|
WO2011140441A2
(en)
|
2010-05-06 |
2011-11-10 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
EP2689019A2
(en)
|
2011-03-23 |
2014-01-29 |
Pioneer Hi-Bred International Inc. |
Methods for producing a complex transgenic trait locus
|
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
EP3604555B1
(en)
|
2011-10-14 |
2024-12-25 |
President and Fellows of Harvard College |
Sequencing by structure assembly
|
|
WO2014163886A1
(en)
|
2013-03-12 |
2014-10-09 |
President And Fellows Of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
*
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
RU2645475C2
(ru)
|
2012-04-25 |
2018-02-21 |
Регенерон Фармасьютикалз, Инк. |
Опосредованное нуклеазой нацеливание с большими нацеливающими векторами
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
LT3401400T
(lt)
|
2012-05-25 |
2019-06-10 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui
|
|
US20150225734A1
(en)
|
2012-06-19 |
2015-08-13 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
CA2875618C
(en)
|
2012-07-11 |
2021-04-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for the treatment of lysosomal storage diseases
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
JP2015527889A
(ja)
*
|
2012-07-25 |
2015-09-24 |
ザ ブロード インスティテュート， インコーポレイテッド |
誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用
|
|
JP6367196B2
(ja)
|
2012-08-14 |
2018-08-01 |
テンエックス・ジェノミクス・インコーポレイテッド |
マイクロカプセル組成物および方法
|
|
US9951386B2
(en)
|
2014-06-26 |
2018-04-24 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
US10752949B2
(en)
|
2012-08-14 |
2020-08-25 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
US11591637B2
(en)
|
2012-08-14 |
2023-02-28 |
10X Genomics, Inc. |
Compositions and methods for sample processing
|
|
US9701998B2
(en)
|
2012-12-14 |
2017-07-11 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
US10584381B2
(en)
|
2012-08-14 |
2020-03-10 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
US10273541B2
(en)
|
2012-08-14 |
2019-04-30 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
US10323279B2
(en)
|
2012-08-14 |
2019-06-18 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
PL4397760T3
(pl)
|
2012-10-23 |
2026-03-30 |
Toolgen Incorporated |
Kompozycja do rozszczepiania docelowego dna zawierająca prowadzące rna specyficzne dla docelowego dna i kwas nukleinowy kodujący białko cas lub białko cas oraz jej zastosowanie
|
|
AU2013352156B2
(en)
|
2012-11-27 |
2018-12-06 |
Children's Medical Center Corporation |
Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
|
|
EP3135765A1
(en)
|
2012-12-06 |
2017-03-01 |
Sigma-Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP2896697B1
(en)
|
2012-12-12 |
2015-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
JP2016504026A
(ja)
*
|
2012-12-12 |
2016-02-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための系、方法および最適化ガイド組成物のエンジニアリング
|
|
IL239317B
(en)
|
2012-12-12 |
2022-07-01 |
Broad Inst Inc |
Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
CN114634950A
(zh)
|
2012-12-12 |
2022-06-17 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
EP3567116A1
(en)
|
2012-12-14 |
2019-11-13 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
US10533221B2
(en)
|
2012-12-14 |
2020-01-14 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
SG10201912991WA
(en)
*
|
2012-12-17 |
2020-03-30 |
Harvard College |
Rna-guided human genome engineering
|
|
EP3919505B1
(en)
|
2013-01-16 |
2023-08-30 |
Emory University |
Uses of cas9-nucleic acid complexes
|
|
KR102190198B1
(ko)
|
2013-02-08 |
2020-12-14 |
10엑스 제노믹스, 인크. |
폴리뉴클레오티드 바코드 생성
|
|
SG11201507378UA
(en)
|
2013-03-14 |
2015-10-29 |
Caribou Biosciences Inc |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US10378027B2
(en)
|
2013-03-15 |
2019-08-13 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US20140273235A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Regents Of The University Of Minnesota |
ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
JP2016522679A
(ja)
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用
|
|
DK2986729T3
(en)
|
2013-04-16 |
2018-10-29 |
Regeneron Pharma |
TARGETED MODIFICATION OF ROOT THROUGH
|
|
SG10201710030QA
(en)
|
2013-06-04 |
2018-01-30 |
Harvard College |
Rna-guided transcriptional regulation
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたＣＲＩＳＰＲ−Ｃａｓ二重ニッカーゼ系、方法および組成物
|
|
CN105793425B
(zh)
|
2013-06-17 |
2021-10-26 |
布罗德研究所有限公司 |
使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
MX2015017312A
(es)
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
EP3738545B1
(en)
|
2013-06-19 |
2023-11-29 |
Kolibree |
Toothbrush system with sensors for a dental hygiene monitoring system
|
|
JP2016528890A
(ja)
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ＣＲＩＳＰＲ／Ｃａｓ系を用いるゲノム編集の治療用の使用
|
|
HUE056760T2
(hu)
*
|
2013-07-11 |
2022-03-28 |
Modernatx Inc |
A CRISPR-hez kapcsolódó fehérjéket és a szintetikus SGRNS-ket kódoló szintetikus polinukleotidokat tartalmazó készítmények és felhasználási módjaik
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CA3221516A1
(en)
|
2013-08-22 |
2015-02-26 |
E. I. Du Pont De Nemours And Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
ES2844174T3
(es)
|
2013-09-18 |
2021-07-21 |
Kymab Ltd |
Métodos, células y organismos
|
|
WO2015054507A1
(en)
|
2013-10-10 |
2015-04-16 |
Pronutria, Inc. |
Nutritive polypeptide production systems, and methods of manufacture and use thereof
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
WO2015088643A1
(en)
|
2013-12-11 |
2015-06-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
RU2016128077A
(ru)
|
2013-12-12 |
2018-12-06 |
Те Брод Инститьют Инк. |
Доставка, применение и применения в терапии систем и композиций crispr-cas для лечения обусловленных hbv и вирусных заболеваний и нарушений
|
|
WO2015089427A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
CN111206032B
(zh)
|
2013-12-12 |
2024-07-19 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
BR112016013213A2
(pt)
|
2013-12-12 |
2017-12-05 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
EP4063503A1
(en)
|
2014-02-11 |
2022-09-28 |
The Regents of the University of Colorado, a body corporate |
Crispr enabled multiplexed genome engineering
|
|
EP3107999A4
(en)
|
2014-02-18 |
2017-10-04 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
EP3971283A1
(en)
|
2014-02-27 |
2022-03-23 |
Monsanto Technology LLC |
Compositions and methods for site directed genomic modification
|
|
WO2015130968A2
(en)
|
2014-02-27 |
2015-09-03 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
EP3115457B1
(en)
|
2014-03-05 |
2019-10-02 |
National University Corporation Kobe University |
Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
CA2948728A1
(en)
|
2014-03-10 |
2015-09-17 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
JP6815986B2
(ja)
|
2014-03-26 |
2021-01-20 |
ユニバーシティ オブ メリーランド， カレッジ パーク |
大型家畜の接合体における標的化ゲノム編集
|
|
WO2015148863A2
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3498845B1
(en)
*
|
2014-04-01 |
2022-06-22 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
|
|
EP3126495A1
(en)
|
2014-04-02 |
2017-02-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
CA2943624A1
(en)
|
2014-04-10 |
2015-10-15 |
10X Genomics, Inc. |
Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
|
|
ES2744186T3
(es)
|
2014-04-25 |
2020-02-24 |
Childrens Medical Center |
Composiciones y métodos para tratar las hemoglobinopatías
|
|
EP3712254A1
(en)
|
2014-05-28 |
2020-09-23 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into gastric tissues through directed differentiation
|
|
KR20170005494A
(ko)
|
2014-05-30 |
2017-01-13 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
잠복 바이러스 감염에 대한 치료제를 전달하는 조성물 및 방법
|
|
EP3154694B1
(en)
|
2014-06-13 |
2025-01-29 |
Children's Medical Center Corporation |
Products and methods to isolate mitochondria
|
|
EP3919621A1
(en)
|
2014-06-23 |
2021-12-08 |
The General Hospital Corporation |
Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
|
|
WO2015200555A2
(en)
*
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
WO2015200869A1
(en)
|
2014-06-26 |
2015-12-30 |
10X Genomics, Inc. |
Analysis of nucleic acid sequences
|
|
US12312640B2
(en)
|
2014-06-26 |
2025-05-27 |
10X Genomics, Inc. |
Analysis of nucleic acid sequences
|
|
EP4574974A3
(en)
|
2014-06-26 |
2025-10-08 |
10x Genomics, Inc. |
Methods of analyzing nucleic acids from individual cells or cell populations
|
|
CN106687594A
(zh)
|
2014-07-11 |
2017-05-17 |
纳幕尔杜邦公司 |
用于产生对草甘膦除草剂具有抗性的植物的组合物和方法
|
|
US10179932B2
(en)
|
2014-07-11 |
2019-01-15 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
CN104195177B
(zh)
*
|
2014-08-05 |
2017-06-09 |
南京大学 |
一种显著提高鱼类基因组编辑效率的方法
|
|
DK3180426T3
(da)
|
2014-08-17 |
2020-03-30 |
Broad Inst Inc |
Genomredigering ved anvendelse af cas9-nickaser
|
|
WO2016028887A1
(en)
|
2014-08-19 |
2016-02-25 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for enrichment of nucleic acids
|
|
CA2959070C
(en)
|
2014-08-27 |
2020-11-10 |
Caribou Biosciences, Inc. |
Methods for increasing cas9-mediated engineering efficiency
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
BR112017003757A2
(pt)
|
2014-09-12 |
2017-12-26 |
Du Pont |
?plantas de milho, partes de planta de milho ou sementes de milho?
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
US10040048B1
(en)
|
2014-09-25 |
2018-08-07 |
Synthego Corporation |
Automated modular system and method for production of biopolymers
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
WO2016069591A2
(en)
|
2014-10-27 |
2016-05-06 |
The Broad Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
US9975122B2
(en)
|
2014-11-05 |
2018-05-22 |
10X Genomics, Inc. |
Instrument systems for integrated sample processing
|
|
EP3215623A4
(en)
|
2014-11-06 |
2018-09-26 |
President and Fellows of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
WO2016073990A2
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
EP3218508A4
(en)
*
|
2014-11-10 |
2018-04-18 |
Modernatx, Inc. |
Multiparametric nucleic acid optimization
|
|
KR101833433B1
(ko)
*
|
2014-11-25 |
2018-02-28 |
한국생명공학연구원 |
돼지 t 세포 및 b 세포 면역결핍 세포주 생산 및 그의 제조 방법
|
|
US11168369B2
(en)
|
2014-11-25 |
2021-11-09 |
The Brigham And Women's Hospital, Inc. |
Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
EP3224362B1
(en)
|
2014-11-26 |
2024-09-25 |
The Regents of The University of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
WO2016089866A1
(en)
|
2014-12-01 |
2016-06-09 |
President And Fellows Of Harvard College |
Rna-guided systems for in vivo gene editing
|
|
WO2016089433A1
(en)
*
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
EP3229586B1
(en)
|
2014-12-10 |
2025-07-30 |
Regents of the University of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3230451B1
(en)
|
2014-12-12 |
2021-04-07 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
WO2016100951A2
(en)
*
|
2014-12-18 |
2016-06-23 |
Integrated Dna Technologies, Inc. |
Crispr-based compositions and methods of use
|
|
WO2016100974A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
EP3245232B1
(en)
|
2015-01-12 |
2021-04-21 |
The Regents of The University of California |
Heterodimeric cas9 and methods of use thereof
|
|
CN107427808B
(zh)
|
2015-01-12 |
2020-10-23 |
10X基因组学有限公司 |
用于制备核酸测序文库的方法和系统以及用其制备的文库
|
|
US11180792B2
(en)
|
2015-01-28 |
2021-11-23 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
SI3250691T1
(sl)
|
2015-01-28 |
2023-10-30 |
Caribou Biosciences, Inc. |
Hibridni dna/rna-polinukleotidi crispr in postopki za uporabo
|
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
|
EP3262173A2
(en)
|
2015-02-23 |
2018-01-03 |
Crispr Therapeutics AG |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
AU2016225179C1
(en)
|
2015-02-23 |
2022-11-03 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
EP3262407B1
(en)
|
2015-02-24 |
2023-08-30 |
10X Genomics, Inc. |
Partition processing methods and systems
|
|
WO2016138488A2
(en)
|
2015-02-26 |
2016-09-01 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
JP6871169B2
(ja)
|
2015-03-02 |
2021-05-12 |
シナイ ヘルス システム |
相同組換え因子
|
|
JP6817215B2
(ja)
|
2015-03-03 |
2021-01-20 |
ザ ジェネラル ホスピタル コーポレイション |
変更ＰＡＭ特異性を有する遺伝子操作ＣＲＩＳＰＲ−Ｃａｓ９ヌクレアーゼ
|
|
EP4019635A1
(en)
*
|
2015-03-25 |
2022-06-29 |
Editas Medicine, Inc. |
Crispr/cas-related methods, compositions and components
|
|
EP3553178A1
(en)
|
2015-03-27 |
2019-10-16 |
E. I. du Pont de Nemours and Company |
Soybean u6 small nuclear rna gene promoters and their use in constitutive expression of small rna genes in plants
|
|
KR102888521B1
(ko)
*
|
2015-04-06 |
2025-11-19 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
EP3286571B1
(en)
|
2015-04-24 |
2021-08-18 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
ES2835861T5
(en)
|
2015-05-08 |
2025-02-18 |
Childrens Medical Ct Corp |
Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction
|
|
CA2988854A1
(en)
|
2015-05-08 |
2016-11-17 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
EP3294896A1
(en)
|
2015-05-11 |
2018-03-21 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
EP3919622A1
(en)
|
2015-06-01 |
2021-12-08 |
Temple University - Of The Commonwealth System of Higher Education |
Methods and compositions for rna-guided treatment of hiv infection
|
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
|
EP3303634B1
(en)
|
2015-06-03 |
2023-08-30 |
The Regents of The University of California |
Cas9 variants and methods of use thereof
|
|
EP3302525A2
(en)
|
2015-06-05 |
2018-04-11 |
Novartis AG |
Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
|
|
KR102796744B1
(ko)
|
2015-06-09 |
2025-04-15 |
에디타스 메디신, 인코포레이티드 |
이식의 개선을 위한 crispr/cas-관련 방법 및 조성물
|
|
US20160362667A1
(en)
*
|
2015-06-10 |
2016-12-15 |
Caribou Biosciences, Inc. |
CRISPR-Cas Compositions and Methods
|
|
JP2018518182A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
ゲノム編集のためのｃｒｉｓｐｒ／ｃａｓ９複合体
|
|
CA2989858A1
(en)
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
EP3436575A1
(en)
|
2015-06-18 |
2019-02-06 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
AU2016279077A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
IL293323B2
(en)
|
2015-06-18 |
2024-01-01 |
Massachusetts Inst Technology |
Crispr enzyme mutations reducing off-target effects
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
WO2017004279A2
(en)
*
|
2015-06-29 |
2017-01-05 |
Massachusetts Institute Of Technology |
Compositions comprising nucleic acids and methods of using the same
|
|
GB2557123B
(en)
|
2015-07-31 |
2021-11-03 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
WO2017027810A2
(en)
|
2015-08-12 |
2017-02-16 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
|
US11214800B2
(en)
|
2015-08-18 |
2022-01-04 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
WO2017035416A2
(en)
*
|
2015-08-25 |
2017-03-02 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016316845B2
(en)
|
2015-08-28 |
2022-03-10 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
CN107922949A
(zh)
*
|
2015-08-31 |
2018-04-17 |
安捷伦科技有限公司 |
用于通过同源重组的基于crispr/cas的基因组编辑的化合物和方法
|
|
DK3348638T3
(da)
|
2015-09-09 |
2023-02-13 |
Univ Kobe Nat Univ Corp |
Fremgangsmåde til at konvertere genomsekvens fra gram-positiv bakterie ved specifikt at konvertere nukleinsyrebase i tilsigtet dna-sekvens, og molekylkompleks anvendt dertil
|
|
CN108350453A
(zh)
|
2015-09-11 |
2018-07-31 |
通用医疗公司 |
核酸酶dsb的完全查询和测序(find-seq)
|
|
SI3350333T1
(sl)
|
2015-09-17 |
2022-04-29 |
ModernaTX,Inc. |
Polinukleotidi, ki zajemajo stabilizacijsko repno regijo
|
|
WO2017048969A1
(en)
*
|
2015-09-17 |
2017-03-23 |
The Regents Of The University Of California |
Variant cas9 polypeptides comprising internal insertions
|
|
EP3353298B1
(en)
*
|
2015-09-21 |
2023-09-13 |
Arcturus Therapeutics, Inc. |
Allele selective gene editing and uses thereof
|
|
EP3353296B1
(en)
|
2015-09-24 |
2020-11-04 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
JP2018529353A
(ja)
|
2015-09-30 |
2018-10-11 |
ザ ジェネラル ホスピタル コーポレイション |
配列決定法による切断事象の包括的生体外報告（ＣＩＲＣＬＥ−ｓｅｑ）
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
EP4089175A1
(en)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
CN109153980B
(zh)
|
2015-10-22 |
2023-04-14 |
布罗德研究所有限公司 |
Vi-b型crispr酶和系统
|
|
EP3350327B1
(en)
|
2015-10-23 |
2018-09-26 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
SG10202104041PA
(en)
|
2015-10-23 |
2021-06-29 |
Harvard College |
Nucleobase editors and uses thereof
|
|
EP3368687B1
(en)
|
2015-10-27 |
2021-09-29 |
The Broad Institute, Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
EP3368689B1
(en)
|
2015-10-28 |
2020-06-17 |
The Broad Institute, Inc. |
Composition for modulating immune responses by use of immune cell gene signature
|
|
WO2017075265A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute, Inc. |
Multiplex analysis of single cell constituents
|
|
WO2017079406A1
(en)
|
2015-11-03 |
2017-05-11 |
President And Fellows Of Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
|
US12043843B2
(en)
|
2015-11-04 |
2024-07-23 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2017083852A1
(en)
|
2015-11-13 |
2017-05-18 |
MOORE, Tara |
Methods for the treatment of corneal dystrophies
|
|
EP3377042A4
(en)
|
2015-11-16 |
2019-05-29 |
The Research Institute at Nationwide Children's Hospital |
MATERIALS AND METHOD FOR THE TREATMENT OF TITIN-BASED MYOPATHIES AND OTHER TITINOPATHIES
|
|
WO2017087910A1
(en)
*
|
2015-11-19 |
2017-05-26 |
10X Genomics, Inc. |
Transformable tagging compositions, methods, and processes incorporating same
|
|
CA3005878A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
|
US11371094B2
(en)
|
2015-11-19 |
2022-06-28 |
10X Genomics, Inc. |
Systems and methods for nucleic acid processing using degenerate nucleotides
|
|
WO2017090761A1
(ja)
*
|
2015-11-27 |
2017-06-01 |
国立大学法人神戸大学 |
標的化したｄｎａ配列の核酸塩基を特異的に変換する、単子葉植物のゲノム配列の変換方法、及びそれに用いる分子複合体
|
|
WO2017095967A2
(en)
|
2015-11-30 |
2017-06-08 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
EP3383411B1
(en)
|
2015-11-30 |
2025-07-09 |
Sana Biotechnology, Inc. |
Sub-mitochondrial particles for use in treating metabolic conditions
|
|
SG10202108763UA
(en)
|
2015-12-04 |
2021-09-29 |
10X Genomics Inc |
Methods and compositions for nucleic acid analysis
|
|
DK3371310T3
(da)
*
|
2015-12-04 |
2019-08-05 |
Caribou Biosciences Inc |
Nucleinsyrekonstruerede targetnucleinsyrer
|
|
US9988624B2
(en)
|
2015-12-07 |
2018-06-05 |
Zymergen Inc. |
Microbial strain improvement by a HTP genomic engineering platform
|
|
US11208649B2
(en)
|
2015-12-07 |
2021-12-28 |
Zymergen Inc. |
HTP genomic engineering platform
|
|
CA3007635A1
(en)
|
2015-12-07 |
2017-06-15 |
Zymergen Inc. |
Promoters from corynebacterium glutamicum
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
WO2017106767A1
(en)
*
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
|
WO2017106569A1
(en)
*
|
2015-12-18 |
2017-06-22 |
The Regents Of The University Of California |
Modified site-directed modifying polypeptides and methods of use thereof
|
|
BR112018013074A2
(en)
|
2015-12-30 |
2018-12-11 |
Novartis Ag |
immune effector cell therapies with enhanced efficacy
|
|
MX2018008345A
(es)
|
2016-01-11 |
2018-12-06 |
Univ Leland Stanford Junior |
Proteínas quiméricas y métodos de inmunoterapia.
|
|
IL304088A
(en)
|
2016-01-11 |
2023-08-01 |
Univ Leland Stanford Junior |
Systems containing chimeric proteins and their uses for controlling gene expression
|
|
ES3057779T3
(en)
|
2016-01-15 |
2026-03-04 |
Childrens Medical Ct Corp |
Therapeutic use of mitochondria and combined mitochondrial agents
|
|
US11845933B2
(en)
*
|
2016-02-03 |
2023-12-19 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide RNA and its applications
|
|
WO2017139309A1
(en)
|
2016-02-12 |
2017-08-17 |
Ceres, Inc. |
Methods and materials for high throughput testing of mutagenized allele combinations
|
|
EP3417061B1
(en)
|
2016-02-18 |
2022-10-26 |
The Regents of the University of California |
Methods and compositions for gene editing in stem cells
|
|
EP3420102B1
(en)
|
2016-02-22 |
2024-04-03 |
Massachusetts Institute of Technology |
Methods for identifying and modulating immune phenotypes
|
|
CA3015665C
(en)
*
|
2016-02-26 |
2020-09-22 |
Lanzatech New Zealand Limited |
Crispr/cas systems for c1-fixing bacteria
|
|
WO2017152023A1
(en)
|
2016-03-04 |
2017-09-08 |
Indoor Biotechnologies Inc. |
Fel d 1 knockouts and associated compositions and methods based on crispr-cas9 genomic editing
|
|
WO2017161043A1
(en)
|
2016-03-16 |
2017-09-21 |
The J. David Gladstone Institutes |
Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US11427861B2
(en)
|
2016-03-17 |
2022-08-30 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
US12012436B2
(en)
|
2016-03-23 |
2024-06-18 |
The Regents Of The University Of California |
Methods of treating mitochondrial disorders
|
|
US12011488B2
(en)
|
2016-03-23 |
2024-06-18 |
The Regents Of The University Of California |
Methods of treating mitochondrial disorders
|
|
WO2017165859A1
(en)
*
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
US11597924B2
(en)
|
2016-03-25 |
2023-03-07 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
EP3443081A4
(en)
|
2016-04-13 |
2019-10-30 |
Duke University |
CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE
|
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
|
US20170298348A1
(en)
*
|
2016-04-14 |
2017-10-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genome editing of human neural stem cells using nucleases
|
|
SG11201810179RA
(en)
*
|
2016-04-19 |
2018-12-28 |
Broad Inst Inc |
Novel crispr enzymes and systems
|
|
AU2017253107B2
(en)
|
2016-04-19 |
2023-07-20 |
Massachusetts Institute Of Technology |
CPF1 complexes with reduced indel activity
|
|
AU2017257624B2
(en)
|
2016-04-25 |
2023-05-25 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
WO2017197343A2
(en)
|
2016-05-12 |
2017-11-16 |
10X Genomics, Inc. |
Microfluidic on-chip filters
|
|
WO2017197338A1
(en)
|
2016-05-13 |
2017-11-16 |
10X Genomics, Inc. |
Microfluidic systems and methods of use
|
|
US10767175B2
(en)
*
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US11788083B2
(en)
*
|
2016-06-17 |
2023-10-17 |
The Broad Institute, Inc. |
Type VI CRISPR orthologs and systems
|
|
ES2915562T3
(es)
|
2016-06-24 |
2022-06-23 |
Univ Colorado Regents |
Métodos para generar bibliotecas combinatorias con código de barras
|
|
US12385034B2
(en)
|
2016-06-24 |
2025-08-12 |
Modernatx, Inc. |
Methods and apparatus for filtration
|
|
WO2018005445A1
(en)
|
2016-06-27 |
2018-01-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting and treating diabetes
|
|
WO2018005589A1
(en)
|
2016-06-28 |
2018-01-04 |
Cellectis |
Altering expression of gene products in plants through targeted insertion of nucleic acid sequences
|
|
US12595478B2
(en)
|
2016-06-29 |
2026-04-07 |
The Broad Institute, Inc. |
Crispr-Cas systems having destabilization domain
|
|
WO2018005793A1
(en)
|
2016-06-30 |
2018-01-04 |
Zymergen Inc. |
Methods for generating a glucose permease library and uses thereof
|
|
JP2019519242A
(ja)
|
2016-06-30 |
2019-07-11 |
ザイマージェン インコーポレイテッド |
細菌ヘモグロビンライブラリーを生成するための方法およびその使用
|
|
EP3484870B1
(en)
|
2016-07-13 |
2022-11-16 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
CA3032822A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR20250103795A
(ko)
|
2016-08-03 |
2025-07-07 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
JP7215808B2
(ja)
|
2016-08-12 |
2023-01-31 |
ツールゲン インコーポレイテッド |
操作された免疫調節エレメントおよび変更された免疫
|
|
WO2018035364A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US11810649B2
(en)
|
2016-08-17 |
2023-11-07 |
The Broad Institute, Inc. |
Methods for identifying novel gene editing elements
|
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
EP3500677A4
(en)
|
2016-08-20 |
2020-04-01 |
Avellino Lab USA, Inc. |
Single guide rna, crispr/cas9 systems, and methods of use thereof
|
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
GB2569252A
(en)
|
2016-08-31 |
2019-06-12 |
Harvard College |
Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
JP7215994B2
(ja)
|
2016-09-06 |
2023-01-31 |
ザ チルドレンズ メディカル センター コーポレーション |
人工多能性幹細胞由来の免疫細胞
|
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
US11306305B2
(en)
|
2016-09-23 |
2022-04-19 |
Board Of Trustees Of Southern Illinois University |
Tuning CRISPR/Cas9 activity with chemically modified nucleotide substitutions
|
|
WO2018064208A1
(en)
|
2016-09-28 |
2018-04-05 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
JP2019532644A
(ja)
|
2016-09-30 |
2019-11-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｒｎａ誘導型核酸修飾酵素及びその使用方法
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
CA3039409A1
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
US11242542B2
(en)
|
2016-10-07 |
2022-02-08 |
Integrated Dna Technologies, Inc. |
S. pyogenes Cas9 mutant genes and polypeptides encoded by same
|
|
SG11201903089RA
(en)
|
2016-10-14 |
2019-05-30 |
Harvard College |
Aav delivery of nucleobase editors
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
GB2573406B
(en)
|
2016-10-18 |
2021-11-10 |
Univ Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
US20180245065A1
(en)
|
2016-11-01 |
2018-08-30 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
|
SG11201903697WA
(en)
|
2016-11-04 |
2019-05-30 |
Childrens Hospital Med Ct |
Liver organoid compositions and methods of making and using same
|
|
CA3042259A1
(en)
|
2016-11-04 |
2018-05-11 |
Flagship Pioneering Innovations V. Inc. |
Novel plant cells, plants, and seeds
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
AU2017364084B2
(en)
|
2016-11-22 |
2024-07-04 |
Integrated Dna Technologies, Inc. |
CRISPR/Cpf1 systems and methods
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
MY206324A
(en)
|
2016-12-08 |
2024-12-10 |
Intellia Therapeutics Inc |
Modified guide rnas
|
|
US12404514B2
(en)
|
2016-12-09 |
2025-09-02 |
The Broad Institute, Inc. |
CRISPR-systems for modifying a trait of interest in a plant
|
|
US11293022B2
(en)
|
2016-12-12 |
2022-04-05 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
|
US20180179553A1
(en)
|
2016-12-14 |
2018-06-28 |
Ligandal, Inc. |
Compositions and methods for nucleic acid and/or protein payload delivery
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
US10550429B2
(en)
|
2016-12-22 |
2020-02-04 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
CA3047163A1
(en)
|
2016-12-22 |
2018-06-28 |
Monsanto Technology Llc |
Genome editing-based crop engineering and production of brachytic plants
|
|
US10815525B2
(en)
|
2016-12-22 |
2020-10-27 |
10X Genomics, Inc. |
Methods and systems for processing polynucleotides
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
SG11201906795SA
(en)
|
2017-01-28 |
2019-08-27 |
Inari Agriculture Inc |
Novel plant cells, plants, and seeds
|
|
EP4310183B1
(en)
|
2017-01-30 |
2025-07-09 |
10X Genomics, Inc. |
Methods and systems for droplet-based single cell barcoding
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
US10995333B2
(en)
|
2017-02-06 |
2021-05-04 |
10X Genomics, Inc. |
Systems and methods for nucleic acid preparation
|
|
CA3049989A1
(en)
|
2017-02-10 |
2018-08-16 |
Zymergen Inc. |
A modular universal plasmid design strategy for the assembly and editing of multiple dna constructs for multiple hosts
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
EP3592381A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Cancer vaccine
|
|
WO2018165629A1
(en)
|
2017-03-10 |
2018-09-13 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
EP3596207B1
(en)
|
2017-03-15 |
2023-12-20 |
The Broad Institute, Inc. |
Novel cas13b orthologues crispr enzymes and systems
|
|
US12180546B2
(en)
|
2017-03-17 |
2024-12-31 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
US11913075B2
(en)
|
2017-04-01 |
2024-02-27 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
WO2018191558A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Modulation of epithelial cell differentiation, maintenance and/or function through t cell action, and markers and methods of use thereof
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
WO2018191520A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
EP3610009A1
(en)
|
2017-04-12 |
2020-02-19 |
The Broad Institute, Inc. |
Novel type vi crispr orthologs and systems
|
|
EP3609997A4
(en)
|
2017-04-14 |
2021-03-03 |
Children's Hospital Medical Center |
COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
|
|
US12350368B2
(en)
|
2017-04-14 |
2025-07-08 |
The Broad Institute, Inc. |
Delivery of large payloads
|
|
EP3612629A1
(en)
|
2017-04-18 |
2020-02-26 |
The Broad Institute, Inc. |
Compositions for detecting secretion and methods of use
|
|
EP3612023A4
(en)
|
2017-04-20 |
2021-05-12 |
Egenesis, Inc. |
METHOD FOR PRODUCING GENETICALLY MODIFIED ANIMALS
|
|
US12208140B2
(en)
|
2017-04-21 |
2025-01-28 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
ES2992912T3
(en)
|
2017-04-21 |
2024-12-19 |
Massachusetts Gen Hospital |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
WO2018204777A2
(en)
|
2017-05-05 |
2018-11-08 |
The Broad Institute, Inc. |
Methods for identification and modification of lncrna associated with target genotypes and phenotypes
|
|
CN110914431B
(zh)
*
|
2017-05-08 |
2024-04-19 |
株式会社图尔金 |
经人工操纵的免疫细胞
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
WO2019103857A1
(en)
|
2017-11-22 |
2019-05-31 |
Iovance Biotherapeutics, Inc. |
Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
|
|
WO2018209324A2
(en)
|
2017-05-11 |
2018-11-15 |
The Broad Institute, Inc. |
Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
WO2018213708A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US12297436B2
(en)
|
2017-05-18 |
2025-05-13 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
AU2018273986A1
(en)
|
2017-05-25 |
2019-12-12 |
The General Hospital Corporation |
Bipartite base editor (BBE) architectures and type-II-C-Cas9 zinc finger editing
|
|
US11788087B2
(en)
|
2017-05-25 |
2023-10-17 |
The Children's Medical Center Corporation |
BCL11A guide delivery
|
|
CN109526228B
(zh)
|
2017-05-26 |
2022-11-25 |
10X基因组学有限公司 |
转座酶可接近性染色质的单细胞分析
|
|
US10844372B2
(en)
|
2017-05-26 |
2020-11-24 |
10X Genomics, Inc. |
Single cell analysis of transposase accessible chromatin
|
|
EP3409104A1
(en)
|
2017-05-31 |
2018-12-05 |
Vilmorin et Cie |
Tomato plant resistant to tomato yellow leaf curl virus, powdery mildew, and nematodes
|
|
WO2020249996A1
(en)
|
2019-06-14 |
2020-12-17 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus
|
|
EP3409106A1
(en)
|
2017-06-01 |
2018-12-05 |
Vilmorin et Cie |
Tolerance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus (tbrfv)
|
|
AU2018280116B2
(en)
|
2017-06-05 |
2025-03-27 |
Research Institute At Nationwide Children's Hospital |
Enhanced modified viral capsid proteins
|
|
US11603544B2
(en)
|
2017-06-05 |
2023-03-14 |
Fred Hutchinson Cancer Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
|
KR20200026874A
(ko)
|
2017-06-06 |
2020-03-11 |
지머젠 인코포레이티드 |
대장균 개량을 위한 htp 게놈 공학 플랫폼
|
|
KR20200026878A
(ko)
|
2017-06-06 |
2020-03-11 |
지머젠 인코포레이티드 |
균류 균주를 개량하기 위한 htp 게놈 공학 플랫폼
|
|
JP7518620B2
(ja)
|
2017-06-09 |
2024-07-18 |
エディタス・メディシン，インコーポレイテッド |
操作されたｃａｓ９ヌクレアーゼ
|
|
IL271275B1
(en)
|
2017-06-13 |
2026-04-01 |
Flagship Pioneering Innovations V Inc |
Preparations containing croons and their uses
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
CA3064601A1
(en)
|
2017-06-26 |
2019-01-03 |
President And Fellows Of Harvard College |
Crispr/cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
EP3645721A1
(en)
|
2017-06-30 |
2020-05-06 |
Novartis AG |
Methods for the treatment of disease with gene editing systems
|
|
JP2020530307A
(ja)
|
2017-06-30 |
2020-10-22 |
インティマ・バイオサイエンス，インコーポレーテッド |
遺伝子治療のためのアデノ随伴ウイルスベクター
|
|
WO2019014564A1
(en)
|
2017-07-14 |
2019-01-17 |
Editas Medicine, Inc. |
SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
|
|
WO2019011118A1
(zh)
*
|
2017-07-14 |
2019-01-17 |
苏州克睿基因生物科技有限公司 |
一种基因编辑系统及基因编辑的方法
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
US12105089B2
(en)
|
2017-07-17 |
2024-10-01 |
The Broad Institute, Inc. |
Cell atlas of the healthy and ulcerative colitis human colon
|
|
US12239646B2
(en)
|
2017-07-19 |
2025-03-04 |
Dana-Farber Cancer Institute, Inc. |
Cancer diagnostic and treatment
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
CA3073448A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
US20190076814A1
(en)
|
2017-09-11 |
2019-03-14 |
Synthego Corporation |
Biopolymer synthesis system and method
|
|
WO2019060759A1
(en)
|
2017-09-21 |
2019-03-28 |
Dana-Farber Cancer Institute, Inc. |
ISOLATION, PRESERVATION, COMPOSITIONS AND USES OF PLANT EXTRACTS JUSTICIA
|
|
AU2018338318B2
(en)
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
BR112020005803A2
(pt)
|
2017-09-25 |
2020-12-01 |
Agrospheres, Inc. |
composições e métodos para produção e administração moduláveis de produtos biológicos
|
|
AU2018339164B2
(en)
*
|
2017-09-28 |
2022-06-16 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
|
US11572574B2
(en)
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
|
WO2019070755A1
(en)
|
2017-10-02 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
US12297457B2
(en)
|
2017-10-10 |
2025-05-13 |
Children's Hospital Medical Center |
Esophageal tissue and/or organoid compositions and methods of making same
|
|
WO2019075197A1
(en)
|
2017-10-11 |
2019-04-18 |
The General Hospital Corporation |
METHODS OF DETECTION OF INDIVIDUAL SITE-SPECIFIC PARASITE GENOMIC DEAMINATION BY BASE EDITING TECHNOLOGIES
|
|
WO2019079362A1
(en)
|
2017-10-16 |
2019-04-25 |
Massachusetts Institute Of Technology |
HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS
|
|
US11795443B2
(en)
|
2017-10-16 |
2023-10-24 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
SG11202003024WA
(en)
|
2017-10-20 |
2020-05-28 |
Hutchinson Fred Cancer Res |
Systems and methods to produce b cells genetically modified to express selected antibodies
|
|
WO2019135816A2
(en)
|
2017-10-23 |
2019-07-11 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
WO2019089803A1
(en)
|
2017-10-31 |
2019-05-09 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
US20210180053A1
(en)
|
2017-11-01 |
2021-06-17 |
Novartis Ag |
Synthetic rnas and methods of use
|
|
WO2019084664A1
(en)
*
|
2017-11-02 |
2019-05-09 |
The Governors Of The University Of Alberta |
Chemically-modified guide rnas to improve crispr-cas protein specificity
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
EP3710039A4
(en)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
|
|
US12221720B2
(en)
|
2017-11-13 |
2025-02-11 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
CN111051523B
(zh)
|
2017-11-15 |
2024-03-19 |
10X基因组学有限公司 |
功能化凝胶珠
|
|
WO2019099943A1
(en)
*
|
2017-11-16 |
2019-05-23 |
Astrazeneca Ab |
Compositions and methods for improving the efficacy of cas9-based knock-in strategies
|
|
US10829815B2
(en)
|
2017-11-17 |
2020-11-10 |
10X Genomics, Inc. |
Methods and systems for associating physical and genetic properties of biological particles
|
|
CN111601883B
(zh)
|
2017-11-17 |
2024-06-21 |
艾欧凡斯生物治疗公司 |
由细针抽吸物和小活检物扩增til
|
|
SG11202005147WA
(en)
|
2017-12-05 |
2020-06-29 |
Vertex Pharma |
Crispr-cas9 modified cd34+ human hematopoietic stem and progenitor cells and uses thereof
|
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019126037A1
(en)
|
2017-12-19 |
2019-06-27 |
City Of Hope |
Modified tracrrnas grnas, and uses thereof
|
|
EP3727394A4
(en)
|
2017-12-21 |
2021-09-08 |
Children's Hospital Medical Center |
DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
|
|
RU2652899C1
(ru)
*
|
2017-12-28 |
2018-05-03 |
Федеральное бюджетное учреждение науки "Центральный научно-исследовательский институт эпидемиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЦНИИ Эпидемиологии Роспотребнадзора) |
РНК-проводники для подавления репликации вируса гепатита B и для элиминации вируса гепатита B из клетки-хозяина
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
US20200362366A1
(en)
|
2018-01-12 |
2020-11-19 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
JP7391854B2
(ja)
|
2018-01-17 |
2023-12-05 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ｄｎａ－ｐｋ阻害剤
|
|
AU2019209292B2
(en)
|
2018-01-17 |
2023-10-05 |
Vertex Pharmaceuticals Incorporated |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
|
BR112020014140A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
inibidores de dna-pk
|
|
US12509492B2
(en)
|
2018-01-19 |
2025-12-30 |
Duke University |
Genome engineering with CRISPR-Cas systems in eukaryotes
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
AR114350A1
(es)
|
2018-01-31 |
2020-08-26 |
Res Institute At Nationwide ChildrenS Hospital |
Terapia genética para la distrofia muscular de cinturas del tipo 2c
|
|
US11268077B2
(en)
|
2018-02-05 |
2022-03-08 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2019150196A1
(en)
|
2018-02-05 |
2019-08-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2019157326A1
(en)
|
2018-02-08 |
2019-08-15 |
Zymergen Inc. |
Genome editing using crispr in corynebacterium
|
|
SG11202007686VA
(en)
|
2018-02-12 |
2020-09-29 |
10X Genomics Inc |
Methods characterizing multiple analytes from individual cells or cell populations
|
|
EP3755792A4
(en)
|
2018-02-23 |
2021-12-08 |
Pioneer Hi-Bred International, Inc. |
NEW CAS9 ORTHOLOGIST
|
|
KR102907245B1
(ko)
|
2018-03-14 |
2026-01-05 |
에디타스 메디신, 인코포레이티드 |
혈색소병증 치료를 위한 시스템 및 방법
|
|
PL235163B1
(pl)
*
|
2018-04-05 |
2020-06-01 |
Inst Hodowli I Aklimatyzacji Roslin Panstwowy Inst Badawczy |
Sekwencja nukleotydowa syntetycznego genu Cas9, kaseta kierująca sgRNA do edytowania genomu roślinnego i wydajny system do ukierunkowanej mutagenezy wybranego regionu genomu roślinnego
|
|
CN116536272A
(zh)
|
2018-04-06 |
2023-08-04 |
儿童医疗中心有限公司 |
用于体细胞重新编程和调整印记的组合物和方法
|
|
WO2019195166A1
(en)
|
2018-04-06 |
2019-10-10 |
10X Genomics, Inc. |
Systems and methods for quality control in single cell processing
|
|
EP3781585A4
(en)
|
2018-04-17 |
2022-01-26 |
The General Hospital Corporation |
SENSITIVE IN VITRO TESTS FOR SUBSTRATE PREFERENCES AND SITE FOR NUCLEIC ACID BINDERS, MODIFIERS AND CLEAVAGE AGENTS
|
|
GB2587970B
(en)
|
2018-04-19 |
2023-02-08 |
Univ California |
Compositions and methods for gene editing
|
|
WO2019204585A1
(en)
|
2018-04-19 |
2019-10-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
|
DK3560330T3
(da)
|
2018-04-24 |
2022-07-11 |
Kws Saat Se & Co Kgaa |
Planter med forbedret fordøjelighed og markørhaplotyper
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
EP3784254A1
(en)
|
2018-04-27 |
2021-03-03 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
JP7568511B2
(ja)
|
2018-04-27 |
2024-10-16 |
ジーンエディット インコーポレイテッド |
カチオン性ポリマーおよびその生体分子送達のための使用
|
|
US12522811B2
(en)
|
2018-05-01 |
2026-01-13 |
The Children's Medical Center Corporation |
Enhanced BCL11A RNP / CRISPR delivery and editing using a 3XNLS-CAS9
|
|
WO2019213013A1
(en)
|
2018-05-02 |
2019-11-07 |
The Children's Medical Center Corporation |
Improved bcl11a micrornas for treating hemoglobinopathies
|
|
WO2019213660A2
(en)
|
2018-05-04 |
2019-11-07 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
WO2019217294A1
(en)
|
2018-05-06 |
2019-11-14 |
Emendobio Inc. |
Differential knockout of an allele of a heterozygous elane gene
|
|
WO2019217758A1
(en)
|
2018-05-10 |
2019-11-14 |
10X Genomics, Inc. |
Methods and systems for molecular library generation
|
|
EP3794130A4
(en)
|
2018-05-16 |
2022-07-27 |
Synthego Corporation |
METHODS AND SYSTEMS FOR DESIGNING AND USING GUIDE RNA
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CN108707628B
(zh)
*
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
|
US20210371932A1
(en)
|
2018-06-01 |
2021-12-02 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
KR20210018437A
(ko)
|
2018-06-07 |
2021-02-17 |
더 브리검 앤드 우먼즈 하스피털, 인크. |
조혈 줄기 세포를 생산하기 위한 방법
|
|
US20220403001A1
(en)
|
2018-06-12 |
2022-12-22 |
Obsidian Therapeutics, Inc. |
Pde5 derived regulatory constructs and methods of use in immunotherapy
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
BR112020025349A2
(pt)
|
2018-06-15 |
2021-03-09 |
KWS SAAT SE & Co. KGaA |
Métodos para melhorar a engenharia e regeneração do genoma em planta
|
|
CN112585269B
(zh)
|
2018-06-15 |
2025-01-07 |
科沃施种子欧洲股份两合公司 |
改善植物中基因组工程化和再生的方法ii
|
|
EP3814527B1
(en)
|
2018-06-26 |
2023-02-22 |
Massachusetts Institute of Technology |
Crispr effector system based amplification methods, systems, and diagnostics
|
|
BR112020025319A2
(pt)
|
2018-06-26 |
2021-03-09 |
The Broad Institute Inc. |
Composições, sistemas e métodos de amplificação baseada em crispr/cas e transposase
|
|
WO2020002579A1
(en)
|
2018-06-29 |
2020-01-02 |
Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis |
Tweak-receptor agonists for use in combination with immunotherapy of a cancer
|
|
WO2020006458A1
(en)
|
2018-06-29 |
2020-01-02 |
Research Institute At Nationwide Children's Hospital |
Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2a
|
|
AU2019291918B2
(en)
|
2018-06-29 |
2025-06-12 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
JP2021530212A
(ja)
|
2018-07-13 |
2021-11-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
レトロトランスポゾンベースの送達媒体及びその使用方法
|
|
US12421500B2
(en)
|
2018-07-26 |
2025-09-23 |
Children's Hospital Medical Center |
Hepato-biliary-pancreatic tissues and methods of making same
|
|
US20200032335A1
(en)
|
2018-07-27 |
2020-01-30 |
10X Genomics, Inc. |
Systems and methods for metabolome analysis
|
|
KR20210053898A
(ko)
|
2018-07-31 |
2021-05-12 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규 crispr 효소 및 시스템
|
|
WO2020028729A1
(en)
|
2018-08-01 |
2020-02-06 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
|
WO2020033601A1
(en)
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Novel cas12b enzymes and systems
|
|
EP3607819A1
(en)
|
2018-08-10 |
2020-02-12 |
Vilmorin et Cie |
Resistance to xanthomonas campestris pv. campestris (xcc) in cauliflower
|
|
EP3821020A4
(en)
|
2018-08-15 |
2022-05-04 |
Zymergen Inc. |
APPLICATIONS OF CRISPRI IN HIGH-PERFORMANCE METABOLIC ENGINEERING
|
|
US12421507B2
(en)
|
2018-08-20 |
2025-09-23 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of CRISPR-CAS9
|
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
EP3841205A4
(en)
|
2018-08-22 |
2022-08-17 |
The Regents of The University of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
US20230021641A1
(en)
*
|
2018-08-23 |
2023-01-26 |
The Broad Institute, Inc. |
Cas9 variants having non-canonical pam specificities and uses thereof
|
|
EP3841204A4
(en)
|
2018-08-23 |
2022-05-18 |
Sangamo Therapeutics, Inc. |
CHANGED TARGET SPECIFIC BASE EDITORS
|
|
US12545910B2
(en)
|
2018-08-31 |
2026-02-10 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US12534743B2
(en)
|
2018-08-31 |
2026-01-27 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US11459551B1
(en)
|
2018-08-31 |
2022-10-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US20210317479A1
(en)
|
2018-09-06 |
2021-10-14 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
US10724052B2
(en)
|
2018-09-07 |
2020-07-28 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
JP2021535753A
(ja)
|
2018-09-12 |
2021-12-23 |
チルドレンズ ホスピタル メディカル センター |
造血幹細胞およびその派生体の生成のためのオルガノイド組成物
|
|
US12398402B2
(en)
|
2018-09-12 |
2025-08-26 |
Fred Hutchinson Cancer Center |
Reducing CD33 expression to selectively protect therapeutic cells
|
|
EP3852813A4
(en)
|
2018-09-18 |
2022-06-22 |
VNV Newco Inc. |
ARC-BASED CAPSIDS AND THEIR USES
|
|
US20210403907A1
(en)
|
2018-09-18 |
2021-12-30 |
Vnv Newco Inc. |
Arc-based capsids and uses thereof
|
|
WO2020069029A1
(en)
|
2018-09-26 |
2020-04-02 |
Emendobio Inc. |
Novel crispr nucleases
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
US20220411783A1
(en)
|
2018-10-12 |
2022-12-29 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
|
US12116458B2
(en)
|
2018-10-24 |
2024-10-15 |
Genedit Inc. |
Cationic polymer with alkyl side chains and use for biomolecule delivery
|
|
WO2020086742A1
(en)
|
2018-10-24 |
2020-04-30 |
Obsidian Therapeutics, Inc. |
Er tunable protein regulation
|
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
SG11202104409YA
(en)
|
2018-10-31 |
2021-05-28 |
Zymergen Inc |
Multiplexed deterministic assembly of dna libraries
|
|
US20220010321A1
(en)
*
|
2018-11-01 |
2022-01-13 |
Keygene N.V. |
Dual guide rna for crispr/cas genome editing in plants cells
|
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
TW202039831A
(zh)
|
2018-11-05 |
2020-11-01 |
美商艾歐凡斯生物治療公司 |
對抗ｐｄ－１抗體呈現難治性之非小細胞肺癌（ｎｓｃｌｃ）病患之治療
|
|
CA3118493A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathway inhibitors
|
|
TW202039829A
(zh)
|
2018-11-05 |
2020-11-01 |
美商艾歐凡斯生物治療公司 |
改善之腫瘤反應性ｔ細胞的選擇
|
|
CR20210295A
(es)
|
2018-11-05 |
2021-07-09 |
Iovance Biotherapeutics Inc |
Procesos para la producción de linfocitos infiltrantes de tumor y usos de estos en inmunoterapia
|
|
MX2021005444A
(es)
|
2018-11-08 |
2021-06-15 |
Triton Algae Innovations Inc |
Procedimientos para la superproduccion de protoporfirina ix en algas y composiciones de la misma.
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
EP3877517A4
(en)
|
2018-11-09 |
2022-09-07 |
Inari Agriculture, Inc. |
RNA-DRIVEN NUCLEASES AND DNA-BINDING PROTEINS
|
|
US11459607B1
(en)
|
2018-12-10 |
2022-10-04 |
10X Genomics, Inc. |
Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
|
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
|
CN113166744B
(zh)
|
2018-12-14 |
2025-02-07 |
先锋国际良种公司 |
用于基因组编辑的新颖crispr-cas系统
|
|
US12264323B2
(en)
|
2018-12-17 |
2025-04-01 |
The Broad Institute, Inc. |
CRISPR CPF1 direct repeat variants
|
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
AU2019406778A1
(en)
|
2018-12-17 |
2021-07-22 |
Massachusetts Institute Of Technology |
Crispr-associated transposase systems and methods of use thereof
|
|
WO2020131547A1
(en)
|
2018-12-19 |
2020-06-25 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
|
EP3931313A2
(en)
|
2019-01-04 |
2022-01-05 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
US11845983B1
(en)
|
2019-01-09 |
2023-12-19 |
10X Genomics, Inc. |
Methods and systems for multiplexing of droplet based assays
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020160044A1
(en)
|
2019-01-28 |
2020-08-06 |
The Broad Institute, Inc. |
In-situ spatial transcriptomics
|
|
EP3918080A1
(en)
|
2019-01-29 |
2021-12-08 |
The University Of Warwick |
Methods for enhancing genome engineering efficiency
|
|
WO2020160371A1
(en)
|
2019-02-01 |
2020-08-06 |
The University Of Hong Kong |
Innervated organoid compositions and methods of making same
|
|
EP3921417A4
(en)
|
2019-02-04 |
2022-11-09 |
The General Hospital Corporation |
VARIANTS OF ADENINE DNA BASES WITH REDUCED OFF-TARGET RNA EDIT
|
|
WO2020163379A1
(en)
|
2019-02-05 |
2020-08-13 |
Emendobio Inc. |
Crispr compositions and methods for promoting gene editing of ribosomal protein s19 (rps19) gene
|
|
WO2020163856A1
(en)
|
2019-02-10 |
2020-08-13 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Modified mitochondrion and methods of use thereof
|
|
US11851683B1
(en)
|
2019-02-12 |
2023-12-26 |
10X Genomics, Inc. |
Methods and systems for selective analysis of cellular samples
|
|
CA3131390A1
(en)
|
2019-02-26 |
2020-09-03 |
Research Institute Of Nationwide Children's Hospital |
Adeno-associated virus vector delivery of b-sarcoglycan and the treatment of muscular dystrophy
|
|
KR20210136050A
(ko)
|
2019-03-01 |
2021-11-16 |
이오반스 바이오테라퓨틱스, 인크. |
액상 종양으로부터의 종양 침윤 림프구의 확장 및 그의 치료 용도
|
|
EP4219700A1
(en)
|
2019-03-07 |
2023-08-02 |
The Regents of the University of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
KR20210149251A
(ko)
|
2019-03-08 |
2021-12-08 |
옵시디안 테라퓨틱스, 인크. |
조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법
|
|
CA3129871A1
(en)
|
2019-03-08 |
2020-09-17 |
Zymergen Inc. |
Iterative genome editing in microbes
|
|
US11053515B2
(en)
|
2019-03-08 |
2021-07-06 |
Zymergen Inc. |
Pooled genome editing in microbes
|
|
WO2020191102A1
(en)
|
2019-03-18 |
2020-09-24 |
The Broad Institute, Inc. |
Type vii crispr proteins and systems
|
|
EP3942043A2
(en)
|
2019-03-19 |
2022-01-26 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
US20220162649A1
(en)
|
2019-04-01 |
2022-05-26 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
CA3136061A1
(en)
|
2019-04-05 |
2020-10-08 |
Osaka University |
Method for producing knock-in cell
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2020219776A1
(en)
|
2019-04-23 |
2020-10-29 |
Genedit Inc. |
Cationic polymer with alkyl side chains
|
|
US11162079B2
(en)
|
2019-05-10 |
2021-11-02 |
The Regents Of The University Of California |
Blood type O Rh-hypo-immunogenic pluripotent cells
|
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
US20220243287A1
(en)
|
2019-05-13 |
2022-08-04 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
|
US12116583B2
(en)
|
2019-05-14 |
2024-10-15 |
Yield10 Bioscience, Inc. |
Modified plants comprising a polynucleotide comprising a non-cognate promoter operably linked to a coding sequence that encodes a transcription factor
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
WO2020236972A2
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
JP2022533713A
(ja)
|
2019-05-21 |
2022-07-25 |
サンガモ セラピューティクス， インコーポレイテッド |
調節性ｔ細胞における制御された導入遺伝子発現
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
JP7805789B2
(ja)
|
2019-05-28 |
2026-01-26 |
ジーンエディット インコーポレイテッド |
生体分子送達のための複数の機能化側鎖を含むポリマー
|
|
MX2021014528A
(es)
|
2019-05-29 |
2022-01-06 |
Monsanto Technology Llc |
Metodos y composiciones para generar alelos dominantes usando edicion del genoma.
|
|
CA3141814A1
(en)
|
2019-05-31 |
2020-12-03 |
Children's Hospital Medical Center |
Shaped organoid compositions and methods of making same
|
|
US20220243178A1
(en)
|
2019-05-31 |
2022-08-04 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
CN114174494A
(zh)
|
2019-05-31 |
2022-03-11 |
儿童医院医学中心 |
产生和扩增造血干细胞的方法
|
|
WO2020254850A1
(en)
|
2019-06-21 |
2020-12-24 |
Vilmorin & Cie |
Improvement of quality and permanence of green color of peppers at maturity and over-maturity
|
|
CN120665955A
(zh)
|
2019-06-25 |
2025-09-19 |
伊纳瑞农业技术有限公司 |
改善的同源依赖修复基因组编辑
|
|
JP2022539248A
(ja)
|
2019-07-02 |
2022-09-07 |
フレッド ハッチンソン キャンサー リサーチ センター |
組換えａｄ３５ベクター及び関連遺伝子治療改善
|
|
US11746354B2
(en)
|
2019-07-19 |
2023-09-05 |
Inari Agriculture Technology, Inc. |
Homology dependent repair genome editing
|
|
WO2021019272A1
(en)
|
2019-07-31 |
2021-02-04 |
Vilmorin & Cie |
Tolerance to tolcndv in cucumber
|
|
WO2021026294A1
(en)
|
2019-08-06 |
2021-02-11 |
Children's Medical Center Corporation |
Methods and compositions for reconstituting microglia
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
WO2021028359A1
(en)
|
2019-08-09 |
2021-02-18 |
Sangamo Therapeutics France |
Controlled expression of chimeric antigen receptors in t cells
|
|
EP4488287A3
(en)
|
2019-08-21 |
2025-03-05 |
Research Institute at Nationwide Children's Hospital |
Adeno-associated virus vector delivery of alpha-sarcoglycan and the treatment of muscular dystrophy
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
AU2020340622A1
(en)
|
2019-09-05 |
2022-03-03 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
US11118195B2
(en)
|
2019-09-05 |
2021-09-14 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
WO2021046451A1
(en)
|
2019-09-06 |
2021-03-11 |
Obsidian Therapeutics, Inc. |
Compositions and methods for dhfr tunable protein regulation
|
|
US12235262B1
(en)
|
2019-09-09 |
2025-02-25 |
10X Genomics, Inc. |
Methods and systems for single cell protein analysis
|
|
US20230025039A1
(en)
|
2019-09-20 |
2023-01-26 |
The Broad Institute, Inc. |
Novel type vi crispr enzymes and systems
|
|
CN114391040A
(zh)
|
2019-09-23 |
2022-04-22 |
欧米茄治疗公司 |
用于调节载脂蛋白b(apob)基因表达的组合物和方法
|
|
AU2020352552A1
(en)
|
2019-09-23 |
2022-03-17 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4α) gene expression
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021074367A1
(en)
|
2019-10-17 |
2021-04-22 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
|
WO2021081378A1
(en)
|
2019-10-25 |
2021-04-29 |
Iovance Biotherapeutics, Inc. |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
GB201916020D0
(en)
|
2019-11-04 |
2019-12-18 |
Univ Of Essex Enterprise Limited |
Crispr-mediated identification of biotinylated proteins and chromatin regions
|
|
WO2021094805A1
(en)
|
2019-11-14 |
2021-05-20 |
Vilmorin & Cie |
Resistance to acidovorax valerianellae in corn salad
|
|
WO2021118990A1
(en)
|
2019-12-11 |
2021-06-17 |
Iovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
|
EP4706689A2
(en)
|
2019-12-19 |
2026-03-11 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|
|
CN116234906A
(zh)
|
2020-01-13 |
2023-06-06 |
萨那生物技术股份有限公司 |
血型抗原的修饰
|
|
IL294715A
(en)
|
2020-01-23 |
2022-09-01 |
Childrens Medical Ct Corp |
Stroma-free t cell differentiation from human pluripotent stem cells
|
|
WO2021151085A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Crispr-cas enzymes with enhanced on-target activity
|
|
WO2021151073A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants
|
|
CN115362264A
(zh)
|
2020-01-29 |
2022-11-18 |
10X基因组学有限公司 |
用于分析物检测的组合物和方法
|
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
|
KR102676313B1
(ko)
*
|
2020-02-27 |
2024-06-17 |
경희대학교 산학협력단 |
유전자 선별 방법 및 장치
|
|
US20240191248A1
(en)
|
2020-02-28 |
2024-06-13 |
KWS SAAT SE & Co. KGaA |
Method for rapid genome modification in recalcitrant plants
|
|
US12473563B2
(en)
|
2020-02-28 |
2025-11-18 |
KWS SAAT SE & Co. KGaA |
Immature inflorescence meristem editing
|
|
WO2021183720A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
US20230165909A1
(en)
|
2020-04-21 |
2023-06-01 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
|
US20250263752A1
(en)
|
2020-04-21 |
2025-08-21 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
|
WO2021217082A1
(en)
|
2020-04-23 |
2021-10-28 |
Genedit Inc. |
Polymer with cationic and hydrophobic side chains
|
|
CA3176826A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
EP4146797A1
(en)
|
2020-05-06 |
2023-03-15 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
|
BR112022022603A2
(pt)
|
2020-05-08 |
2023-01-17 |
Broad Inst Inc |
Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla
|
|
CN121884957A
(zh)
|
2020-05-22 |
2026-04-17 |
因斯特罗公司 |
使用机器学习模型预测疾病结果
|
|
WO2021239986A1
(en)
|
2020-05-29 |
2021-12-02 |
KWS SAAT SE & Co. KGaA |
Plant haploid induction
|
|
WO2021245435A1
(en)
|
2020-06-03 |
2021-12-09 |
Vilmorin & Cie |
Melon plants resistant to scab disease, aphids and powdery mildew
|
|
BR112022024738A2
(pt)
|
2020-06-05 |
2023-03-07 |
Vilmorin & Cie |
Planta, célula de planta, cultura de tecidos de células, parte de planta, semente, uso de uma planta, métodos para detectar e/ou selecionar plantas, conferir resistência ao tobrfv, melhorar o rendimento de tomateiros e reduzir a perda na produção de tomate e usos de um marcador
|
|
EP4161552A1
(en)
|
2020-06-05 |
2023-04-12 |
The Broad Institute, Inc. |
Compositions and methods for treating neoplasia
|
|
EP4172340A1
(en)
|
2020-06-29 |
2023-05-03 |
KWS SAAT SE & Co. KGaA |
Boosting homology directed repair in plants
|
|
CN116096378A
(zh)
|
2020-08-10 |
2023-05-09 |
诺华股份有限公司 |
视网膜变性疾病的治疗
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
JP7830442B2
(ja)
|
2020-10-02 |
2026-03-16 |
ビルモラン エ コンパニー |
貯蔵寿命が延長されたメロン
|
|
EP4225330A1
(en)
|
2020-10-06 |
2023-08-16 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
US20240026369A1
(en)
|
2020-10-27 |
2024-01-25 |
KWS SAAT SE & Co. KGaA |
Use of enhanced pol theta activity for eukaryotic genome engineering
|
|
EP4242237A4
(en)
|
2020-11-06 |
2025-01-01 |
Editforce, Inc. |
FOKI NUCLEASE DOMAIN VARIANT
|
|
EP4243608A1
(en)
|
2020-11-11 |
2023-09-20 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Fusion protein for editing endogenous dna of a eukaryotic cell
|
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
|
EP4255172A1
(en)
|
2020-12-03 |
2023-10-11 |
Vilmorin & Cie |
Tomato plants resistant to tobrfv, tmv, tomv and tommv and corresponding resistance genes
|
|
CA3202483A1
(en)
|
2020-12-17 |
2022-06-23 |
Maria Fardis |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
|
US20240123067A1
(en)
|
2020-12-17 |
2024-04-18 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocyte therapies
|
|
EP4019639A1
(en)
|
2020-12-22 |
2022-06-29 |
KWS SAAT SE & Co. KGaA |
Promoting regeneration and transformation in beta vulgaris
|
|
IL303901A
(en)
*
|
2020-12-22 |
2023-08-01 |
Ensoma Inc |
Adenoviral serotype 35 helper vectors
|
|
KR20230124682A
(ko)
|
2020-12-23 |
2023-08-25 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
Rna를 봉입하는 아넬로바이러스 캡시드의 시험관 내어셈블리
|
|
KR20230146007A
(ko)
|
2020-12-31 |
2023-10-18 |
크리스퍼 테라퓨틱스 아게 |
범용 공여자 세포
|
|
WO2022165260A1
(en)
|
2021-01-29 |
2022-08-04 |
Iovance Biotherapeutics, Inc. |
Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
|
|
JP2024510505A
(ja)
|
2021-03-19 |
2024-03-07 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
Ｃｄ３９／ｃｄ６９選択に関連した腫瘍浸潤リンパ球（ｔｉｌ）拡張及びｔｉｌにおける遺伝子ノックアウトのための方法
|
|
WO2022204564A2
(en)
|
2021-03-25 |
2022-09-29 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for t-cell coculture potency assays and use with cell therapy products
|
|
US20250243244A1
(en)
|
2021-03-31 |
2025-07-31 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
|
WO2022208489A1
(en)
|
2021-04-02 |
2022-10-06 |
Vilmorin & Cie |
Semi-determinate or determinate growth habit trait in cucurbita
|
|
KR20240037185A
(ko)
|
2021-04-19 |
2024-03-21 |
이오반스 바이오테라퓨틱스, 인크. |
키메라 공동자극 수용체, 케모카인 수용체, 및 세포 면역치료에서의 이의 용도
|
|
CA3217862A1
(en)
|
2021-05-05 |
2022-11-10 |
Radius Pharmaceuticals, Inc. |
Animal model having homologous recombination of mouse pth1 receptor
|
|
EP4337261A2
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating mrna splicing
|
|
AU2022271873A1
(en)
|
2021-05-10 |
2024-01-04 |
Entrada Therapeutics, Inc. |
Compositions and methods for intracellular therapeutics
|
|
WO2022240721A1
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
|
JP2024519029A
(ja)
|
2021-05-17 |
2024-05-08 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
Ｐｄ－１遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用
|
|
AU2022276078A1
(en)
|
2021-05-17 |
2024-01-04 |
Nogra Pharma Limited |
Il-34 antisense agents and methods of using same
|
|
GB202107057D0
(en)
|
2021-05-18 |
2021-06-30 |
Univ York |
Glycosylation method
|
|
WO2022243437A1
(en)
|
2021-05-19 |
2022-11-24 |
KWS SAAT SE & Co. KGaA |
Sample preparation with oppositely oriented guide polynucleotides
|
|
EP4419672A2
(en)
|
2021-06-01 |
2024-08-28 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing, or modifying genes
|
|
WO2022256440A2
(en)
|
2021-06-01 |
2022-12-08 |
Arbor Biotechnologies, Inc. |
Gene editing systems comprising a crispr nuclease and uses thereof
|
|
EP4352131A1
(en)
|
2021-06-11 |
2024-04-17 |
Genedit Inc. |
Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups
|
|
EP4370676A2
(en)
|
2021-06-18 |
2024-05-22 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing or modifying human genes
|
|
GEAP202416440A
(en)
|
2021-06-23 |
2024-04-25 |
Entrada Therapeutics Inc |
Antisense compounds and methods for targeting cug repeats
|
|
WO2023283359A2
(en)
|
2021-07-07 |
2023-01-12 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
JP2024526898A
(ja)
|
2021-07-22 |
2024-07-19 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
固形腫瘍断片の凍結保存のための方法
|
|
WO2023009716A1
(en)
|
2021-07-28 |
2023-02-02 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
|
CA3221517A1
(en)
|
2021-07-30 |
2023-02-02 |
Monika KLOIBER-MAITZ |
Plants with improved digestibility and marker haplotypes
|
|
MX2024001624A
(es)
|
2021-08-06 |
2024-04-30 |
Vilmorin & Cie |
Resistencia a leveillula taurica en el pimiento.
|
|
WO2023029532A1
(en)
*
|
2021-08-30 |
2023-03-09 |
Huigene Therapeutics Co., Ltd. |
Engineered cas6 protein and uses thereof
|
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
|
EP4596697A3
(en)
|
2021-09-28 |
2025-08-27 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
US12285497B2
(en)
|
2021-10-15 |
2025-04-29 |
Research Institute At Nationwide Children's Hospital |
Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy
|
|
EP4166670A1
(en)
|
2021-10-18 |
2023-04-19 |
KWS SAAT SE & Co. KGaA |
Plant-tag-based weeding control
|
|
CA3235824A1
(en)
|
2021-10-27 |
2023-05-04 |
Frederick G. Vogt |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
|
WO2023077148A1
(en)
|
2021-11-01 |
2023-05-04 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
EP4426832A1
(en)
|
2021-11-03 |
2024-09-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Precise genome editing using retrons
|
|
US20250032618A1
(en)
|
2021-11-10 |
2025-01-30 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
|
US20240408236A1
(en)
|
2021-11-26 |
2024-12-12 |
Epigenic Therapeutics, Inc. |
Method of modulating pcsk9 and uses thereof
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
WO2023115041A1
(en)
|
2021-12-17 |
2023-06-22 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
CA3243006A1
(en)
|
2021-12-21 |
2025-02-27 |
Alia Therapeutics Srl |
TYPE II CAS PROTEINS AND THEIR APPLICATIONS
|
|
EP4452335A1
(en)
|
2021-12-22 |
2024-10-30 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
KR20240133725A
(ko)
|
2021-12-23 |
2024-09-04 |
유니버시티 오브 매사추세츠 |
취약 x 관련 장애의 치료용 치료제
|
|
WO2023133595A2
(en)
|
2022-01-10 |
2023-07-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2023147488A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
|
EP4472646A1
(en)
|
2022-02-01 |
2024-12-11 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
EP4486881A1
(en)
|
2022-03-01 |
2025-01-08 |
Celyntra Therapeutics SA |
Composition and methods for transgene insertion
|
|
WO2023194359A1
(en)
|
2022-04-04 |
2023-10-12 |
Alia Therapeutics Srl |
Compositions and methods for treatment of usher syndrome type 2a
|
|
EP4256950A1
(en)
|
2022-04-06 |
2023-10-11 |
Vilmorin et Cie |
Tolerance to cgmmv in cucumber
|
|
CA3247638A1
(en)
|
2022-04-06 |
2023-10-12 |
Maria Fardis |
TREATMENT OF PATIENTS WITH NON-SMALL CELL LUNG CARCINOMA (NSCLC) WITH TUMOR-INFILTRATING LYMPHOCYTE THERAPIES
|
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
WO2023219933A1
(en)
|
2022-05-09 |
2023-11-16 |
Entrada Therapeutics, Inc. |
Compositions and methods for delivery of nucleic acid therapeutics
|
|
US20250281537A1
(en)
|
2022-05-10 |
2025-09-11 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist
|
|
US20250308637A1
(en)
|
2022-05-20 |
2025-10-02 |
Celyntra Therapeutics Sa |
Systems and methods for assessing risk of genome editing events
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
WO2023230570A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
|
CA3254044A1
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
COMPOSITIONS AND MODULATION METHODS OF TUMOR SUPPRESSANTS AND ONCOGENS
|
|
CN119563038A
(zh)
|
2022-05-25 |
2025-03-04 |
旗舰创业创新七公司 |
用于调节免疫应答的组合物和方法
|
|
EP4532768A2
(en)
|
2022-05-25 |
2025-04-09 |
Flagship Pioneering Innovations VII, LLC |
Compositions and methods for modulating circulating factors
|
|
JP2025517967A
(ja)
|
2022-05-25 |
2025-06-12 |
フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー |
サイトカインを調節するための組成物及び方法
|
|
KR20250044484A
(ko)
|
2022-06-24 |
2025-03-31 |
튠 쎄라퓨틱스, 인코포레이티드 |
표적 유전자 억제를 통해 저밀도 지단백질을 감소시키기 위한 조성물, 시스템, 및 방법
|
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
JP7152094B1
(ja)
*
|
2022-06-30 |
2022-10-12 |
リージョナルフィッシュ株式会社 |
ｔｒａｃｒＲＮＡユニット、及びゲノム編集方法
|
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
CN120344660A
(zh)
|
2022-07-18 |
2025-07-18 |
雷纳嘉德医疗管理公司 |
基因编辑组分、系统和使用方法
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
US20260055146A1
(en)
|
2022-08-24 |
2026-02-26 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
US20250386788A1
(en)
|
2022-08-26 |
2025-12-25 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
|
KR20240034661A
(ko)
*
|
2022-09-06 |
2024-03-14 |
주식회사 툴젠 |
캄필로박터 제주니 유래 Cas9의 가이드 RNA 구조변화를 통한 유전자교정 향상 시스템
|
|
CA3267752A1
(en)
|
2022-09-16 |
2024-03-21 |
Alia Therapeutics Srl |
ENQP TYPE II CAS PROTEINS AND THEIR APPLICATIONS
|
|
WO2024064838A1
(en)
|
2022-09-21 |
2024-03-28 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
EP4612277A1
(en)
|
2022-11-04 |
2025-09-10 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
|
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
|
WO2024105162A1
(en)
|
2022-11-16 |
2024-05-23 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
|
KR20250122544A
(ko)
|
2022-11-21 |
2025-08-13 |
이오반스 바이오테라퓨틱스, 인크. |
종양 침윤 림프구의 확장을 위한 2차원 공정 및 이를 통한 요법
|
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
KR20250153183A
(ko)
|
2022-12-19 |
2025-10-24 |
카마우 테라퓨틱스, 인크. |
P53 결합 단백질인 53bp1의 개선된 펩타이드 저해제
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
WO2024141599A1
(en)
|
2022-12-29 |
2024-07-04 |
Vilmorin & Cie |
Tomato plants resistant to resistance-breaking tswv strains and corresponding resistance genes
|
|
CN115982034B
(zh)
*
|
2022-12-30 |
2023-11-28 |
云舟生物科技(广州)股份有限公司 |
载体构建系统虚拟终端的测试方法、存储介质及电子设备
|
|
JP2026502531A
(ja)
|
2023-01-11 |
2026-01-23 |
アリア セラピューティクス エスアールエル |
Ｉｉ型ｃａｓタンパク質およびその適用
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
CN120712355A
(zh)
|
2023-02-15 |
2025-09-26 |
阿伯生物技术公司 |
用于抑制抑微管装配蛋白2（stmn2）转录物中的异常剪接的基因编辑方法
|
|
WO2024175308A1
(en)
|
2023-02-22 |
2024-08-29 |
KWS SAAT SE & Co. KGaA |
Plants with improved performance
|
|
US12225874B2
(en)
|
2023-03-27 |
2025-02-18 |
Redsea Science And Technology Inc. |
Tomato plant designated ‘X22-31’
|
|
WO2024206911A2
(en)
|
2023-03-30 |
2024-10-03 |
Children's Hospital Medical Center |
Clinical-grade organoids
|
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
WO2024220574A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
TW202449159A
(zh)
|
2023-04-19 |
2024-12-16 |
美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 |
用於產生文庫之組合物及方法
|
|
CN121443140A
(zh)
|
2023-04-21 |
2026-01-30 |
非营利性组织佛兰芒综合大学生物技术研究所 |
用于作物产量提升的等位基因组合
|
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
|
WO2024223900A1
(en)
|
2023-04-28 |
2024-10-31 |
Vilmorin & Cie |
Genetic determinants conferring improved tobrfv resistance
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
IL324634A
(en)
|
2023-05-15 |
2026-01-01 |
Nchroma Bio Inc |
Compositions and methods for epigenetic regulation of hbv gene expression
|
|
EP4713433A2
(en)
|
2023-05-18 |
2026-03-25 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
AU2024274792A1
(en)
|
2023-05-23 |
2025-10-23 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
|
WO2024253957A1
(en)
|
2023-06-07 |
2024-12-12 |
Northwestern University |
Targeting autoimmunity-associated t cells through regulation of transcription factors
|
|
EP4731750A2
(en)
|
2023-06-23 |
2026-04-29 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
|
WO2025006419A1
(en)
|
2023-06-26 |
2025-01-02 |
Flagship Pioneering Innovations Vii, Llc |
Engineered plasmodia and related methods
|
|
EP4734755A1
(en)
|
2023-06-28 |
2026-05-06 |
Vilmorin & Cie |
Pepper resistance to meloidogyne enterolobii
|
|
CN121548346A
(zh)
|
2023-07-24 |
2026-02-17 |
维尔莫林公司 |
甜瓜对cysdv的抗性
|
|
IL326289A
(en)
|
2023-08-01 |
2026-04-01 |
Kws Saat Se & Co Kgaa |
A method for reducing off-flavors in alternative proteins
|
|
WO2025027133A1
(en)
|
2023-08-01 |
2025-02-06 |
KWS SAAT SE & Co. KGaA |
Method of improving gelation properties of alternative proteins
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025049959A2
(en)
|
2023-09-01 |
2025-03-06 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025054540A1
(en)
|
2023-09-08 |
2025-03-13 |
Iovance Biotherapeutics, Inc. |
Methods of gene-editing using programmable nucleases
|
|
WO2025064408A1
(en)
|
2023-09-18 |
2025-03-27 |
The Broad Institute, Inc. |
Compositions and methods for treating cardiovascular disease
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025072803A1
(en)
|
2023-09-29 |
2025-04-03 |
Children's Hospital Medical Center |
Ntrk2 signaling-mediated alveolar capillary injury and repair
|
|
EP4554371A4
(en)
|
2023-10-03 |
2026-04-22 |
Inari Agriculture Tech Inc |
GRNA VIRAL ADMINISTRATION IN GRAFTS
|
|
AU2024357861A1
(en)
|
2023-10-12 |
2026-04-23 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
WO2025101484A1
(en)
|
2023-11-06 |
2025-05-15 |
Iovance Biotherapeutics, Inc. |
Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
|
|
WO2025132866A1
(en)
|
2023-12-21 |
2025-06-26 |
KWS SAAT SE & Co. KGaA |
Maize plants with improved disease resistance
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025155753A2
(en)
|
2024-01-17 |
2025-07-24 |
Renagade Therapeutics Management Inc. |
Improved gene editing system, guides, and methods
|
|
WO2025153582A1
(en)
|
2024-01-17 |
2025-07-24 |
KWS SAAT SE & Co. KGaA |
Maize plants with improved disease resistance
|
|
WO2025168705A1
(en)
|
2024-02-08 |
2025-08-14 |
Vib Vzw |
Means and methods for the production of saponins with endosomal escape-enhancing properties
|
|
WO2025171210A1
(en)
|
2024-02-09 |
2025-08-14 |
Arbor Biotechnologies, Inc. |
Compositions and methods for gene editing via homology-mediated end joining
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
WO2025186284A1
(en)
|
2024-03-05 |
2025-09-12 |
Vilmorin & Cie |
Increased yield in cucumber
|
|
WO2025196502A1
(en)
|
2024-03-20 |
2025-09-25 |
North Carolina Agricultural & Technical State University |
Choline kinase inhibitors as a therapeutic treatment for obesity
|
|
WO2025212920A1
(en)
|
2024-04-03 |
2025-10-09 |
Children's Hospital Medical Center |
Multi-zonal liver organoids
|
|
WO2025217202A1
(en)
|
2024-04-08 |
2025-10-16 |
Children's Hospital Medical Center |
Bile duct organoid
|
|
US20250332260A1
(en)
|
2024-04-10 |
2025-10-30 |
Garuda Therapeutics, Inc. |
Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
|
|
EP4677108A1
(en)
|
2024-04-22 |
2026-01-14 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025240947A1
(en)
|
2024-05-17 |
2025-11-20 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
WO2025259610A1
(en)
|
2024-06-10 |
2025-12-18 |
Northwestern University |
Genetic modulators of kras protein expression and their uses
|
|
WO2025259554A1
(en)
|
2024-06-13 |
2025-12-18 |
J.R. Simplot Company |
Engineering remontant flowering in rosaceae
|
|
WO2026006542A2
(en)
|
2024-06-26 |
2026-01-02 |
Yale University |
Compositions and methods for crispr/cas9 based reactivation of human angelman syndrome
|
|
WO2026015829A2
(en)
|
2024-07-12 |
2026-01-15 |
Arbor Biotechnologies, Inc. |
Small reverse transcriptases and gene editing systems comprising such
|
|
WO2026015832A2
(en)
|
2024-07-12 |
2026-01-15 |
Arbor Biotechnologies, Inc. |
Reverse transcriptases and gene editing systems comprising such
|
|
WO2026017833A1
(en)
|
2024-07-17 |
2026-01-22 |
Vilmorin & Cie |
Tswv-resistant pepper
|
|
EP4686414A1
(en)
|
2024-08-01 |
2026-02-04 |
KWS SAAT SE & Co. KGaA |
Method of improving gelation properties of pea proteins
|
|
FR3165152A3
(fr)
|
2024-08-01 |
2026-02-06 |
KWS SAAT SE & Co. KGaA |
Lignées de pois au profil gustatif amélioré
|
|
FR3165153A3
(fr)
|
2024-08-01 |
2026-02-06 |
KWS SAAT SE & Co. KGaA |
Lignées de pois au profil gustatif amélioré des ingrédients à base de pois
|
|
WO2026036000A1
(en)
|
2024-08-08 |
2026-02-12 |
Invaio Sciences, Inc. |
Nature-derived lipid particles for use in agriculture
|
|
WO2026047626A1
(en)
|
2024-08-30 |
2026-03-05 |
Inceptor Bio, Llc |
Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy
|
|
WO2026060399A2
(en)
|
2024-09-16 |
2026-03-19 |
Northwestern University |
T cell lymphoma mutations, compositions, and uses to enhance engineered t cell therapies
|
|
WO2026060398A2
(en)
|
2024-09-16 |
2026-03-19 |
Northwestern University |
B cell lymphoma mutations, compositions, and uses to enhance engineered t cell therapies
|
|
WO2026062237A1
(en)
|
2024-09-20 |
2026-03-26 |
KWS SAAT SE & Co. KGaA |
Improved color-coded male sterile system for targeted selection of cereal plants
|
|
WO2026096383A1
(en)
|
2024-10-28 |
2026-05-07 |
The Broad Institute, Inc. |
Compositions and methods for inducing phagocytosis
|