JP2019524140A5 - - Google Patents
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- Publication number
- JP2019524140A5 JP2019524140A5 JP2019507817A JP2019507817A JP2019524140A5 JP 2019524140 A5 JP2019524140 A5 JP 2019524140A5 JP 2019507817 A JP2019507817 A JP 2019507817A JP 2019507817 A JP2019507817 A JP 2019507817A JP 2019524140 A5 JP2019524140 A5 JP 2019524140A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- exon
- region
- dgkα
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims 49
- 210000002865 immune cell Anatomy 0.000 claims 20
- 150000007523 nucleic acids Chemical group 0.000 claims 19
- 230000000295 complement effect Effects 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 108091033409 CRISPR Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 238000000034 method Methods 0.000 claims 6
- 102100035102 E3 ubiquitin-protein ligase MYCBP2 Human genes 0.000 claims 4
- 230000004957 immunoregulator effect Effects 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 241000589875 Campylobacter jejuni Species 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 241000193996 Streptococcus pyogenes Species 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000001814 protein method Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023004738A JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2024089774A JP2024113020A (ja) | 2016-08-12 | 2024-06-03 | 操作された免疫調節エレメントおよび変更された免疫 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160103308 | 2016-08-12 | ||
| KR10-2016-0103308 | 2016-08-12 | ||
| US201762502822P | 2017-05-08 | 2017-05-08 | |
| US62/502,822 | 2017-05-08 | ||
| PCT/KR2017/008835 WO2018030874A1 (ko) | 2016-08-12 | 2017-08-14 | 조작된 면역조절요소 및 이에 의해 변형된 면역 활성 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023004738A Division JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524140A JP2019524140A (ja) | 2019-09-05 |
| JP2019524140A5 true JP2019524140A5 (enExample) | 2020-09-24 |
| JP7215808B2 JP7215808B2 (ja) | 2023-01-31 |
Family
ID=65438099
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507817A Active JP7215808B2 (ja) | 2016-08-12 | 2017-08-14 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2023004738A Pending JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2024089774A Pending JP2024113020A (ja) | 2016-08-12 | 2024-06-03 | 操作された免疫調節エレメントおよび変更された免疫 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023004738A Pending JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2024089774A Pending JP2024113020A (ja) | 2016-08-12 | 2024-06-03 | 操作された免疫調節エレメントおよび変更された免疫 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12012598B2 (enExample) |
| EP (1) | EP3498846B1 (enExample) |
| JP (3) | JP7215808B2 (enExample) |
| KR (1) | KR102276371B1 (enExample) |
| CN (1) | CN109844118B (enExample) |
| AU (1) | AU2017308473B2 (enExample) |
| BR (1) | BR112019002779A2 (enExample) |
| CA (1) | CA3033736C (enExample) |
| ES (1) | ES2998057T3 (enExample) |
| RU (2) | RU2767206C2 (enExample) |
| SG (1) | SG11201901184QA (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US12012598B2 (en) * | 2016-08-12 | 2024-06-18 | Toolgen Incorporated | Manipulated immunoregulatory element and immunity altered thereby |
| US12275963B2 (en) | 2017-05-08 | 2025-04-15 | Toolgen Incorporated | Artificially manipulated immune cell |
| CN107164377A (zh) * | 2017-06-12 | 2017-09-15 | 王小平 | 基于碱基编辑的基因敲除方法及其应用 |
| US11441135B2 (en) | 2017-07-07 | 2022-09-13 | Toolgen Incorporated | Target-specific CRISPR mutant |
| CN112040986A (zh) * | 2018-03-15 | 2020-12-04 | Ksq治疗公司 | 用于改进的免疫疗法的基因调控组合物和方法 |
| CN110904045A (zh) * | 2018-09-17 | 2020-03-24 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| CN111321171A (zh) * | 2018-12-14 | 2020-06-23 | 江苏集萃药康生物科技有限公司 | 一种应用CRISPR/Cas9介导ES打靶技术制备基因打靶动物模型的方法 |
| CN110373385A (zh) * | 2019-07-12 | 2019-10-25 | 赛德特生物科技开发有限公司 | 改善神经细胞功能的免疫细胞培养基及其制备方法与应用 |
| PH12022550548A1 (en) * | 2019-09-06 | 2023-11-20 | Crispr Therapeutics Ag | Genetically engineered t cells having improved persistence in culture |
| EP4501951A3 (en) * | 2020-08-25 | 2025-04-30 | Kite Pharma, Inc. | T cells with improved functionality |
| KR20240004245A (ko) * | 2021-02-10 | 2024-01-11 | 카테릭스 피티와이. 리미티드 | 기능이 향상된 줄기세포 유래 면역세포를 생성하는 방법 및 조성물 |
| CN114807044B (zh) * | 2021-04-30 | 2023-09-08 | 四川大学华西医院 | 一种具有高nkt细胞比例的car-cik细胞制备方法及应用 |
| CN115947865A (zh) * | 2021-09-18 | 2023-04-11 | 上海美丽人生医疗科技有限公司 | 一种嵌合抗原受体、表达构建物、car-t细胞及其应用 |
| CN115894706A (zh) * | 2021-09-30 | 2023-04-04 | 北京康辰药业股份有限公司 | 靶向PD-L1和FasL的融合蛋白、核苷酸序列及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050244851A1 (en) * | 2004-01-13 | 2005-11-03 | Affymetrix, Inc. | Methods of analysis of alternative splicing in human |
| US20050221354A1 (en) * | 2004-02-18 | 2005-10-06 | Wyeth | Nucleic acid arrays for monitoring expression profiles of drug target genes |
| US7901882B2 (en) * | 2006-03-31 | 2011-03-08 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
| CN102333277B (zh) | 2011-07-29 | 2014-08-06 | 上海合合信息科技发展有限公司 | 结合地理位置信息和蓝牙技术的电子名片传递方法及系统 |
| US20130129668A1 (en) * | 2011-09-01 | 2013-05-23 | The Regents Of The University Of California | Diagnosis and treatment of arthritis using epigenetics |
| ES2728782T3 (es) | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| WO2014039513A2 (en) * | 2012-09-04 | 2014-03-13 | The Trustees Of The University Of Pennsylvania | Inhibition of diacylglycerol kinase to augment adoptive t cell transfer |
| WO2014059173A2 (en) | 2012-10-10 | 2014-04-17 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| KR102955556B1 (ko) * | 2012-12-12 | 2026-04-22 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| CN105209621B (zh) * | 2012-12-12 | 2021-05-25 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| SG10201707569YA (en) * | 2012-12-12 | 2017-10-30 | Broad Inst Inc | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |
| MX380562B (es) | 2012-12-12 | 2025-03-12 | Broad Inst Inc | Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias. |
| US11311575B2 (en) * | 2013-05-13 | 2022-04-26 | Cellectis | Methods for engineering highly active T cell for immunotherapy |
| EP2997146A4 (en) | 2013-05-15 | 2017-04-26 | Sangamo BioSciences, Inc. | Methods and compositions for treatment of a genetic condition |
| JP6608807B2 (ja) | 2013-05-29 | 2019-11-20 | セレクティス | Ｒｎａガイドｃａｓヌクレアーゼ系を用いることによって免疫療法のためにｔ細胞を操作するための方法 |
| CA2912389C (en) * | 2013-06-10 | 2020-01-28 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Methods and compositions for reducing immunosupression by tumor cells |
| ES2918501T3 (es) | 2013-12-19 | 2022-07-18 | Novartis Ag | Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos |
| DK3105317T3 (en) | 2014-02-14 | 2019-01-14 | Cellectis | Immunotherapy cells that are genetically engineered to target antigen on both immune cells and pathological cells |
| CN122399016A (zh) * | 2014-03-15 | 2026-07-17 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| US10738278B2 (en) | 2014-07-15 | 2020-08-11 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| CN106536721B (zh) * | 2014-08-06 | 2020-12-04 | 车医科学大学校产学协力团 | 核酸酶介导的编辑编码hla的基因所产生的免疫相容性细胞 |
| KR102546296B1 (ko) | 2014-10-31 | 2023-06-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도 |
| JP6190995B2 (ja) | 2014-11-17 | 2017-09-06 | 国立大学法人 東京医科歯科大学 | 簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法 |
| US20190388469A1 (en) | 2015-01-30 | 2019-12-26 | The Regents Of The University Of California | Protein delivery in primary hematopoietic cells |
| CN107787367B (zh) * | 2015-04-06 | 2021-10-26 | 里兰斯坦福初级大学理事会 | 用于crispr/cas介导的基因调控的化学修饰的引导rna |
| WO2018030874A1 (ko) | 2016-08-12 | 2018-02-15 | 주식회사 툴젠 | 조작된 면역조절요소 및 이에 의해 변형된 면역 활성 |
| US12012598B2 (en) | 2016-08-12 | 2024-06-18 | Toolgen Incorporated | Manipulated immunoregulatory element and immunity altered thereby |
| WO2018068053A2 (en) | 2016-10-07 | 2018-04-12 | Integrated Dna Technologies, Inc. | S. pyogenes cas9 mutant genes and polypeptides encoded by same |
| EP3336107A1 (en) | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
| US12275963B2 (en) | 2017-05-08 | 2025-04-15 | Toolgen Incorporated | Artificially manipulated immune cell |
| US12467050B2 (en) | 2017-10-02 | 2025-11-11 | Georgia Tech Research Corporation | Methods and compositions for engineering synthetic bioswitches for remote control of biological activity |
| BR112020011223A2 (pt) | 2017-12-08 | 2020-11-17 | Juno Therapeutics Inc | marcadores fenotípicos para terapia celular e mé-todos relacionados |
| US12473533B2 (en) | 2018-07-09 | 2025-11-18 | The Regents Of The University Of California | Gene targets for T-cell-based immunotherapy |
-
2017
- 2017-08-14 US US16/324,955 patent/US12012598B2/en active Active
- 2017-08-14 EP EP17839891.3A patent/EP3498846B1/en active Active
- 2017-08-14 JP JP2019507817A patent/JP7215808B2/ja active Active
- 2017-08-14 AU AU2017308473A patent/AU2017308473B2/en active Active
- 2017-08-14 CN CN201780063250.1A patent/CN109844118B/zh active Active
- 2017-08-14 ES ES17839891T patent/ES2998057T3/es active Active
- 2017-08-14 RU RU2019106669A patent/RU2767206C2/ru active
- 2017-08-14 BR BR112019002779-3A patent/BR112019002779A2/pt not_active Application Discontinuation
- 2017-08-14 RU RU2022103870A patent/RU2022103870A/ru unknown
- 2017-08-14 CA CA3033736A patent/CA3033736C/en active Active
- 2017-08-14 SG SG11201901184QA patent/SG11201901184QA/en unknown
-
2019
- 2019-06-11 KR KR1020190068999A patent/KR102276371B1/ko active Active
-
2023
- 2023-01-16 JP JP2023004738A patent/JP2023052426A/ja active Pending
-
2024
- 2024-05-07 US US18/657,145 patent/US20240301424A1/en active Pending
- 2024-06-03 JP JP2024089774A patent/JP2024113020A/ja active Pending
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