JP2018183180A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018183180A5 JP2018183180A5 JP2018146232A JP2018146232A JP2018183180A5 JP 2018183180 A5 JP2018183180 A5 JP 2018183180A5 JP 2018146232 A JP2018146232 A JP 2018146232A JP 2018146232 A JP2018146232 A JP 2018146232A JP 2018183180 A5 JP2018183180 A5 JP 2018183180A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- tale
- seq
- polypeptide
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000018120 Recombinases Human genes 0.000 claims description 77
- 108010091086 Recombinases Proteins 0.000 claims description 77
- 108090000623 proteins and genes Proteins 0.000 claims description 63
- 102000004169 proteins and genes Human genes 0.000 claims description 59
- 108020004707 nucleic acids Proteins 0.000 claims description 37
- 102000039446 nucleic acids Human genes 0.000 claims description 37
- 150000007523 nucleic acids Chemical class 0.000 claims description 37
- 102000037865 fusion proteins Human genes 0.000 claims description 36
- 108020001507 fusion proteins Proteins 0.000 claims description 36
- 229920001184 polypeptide Polymers 0.000 claims description 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 230000014509 gene expression Effects 0.000 claims description 14
- 239000012636 effector Substances 0.000 claims description 11
- 230000002103 transcriptional effect Effects 0.000 claims description 11
- 210000004899 c-terminal region Anatomy 0.000 claims description 10
- 230000006798 recombination Effects 0.000 claims description 10
- 238000005215 recombination Methods 0.000 claims description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 230000035772 mutation Effects 0.000 claims description 9
- 101710163270 Nuclease Proteins 0.000 claims description 7
- 125000000539 amino acid group Chemical group 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 7
- 241000232299 Ralstonia Species 0.000 claims description 4
- 230000010354 integration Effects 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108091023040 Transcription factor Proteins 0.000 claims description 2
- 102000040945 Transcription factor Human genes 0.000 claims description 2
- 102000008300 Mutant Proteins Human genes 0.000 claims 8
- 108010021466 Mutant Proteins Proteins 0.000 claims 8
- 108010073062 Transcription Activator-Like Effectors Proteins 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 54
- 241000187432 Streptomyces coelicolor Species 0.000 description 21
- 210000000349 chromosome Anatomy 0.000 description 20
- 230000003197 catalytic effect Effects 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 7
- 241000187747 Streptomyces Species 0.000 description 6
- 201000008827 tuberculosis Diseases 0.000 description 6
- 239000003937 drug carrier Substances 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 241000701950 Bacillus phage phi105 Species 0.000 description 3
- 241000935762 Bacillus virus SPbeta Species 0.000 description 3
- 101100004560 Bacteroides fragilis ccrA gene Proteins 0.000 description 3
- 101100114777 Brucella suis biovar 1 (strain 1330) crcB2 gene Proteins 0.000 description 3
- 241001493117 Lactococcus phage TP901-1 Species 0.000 description 3
- 241000186781 Listeria Species 0.000 description 3
- 241000123765 Listeria phage A118 Species 0.000 description 3
- 241000193996 Streptococcus pyogenes Species 0.000 description 3
- 241001263399 Streptococcus pyogenes phage Species 0.000 description 3
- 241000701955 Streptomyces virus phiC31 Species 0.000 description 3
- 238000001415 gene therapy Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000002708 random mutagenesis Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696689P | 2012-09-04 | 2012-09-04 | |
| US61/696,689 | 2012-09-04 | ||
| US201361753763P | 2013-01-17 | 2013-01-17 | |
| US61/753,763 | 2013-01-17 | ||
| US201361818364P | 2013-05-01 | 2013-05-01 | |
| US61/818,364 | 2013-05-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Division JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114229A Division JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018183180A JP2018183180A (ja) | 2018-11-22 |
| JP2018183180A5 true JP2018183180A5 (enExample) | 2019-02-21 |
| JP6728283B2 JP6728283B2 (ja) | 2020-07-22 |
Family
ID=50237752
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Active JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
| JP2018146232A Active JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Active JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9902962B2 (enExample) |
| EP (3) | EP2893022B1 (enExample) |
| JP (4) | JP6442406B2 (enExample) |
| KR (3) | KR102201867B1 (enExample) |
| CN (2) | CN104781404B (enExample) |
| AU (3) | AU2013312801B2 (enExample) |
| BR (1) | BR112015004696B1 (enExample) |
| CA (1) | CA2883511C (enExample) |
| DK (1) | DK2893022T3 (enExample) |
| IL (1) | IL237442B (enExample) |
| SG (2) | SG11201501525QA (enExample) |
| WO (1) | WO2014039585A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3059768A1 (en) | 2008-09-05 | 2010-03-11 | President And Fellows Of Harvard College | Continuous directed evolution of proteins and nucleic acids |
| JP6088438B2 (ja) | 2010-12-22 | 2017-03-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 連続的定向進化 |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9902962B2 (en) * | 2012-09-04 | 2018-02-27 | The Scripps Research Institute | Chimeric polypeptides having targeted binding specificity |
| US9708589B2 (en) * | 2012-12-18 | 2017-07-18 | Monsanto Technology Llc | Compositions and methods for custom site-specific DNA recombinases |
| US10793867B2 (en) | 2013-03-15 | 2020-10-06 | Monsanto Technology, Llc | Methods for targeted transgene-integration using custom site-specific DNA recombinases |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| WO2015134121A2 (en) | 2014-01-20 | 2015-09-11 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| US10507232B2 (en) | 2014-04-02 | 2019-12-17 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| JP6796773B2 (ja) | 2014-07-30 | 2020-12-09 | ツムトー バイオロジクス、インコーポレイテッド | 非フコシル化タンパク質および方法 |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2016077052A2 (en) | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
| US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) * | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| WO2017019895A1 (en) | 2015-07-30 | 2017-02-02 | President And Fellows Of Harvard College | Evolution of talens |
| US11339408B2 (en) | 2015-08-20 | 2022-05-24 | Applied Stemcell, Inc. | Nuclease with enhanced efficiency of genome editing |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CN109804066A (zh) * | 2016-08-09 | 2019-05-24 | 哈佛大学的校长及成员们 | 可编程cas9-重组酶融合蛋白及其用途 |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018187796A1 (en) * | 2017-04-07 | 2018-10-11 | Donald Danforth Plant Science Center | Methods for increasing resistance to cotton bacterial blight and plants produced thereby |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2019010164A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | Evolution of trna synthetases |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US12060553B2 (en) | 2017-08-25 | 2024-08-13 | President And Fellows Of Harvard College | Evolution of BoNT peptidases |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| WO2019056002A1 (en) | 2017-09-18 | 2019-03-21 | President And Fellows Of Harvard College | CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| EP3781193A4 (en) | 2018-04-18 | 2022-01-26 | Altius Institute For Biomedical Sciences | Animal pathogen-derived polypeptides and uses thereof for genetic engineering |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| US12264181B2 (en) | 2018-06-27 | 2025-04-01 | Altius Institute For Biomedical Sciences | Nucleic acid binding domains and methods of use thereof |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN109771403A (zh) * | 2019-01-24 | 2019-05-21 | 广州医科大学附属第一医院 | 一种大鼠造影剂肾病模型的构建方法 |
| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| TW202132565A (zh) * | 2019-11-01 | 2021-09-01 | 美商聖加莫治療股份有限公司 | Ｇｉｎ重組酶變異體 |
| US12012433B1 (en) * | 2020-02-27 | 2024-06-18 | Integrated Dna Technologies Inc. | Expression and purification of Cas enzymes |
| EP4143324A2 (en) | 2020-05-01 | 2023-03-08 | Integrated DNA Technologies, Inc. | Lachnospiraceae sp cas12a mutants with enhanced cleavage activity at non-canonical tttt protospacer adjacent motifs |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| WO2022016118A2 (en) * | 2020-07-17 | 2022-01-20 | Cb Therapeutics, Inc. | Prenyltransferase enzymes |
| KR102265501B1 (ko) * | 2020-12-17 | 2021-06-15 | 국립해양생물자원관 | 다중구리 산화효소 펩타이드를 포함하는 구리대사 관련 신경계 질환의 예방 또는 치료용 조성물 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0644936A1 (en) * | 1992-06-11 | 1995-03-29 | New York University | Chimeric receptor polypeptides, human h13 proteins and uses thereof |
| US20050084885A1 (en) | 1994-01-18 | 2005-04-21 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US7277941B2 (en) | 1998-03-11 | 2007-10-02 | Commvault Systems, Inc. | System and method for providing encryption in a storage network by storing a secured encryption key with encrypted archive data in an archive storage device |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| EP1181359A1 (en) | 1999-05-28 | 2002-02-27 | Sangamo Biosciences Inc. | Gene switches |
| AU776576B2 (en) | 1999-12-06 | 2004-09-16 | Sangamo Biosciences, Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
| US7026462B2 (en) | 2000-12-07 | 2006-04-11 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| CA2435394C (en) | 2001-01-22 | 2018-01-09 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
| US7067617B2 (en) | 2001-02-21 | 2006-06-27 | The Scripps Research Institute | Zinc finger binding domains for nucleotide sequence ANN |
| JP2005500061A (ja) | 2001-08-20 | 2005-01-06 | ザ スクリップス リサーチ インスティテュート | Ｃｎｎについての亜鉛フィンガー結合ドメイン |
| US20060078880A1 (en) | 2002-02-07 | 2006-04-13 | The Scripps Research Institute | Zinc finger libraries |
| US20060211846A1 (en) | 2002-02-13 | 2006-09-21 | Barbas Carlos F Iii | Zinc finger binding domains for nucleotide sequence ANN |
| KR20090031938A (ko) * | 2006-07-05 | 2009-03-30 | 더 스크립스 리서치 인스티튜트 | 방향성 진화로 촉매 작용을 최적화시킨 키메라 징크 핑거 리컴비나제 |
| CA2783351C (en) * | 2009-12-10 | 2021-09-07 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| CA2798988C (en) * | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
| AU2010360293B2 (en) * | 2010-09-06 | 2016-06-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between Xa10 and AvrXa10 |
| US9499592B2 (en) * | 2011-01-26 | 2016-11-22 | President And Fellows Of Harvard College | Transcription activator-like effectors |
| HK1200871A1 (en) * | 2011-11-16 | 2015-08-14 | Sangamo Therapeutics, Inc. | Modified dna-binding proteins and uses thereof |
| US9688997B2 (en) * | 2011-12-29 | 2017-06-27 | Iowa State University Research Foundation, Inc. | Genetically modified plants with resistance to Xanthomonas and other bacterial plant pathogens |
| US9902962B2 (en) * | 2012-09-04 | 2018-02-27 | The Scripps Research Institute | Chimeric polypeptides having targeted binding specificity |
-
2013
- 2013-09-04 US US14/425,944 patent/US9902962B2/en active Active
- 2013-09-04 SG SG11201501525QA patent/SG11201501525QA/en unknown
- 2013-09-04 EP EP13834893.3A patent/EP2893022B1/en active Active
- 2013-09-04 AU AU2013312801A patent/AU2013312801B2/en not_active Revoked
- 2013-09-04 CN CN201380057657.5A patent/CN104781404B/zh active Active
- 2013-09-04 DK DK13834893.3T patent/DK2893022T3/da active
- 2013-09-04 BR BR112015004696-7A patent/BR112015004696B1/pt active IP Right Grant
- 2013-09-04 KR KR1020157008001A patent/KR102201867B1/ko active Active
- 2013-09-04 EP EP22181257.1A patent/EP4148134A1/en active Pending
- 2013-09-04 WO PCT/US2013/058100 patent/WO2014039585A2/en not_active Ceased
- 2013-09-04 EP EP20167774.7A patent/EP3750999B1/en active Active
- 2013-09-04 CN CN201811108126.5A patent/CN109517068B/zh active Active
- 2013-09-04 CA CA2883511A patent/CA2883511C/en active Active
- 2013-09-04 KR KR1020217000390A patent/KR102357105B1/ko active Active
- 2013-09-04 JP JP2015530154A patent/JP6442406B2/ja active Active
- 2013-09-04 SG SG10201701675PA patent/SG10201701675PA/en unknown
- 2013-09-04 KR KR1020227002477A patent/KR102596125B1/ko active Active
-
2015
- 2015-02-26 IL IL23744215A patent/IL237442B/en active IP Right Grant
-
2018
- 2018-01-23 US US15/878,043 patent/US10829766B2/en active Active
- 2018-08-02 JP JP2018146232A patent/JP6728283B2/ja active Active
-
2019
- 2019-02-08 AU AU2019200922A patent/AU2019200922B2/en active Active
-
2020
- 2020-07-01 JP JP2020114229A patent/JP7100681B2/ja active Active
- 2020-09-24 US US17/031,149 patent/US11466277B2/en active Active
-
2021
- 2021-09-30 AU AU2021240252A patent/AU2021240252B2/en active Active
-
2022
- 2022-07-01 JP JP2022106801A patent/JP7459174B2/ja active Active
- 2022-09-23 US US17/951,849 patent/US20230304022A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018183180A5 (enExample) | ||
| US11332727B2 (en) | Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector | |
| JP6728283B2 (ja) | 標的結合特異性を有するキメラポリペプチド | |
| JP2020178703A5 (enExample) | ||
| JP2015532654A5 (enExample) | ||
| Chaconas et al. | Changing of the guard: How the Lyme disease spirochete subverts the host immune response | |
| Johnsen et al. | Engineering increased stability in the antimicrobial peptide pediocin PA-1 | |
| WO2017031483A1 (en) | Nuclease with enhanced efficiency of genome editing | |
| JP2009542228A5 (enExample) | ||
| JP2019500899A5 (enExample) | ||
| Bouvier et al. | Structural features of single-stranded integron cassette attC sites and their role in strand selection | |
| WO2019209914A2 (en) | Homology-directed repair template design and delivery to edit hemoglobin-related mutations | |
| Schwendener et al. | New transposon Tn 6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga (E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene | |
| JP2016165307A5 (enExample) | ||
| JP2011514144A5 (enExample) | ||
| JP2019524140A5 (enExample) | ||
| JP2021505201A5 (enExample) | ||
| Sørvig et al. | Plasmid p256 from Lactobacillus plantarum represents a new type of replicon in lactic acid bacteria, and contains a toxin–antitoxin-like plasmid maintenance system | |
| Subedi et al. | Sequence analysis reveals genetic exchanges and intraspecific spread of SaPI2, a pathogenicity island involved in menstrual toxic shock | |
| Zhang et al. | A simple, universal, efficient PCR-based gene synthesis method: sequential OE-PCR gene synthesis | |
| JP2003503355A5 (enExample) | ||
| Bourgoin et al. | Characterization of a mosaic ISS1 element and evidence for the recent horizontal transfer of two different types of ISS1 between Streptococcus thermophilus and Lactococcus lactis | |
| Manganelli et al. | Conjugative transposon Tn916: evidence for excision with formation of 5'-protruding termini | |
| Kazi et al. | Characterization of a novel theta-type plasmid pSM409 of Enterococcus faecium RME isolated from raw milk | |
| LaRoche-Johnston et al. | Recent horizontal transfer, functional adaptation and dissemination of a bacterial group II intron |