2019-05-21 广州医科大学附属第一医院 一种大鼠造影剂肾病模型的构建方法
EP3942043A2 (en) 2019-03-19 2022-01-26 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
WO2020214842A1 (en) 2019-04-17 2020-10-22 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
TW202132565A (zh) * 2019-11-01 2021-09-01 美商聖加莫治療股份有限公司 Ｇｉｎ重組酶變異體
US12012433B1 (en) * 2020-02-27 2024-06-18 Integrated Dna Technologies Inc. Expression and purification of Cas enzymes
CA3176675A1 (en) 2020-05-01 2021-11-04 Integrated Dna Technologies, Inc. Lachnospiraceae sp. cas12a mutants with enhanced cleavage activity at non-canonical tttt protospacer adjacent motifs
BR112022022603A2 (pt) 2020-05-08 2023-01-17 Broad Inst Inc Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla
US20230313154A1 (en) * 2020-07-17 2023-10-05 Cb Therapeutics, Inc. Prenyltransferase enzymes
KR102265501B1 (ko) * 2020-12-17 2021-06-15 국립해양생물자원관 다중구리 산화효소 펩타이드를 포함하는 구리대사 관련 신경계 질환의 예방 또는 치료용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110301073A1 (en) * 2010-05-17 2011-12-08 Sangamo Biosciences, Inc. Novel DNA-binding proteins and uses thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4532293A (en) * 1992-06-11 1994-01-04 New York University Chimeric receptor polypeptides, human h13 proteins and uses thereof
US20050084885A1 (en) 1994-01-18 2005-04-21 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6242568B1 (en) 1994-01-18 2001-06-05 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
WO2000073434A1 (en) 1999-05-28 2000-12-07 Sangamo Biosciences, Inc. Gene switches
US7277941B2 (en) 1998-03-11 2007-10-02 Commvault Systems, Inc. System and method for providing encryption in a storage network by storing a secured encryption key with encrypted archive data in an archive storage device
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7013219B2 (en) 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
HK1049515B (en) 1999-12-06 2006-01-13 Sangamo Biosciences Inc. Methods of using randomized libraries of zinc finger proteins for the identification of gene function
AU2884102A (en) 2000-12-07 2002-06-18 Sangamo Biosciences Inc Regulation of angiogenesis with zinc finger proteins
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
CA2435394C (en) 2001-01-22 2018-01-09 Sangamo Biosciences, Inc. Modified zinc finger binding proteins
US7067617B2 (en) 2001-02-21 2006-06-27 The Scripps Research Institute Zinc finger binding domains for nucleotide sequence ANN
WO2003016496A2 (en) 2001-08-20 2003-02-27 The Scripps Research Institute Zinc finger binding domains for cnn
CA2475276A1 (en) 2002-02-07 2003-08-14 The Scripps Research Institute Zinc finger libraries
US20060211846A1 (en) 2002-02-13 2006-09-21 Barbas Carlos F Iii Zinc finger binding domains for nucleotide sequence ANN
WO2008006028A2 (en) 2006-07-05 2008-01-10 The Scripps Research Institute Chimeric zinc finger recombinases optimized for catalysis by directed evolution
NO2510096T3 (enExample) * 2009-12-10 2015-03-21
CN103210087B (zh) * 2010-09-06 2015-04-29 淡马锡生命科学研究院有限公司 Xa10与AvrXa10之间的分子相互作用
US9499592B2 (en) * 2011-01-26 2016-11-22 President And Fellows Of Harvard College Transcription activator-like effectors
HK1200871A1 (en) * 2011-11-16 2015-08-14 Sangamo Therapeutics, Inc. Modified dna-binding proteins and uses thereof
WO2013101877A2 (en) * 2011-12-29 2013-07-04 Iowa State University Research Foundation, Inc. Genetically modified plants with resistance to xanthomonas and other bacterial plant pathogens
KR102201867B1 (ko) * 2012-09-04 2021-01-12 더 스크립스 리서치 인스티튜트 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110301073A1 (en) * 2010-05-17 2011-12-08 Sangamo Biosciences, Inc. Novel DNA-binding proteins and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C. MUSSOLINO ET AL, "A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity", NUCLEIC ACIDS RESEARCH, (2011-08-03), vol. 39, no. 21, doi:10.1093/nar/gkr597, ISSN 0305-1048, pages 9283 - 9293 *

Also Published As

Publication number Publication date
BR112015004696B1 (pt) 2022-07-19
AU2021240252A1 (en) 2021-10-28
AU2019200922B2 (en) 2021-07-08
KR20150070120A (ko) 2015-06-24
IL237442A0 (en) 2015-04-30
SG10201701675PA (en) 2017-04-27
JP2018183180A (ja) 2018-11-22
CN109517068B (zh) 2023-07-25
KR102596125B1 (ko) 2023-10-30
JP7459174B2 (ja) 2024-04-01
CA2883511A1 (en) 2014-03-13
US20150284728A1 (en) 2015-10-08
EP4148134A1 (en) 2023-03-15
DK2893022T3 (da) 2020-07-27
AU2019200922A1 (en) 2019-02-28
US9902962B2 (en) 2018-02-27
JP6728283B2 (ja) 2020-07-22
EP2893022A2 (en) 2015-07-15
JP2022130649A (ja) 2022-09-06
KR102357105B1 (ko) 2022-02-08
US20230304022A1 (en) 2023-09-28
AU2021240252B2 (en) 2024-06-06
US11466277B2 (en) 2022-10-11
KR20210008437A (ko) 2021-01-21
CN104781404A (zh) 2015-07-15
JP2015532654A (ja) 2015-11-12
WO2014039585A2 (en) 2014-03-13
KR102201867B1 (ko) 2021-01-12
EP3750999A1 (en) 2020-12-16
IL237442B (en) 2019-11-28
US10829766B2 (en) 2020-11-10
EP2893022A4 (en) 2016-03-02
US20180230474A1 (en) 2018-08-16
KR20220016303A (ko) 2022-02-08
SG11201501525QA (en) 2015-03-30
JP2020178703A (ja) 2020-11-05
US20210147854A1 (en) 2021-05-20
EP2893022B1 (en) 2020-05-13
CA2883511C (en) 2024-05-07
CN104781404B (zh) 2018-10-26
WO2014039585A3 (en) 2014-05-22
JP7100681B2 (ja) 2022-07-13
AU2013312801A1 (en) 2015-03-26
EP3750999B1 (en) 2022-06-29
CN109517068A (zh) 2019-03-26
JP6442406B2 (ja) 2018-12-19
BR112015004696A2 (pt) 2017-11-21

Similar Documents

Publication Publication Date Title
AU2021240252B2 (en) Chimeric polypeptides having targeted binding specificity
US20240229077A1 (en) Methods and compositions for prime editing nucleotide sequences
US20210277366A1 (en) ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
AU2017378482A1 (en) Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
KR20220058579A (ko) 보편적 공여자 세포
KR20220052370A (ko) 보편적 공여자 세포
US11278570B2 (en) Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
HK40043614A (en) Chimeric polypeptides having targeted binding specificity
HK40043614B (en) Chimeric polypeptides having targeted binding specificity
HK40089287A (en) Chimeric polypeptides having targeted binding specificity
US8759089B2 (en) Methods and systems for high homologous recombination (“HR”) targeting efficiency

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MAK Offer to surrender letters patent
MAL Surrender and revocation of letters patent

Effective date: 20210923