KR102201867B1 - 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들 - Google Patents

표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들 Download PDF

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KR102201867B1
KR102201867B1 KR1020157008001A KR20157008001A KR102201867B1 KR 102201867 B1 KR102201867 B1 KR 102201867B1 KR 1020157008001 A KR1020157008001 A KR 1020157008001A KR 20157008001 A KR20157008001 A KR 20157008001A KR 102201867 B1 KR102201867 B1 KR 102201867B1
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3세 카를로스 에프. 바바스
앤드류 메르세르
브라이언 엠. 램
토마스 가이
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더 스크립스 리서치 인스티튜트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biodiversity & Conservation Biology (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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KR1020157008001A 2012-09-04 2013-09-04 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들 Active KR102201867B1 (ko)

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KR1020217000390A KR102357105B1 (ko) 2012-09-04 2013-09-04 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들

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US201261696689P 2012-09-04 2012-09-04
US61/696,689 2012-09-04
US201361753763P 2013-01-17 2013-01-17
US61/753,763 2013-01-17
US201361818364P 2013-05-01 2013-05-01
US61/818,364 2013-05-01
PCT/US2013/058100 WO2014039585A2 (en) 2012-09-04 2013-09-04 Chimeric polypeptides having targeted binding specificity

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KR1020227002477A Active KR102596125B1 (ko) 2012-09-04 2013-09-04 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들
KR1020217000390A Active KR102357105B1 (ko) 2012-09-04 2013-09-04 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들

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KR1020217000390A Active KR102357105B1 (ko) 2012-09-04 2013-09-04 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들

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US (4) US9902962B2 (enExample)
EP (3) EP4148134A1 (enExample)
JP (4) JP6442406B2 (enExample)
KR (3) KR102201867B1 (enExample)
CN (2) CN104781404B (enExample)
AU (3) AU2013312801B2 (enExample)
BR (1) BR112015004696B1 (enExample)
CA (1) CA2883511C (enExample)
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IL (1) IL237442B (enExample)
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CN109517068B (zh) 2023-07-25
WO2014039585A2 (en) 2014-03-13
KR102357105B1 (ko) 2022-02-08
EP2893022A4 (en) 2016-03-02
BR112015004696A2 (pt) 2017-11-21
KR102596125B1 (ko) 2023-10-30
KR20150070120A (ko) 2015-06-24
WO2014039585A3 (en) 2014-05-22
IL237442A0 (en) 2015-04-30
JP7100681B2 (ja) 2022-07-13
CN109517068A (zh) 2019-03-26
AU2013312801B2 (en) 2018-11-15
CN104781404A (zh) 2015-07-15
SG10201701675PA (en) 2017-04-27
KR20220016303A (ko) 2022-02-08
JP6728283B2 (ja) 2020-07-22
US20150284728A1 (en) 2015-10-08
JP2015532654A (ja) 2015-11-12
KR20210008437A (ko) 2021-01-21
AU2013312801A1 (en) 2015-03-26
AU2019200922A1 (en) 2019-02-28
EP3750999B1 (en) 2022-06-29
JP2020178703A (ja) 2020-11-05
EP4148134A1 (en) 2023-03-15
JP7459174B2 (ja) 2024-04-01
US12662677B2 (en) 2026-06-23
AU2021240252B2 (en) 2024-06-06
US20230304022A1 (en) 2023-09-28
BR112015004696B1 (pt) 2022-07-19
CA2883511C (en) 2024-05-07
SG11201501525QA (en) 2015-03-30
EP2893022B1 (en) 2020-05-13
JP2018183180A (ja) 2018-11-22
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US20180230474A1 (en) 2018-08-16
DK2893022T3 (da) 2020-07-27
US20210147854A1 (en) 2021-05-20
CA2883511A1 (en) 2014-03-13
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AU2019200922B2 (en) 2021-07-08
JP6442406B2 (ja) 2018-12-19
US9902962B2 (en) 2018-02-27
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IL237442B (en) 2019-11-28
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