|
US9314005B2
(en)
|
2009-07-01 |
2016-04-19 |
Transposagen Biopharmaceuticals, Inc. |
Genetically modified rat models for severe combined immunodeficiency (SCID)
|
|
WO2011140441A2
(en)
|
2010-05-06 |
2011-11-10 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
|
US10920242B2
(en)
|
2011-02-25 |
2021-02-16 |
Recombinetics, Inc. |
Non-meiotic allele introgression
|
|
WO2012129373A2
(en)
|
2011-03-23 |
2012-09-27 |
Pioneer Hi-Bred International, Inc. |
Methods for producing a complex transgenic trait locus
|
|
JP6261500B2
(ja)
|
2011-07-22 |
2018-01-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ヌクレアーゼ切断特異性の評価および改善
|
|
US10501791B2
(en)
|
2011-10-14 |
2019-12-10 |
President And Fellows Of Harvard College |
Sequencing by structure assembly
|
|
WO2014163886A1
(en)
|
2013-03-12 |
2014-10-09 |
President And Fellows Of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
KR101904508B1
(ko)
|
2012-04-25 |
2018-10-04 |
리제너론 파마슈티칼스 인코포레이티드 |
큰 표적화 벡터를 사용한 뉴클레아제-중재된 표적화
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
MY189533A
(en)
|
2012-05-25 |
2022-02-16 |
Univ California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
EP3816281A1
(en)
|
2012-07-11 |
2021-05-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for the treatment of lysosomal storage diseases
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
KR20230065381A
(ko)
*
|
2012-07-25 |
2023-05-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유도 ｄｎａ 결합 단백질 및 게놈 교란 도구 및 이의 적용
|
|
WO2014065596A1
(en)
|
2012-10-23 |
2014-05-01 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
US10968446B2
(en)
|
2012-11-01 |
2021-04-06 |
Massachusetts Institute Of Technology |
Directed evolution of synthetic gene cluster
|
|
AU2013355214B2
(en)
|
2012-12-06 |
2017-06-15 |
Sigma-Aldrich Co. Llc |
Crispr-based genome modification and regulation
|
|
DK2921557T3
(en)
|
2012-12-12 |
2016-11-07 |
Broad Inst Inc |
Design of systems, methods and optimized sequence manipulation guide compositions
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
CA2894668A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells
|
|
CN105209621B
(zh)
|
2012-12-12 |
2021-05-25 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
EP4299741A3
(en)
|
2012-12-12 |
2024-02-28 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
EP4481048A3
(en)
|
2012-12-17 |
2025-02-26 |
President and Fellows of Harvard College |
Rna-guided human genome engineering
|
|
CN104995302B
(zh)
|
2013-01-16 |
2021-08-31 |
爱默蕾大学 |
Cas9-核酸复合物及其相关用途
|
|
US10660943B2
(en)
*
|
2013-02-07 |
2020-05-26 |
The Rockefeller University |
Sequence specific antimicrobials
|
|
US11135273B2
(en)
|
2013-02-07 |
2021-10-05 |
The Rockefeller University |
Sequence specific antimicrobials
|
|
WO2014150624A1
(en)
|
2013-03-14 |
2014-09-25 |
Caribou Biosciences, Inc. |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
KR102210319B1
(ko)
|
2013-03-15 |
2021-02-01 |
더 제너럴 하스피탈 코포레이션 |
특정 게놈 좌위에 대한 유전적 및 후성적 조절 단백질의 rna-안내 표적화
|
|
US20140364333A1
(en)
*
|
2013-03-15 |
2014-12-11 |
President And Fellows Of Harvard College |
Methods for Live Imaging of Cells
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
WO2014165825A2
(en)
|
2013-04-04 |
2014-10-09 |
President And Fellows Of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
RS62263B1
(sr)
|
2013-04-16 |
2021-09-30 |
Regeneron Pharma |
Ciljana modifikacija genoma pacova
|
|
US9873907B2
(en)
|
2013-05-29 |
2018-01-23 |
Agilent Technologies, Inc. |
Method for fragmenting genomic DNA using CAS9
|
|
US20160122774A1
(en)
*
|
2013-05-29 |
2016-05-05 |
Cellectis |
A method for producing precise dna cleavage using cas9 nickase activity
|
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
|
MY177814A
(en)
*
|
2013-06-04 |
2020-09-23 |
Harvard College |
Rna-guided transcriptional regulation
|
|
KR102733409B1
(ko)
|
2013-06-05 |
2024-11-21 |
듀크 유니버시티 |
Rna-가이드 유전자 편집 및 유전자 조절
|
|
EP3008181B1
(en)
|
2013-06-11 |
2019-11-06 |
The Regents of The University of California |
Methods and compositions for target dna modification
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
KR20160056869A
(ko)
*
|
2013-06-17 |
2016-05-20 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
WO2014204727A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
EP3011031B1
(en)
|
2013-06-17 |
2020-09-30 |
The Broad Institute Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
|
DK3011029T3
(da)
|
2013-06-17 |
2020-03-16 |
Broad Inst Inc |
Administration, modificering og optimering af tandem-guidesystemer, fremgangsmåder og sammensætninger til sekvensmanipulering
|
|
JP2016528890A
(ja)
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ＣＲＩＳＰＲ／Ｃａｓ系を用いるゲノム編集の治療用の使用
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US20160208272A1
(en)
|
2013-08-22 |
2016-07-21 |
E. I. Du Pont De Nemours And Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
DK3041498T3
(da)
|
2013-09-05 |
2022-05-09 |
Massachusetts Inst Technology |
Afstemning af mikrobielle populationer med programmerbare nukleaser
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
WO2015040402A1
(en)
*
|
2013-09-18 |
2015-03-26 |
Kymab Limited |
Methods. cells & organisms
|
|
WO2015054507A1
(en)
|
2013-10-10 |
2015-04-16 |
Pronutria, Inc. |
Nutritive polypeptide production systems, and methods of manufacture and use thereof
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
US11326209B2
(en)
|
2013-11-07 |
2022-05-10 |
Massachusetts Institute Of Technology |
Cell-based genomic recorded accumulative memory
|
|
PT3066201T
(pt)
|
2013-11-07 |
2018-06-04 |
Massachusetts Inst Technology |
Métodos e composições relacionadas com crispr com arng reguladores
|
|
RU2725520C2
(ru)
|
2013-12-11 |
2020-07-02 |
Регенерон Фармасьютикалс, Инк. |
Способы и композиции для направленной модификации генома
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
US9068179B1
(en)
|
2013-12-12 |
2015-06-30 |
President And Fellows Of Harvard College |
Methods for correcting presenilin point mutations
|
|
KR20250068794A
(ko)
|
2013-12-12 |
2025-05-16 |
더 브로드 인스티튜트, 인코퍼레이티드 |
게놈 편집을 위한 ｃｒｉｓｐｒ-ｃａｓ 시스템 및 조성물의 전달, 용도 및 치료적 응용
|
|
WO2015089419A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
CA2932479A1
(en)
|
2013-12-12 |
2015-06-18 |
The Rockefeller University |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
US9994831B2
(en)
|
2013-12-12 |
2018-06-12 |
The Regents Of The University Of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
CN106103705A
(zh)
|
2013-12-12 |
2016-11-09 |
布罗德研究所有限公司 |
核苷酸重复障碍中crispr‑cas系统的组合物和使用方法
|
|
EP4026909A1
(en)
|
2013-12-19 |
2022-07-13 |
Novartis AG |
Human mesothelin chimeric antigen receptors and uses thereof
|
|
US9963689B2
(en)
|
2013-12-31 |
2018-05-08 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
|
CA2938456C
(en)
|
2014-02-11 |
2022-06-21 |
The Regents Of The University Of Colorado, A Body Corporate |
Crispr enabled multiplexed genome engineering
|
|
RU2016136977A
(ru)
|
2014-02-18 |
2018-03-20 |
Дьюк Юниверсити |
Композиции для инактивации репликации вируса и способы их получения и применения
|
|
EP3971283A1
(en)
|
2014-02-27 |
2022-03-23 |
Monsanto Technology LLC |
Compositions and methods for site directed genomic modification
|
|
EP3514246B1
(en)
|
2014-02-27 |
2021-11-17 |
The Broad Institute, Inc. |
T cell balance gene expression and methods of use thereof
|
|
SG11201609211VA
(en)
|
2014-03-05 |
2016-12-29 |
Nat Univ Corp Univ Kobe |
Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
|
|
EP3114227B1
(en)
|
2014-03-05 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
EP3116997B1
(en)
|
2014-03-10 |
2019-05-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3593812A3
(en)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
|
CN106459951A
(zh)
|
2014-03-26 |
2017-02-22 |
马里兰大学派克分院 |
驯养的大型动物的受精卵中的靶向基因组编辑
|
|
EP3126495A1
(en)
|
2014-04-02 |
2017-02-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
SI3888674T1
(sl)
|
2014-04-07 |
2024-08-30 |
Novartis Ag |
Zdravljenje raka z uporabo antigenskega himernega receptorja proti-CD19
|
|
HUE051354T2
(hu)
*
|
2014-04-14 |
2021-03-01 |
Nemesis Bioscience Ltd |
Terapeutikum
|
|
GB201406970D0
(en)
*
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
|
CA2946881A1
(en)
|
2014-04-28 |
2015-11-05 |
Recombinetics, Inc. |
Multiplex gene editing in swine
|
|
US10280419B2
(en)
|
2014-05-09 |
2019-05-07 |
UNIVERSITé LAVAL |
Reduction of amyloid beta peptide production via modification of the APP gene using the CRISPR/Cas system
|
|
PL3145934T3
(pl)
|
2014-05-19 |
2021-08-16 |
Pfizer Inc. |
Podstawione związki 6,8-dioksabicyklo[3.2.1]oktano-2,3-diolu jako środki kierujące do ASGPR
|
|
EP3149156B1
(en)
|
2014-05-28 |
2021-02-17 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into gastric tissues through directed differentiation
|
|
CN106536056B
(zh)
|
2014-06-13 |
2021-07-16 |
儿童医学中心公司 |
分离线粒体的产品和方法
|
|
WO2015200378A1
(en)
|
2014-06-23 |
2015-12-30 |
The General Hospital Corporation |
Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
|
|
AU2015288157A1
(en)
|
2014-07-11 |
2017-01-19 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
BR122023024818A2
(pt)
*
|
2014-07-11 |
2023-12-26 |
Pioneer Hi-Bred International, Inc. |
Rna guia, polinucleotídeo e complexo de ribonucleoproteínas
|
|
US10179932B2
(en)
|
2014-07-11 |
2019-01-15 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
WO2016011203A1
(en)
|
2014-07-15 |
2016-01-21 |
Life Technologies Corporation |
Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
|
|
JP6831777B2
(ja)
|
2014-07-21 |
2021-02-17 |
ノバルティス アーゲー |
Ｃｄ３３キメラ抗原受容体を使用する癌の処置
|
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
JP7054622B2
(ja)
|
2014-07-21 |
2022-04-14 |
ノバルティス アーゲー |
ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
|
|
EP3193915A1
(en)
|
2014-07-21 |
2017-07-26 |
Novartis AG |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
WO2016019300A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Subset-optimized chimeric antigen receptor-containing t-cells
|
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
|
AU2015301460B2
(en)
|
2014-08-14 |
2021-04-08 |
Novartis Ag |
Treatment of cancer using GFR alpha-4 chimeric antigen receptor
|
|
WO2016028682A1
(en)
|
2014-08-17 |
2016-02-25 |
The Broad Institute Inc. |
Genome editing using cas9 nickases
|
|
WO2016028896A1
(en)
|
2014-08-19 |
2016-02-25 |
Novartis Ag |
Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
|
|
NZ728437A
(en)
|
2014-08-27 |
2018-02-23 |
Caribou Biosciences Inc |
Methods for increasing cas9-mediated engineering efficiency
|
|
WO2016033298A1
(en)
|
2014-08-28 |
2016-03-03 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
EP3188763B1
(en)
*
|
2014-09-02 |
2020-05-13 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification
|
|
EP3628739B1
(en)
|
2014-09-12 |
2024-05-01 |
Corteva Agriscience LLC |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
|
US10577417B2
(en)
|
2014-09-17 |
2020-03-03 |
Novartis Ag |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
|
CA2959737A1
(en)
|
2014-09-23 |
2016-03-31 |
Aggenetics, Inc. |
Materials and methods for producing animals with short hair
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
US10040048B1
(en)
|
2014-09-25 |
2018-08-07 |
Synthego Corporation |
Automated modular system and method for production of biopolymers
|
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
WO2016061073A1
(en)
*
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
|
CN105602935B
(zh)
*
|
2014-10-20 |
2020-11-13 |
聂凌云 |
一种新型线粒体基因组编辑工具
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
US20170247762A1
(en)
|
2014-10-27 |
2017-08-31 |
The Board Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
US9816080B2
(en)
*
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
WO2016073955A2
(en)
|
2014-11-06 |
2016-05-12 |
President And Fellows Of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
CN107406838A
(zh)
|
2014-11-06 |
2017-11-28 |
纳幕尔杜邦公司 |
Rna引导的内切核酸酶向细胞中的肽介导的递送
|
|
AU2015342749B2
(en)
|
2014-11-07 |
2022-01-27 |
Editas Medicine, Inc. |
Methods for improving CRISPR/Cas-mediated genome-editing
|
|
IL301900A
(en)
|
2014-11-21 |
2023-06-01 |
Regeneron Pharma |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
EP3626832B1
(en)
|
2014-11-25 |
2024-06-12 |
The Brigham and Women's Hospital, Inc. |
Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
EP3224362B1
(en)
|
2014-11-26 |
2024-09-25 |
The Regents of The University of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
US20180105834A1
(en)
*
|
2014-11-27 |
2018-04-19 |
Institute Of Animal Sciences, Chinese Academy Of Agrigultural Sciences |
A method of site-directed insertion to h11 locus in pigs by using site-directed cutting system
|
|
EP4400584A3
(en)
|
2014-12-03 |
2024-10-16 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
AU2015360502A1
(en)
|
2014-12-10 |
2017-06-29 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
WO2016094867A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
US20170327834A1
(en)
|
2014-12-15 |
2017-11-16 |
Syngenta Participations Ag |
Pesticidal microrna carriers and use thereof
|
|
WO2016100272A1
(en)
*
|
2014-12-16 |
2016-06-23 |
Danisco Us Inc |
Fungal genome modification systems and methods of use
|
|
US20170369866A1
(en)
*
|
2014-12-17 |
2017-12-28 |
E I Du Pont De Nemours And Company |
Compositions and methods for efficient gene editing in e. coli using guide rna/cas endonuclease systems in combination with circular polynucleotide modification templates
|
|
WO2016100974A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
US20190054117A1
(en)
|
2014-12-19 |
2019-02-21 |
Novartis Ag |
Dimerization switches and uses thereof
|
|
US10190106B2
(en)
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
|
CA2969151A1
(en)
|
2014-12-23 |
2016-06-30 |
Syngenta Participations Ag |
Methods and compositions for identifying and enriching for cells comprising site specific genomic modifications
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
CA2972454C
(en)
|
2014-12-31 |
2024-09-10 |
Viridos, Inc. |
Compositions and methods for high efficiency in in vivo genome editing
|
|
EP3245232B1
(en)
|
2015-01-12 |
2021-04-21 |
The Regents of The University of California |
Heterodimeric cas9 and methods of use thereof
|
|
US11180792B2
(en)
|
2015-01-28 |
2021-11-23 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
KR102319192B1
(ko)
|
2015-01-28 |
2021-10-28 |
카리부 바이오사이언시스 인코포레이티드 |
Crispr 하이브리드 dna/rna 폴리뉴클레오티드 및 사용 방법
|
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
|
EP3262193A2
(en)
|
2015-02-26 |
2018-01-03 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
EP3265560B1
(en)
|
2015-03-02 |
2021-12-08 |
Sinai Health System |
Homologous recombination factors
|
|
US9944912B2
(en)
|
2015-03-03 |
2018-04-17 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
|
|
CN104673816A
(zh)
*
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
|
CN107567499A
(zh)
|
2015-03-27 |
2018-01-09 |
纳幕尔杜邦公司 |
大豆u6核小rna基因启动子及其在植物小rna基因的组成型表达中的用途
|
|
EP3280803B1
(en)
|
2015-04-06 |
2021-05-26 |
The Board of Trustees of the Leland Stanford Junior University |
Chemically modified guide rnas for crispr/cas-mediated gene regulation
|
|
US11267874B2
(en)
*
|
2015-04-16 |
2022-03-08 |
President And Fellows Of Harvard College |
Sensor systems for target ligands and uses thereof
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
WO2016172727A1
(en)
|
2015-04-24 |
2016-10-27 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
EP3289104B1
(en)
|
2015-04-29 |
2020-11-04 |
New York University |
Method for treating high-grade gliomas
|
|
CN106191040B
(zh)
*
|
2015-04-30 |
2021-09-14 |
杭州菁因康生物科技有限公司 |
基因打靶方法
|
|
NZ738068A
(en)
|
2015-05-06 |
2019-07-26 |
Snipr Tech Ltd |
Altering microbial populations & modifying microbiota
|
|
JP2018515139A
(ja)
|
2015-05-08 |
2018-06-14 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
万能ドナー幹細胞および関連する方法
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
US10676723B2
(en)
|
2015-05-11 |
2020-06-09 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
US20180291372A1
(en)
*
|
2015-05-14 |
2018-10-11 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
|
EP3294878A1
(en)
|
2015-05-15 |
2018-03-21 |
Pioneer Hi-Bred International, Inc. |
Guide rna/cas endonuclease systems
|
|
WO2016187904A1
(zh)
*
|
2015-05-22 |
2016-12-01 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
|
WO2016191684A1
(en)
*
|
2015-05-28 |
2016-12-01 |
Finer Mitchell H |
Genome editing vectors
|
|
CN108026536A
(zh)
*
|
2015-05-29 |
2018-05-11 |
北卡罗来纳州立大学 |
使用crispr核酸筛选细菌、古细菌、藻类和酵母的方法
|
|
WO2016196539A2
(en)
|
2015-06-01 |
2016-12-08 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions for rna-guided treatment of hiv infection
|
|
WO2016196655A1
(en)
|
2015-06-03 |
2016-12-08 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
|
CN108368502B
(zh)
|
2015-06-03 |
2022-03-18 |
内布拉斯加大学董事委员会 |
使用单链dna的dna编辑
|
|
US20180296537A1
(en)
|
2015-06-05 |
2018-10-18 |
Novartis Ag |
Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
|
|
EP3307887A1
(en)
|
2015-06-09 |
2018-04-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
WO2016198500A1
(en)
*
|
2015-06-10 |
2016-12-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for rna-guided treatment of human cytomegalovirus (hcmv) infection
|
|
MA45481A
(fr)
|
2015-06-10 |
2018-04-18 |
Univ Texas |
Utilisation d'exosomes pour le traitement de maladies
|
|
EP3307888A1
(en)
*
|
2015-06-12 |
2018-04-18 |
Erasmus University Medical Center Rotterdam |
New crispr assays
|
|
US11643668B2
(en)
|
2015-06-17 |
2023-05-09 |
The Uab Research Foundation |
CRISPR/Cas9 complex for genomic editing
|
|
CA2989858A1
(en)
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
AU2016279062A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
FI3430134T3
(fi)
|
2015-06-18 |
2023-01-13 |
|
Uusia CRISPR-entsyymejä ja järjestelmiä
|
|
KR102840885B1
(ko)
|
2015-06-18 |
2025-07-30 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적외 효과를 감소시키는 crispr 효소 돌연변이
|
|
EP4545544A3
(en)
|
2015-06-29 |
2025-10-08 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
KR102461443B1
(ko)
|
2015-07-13 |
2022-10-31 |
피벗 바이오, 인크. |
식물 형질 개선을 위한 방법 및 조성물
|
|
US11479793B2
(en)
|
2015-07-15 |
2022-10-25 |
Rutgers, The State University Of New Jersey |
Nuclease-independent targeted gene editing platform and uses thereof
|
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
WO2017023803A1
(en)
|
2015-07-31 |
2017-02-09 |
Regents Of The University Of Minnesota |
Modified cells and methods of therapy
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
US11667691B2
(en)
|
2015-08-07 |
2023-06-06 |
Novartis Ag |
Treatment of cancer using chimeric CD3 receptor proteins
|
|
EP3334484B1
(en)
|
2015-08-12 |
2024-12-25 |
The General Hospital Corporation |
Compositions that promote hypoxia or the hypoxia response for the treatment and prevention of mitochondrial dysfunction
|
|
WO2017027910A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
WO2017031370A1
(en)
|
2015-08-18 |
2017-02-23 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
EA201890565A1
(ru)
|
2015-08-25 |
2019-04-30 |
Дьюк Юниверсити |
Композиции и способы улучшения специфичности в геномной инженерии с применением рнк-направляемых эндонуклеаз
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
KR102668608B1
(ko)
|
2015-08-28 |
2024-05-24 |
더 제너럴 하스피탈 코포레이션 |
조작된 crispr-cas9 뉴클레아제
|
|
JP6664693B2
(ja)
|
2015-09-09 |
2020-03-13 |
国立大学法人神戸大学 |
標的化したｄｎａ配列の核酸塩基を特異的に変換する、グラム陽性菌のゲノム配列の変換方法、及びそれに用いる分子複合体
|
|
IL241462A0
(en)
|
2015-09-10 |
2015-11-30 |
Yeda Res & Dev |
Heterologous engineering of betalain pigments in plants
|
|
WO2017044843A1
(en)
|
2015-09-11 |
2017-03-16 |
The General Hospital Corporation |
Full interrogation of nuclease dsbs and sequencing (find-seq)
|
|
WO2017053879A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
AU2016331185A1
(en)
|
2015-09-30 |
2018-04-26 |
The General Hospital Corporation |
Comprehensive in vitro reporting of cleavage events by sequencing (CIRCLE-seq)
|
|
EP3359664A4
(en)
|
2015-10-05 |
2019-03-20 |
Massachusetts Institute Of Technology |
NITROGEN FIXATION WITH REINFORCED NIF CLUSTERS
|
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
WO2017066175A1
(en)
|
2015-10-12 |
2017-04-20 |
E. I. Du Pont De Nemours And Company |
Protected dna templates for gene modification and increased homologous recombination in cells and methods of use
|
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
EP3362561A2
(en)
*
|
2015-10-16 |
2018-08-22 |
Astrazeneca AB |
Inducible modification of a cell genome
|
|
EP4636083A2
(en)
|
2015-10-20 |
2025-10-22 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods and products for genetic engineering
|
|
US10968253B2
(en)
|
2015-10-20 |
2021-04-06 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
|
US20180282763A1
(en)
|
2015-10-20 |
2018-10-04 |
Pioneer Hi-Bred International, Inc. |
Restoring function to a non-functional gene product via guided cas systems and methods of use
|
|
KR20250021623A
(ko)
|
2015-10-22 |
2025-02-13 |
더 브로드 인스티튜트, 인코퍼레이티드 |
타입 vi-b crispr 효소 및 시스템
|
|
DK3350327T3
(en)
|
2015-10-23 |
2019-01-21 |
Caribou Biosciences Inc |
CONSTRUCTED CRISPR CLASS-2-NUCLEIC ACID TARGETING-NUCLEIC ACID
|
|
EP3365356B1
(en)
|
2015-10-23 |
2023-06-28 |
President and Fellows of Harvard College |
Nucleobase editors and uses thereof
|
|
WO2017074788A1
(en)
|
2015-10-27 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
EP3368689B1
(en)
|
2015-10-28 |
2020-06-17 |
The Broad Institute, Inc. |
Composition for modulating immune responses by use of immune cell gene signature
|
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
US11092607B2
(en)
|
2015-10-28 |
2021-08-17 |
The Board Institute, Inc. |
Multiplex analysis of single cell constituents
|
|
GB2559526B
(en)
|
2015-11-03 |
2021-02-17 |
Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
|
EP3370513A1
(en)
*
|
2015-11-06 |
2018-09-12 |
The Jackson Laboratory |
Large genomic dna knock-in and uses thereof
|
|
TW201737944A
(zh)
*
|
2015-11-12 |
2017-11-01 |
輝瑞大藥廠 |
使用crispr-cas9之組織特異性基因組工程
|
|
US11306308B2
(en)
|
2015-11-13 |
2022-04-19 |
Massachusetts Institute Of Technology |
High-throughput CRISPR-based library screening
|
|
KR20180120670A
(ko)
|
2015-11-13 |
2018-11-06 |
아벨리노 랩 유에스에이, 인크. |
각막 이상증의 치료 방법
|
|
HK1257955A1
(zh)
|
2015-11-16 |
2019-11-01 |
The Research Institute At Nationwide Children's Hospital |
用於治疗肌联蛋白类肌病和其他肌联蛋白病变的材料和方法
|
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
|
WO2017087885A1
(en)
|
2015-11-19 |
2017-05-26 |
Dana-Farber Cancer Institute, Inc. |
Methods of identifying compounds that interfere with erg-driven misguidance of baf complexes in tmprss2-erg driven prostate cancers
|
|
KR102061438B1
(ko)
*
|
2015-11-27 |
2019-12-31 |
고쿠리츠다이가쿠호진 고베다이가쿠 |
표적화 dna 서열 중의 핵산 염기가 특이적으로 전환되어 있는 단자엽식물 게놈 서열을 전환시키는 방법, 및 그것에 사용되는 분자 복합체
|
|
WO2017095944A1
(en)
|
2015-11-30 |
2017-06-08 |
Flagship Pioneering, Inc. |
Methods and compositions relating to chondrisomes from blood products
|
|
WO2017095967A2
(en)
|
2015-11-30 |
2017-06-08 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
CN105296518A
(zh)
*
|
2015-12-01 |
2016-02-03 |
中国农业大学 |
一种用于CRISPR/Cas9技术的同源臂载体构建方法
|
|
NZ756843A
(en)
|
2015-12-04 |
2021-07-30 |
Caribou Biosciences Inc |
Engineered nucleic-acid targeting nucleic acids
|
|
US11208649B2
(en)
|
2015-12-07 |
2021-12-28 |
Zymergen Inc. |
HTP genomic engineering platform
|
|
JP6821598B2
(ja)
|
2015-12-07 |
2021-01-27 |
ザイマージェン インコーポレイテッド |
Ｃｏｒｙｎｅｂａｃｔｅｒｉｕｍ ｇｌｕｔａｍｉｃｕｍ由来のプロモーター
|
|
US9988624B2
(en)
|
2015-12-07 |
2018-06-05 |
Zymergen Inc. |
Microbial strain improvement by a HTP genomic engineering platform
|
|
DK3387134T3
(da)
|
2015-12-11 |
2020-12-21 |
Danisco Us Inc |
Fremgangsmåder og sammensætninger til øget nukleasemedieret genommodifikation og reducerede virkninger uden for målstedet
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
EP3708665A1
(en)
|
2015-12-18 |
2020-09-16 |
Danisco US Inc. |
Methods and compositions for t-rna based guide rna expression
|
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
|
CN109072195A
(zh)
|
2015-12-30 |
2018-12-21 |
诺华股份有限公司 |
具有增强功效的免疫效应细胞疗法
|
|
CN108463229B
(zh)
|
2016-01-11 |
2023-10-17 |
斯坦福大学托管董事会 |
嵌合蛋白和免疫治疗方法
|
|
CN109312335B
(zh)
|
2016-01-11 |
2023-10-24 |
斯坦福大学托管董事会 |
嵌合蛋白和调节基因表达的方法
|
|
EP4653048A2
(en)
|
2016-01-15 |
2025-11-26 |
The Children's Medical Center Corporation |
Therapeutic use of mitochondria and combined mitochondrial agents
|
|
US11136589B2
(en)
|
2016-01-26 |
2021-10-05 |
Pioneer Hi-Bred International, Inc. |
Waxy corn
|
|
US10876129B2
(en)
|
2016-02-12 |
2020-12-29 |
Ceres, Inc. |
Methods and materials for high throughput testing of mutagenized allele combinations
|
|
US10973930B2
(en)
|
2016-02-18 |
2021-04-13 |
The Penn State Research Foundation |
Generating GABAergic neurons in brains
|
|
US20190249172A1
(en)
|
2016-02-18 |
2019-08-15 |
The Regents Of The University Of California |
Methods and compositions for gene editing in stem cells
|
|
EP3420102B1
(en)
|
2016-02-22 |
2024-04-03 |
Massachusetts Institute of Technology |
Methods for identifying and modulating immune phenotypes
|
|
WO2017151444A1
(en)
|
2016-02-29 |
2017-09-08 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by crispr proteins
|
|
CA3016571A1
(en)
|
2016-03-04 |
2017-09-08 |
Indoor Biotechnologies Inc. |
Fel d 1 knockouts and associated compositions and methods based on crispr-cas9 genomic editing
|
|
WO2017155714A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
WO2017155715A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
EP3699280A3
(en)
|
2016-03-11 |
2020-11-18 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
JP2019515654A
(ja)
|
2016-03-16 |
2019-06-13 |
ザ ジェイ． デヴィッド グラッドストーン インスティテューツ |
肥満及び／又は糖尿病を処置するための方法及び組成物、並びに候補処置薬剤を識別するための方法及び組成物
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US11427861B2
(en)
|
2016-03-17 |
2022-08-30 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
CA3016504A1
(en)
|
2016-03-23 |
2017-09-28 |
Dana-Farber Cancer Institute, Inc. |
Methods for enhancing the efficiency of gene editing
|
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
US11236313B2
(en)
|
2016-04-13 |
2022-02-01 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
PL3443096T3
(pl)
|
2016-04-15 |
2023-06-19 |
Novartis Ag |
Kompozycje i sposoby do selektywnej ekspresji chimerycznych receptorów antygenowych
|
|
US12410416B2
(en)
|
2016-04-19 |
2025-09-09 |
The Broad Institute, Inc. |
CRISPR enzymes and systems with modified pam specificity
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
PL3445406T3
(pl)
*
|
2016-04-20 |
2022-02-07 |
Centro De Investigaciones Energéticas, Medioambientales Y Tecnológicas, O.A., M.P. |
Kompozycje i sposoby zwiększonej ekspresji genów PKLR
|
|
CN105861485B
(zh)
*
|
2016-04-20 |
2021-08-17 |
上海伊丽萨生物科技有限公司 |
一种提高基因置换效率的方法
|
|
EP4613756A3
(en)
|
2016-04-25 |
2025-11-12 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
WO2017201425A1
(en)
*
|
2016-05-20 |
2017-11-23 |
The Trustees Columbia University In The City Of New York |
Anabolic enhancers for ameliorating neurodegeneration
|
|
JP2019516774A
(ja)
|
2016-05-24 |
2019-06-20 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ |
Ｋｕ阻害剤およびその使用
|
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
WO2017219027A1
(en)
|
2016-06-17 |
2017-12-21 |
The Broad Institute Inc. |
Type vi crispr orthologs and systems
|
|
EP4282478A3
(en)
|
2016-06-21 |
2024-03-06 |
The Curators of the University of Missouri |
Modified dystrophin proteins
|
|
ES2915562T3
(es)
|
2016-06-24 |
2022-06-23 |
Univ Colorado Regents |
Métodos para generar bibliotecas combinatorias con código de barras
|
|
EP3474849B1
(en)
|
2016-06-27 |
2025-05-21 |
The Broad Institute, Inc. |
Compositions and methods for detecting and treating diabetes
|
|
JP2019519241A
(ja)
|
2016-06-30 |
2019-07-11 |
ザイマージェン インコーポレイテッド |
グルコース透過酵素ライブラリーを生成するための方法およびその使用
|
|
US10544390B2
(en)
|
2016-06-30 |
2020-01-28 |
Zymergen Inc. |
Methods for generating a bacterial hemoglobin library and uses thereof
|
|
US11359234B2
(en)
|
2016-07-01 |
2022-06-14 |
Microsoft Technology Licensing, Llc |
Barcoding sequences for identification of gene expression
|
|
US10669558B2
(en)
|
2016-07-01 |
2020-06-02 |
Microsoft Technology Licensing, Llc |
Storage through iterative DNA editing
|
|
US20180004537A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Molecular State Machines
|
|
MA45670A
(fr)
|
2016-07-13 |
2019-05-22 |
Vertex Pharma |
Procédés, compositions et kits pour augmenter l'efficacité d'édition du génome
|
|
AU2017295886C1
(en)
|
2016-07-15 |
2024-05-16 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
EP3494220A1
(en)
|
2016-08-02 |
2019-06-12 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
EP3497214B1
(en)
|
2016-08-09 |
2023-06-28 |
President and Fellows of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
KR20180018457A
(ko)
*
|
2016-08-12 |
2018-02-21 |
주식회사 툴젠 |
조작된 면역조절요소 및 이에 의해 변형된 면역 활성
|
|
JP7215808B2
(ja)
|
2016-08-12 |
2023-01-31 |
ツールゲン インコーポレイテッド |
操作された免疫調節エレメントおよび変更された免疫
|
|
US11630103B2
(en)
|
2016-08-17 |
2023-04-18 |
The Broad Institute, Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
EP4485466A3
(en)
|
2016-08-17 |
2025-04-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
CN110312799A
(zh)
|
2016-08-17 |
2019-10-08 |
博德研究所 |
新型crispr酶和系统
|
|
EP3500677A4
(en)
*
|
2016-08-20 |
2020-04-01 |
Avellino Lab USA, Inc. |
Single guide rna, crispr/cas9 systems, and methods of use thereof
|
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
CA3035534A1
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
|
IL247752A0
(en)
|
2016-09-11 |
2016-11-30 |
Yeda Res & Dev |
Compositions and methods for modulating gene expression for site-directed mutagenesis
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
US12499971B2
(en)
|
2016-09-28 |
2025-12-16 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
US20190203230A1
(en)
|
2016-09-28 |
2019-07-04 |
Novartis Ag |
Porous membrane-based macromolecule delivery system
|
|
EA201990860A1
(ru)
|
2016-09-30 |
2019-10-31 |
|
Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения
|
|
WO2018064371A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
WO2018067546A1
(en)
|
2016-10-03 |
2018-04-12 |
President And Fellows Of Harvard College |
Delivery of therapeutic rnas via arrdc1-mediated microvesicles
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
US12012605B2
(en)
|
2016-10-13 |
2024-06-18 |
Pioneer Hi-Bred International, Inc. |
Generating northern leaf blight resistant maize
|
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
US10738338B2
(en)
|
2016-10-18 |
2020-08-11 |
The Research Foundation for the State University |
Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
|
|
CA3041068A1
(en)
|
2016-10-18 |
2018-04-26 |
Regents Of The University Of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
JP7157052B2
(ja)
*
|
2016-10-28 |
2022-10-19 |
ジェネトン |
筋緊張性ジストロフィーの治療のための組成物および方法
|
|
WO2018081531A2
(en)
|
2016-10-28 |
2018-05-03 |
Ariad Pharmaceuticals, Inc. |
Methods for human t-cell activation
|
|
WO2018076335A1
(en)
|
2016-10-31 |
2018-05-03 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Compositions and methods for enhancing abiotic stress tolerance
|
|
EP3535396A1
(en)
|
2016-11-01 |
2019-09-11 |
Novartis AG |
Methods and compositions for enhancing gene editing
|
|
AU2017355507B2
(en)
|
2016-11-04 |
2023-09-21 |
Flagship Pioneering Innovations V. Inc. |
Novel plant cells, plants, and seeds
|
|
KR102546194B1
(ko)
|
2016-11-04 |
2023-06-21 |
칠드런즈 호스피탈 메디칼 센터 |
간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
CN110168102A
(zh)
|
2016-11-15 |
2019-08-23 |
基因组影像公司 |
利用分子梳理监测经修饰的核酸酶诱导的基因编辑事件的方法
|
|
EP3548637A1
(en)
|
2016-11-29 |
2019-10-09 |
Genomic Vision |
Method for designing a set of polynucleotide sequences for analysis of specific events in a genetic region of interest
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
US12404514B2
(en)
|
2016-12-09 |
2025-09-02 |
The Broad Institute, Inc. |
CRISPR-systems for modifying a trait of interest in a plant
|
|
KR20210035022A
(ko)
|
2016-12-14 |
2021-03-31 |
리간달 인코포레이티드 |
핵산 및/또는 단백질 적재물 전달을 위한 조성물 및 방법
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
US12241074B2
(en)
|
2016-12-22 |
2025-03-04 |
Monsanto Technology Llc |
Genome editing-based crop engineering and production of brachytic plants
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
JP7219972B2
(ja)
|
2017-01-05 |
2023-02-09 |
ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー |
Ｄｎａ二本鎖切断に非依存的な標的化遺伝子編集プラットフォームおよびその用途
|
|
WO2018127585A1
(en)
|
2017-01-06 |
2018-07-12 |
Txcell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
|
EP3346001A1
(en)
|
2017-01-06 |
2018-07-11 |
TXCell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
|
JP7229923B2
(ja)
|
2017-01-06 |
2023-02-28 |
エディタス・メディシン、インコーポレイテッド |
ヌクレアーゼ切断を評価する方法
|
|
US11519009B2
(en)
|
2017-01-09 |
2022-12-06 |
University Of Massachusetts |
Complexes for gene deletion and editing
|
|
UA129256C2
(uk)
|
2017-01-12 |
2025-03-05 |
Півот Байо, Інк. |
Спосіб ідентифікації штаму мікроорганізму, який продукує азот, небобова рослина, колонізована таким штамом, спосіб збільшення фіксації азоту у небобових рослин та композиція для збільшення фіксації азоту у небобових рослин
|
|
US11535662B2
(en)
|
2017-01-26 |
2022-12-27 |
Novartis Ag |
CD28 compositions and methods for chimeric antigen receptor therapy
|
|
WO2018140899A1
(en)
|
2017-01-28 |
2018-08-02 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
|
WO2018144535A1
(en)
|
2017-01-31 |
2018-08-09 |
Novartis Ag |
Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
KR20190116282A
(ko)
|
2017-02-10 |
2019-10-14 |
지머젠 인코포레이티드 |
복수의 숙주를 위한 다중 dna 구조체의 조립 및 편집을 위한 모듈식 범용 플라스미드 디자인 전략
|
|
US10828330B2
(en)
|
2017-02-22 |
2020-11-10 |
IO Bioscience, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
|
CA3054307A1
(en)
*
|
2017-02-22 |
2018-08-30 |
Io Biosciences, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
|
EP3589647A1
(en)
|
2017-02-28 |
2020-01-08 |
Novartis AG |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
WO2018165631A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
KR20190127797A
(ko)
|
2017-03-10 |
2019-11-13 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
시토신에서 구아닌으로의 염기 편집제
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
JP2020511141A
(ja)
|
2017-03-15 |
2020-04-16 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新規Ｃａｓ１３ｂオルソログＣＲＩＳＰＲ酵素及び系
|
|
WO2018170436A1
(en)
|
2017-03-16 |
2018-09-20 |
Jacobs Farm Del Cabo |
Basil with high tolerance to downy mildew
|
|
WO2018170515A1
(en)
|
2017-03-17 |
2018-09-20 |
The Broad Institute, Inc. |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
WO2018183878A1
(en)
|
2017-03-31 |
2018-10-04 |
Pioneer Hi-Bred International, Inc. |
Expression modulating elements and use thereof
|
|
EP3606518A4
(en)
|
2017-04-01 |
2021-04-07 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTION AND MODULATION OF IMMUNOTHERAPY RESISTANCE GENE SIGNATURE IN CANCER
|
|
EP3610266A4
(en)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
TUMOR SIGNATURE FOR METASTASIS, COMPOSITIONS OF MATERIAL AND THEIR METHODS OF USE
|
|
WO2018191520A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
KR20240155360A
(ko)
|
2017-04-12 |
2024-10-28 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규 타입 vi crispr 오르소로그 및 시스템
|
|
WO2018191750A2
(en)
|
2017-04-14 |
2018-10-18 |
The Broad Institute Inc. |
Novel delivery of large payloads
|
|
WO2018191673A1
(en)
|
2017-04-14 |
2018-10-18 |
Children's Hospital Medical Center |
Multi donor stem cell compositions and methods of making same
|
|
WO2018195019A1
(en)
|
2017-04-18 |
2018-10-25 |
The Broad Institute Inc. |
Compositions for detecting secretion and methods of use
|
|
US11834670B2
(en)
|
2017-04-19 |
2023-12-05 |
Global Life Sciences Solutions Usa Llc |
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
|
|
CN116555353A
(zh)
|
2017-04-20 |
2023-08-08 |
E开创生物技术股份有限公司 |
产生基因修改的动物的方法
|
|
EP3612551B1
(en)
|
2017-04-21 |
2024-09-04 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
WO2018195486A1
(en)
|
2017-04-21 |
2018-10-25 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
WO2018201086A1
(en)
|
2017-04-28 |
2018-11-01 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
|
US20200179511A1
(en)
|
2017-04-28 |
2020-06-11 |
Novartis Ag |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
EP3615055A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
US12275963B2
(en)
|
2017-05-08 |
2025-04-15 |
Toolgen Incorporated |
Artificially manipulated immune cell
|
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
US12226479B2
(en)
|
2017-05-11 |
2025-02-18 |
The General Hospital Corporation |
Methods and compositions of use of CD8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
EP3625342B1
(en)
|
2017-05-18 |
2022-08-24 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11866697B2
(en)
|
2017-05-18 |
2024-01-09 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11326157B2
(en)
|
2017-05-25 |
2022-05-10 |
The General Hospital Corporation |
Base editors with improved precision and specificity
|
|
EP3409104A1
(en)
|
2017-05-31 |
2018-12-05 |
Vilmorin et Cie |
Tomato plant resistant to tomato yellow leaf curl virus, powdery mildew, and nematodes
|
|
EP3409106A1
(en)
|
2017-06-01 |
2018-12-05 |
Vilmorin et Cie |
Tolerance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus (tbrfv)
|
|
WO2020249996A1
(en)
|
2019-06-14 |
2020-12-17 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus
|
|
CA3102054A1
(en)
|
2017-06-05 |
2018-12-13 |
Fred Hutchinson Cancer Research Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
|
CA3065946A1
(en)
|
2017-06-05 |
2018-12-13 |
Research Institute At Nationwide Children's Hospital |
Enhanced modified viral capsid proteins
|
|
KR20200026874A
(ko)
|
2017-06-06 |
2020-03-11 |
지머젠 인코포레이티드 |
대장균 개량을 위한 htp 게놈 공학 플랫폼
|
|
KR20200026878A
(ko)
|
2017-06-06 |
2020-03-11 |
지머젠 인코포레이티드 |
균류 균주를 개량하기 위한 htp 게놈 공학 플랫폼
|
|
KR102541398B1
(ko)
|
2017-06-08 |
2023-06-07 |
고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 |
Dna가 편집된 진핵 세포를 제조하는 방법 및 당해 방법에 사용되는 키트
|
|
MX2019014640A
(es)
|
2017-06-09 |
2020-10-05 |
Editas Medicine Inc |
Nucleasas de repeticiones palíndromicas agrupadas y regularmente interespaciadas de proteina asociada 9 (cas9) genomanipuladas.
|
|
MA52134A
(fr)
|
2017-06-09 |
2020-04-15 |
Vilmorin & Cie |
Compositions et procédés pour l'édition génomique
|
|
KR20200038236A
(ko)
|
2017-06-13 |
2020-04-10 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
큐론을 포함하는 조성물 및 그의 용도
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
EP3638317A4
(en)
|
2017-06-15 |
2021-03-17 |
The Regents of The University of California |
TARGETED NONVIRAL DNA INSERTIONS
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
EP3645054A4
(en)
|
2017-06-26 |
2021-03-31 |
The Broad Institute, Inc. |
CRISPR / CAS-ADENINE DESAMINASE COMPOSITIONS, TARGETED NUCLEIC ACID EDITING SYSTEMS AND METHODS
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
WO2019003193A1
(en)
|
2017-06-30 |
2019-01-03 |
Novartis Ag |
METHODS FOR TREATING DISEASES USING GENE EDITING SYSTEMS
|
|
JP2020530307A
(ja)
|
2017-06-30 |
2020-10-22 |
インティマ・バイオサイエンス，インコーポレーテッド |
遺伝子治療のためのアデノ随伴ウイルスベクター
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
WO2019014581A1
(en)
|
2017-07-14 |
2019-01-17 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE
|
|
US12105089B2
(en)
|
2017-07-17 |
2024-10-01 |
The Broad Institute, Inc. |
Cell atlas of the healthy and ulcerative colitis human colon
|
|
US10510743B2
(en)
*
|
2017-07-18 |
2019-12-17 |
Hong Kong Applied Science and Technology Research Institute Company, Limited |
Step fin field-effect-transistor (FinFET) with slim top of fin and thick bottom of fin for electro-static-discharge (ESD) or electrical over-stress (EOS) protection
|
|
KR102652494B1
(ko)
*
|
2017-07-18 |
2024-03-28 |
제노비에 에이비 |
전장 t-세포 수용체 오픈 리딩 프레임의 신속한 조립 및 다양화를 위한 2-성분 벡터 라이브러리 시스템
|
|
WO2019018694A1
(en)
|
2017-07-19 |
2019-01-24 |
Dana-Farber Cancer Institute, Inc. |
DIAGNOSIS AND TREATMENT OF CANCER
|
|
WO2019023291A2
(en)
|
2017-07-25 |
2019-01-31 |
Dana-Farber Cancer Institute, Inc. |
COMPOSITIONS AND METHODS FOR PRODUCTION AND DECODING OF GUIDE RNA LIBRARIES AND USES THEREOF
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
EP3950957A1
(en)
|
2017-08-08 |
2022-02-09 |
Depixus |
In vitro isolation and enrichment of nucleic acids using site-specific nucleases
|
|
US11970720B2
(en)
|
2017-08-22 |
2024-04-30 |
Salk Institute For Biological Studies |
RNA targeting methods and compositions
|
|
US10476825B2
(en)
|
2017-08-22 |
2019-11-12 |
Salk Institue for Biological Studies |
RNA targeting methods and compositions
|
|
CA3073448A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
SG11202001008RA
(en)
|
2017-08-25 |
2020-03-30 |
Codiak Biosciences Inc |
Preparation of therapeutic exosomes using membrane proteins
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
JP2020534812A
(ja)
*
|
2017-09-08 |
2020-12-03 |
ライフ テクノロジーズ コーポレイション |
改良された相同組換えおよびその組成物のための方法
|
|
US20190076814A1
(en)
|
2017-09-11 |
2019-03-14 |
Synthego Corporation |
Biopolymer synthesis system and method
|
|
US10709151B2
(en)
|
2017-09-15 |
2020-07-14 |
Covercress, Inc. |
Low fiber pennycress meal and methods of making
|
|
JP7281774B2
(ja)
|
2017-09-19 |
2023-05-26 |
ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア |
抗ｈｌａ－ａ２抗体及びその使用方法
|
|
IL273401B2
(en)
|
2017-09-20 |
2025-05-01 |
Univ British Columbia |
Novel antibodies against human leukocyte antigens type A2 and their uses
|
|
CN109517820B
(zh)
|
2017-09-20 |
2021-09-24 |
北京宇繁生物科技有限公司 |
一种靶向HPK1的gRNA以及HPK1基因编辑方法
|
|
US11917978B2
(en)
|
2017-09-21 |
2024-03-05 |
The Conard Pyle Company |
Miniature rose plant named ‘meibenbino’
|
|
CA3073848A1
(en)
|
2017-09-21 |
2019-03-28 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
CA3076249A1
(en)
|
2017-09-21 |
2019-03-28 |
Dana-Farber Cancer Institute, Inc. |
Isolation, preservation, compositions and uses of extracts from justicia plants
|
|
US11252928B2
(en)
|
2017-09-21 |
2022-02-22 |
The Condard-Pyle Company |
Miniature rose plant named ‘Meibenbino’
|
|
MX2020003074A
(es)
|
2017-09-25 |
2020-09-14 |
Agrospheres Inc |
Composiciones y metodos para la produccion y la administracion expansible de productos biologicos.
|
|
WO2019070755A1
(en)
|
2017-10-02 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
|
|
EP3692152B1
(en)
|
2017-10-04 |
2025-09-03 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
EP3694603A4
(en)
|
2017-10-10 |
2021-07-14 |
Children's Hospital Medical Center |
ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
|
|
WO2019075197A1
(en)
|
2017-10-11 |
2019-04-18 |
The General Hospital Corporation |
METHODS OF DETECTION OF INDIVIDUAL SITE-SPECIFIC PARASITE GENOMIC DEAMINATION BY BASE EDITING TECHNOLOGIES
|
|
WO2019079362A1
(en)
|
2017-10-16 |
2019-04-25 |
Massachusetts Institute Of Technology |
HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS
|
|
AU2018352583B2
(en)
|
2017-10-16 |
2025-04-17 |
Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P. |
Lentiviral vectors for delivery of PKLR to treat Pyruvate Kinase Deficiency
|
|
CN111757937A
(zh)
|
2017-10-16 |
2020-10-09 |
布罗德研究所股份有限公司 |
腺苷碱基编辑器的用途
|
|
IL274082B1
(en)
|
2017-10-20 |
2025-09-01 |
Hutchinson Fred Cancer Res |
Systems and methods for producing genetically engineered B cells for expression of selected antibodies
|
|
US12227742B2
(en)
|
2017-10-23 |
2025-02-18 |
The Broad Institute, Inc. |
Nucleic acid modifiers
|
|
CN111587287B
(zh)
|
2017-10-25 |
2025-02-18 |
皮沃特生物股份有限公司 |
用于改良固氮的工程微生物的方法和组合物
|
|
BR112020008002A2
(pt)
|
2017-10-25 |
2020-11-03 |
Pivot Bio, Inc. |
alvos gênicos para fixação de nitrogênio para aprimorar traços de plantas
|
|
KR102770787B1
(ko)
|
2017-10-27 |
2025-02-19 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
내인성 t 세포 수용체의 표적화된 대체
|
|
WO2019089798A1
(en)
|
2017-10-31 |
2019-05-09 |
Novartis Ag |
Anti-car compositions and methods
|
|
WO2019089803A1
(en)
|
2017-10-31 |
2019-05-09 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
BR112020008654A2
(pt)
|
2017-11-01 |
2020-11-10 |
The Regents Of The University Of California |
composições casz e métodos de uso
|
|
US20210180053A1
(en)
|
2017-11-01 |
2021-06-17 |
Novartis Ag |
Synthetic rnas and methods of use
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
US20200255830A1
(en)
|
2017-11-02 |
2020-08-13 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
|
JP2021508251A
(ja)
|
2017-11-06 |
2021-03-04 |
深▲セン▼市三▲啓▼生物技▲術▼有限公司Ｓｈｅｎｚｈｅｎ Ｃｅｌｌ Ｉｎｓｐｉｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． |
アルツハイマー病をモデル化する新しいヒト誘発多能性幹細胞株およびその使用
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
US12018080B2
(en)
|
2017-11-13 |
2024-06-25 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway
|
|
WO2019094984A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
AU2018368786B2
(en)
|
2017-11-17 |
2025-05-22 |
Iovance Biotherapeutics, Inc. |
TIL expansion from fine needle aspirates and small biopsies
|
|
JP2021503885A
(ja)
|
2017-11-22 |
2021-02-15 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
末梢血からの末梢血リンパ球（ｐｂｌ）の拡大培養
|
|
BR112020010326A2
(pt)
*
|
2017-12-05 |
2020-10-20 |
Synthetic Genomics, Inc. |
aperfeiçoamento da produtividade lipídica de algas através da modificação genética de uma proteína de sinalização
|
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
EP3720869A4
(en)
|
2017-12-08 |
2021-11-24 |
Synthetic Genomics, Inc. |
IMPROVEMENT OF ALGAE LIPID PRODUCTIVITY BY GENETIC MODIFICATION OF A PROTEIN CONTAINING A TPR DOMAIN
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
EP3707253A1
(en)
|
2017-12-15 |
2020-09-16 |
Danisco US Inc. |
Cas9 variants and methods of use
|
|
EP3724216A1
(en)
|
2017-12-15 |
2020-10-21 |
Dana Farber Cancer Institute, Inc. |
Stabilized peptide-mediated targeted protein degradation
|
|
EP3727394A4
(en)
|
2017-12-21 |
2021-09-08 |
Children's Hospital Medical Center |
DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
|
|
WO2019133934A2
(en)
|
2017-12-28 |
2019-07-04 |
Codiak Biosciences, Inc. |
Exosomes for immuno-oncology and anti-inflammatory therapy
|
|
US20190201548A1
(en)
|
2017-12-29 |
2019-07-04 |
Rubius Therapeutics, Inc. |
Gene editing and targeted transcriptional modulation for engineering erythroid cells
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
CN111566121A
(zh)
|
2018-01-12 |
2020-08-21 |
巴斯夫欧洲公司 |
小麦7a染色体上决定每穗小穗数QTL的基因
|
|
KR20200110687A
(ko)
|
2018-01-17 |
2020-09-24 |
버텍스 파마슈티칼스 인코포레이티드 |
유전체 편집 효율을 증가시키기 위한 퀴녹살리논 화합물, 조성물, 방법 및 키트
|
|
ES2980444T3
(es)
|
2018-01-17 |
2024-10-01 |
Vertex Pharma |
Inhibidores de ADN-PK
|
|
JP7466448B2
(ja)
|
2018-01-17 |
2024-04-12 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ｄｎａ－ｐｋ阻害剤
|
|
WO2019143926A1
(en)
|
2018-01-19 |
2019-07-25 |
Covercress Inc. |
Low glucosinolate pennycress meal and methods of making
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
EP3746124A4
(en)
|
2018-01-30 |
2021-10-27 |
Foghorn Therapeutics Inc. |
COMPOUNDS AND THEIR USES
|
|
KR102136132B1
(ko)
*
|
2018-01-31 |
2020-07-22 |
서울대학교 산학협력단 |
CRISPR/Cas9 시스템을 통한 닭 백혈병 바이러스(Avian Leukosis Virus, ALV) 저항성 조류의 제조방법
|
|
JP7361701B2
(ja)
|
2018-01-31 |
2023-10-16 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
肢帯型筋ジストロフィー２ｃ型のための遺伝子治療
|
|
KR20200119239A
(ko)
|
2018-02-08 |
2020-10-19 |
지머젠 인코포레이티드 |
코리네박테리움에서 crispr을 사용하는 게놈 편집
|
|
JP7109547B2
(ja)
*
|
2018-02-15 |
2022-07-29 |
シグマ－アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー |
真核ゲノム修飾のための操作されたＣａｓ９システム
|
|
CA3091267A1
(en)
|
2018-02-23 |
2019-08-29 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 orthologs
|
|
US11390876B2
(en)
|
2018-03-09 |
2022-07-19 |
Pioneer Hi-Bred International, Inc. |
Compositions and methods for modification of fatty acids in soybean
|
|
ES2953541T3
(es)
|
2018-03-14 |
2023-11-14 |
Arbor Biotechnologies Inc |
Sistemas y enzimas novedosos de direccionamiento a ADN y ARN de CRISPR
|
|
WO2019178427A1
(en)
|
2018-03-14 |
2019-09-19 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
|
JP7706888B2
(ja)
|
2018-03-14 |
2025-07-14 |
エディタス・メディシン、インコーポレイテッド |
異常ヘモグロビン症の治療のためのシステム及び方法
|
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
|
US20210155959A1
(en)
|
2018-04-06 |
2021-05-27 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
|
US11981739B2
(en)
|
2018-04-13 |
2024-05-14 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
|
CA3097044A1
(en)
|
2018-04-17 |
2019-10-24 |
The General Hospital Corporation |
Sensitive in vitro assays for substrate preferences and sites of nucleic acid binding, modifying, and cleaving agents
|
|
WO2019204585A1
(en)
|
2018-04-19 |
2019-10-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
|
WO2019204766A1
(en)
|
2018-04-19 |
2019-10-24 |
The Regents Of The University Of California |
Compositions and methods for gene editing
|
|
SI3560330T1
(sl)
|
2018-04-24 |
2022-08-31 |
KWS SAAT SE & Co. KGaA |
Rastline z izboljšano prebavljivostjo in markerskimi haplotipi
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
|
IL314291A
(en)
|
2018-04-27 |
2024-09-01 |
Genedit Inc |
Cationic polymer and use for biomolecule delivery
|
|
US12281301B2
(en)
|
2018-04-27 |
2025-04-22 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
TW202446952A
(zh)
|
2018-04-27 |
2024-12-01 |
美商艾歐凡斯生物治療公司 |
腫瘤浸潤性淋巴細胞之基因編輯和彼於免疫治療之用途
|
|
US20210386829A1
(en)
|
2018-05-04 |
2021-12-16 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
US20210198664A1
(en)
|
2018-05-16 |
2021-07-01 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated systems and components
|
|
CN112654710A
(zh)
|
2018-05-16 |
2021-04-13 |
辛瑟高公司 |
用于指导rna设计和使用的方法和系统
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CN112204156A
(zh)
|
2018-05-25 |
2021-01-08 |
先锋国际良种公司 |
用于通过调节重组率来改善育种的系统和方法
|
|
CN108707628B
(zh)
*
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
|
US20210371932A1
(en)
|
2018-06-01 |
2021-12-02 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
EP3578658A1
(en)
|
2018-06-08 |
2019-12-11 |
Johann Wolfgang Goethe-Universität Frankfurt |
Method for generating a gene editing vector with fixed guide rna pairs
|
|
WO2019241315A1
(en)
|
2018-06-12 |
2019-12-19 |
Obsidian Therapeutics, Inc. |
Pde5 derived regulatory constructs and methods of use in immunotherapy
|
|
CN112203725A
(zh)
|
2018-06-13 |
2021-01-08 |
诺华股份有限公司 |
Bcma嵌合抗原受体及其用途
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
CA3102264A1
(en)
*
|
2018-06-19 |
2019-12-26 |
Lunella Biotech, Inc. |
"energetic" cancer stem cells (e-cscs): a new hyper-metabolic and proliferative tumor cell phenotype, driven by mitochondrial energy
|
|
US20210269866A1
(en)
|
2018-06-26 |
2021-09-02 |
The Broad Institute, Inc. |
Crispr effector system based amplification methods, systems, and diagnostics
|
|
CA3101066A1
(en)
|
2018-06-26 |
2020-01-02 |
The Broad Institute, Inc. |
Crispr/cas and transposase based amplification compositions, systems and methods
|
|
AU2019291824A1
(en)
|
2018-06-27 |
2021-01-14 |
Pivot Bio, Inc. |
Agricultural compositions comprising remodeled nitrogen fixing microbes
|
|
CA3104856A1
(en)
|
2018-06-29 |
2020-01-02 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
WO2020002592A1
(en)
|
2018-06-29 |
2020-01-02 |
Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis |
Traf2 inhibitors for use in the treatment of a cancer
|
|
WO2020006458A1
(en)
|
2018-06-29 |
2020-01-02 |
Research Institute At Nationwide Children's Hospital |
Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2a
|
|
AU2019302747B2
(en)
|
2018-07-11 |
2025-11-20 |
Pivot Bio, Inc. |
Temporally and spatially targeted dynamic nitrogen delivery by remodeled microbes
|
|
WO2020014528A1
(en)
|
2018-07-13 |
2020-01-16 |
The Regents Of The University Of California |
Retrotransposon-based delivery vehicle and methods of use thereof
|
|
WO2020018142A1
(en)
|
2018-07-16 |
2020-01-23 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
|
JP7506657B2
(ja)
|
2018-07-26 |
2024-06-26 |
チルドレンズ ホスピタル メディカル センター |
肝胆膵組織およびその作製方法
|
|
AU2019314433A1
(en)
|
2018-07-31 |
2021-03-25 |
Massachusetts Institute Of Technology |
Novel CRISPR enzymes and systems
|
|
EP3830301B1
(en)
|
2018-08-01 |
2024-05-22 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
|
WO2020033601A1
(en)
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Novel cas12b enzymes and systems
|
|
US20210292389A1
(en)
|
2018-08-10 |
2021-09-23 |
Sangamo Therapeutics France |
New car constructs comprising tnfr2 domains
|
|
EP3607819A1
(en)
|
2018-08-10 |
2020-02-12 |
Vilmorin et Cie |
Resistance to xanthomonas campestris pv. campestris (xcc) in cauliflower
|
|
WO2020086144A2
(en)
|
2018-08-15 |
2020-04-30 |
Zymergen Inc. |
APPLICATIONS OF CRISPRi IN HIGH THROUGHPUT METABOLIC ENGINEERING
|
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
|
WO2020041387A1
(en)
|
2018-08-20 |
2020-02-27 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
WO2020041456A1
(en)
|
2018-08-22 |
2020-02-27 |
The Regents Of The University Of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
KR102712986B1
(ko)
|
2018-08-23 |
2024-10-07 |
상가모 테라퓨틱스, 인코포레이티드 |
조작된 표적 특이적 염기 편집기
|
|
MX2021002418A
(es)
|
2018-08-30 |
2021-04-28 |
Univ North Carolina Chapel Hill |
Genes sinteticos activados por retroalimentacion, casetes de coincidencia de semilla objetivo y sus usos.
|
|
US11459551B1
(en)
|
2018-08-31 |
2022-10-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP3847650A1
(en)
|
2018-09-06 |
2021-07-14 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
US12428622B2
(en)
|
2018-09-12 |
2025-09-30 |
Children's Hospital Medical Center |
Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
|
|
EP3849565A4
(en)
|
2018-09-12 |
2022-12-28 |
Fred Hutchinson Cancer Research Center |
REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS
|
|
KR20210070305A
(ko)
|
2018-09-18 |
2021-06-14 |
브이엔브이 뉴코 인크. |
Arc 기반 캡시드 및 이의 용도
|
|
CN109265562B
(zh)
*
|
2018-09-26 |
2021-03-30 |
北京市农林科学院 |
一种切刻酶及其在基因组碱基替换中的应用
|
|
GB201815820D0
(en)
|
2018-09-28 |
2018-11-14 |
Univ Wageningen |
Off-target activity inhibitors for guided endonucleases
|
|
WO2020072254A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for killing target cells
|
|
US12264313B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
|
US10711267B2
(en)
|
2018-10-01 |
2020-07-14 |
North Carolina State University |
Recombinant type I CRISPR-Cas system
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
WO2020077236A1
(en)
|
2018-10-12 |
2020-04-16 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
US12473334B2
(en)
|
2018-10-17 |
2025-11-18 |
Dana-Farber Cancer Institute, Inc. |
SWI/SNF family chromatin remodeling complexes and uses thereof
|
|
US20210386788A1
(en)
|
2018-10-24 |
2021-12-16 |
Obsidian Therapeutics, Inc. |
Er tunable protein regulation
|
|
WO2020086910A1
(en)
|
2018-10-24 |
2020-04-30 |
Genedit Inc. |
Cationic polymer with alkyl side chains and use for biomolecule delivery
|
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
CN111757889B
(zh)
*
|
2018-10-29 |
2021-05-25 |
中国农业大学 |
新型CRISPR/Cas12f酶和系统
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
MX2021005028A
(es)
|
2018-10-31 |
2021-08-24 |
Zymergen Inc |
Ensamble determinista multiplexado de genotecas de adn.
|
|
JP2022505671A
(ja)
|
2018-10-31 |
2022-01-14 |
パイオニア ハイ－ブレッド インターナショナル， インコーポレイテッド |
オクロバクトラム媒介遺伝子編集のための組成物及び方法
|
|
WO2020093025A1
(en)
*
|
2018-11-01 |
2020-05-07 |
Synthego Corporation |
Methods for knock-out of a target sequence through introduction of a premature stop codon
|
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
MX2021004953A
(es)
|
2018-11-05 |
2021-08-11 |
Iovance Biotherapeutics Inc |
Seleccion de celulas t reactivas al tumor mejoradas.
|
|
ES3021682T3
(en)
|
2018-11-05 |
2025-05-27 |
Iovance Biotherapeutics Inc |
Tumour infiltrating lymphocytes for use in treating nsclc patients refractory to anti-pd-1 antibodies
|
|
CN113272421B
(zh)
|
2018-11-05 |
2025-02-18 |
艾欧凡斯生物治疗公司 |
用于产生肿瘤浸润性淋巴细胞的方法及其在免疫疗法中的用途
|
|
JP2022506508A
(ja)
|
2018-11-05 |
2022-01-17 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
Ａｋｔ経路阻害剤を利用したｔｉｌの拡大培養
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
EP3877517A4
(en)
|
2018-11-09 |
2022-09-07 |
Inari Agriculture, Inc. |
RNA-DRIVEN NUCLEASES AND DNA-BINDING PROTEINS
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
WO2020102659A1
(en)
|
2018-11-15 |
2020-05-22 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
|
WO2020117898A1
(en)
|
2018-12-05 |
2020-06-11 |
Abeona Therapeutics Inc. |
Recombinant adeno-associated viral vector for gene delivery
|
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
|
AU2019398351A1
(en)
|
2018-12-14 |
2021-06-03 |
Pioneer Hi-Bred International, Inc. |
Novel CRISPR-Cas systems for genome editing
|
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
US12264323B2
(en)
|
2018-12-17 |
2025-04-01 |
The Broad Institute, Inc. |
CRISPR CPF1 direct repeat variants
|
|
WO2020131862A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
|
EP3877525A2
(en)
|
2018-12-18 |
2021-09-15 |
Braskem S.A. |
Co-production pathway for 3-hp and acetyl-coa derivatives from malonate semialdehyde
|
|
JP2022515782A
(ja)
|
2018-12-19 |
2022-02-22 |
ニュークレイン リミテッド ライアビリティ カンパニー |
分子診断のための装置および方法
|
|
US20220193131A1
(en)
|
2018-12-19 |
2022-06-23 |
Iovance Biotherapeutics, Inc. |
Methods of Expanding Tumor Infiltrating Lymphocytes Using Engineered Cytokine Receptor Pairs and Uses Thereof
|
|
AU2019401485A1
(en)
|
2018-12-21 |
2021-06-24 |
Pivot Bio, Inc. |
Methods, compositions, and media for improving plant traits
|
|
US12486513B2
(en)
|
2018-12-28 |
2025-12-02 |
Braskem S.A. |
Modulation of carbon flux through the meg and C3 pathways for the improved production of monoethylene glycol and C3 compounds
|
|
JP2022517324A
(ja)
|
2019-01-03 |
2022-03-08 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
癌を患っている被験者における、ｃｄ８陽性ｔ細胞依存性免疫応答を増強させるための方法及び医薬組成物
|
|
WO2020142754A2
(en)
|
2019-01-04 |
2020-07-09 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
CA3123940A1
(en)
|
2019-01-07 |
2020-07-16 |
Pivot Bio, Inc. |
Plant colonization assays using natural microbial barcodes
|
|
WO2020148206A1
(en)
|
2019-01-14 |
2020-07-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and kits for generating and selecting a variant of a binding protein with increased binding affinity and/or specificity
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
EP3917529A4
(en)
|
2019-01-29 |
2022-11-02 |
Foghorn Therapeutics Inc. |
Compounds and uses thereof
|
|
EP3921417A4
(en)
|
2019-02-04 |
2022-11-09 |
The General Hospital Corporation |
VARIANTS OF ADENINE DNA BASES WITH REDUCED OFF-TARGET RNA EDIT
|
|
WO2020163528A1
(en)
*
|
2019-02-06 |
2020-08-13 |
TearClear Corp. |
Systems and methods for preservative removal from ophthalmic formulations comprising complexing agents
|
|
US12180487B2
(en)
|
2019-02-06 |
2024-12-31 |
Fred Hutchinson Cancer Center |
Minicircle producing bacteria engineered to differentially methylate nucleic acid molecules therein
|
|
US12460230B2
(en)
|
2019-02-10 |
2025-11-04 |
The J. David Gladstone Institutes |
Modified mitochondrion and methods of use thereof
|
|
EP3930765A1
(en)
|
2019-02-26 |
2022-01-05 |
Research Institute at Nationwide Children's Hospital |
Adeno-associated virus vector delivery of b-sarcoglycan and the treatment of muscular dystrophy
|
|
CA3132051A1
(en)
|
2019-03-01 |
2020-09-10 |
Braskem S.A. |
Method for the in vivo synthesis of 4-hydroxymethylfurfural and derivatives thereof
|
|
SG11202109331QA
(en)
|
2019-03-01 |
2021-09-29 |
Iovance Biotherapeutics Inc |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
CN110177061B
(zh)
*
|
2019-03-01 |
2023-04-07 |
致讯科技(天津)有限公司 |
一种异构网络中信号干扰的协调方法
|
|
WO2020181180A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to c:g base editors and uses thereof
|
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
|
US20220170013A1
(en)
|
2019-03-06 |
2022-06-02 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
|
MX2021010559A
(es)
|
2019-03-07 |
2021-12-15 |
Univ California |
Polipéptidos efectores de crispr-cas y métodos de uso de estos.
|
|
CN113966397A
(zh)
|
2019-03-08 |
2022-01-21 |
黑曜石疗法公司 |
人碳酸酐酶2组合物和用于可调调节的方法
|
|
KR20210136997A
(ko)
|
2019-03-08 |
2021-11-17 |
지머젠 인코포레이티드 |
미생물에서 반복적 게놈 편집
|
|
US11053515B2
(en)
|
2019-03-08 |
2021-07-06 |
Zymergen Inc. |
Pooled genome editing in microbes
|
|
US11781131B2
(en)
|
2019-03-18 |
2023-10-10 |
Regeneron Pharmaceuticals, Inc. |
CRISPR/Cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
|
CN113631700B
(zh)
|
2019-03-18 |
2025-07-18 |
瑞泽恩制药公司 |
用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台
|
|
US12281299B2
(en)
|
2019-03-19 |
2025-04-22 |
Massachusetts Institute Of Technology |
Control of nitrogen fixation in rhizobia that associate with cereals
|
|
MX2021011426A
(es)
|
2019-03-19 |
2022-03-11 |
Broad Inst Inc |
Metodos y composiciones para editar secuencias de nucleótidos.
|
|
WO2020206036A1
(en)
|
2019-04-01 |
2020-10-08 |
The Broad Institute, Inc. |
Novel nucleic acid modifier
|
|
RU2710731C1
(ru)
*
|
2019-04-02 |
2020-01-10 |
Общество с ограниченной ответственностью "Зеленые линии" |
Система редактирования генома дрожжей debaryomyces hansenii на основе crispr/cas9
|
|
BR112021018925A2
(pt)
|
2019-04-04 |
2022-01-18 |
Braskem Sa |
Modificação metabólica para consumo simultâneo de xilose e glicose para produção de produtos químicos a partir de açúcares de segunda geração
|
|
EP4530351A3
(en)
*
|
2019-04-12 |
2025-06-18 |
Astrazeneca AB |
Compositions and methods for improved gene editing
|
|
EP3956349A1
(en)
|
2019-04-17 |
2022-02-23 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN114007597A
(zh)
|
2019-04-23 |
2022-02-01 |
基因编辑有限公司 |
具有烷基侧链的阳离子聚合物
|
|
US20220251152A1
(en)
|
2019-04-24 |
2022-08-11 |
Novartis Ag |
Compositions and methods for selective protein degradation
|
|
AU2020261427A1
(en)
|
2019-04-24 |
2021-11-11 |
Pivot Bio, Inc. |
Gene targets for nitrogen fixation targeting for improving plant traits
|
|
US11162079B2
(en)
|
2019-05-10 |
2021-11-02 |
The Regents Of The University Of California |
Blood type O Rh-hypo-immunogenic pluripotent cells
|
|
CN113825838A
(zh)
|
2019-05-10 |
2021-12-21 |
巴斯夫欧洲公司 |
增强植物中基因表达的调节性核酸分子
|
|
CN114096684B
(zh)
|
2019-05-13 |
2024-11-19 |
科沃施种子欧洲股份两合公司 |
玉米的耐旱性
|
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
EP3973054A1
(en)
|
2019-05-20 |
2022-03-30 |
The Broad Institute Inc. |
Aav delivery of nucleobase editors
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
US20220220469A1
(en)
|
2019-05-20 |
2022-07-14 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
CA3142035A1
(en)
|
2019-05-28 |
2020-12-03 |
Genedit Inc. |
Polymer comprising multiple functionalized sidechains for biomolecule delivery
|
|
CA3138214A1
(en)
|
2019-05-29 |
2020-12-03 |
Monsanto Technology Llc |
Methods and compositions for generating dominant alleles using genome editing
|
|
JP7610533B2
(ja)
|
2019-05-31 |
2025-01-08 |
チルドレンズ ホスピタル メディカル センター |
造血幹細胞の生成および拡大方法
|
|
US20220243178A1
(en)
|
2019-05-31 |
2022-08-04 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
KR20220025757A
(ko)
*
|
2019-06-01 |
2022-03-03 |
시벡 바이오테크놀로지스, 엘엘씨 |
진핵 세포에 유전자 편집 시스템을 전달하기 위한 박테리아 플랫폼
|
|
WO2020244759A1
(en)
|
2019-06-05 |
2020-12-10 |
Klemm & Sohn Gmbh & Co. Kg |
New plants having a white foliage phenotype
|
|
US11845957B2
(en)
|
2019-06-14 |
2023-12-19 |
Regeneron Pharmaceuticals, Inc. |
Models of tauopathy
|
|
WO2020254850A1
(en)
|
2019-06-21 |
2020-12-24 |
Vilmorin & Cie |
Improvement of quality and permanence of green color of peppers at maturity and over-maturity
|
|
JP7650829B2
(ja)
|
2019-06-24 |
2025-03-25 |
プロメガ コーポレイション |
細胞中に生体分子を送達するための修飾ポリアミンポリマー
|
|
US11041172B2
(en)
|
2019-06-25 |
2021-06-22 |
Inari Agriculture, Inc. |
Homology dependent repair genome editing
|
|
CN114729383A
(zh)
|
2019-07-02 |
2022-07-08 |
弗莱德哈钦森癌症研究中心 |
重组ad35载体及相关基因疗法改进
|
|
GB201909597D0
(en)
|
2019-07-03 |
2019-08-14 |
Univ Wageningen |
Crispr type v-u1 system from mycobacterium mucogenicum and uses thereof
|
|
KR20220032066A
(ko)
|
2019-07-08 |
2022-03-15 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
생물막을 파괴하기 위한 항체 조성물
|
|
CN110452966A
(zh)
*
|
2019-07-17 |
2019-11-15 |
浙江善测禾骑士生物科技有限公司 |
一种利用raa-crispr蛋白酶系统快速检测方法
|
|
CN110387405A
(zh)
*
|
2019-07-17 |
2019-10-29 |
浙江善测禾骑士生物科技有限公司 |
一种快速检测核酸的(rt)raa-crispr系统
|
|
WO2021009299A1
(en)
|
2019-07-17 |
2021-01-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Bcl-xl:fkbp12 fusion proteins suitable for screening agents capable of slowing down the aging process
|
|
WO2021019272A1
(en)
|
2019-07-31 |
2021-02-04 |
Vilmorin & Cie |
Tolerance to tolcndv in cucumber
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
WO2021028359A1
(en)
|
2019-08-09 |
2021-02-18 |
Sangamo Therapeutics France |
Controlled expression of chimeric antigen receptors in t cells
|
|
EP4013859A4
(en)
*
|
2019-08-15 |
2023-10-11 |
The Rockefeller University |
CRISPR-BASED GENOME EDITING WITH CELL SURFACE DISPLAY TO PRODUCE HOMOZYGOTICLY ENGINEERED EUKARYOTIC CELLS
|
|
WO2021030666A1
(en)
|
2019-08-15 |
2021-02-18 |
The Broad Institute, Inc. |
Base editing by transglycosylation
|
|
SI4017871T1
(sl)
|
2019-08-21 |
2024-06-28 |
Research Institute At Nationwide Children's Hospital |
Dostava alfa-sarkoglikana z adeno povezanim virusnim vektorjem in zdravljenje mišične distrofije
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
WO2021046451A1
(en)
|
2019-09-06 |
2021-03-11 |
Obsidian Therapeutics, Inc. |
Compositions and methods for dhfr tunable protein regulation
|
|
EP4028047A4
(en)
|
2019-09-09 |
2023-07-26 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
|
WO2021048316A1
(en)
|
2019-09-12 |
2021-03-18 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
CN110541001A
(zh)
*
|
2019-09-20 |
2019-12-06 |
福建上源生物科学技术有限公司 |
精确大片段基因删除结合终止密码子插入的基因敲除法
|
|
EP4031660A1
(en)
|
2019-09-20 |
2022-07-27 |
The Broad Institute, Inc. |
Novel type vi crispr enzymes and systems
|
|
WO2021061707A1
(en)
|
2019-09-23 |
2021-04-01 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein b (apob) gene expression
|
|
CA3147643A1
(en)
|
2019-09-23 |
2021-04-01 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (hnf4.alpha.) gene expression
|
|
AU2020353149A1
(en)
|
2019-09-26 |
2022-04-14 |
President And Fellows Of Harvard College |
Minimal arrestin domain containing protein 1 (ARRDC1) constructs
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
WO2021069387A1
(en)
|
2019-10-07 |
2021-04-15 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
EP3808766A1
(en)
|
2019-10-15 |
2021-04-21 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
|
EP4045522A1
(en)
|
2019-10-17 |
2022-08-24 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
|
CA3155727A1
(en)
|
2019-10-25 |
2021-04-29 |
Cecile Chartier-Courtaud |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
EP4057802A1
(en)
|
2019-11-14 |
2022-09-21 |
Vilmorin & Cie |
Resistance to acidovorax valerianellae in corn salad
|
|
AU2020388387A1
(en)
|
2019-11-22 |
2022-06-02 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
|
US20230086199A1
(en)
|
2019-11-26 |
2023-03-23 |
The Broad Institute, Inc. |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
|
US20230002455A1
(en)
|
2019-11-29 |
2023-01-05 |
Basf Se |
Increasing resistance against fungal infections in plants
|
|
AU2020394910B2
(en)
*
|
2019-12-02 |
2025-10-02 |
Council Of Scientific & Industrial Research |
Method and kit for detection of polynucleotide
|
|
EP4069852A1
(en)
|
2019-12-03 |
2022-10-12 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
JP7677646B2
(ja)
|
2019-12-10 |
2025-05-15 |
ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー |
複製タンパク質ａ（ｒｐａ）－ｄｎａ相互作用阻害剤
|
|
CA3161104A1
(en)
|
2019-12-11 |
2021-06-17 |
Cecile Chartier-Courtaud |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
|
CN114787362A
(zh)
|
2019-12-13 |
2022-07-22 |
中外制药株式会社 |
检测细胞外嘌呤受体配体的系统和导入该系统的非人动物
|
|
CA3161898A1
(en)
|
2019-12-19 |
2021-06-24 |
Basf Se |
Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals
|
|
MX2022007714A
(es)
|
2019-12-20 |
2022-07-19 |
Basf Se |
Disminucion de la toxicidad de terpenos y aumento de la posible produccion en microorganismos.
|
|
WO2021221690A1
(en)
|
2020-05-01 |
2021-11-04 |
Pivot Bio, Inc. |
Modified bacterial strains for improved fixation of nitrogen
|
|
EP4090743A1
(en)
|
2020-01-13 |
2022-11-23 |
Sana Biotechnology, Inc. |
Modification of blood type antigens
|
|
EP4093857A4
(en)
|
2020-01-23 |
2024-02-21 |
The Children's Medical Center Corporation |
DIFFERENTIATION OF STROMA-FREE T CELLS FROM HUMAN PLURIPOTENT STEM CELLS
|
|
WO2021151085A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Crispr-cas enzymes with enhanced on-target activity
|
|
EP4093864A4
(en)
|
2020-01-24 |
2024-04-10 |
The General Hospital Corporation |
Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants
|
|
PH12022551937A1
(en)
|
2020-01-29 |
2023-10-23 |
Foghorn Therapeutics Inc |
Compounds and uses thereof
|
|
US20230235309A1
(en)
|
2020-02-05 |
2023-07-27 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
|
US12116580B2
(en)
|
2020-02-21 |
2024-10-15 |
The Board Of Trustees Of The University Of Illinois |
Genetic toolbox for metabolic engineering of non-conventional yeast
|
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
|
WO2021183720A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
|
JP2023518538A
(ja)
|
2020-03-20 |
2023-05-02 |
インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） |
ヒトｃｄ４５ｒｃに特異的なキメラ抗原受容体およびその使用
|
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
WO2021216623A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
|
WO2021216622A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
|
WO2021217082A1
(en)
|
2020-04-23 |
2021-10-28 |
Genedit Inc. |
Polymer with cationic and hydrophobic side chains
|
|
US12281980B2
(en)
|
2020-05-01 |
2025-04-22 |
Pivot Bio, Inc. |
Measurement of nitrogen fixation and incorporation
|
|
CA3172322A1
(en)
|
2020-05-01 |
2021-11-04 |
Karsten TEMME |
Modified bacterial strains for improved fixation of nitrogen
|
|
BR112022021933A2
(pt)
|
2020-05-01 |
2022-12-13 |
Pivot Bio Inc |
Composição agrícola líquida, tecido vegetal agrícola, e, métodos para aplicar uma bactéria diazotrófica, manter uma população de uma bactéria, aumentar a produtividade da cultura vegetal agrícola, fornecer nitrogênio atmosférico, aumentar a produtividade do milho por acre, reduzir a variabilidade no campo da produtividade e melhorar a estabilidade de uma composição agrícola líquida
|
|
CA3176826A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
WO2021224633A1
(en)
|
2020-05-06 |
2021-11-11 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
|
MX2022014008A
(es)
|
2020-05-08 |
2023-02-09 |
Broad Inst Inc |
Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo.
|
|
US20230295559A1
(en)
|
2020-05-13 |
2023-09-21 |
Pivot Bio, Inc. |
De-repression of nitrogen fixation in gram-positive microorganisms
|
|
US12383555B2
(en)
|
2020-05-20 |
2025-08-12 |
Foghorn Therapeutics Inc. |
Methods of treating cancers
|
|
GB202007943D0
(en)
|
2020-05-27 |
2020-07-08 |
Snipr Biome Aps |
Products & methods
|
|
BR112022023443A2
(pt)
|
2020-05-29 |
2022-12-20 |
Kws Saat Se & Co Kgaa |
Indução de haploides em plantas
|
|
WO2021245435A1
(en)
|
2020-06-03 |
2021-12-09 |
Vilmorin & Cie |
Melon plants resistant to scab disease, aphids and powdery mildew
|
|
MA59015B1
(fr)
|
2020-06-05 |
2023-11-30 |
Vilmorin & Cie |
Résistance des plants de tomate - solanum lycopersicum - au tobrfv
|
|
WO2021248052A1
(en)
|
2020-06-05 |
2021-12-09 |
The Broad Institute, Inc. |
Compositions and methods for treating neoplasia
|
|
CA3185455A1
(en)
|
2020-06-11 |
2021-12-16 |
Novartis Ag |
Zbtb32 inhibitors and uses thereof
|
|
EP4179079A1
(en)
|
2020-07-10 |
2023-05-17 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
|
US20230287458A1
(en)
|
2020-07-14 |
2023-09-14 |
Abeona Therapeutics Inc. |
Recombinant adeno-associated viral vectors for multipartite gene delivery
|
|
EP4189071A1
(en)
|
2020-08-03 |
2023-06-07 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Population of treg cells functionally committed to exert a regulatory activity and their use for adoptive therapy
|
|
US20240011030A1
(en)
|
2020-08-10 |
2024-01-11 |
Novartis Ag |
Treatments for retinal degenerative diseases
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
CN116134143A
(zh)
|
2020-08-18 |
2023-05-16 |
先锋国际良种公司 |
多种抗病基因及其基因组堆叠件
|
|
ES2984902T3
(es)
|
2020-08-20 |
2024-10-31 |
A2 Biotherapeutics Inc |
Composiciones y métodos para tratar cánceres positivos para EGFR
|
|
MX2023002017A
(es)
|
2020-08-20 |
2023-04-28 |
A2 Biotherapeutics Inc |
Composiciones y métodos para tratar cánceres positivos para ceacam.
|
|
EP4100028A4
(en)
|
2020-08-20 |
2023-07-26 |
A2 Biotherapeutics, Inc. |
COMPOSITIONS AND METHODS FOR TREATMENT OF MESOTHELIN-POSITIVE CARCINOMAS
|
|
CN112080587A
(zh)
*
|
2020-08-31 |
2020-12-15 |
上海海关动植物与食品检验检疫技术中心 |
用于高效检测新型冠状病毒的raa-crispr扩增引物组、试剂盒及方法
|
|
KR102424351B1
(ko)
*
|
2020-09-21 |
2022-08-05 |
한국과학기술원 |
파브알부민 유전자 발현 억제용 CRISPR/Cas9 시스템 및 이의 용도
|
|
WO2022188039A1
(en)
|
2021-03-09 |
2022-09-15 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
WO2022068912A1
(en)
|
2020-09-30 |
2022-04-07 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
US11944063B2
(en)
|
2020-09-30 |
2024-04-02 |
Spring Meadow Nursery, Inc. |
Hydrangea ‘SMNHPH’
|
|
IL301846A
(en)
|
2020-10-02 |
2023-06-01 |
Vilmorin & Cie |
A hotel with an extended shelf life
|
|
JP2023546359A
(ja)
|
2020-10-06 |
2023-11-02 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
腫瘍浸潤リンパ球療法によるｎｓｃｌｃ患者の治療
|
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
EP3984355B1
(en)
|
2020-10-16 |
2024-05-15 |
Klemm & Sohn GmbH & Co. KG |
Double-flowering dwarf calibrachoa
|
|
US11155884B1
(en)
|
2020-10-16 |
2021-10-26 |
Klemm & Sohn Gmbh & Co. Kg |
Double-flowering dwarf Calibrachoa
|
|
US11530419B2
(en)
|
2020-10-30 |
2022-12-20 |
Fortiphyte, Inc. |
Pathogen resistance in plants
|
|
US20240033358A1
(en)
|
2020-11-13 |
2024-02-01 |
Novartis Ag |
Combination therapies with chimeric antigen receptor (car)-expressing cells
|
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
|
CA3203609A1
(en)
|
2020-12-03 |
2022-06-09 |
Vilmorin & Cie |
Tomato plants resistant to tobrfv, tmv, tomv and tommv and corresponding resistance genes
|
|
CA3202483A1
(en)
|
2020-12-17 |
2022-06-23 |
Maria Fardis |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
|
US20240123067A1
(en)
|
2020-12-17 |
2024-04-18 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocyte therapies
|
|
CA3206361A1
(en)
|
2020-12-23 |
2022-06-30 |
Flagship Pioneering Innovations V, Inc. |
In vitro assembly of anellovirus capsids enclosing rna
|
|
WO2022148955A1
(en)
|
2021-01-05 |
2022-07-14 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
|
WO2022150776A1
(en)
*
|
2021-01-11 |
2022-07-14 |
Vedere Bio Ii, Inc. |
OPTOGENETIC COMPOSITIONS COMPRISING A CBh PROMOTER SEQUENCE AND METHODS FOR USE
|
|
CA3207102A1
(en)
|
2021-01-12 |
2022-07-21 |
March Therapeutics, Inc. |
Context-dependent, double-stranded dna-specific deaminases and uses thereof
|
|
CA3206549A1
(en)
|
2021-01-29 |
2022-08-04 |
Frederick G. Vogt |
Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
|
|
EP4288541A1
(en)
|
2021-02-05 |
2023-12-13 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
KR20230147109A
(ko)
|
2021-02-16 |
2023-10-20 |
에이투 바이오쎄라퓨틱스, 인크. |
Her2 양성 암을 치료하기 위한 조성물 및 방법
|
|
CN115427561B
(zh)
|
2021-03-09 |
2024-06-04 |
辉大(上海)生物科技有限公司 |
工程化CRISPR/Cas13系统及其用途
|
|
TW202304480A
(zh)
|
2021-03-19 |
2023-02-01 |
美商艾歐凡斯生物治療公司 |
腫瘤浸潤淋巴球（ｔｉｌ）中之與ｃｄ３９／ｃｄ６９選擇及基因剔除相關之ｔｉｌ擴增之方法
|
|
JP2024519601A
(ja)
|
2021-03-31 |
2024-05-20 |
エントラーダ セラピューティクス，インコーポレイティド |
環状細胞透過性ペプチド
|
|
WO2022208489A1
(en)
|
2021-04-02 |
2022-10-06 |
Vilmorin & Cie |
Semi-determinate or determinate growth habit trait in cucurbita
|
|
AU2022256513A1
(en)
|
2021-04-16 |
2023-11-02 |
Beam Therapeutics Inc. |
Genetic modification of hepatocytes
|
|
IL307800A
(en)
|
2021-04-19 |
2023-12-01 |
Iovance Biotherapeutics Inc |
Chimeric costimulatory receptors, chemokine receptors and their use in cellular immunotherapy
|
|
WO2022235929A1
(en)
|
2021-05-05 |
2022-11-10 |
Radius Pharmaceuticals, Inc. |
Animal model having homologous recombination of mouse pth1 receptor
|
|
EP4337263A1
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
|
CA3217463A1
(en)
|
2021-05-10 |
2022-11-17 |
Ziqing QIAN |
Compositions and methods for modulating mrna splicing
|
|
IL308353A
(en)
|
2021-05-10 |
2024-01-01 |
Entrada Therapeutics Inc |
Compositions and methods for modulating tissue distribution of intracellular therapies
|
|
EP4337770A1
(en)
|
2021-05-13 |
2024-03-20 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Compositions and methods for treating sickle cell diseases
|
|
JP2024519029A
(ja)
|
2021-05-17 |
2024-05-08 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
Ｐｄ－１遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用
|
|
BR112023024985A2
(pt)
|
2021-06-01 |
2024-02-20 |
Arbor Biotechnologies Inc |
Sistemas de edição de genes compreendendo uma crispr nuclease e usos dos mesmos
|
|
US20240287487A1
(en)
|
2021-06-11 |
2024-08-29 |
The Broad Institute, Inc. |
Improved cytosine to guanine base editors
|
|
US20240285781A1
(en)
|
2021-06-11 |
2024-08-29 |
GenEdit, Inc. |
Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups
|
|
US20240271212A1
(en)
*
|
2021-06-14 |
2024-08-15 |
The University Of Chicago |
Characterization and treatment of asthma
|
|
CA3222824A1
(en)
|
2021-06-23 |
2022-12-29 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
|
AU2022301301A1
(en)
|
2021-07-02 |
2023-12-14 |
Pivot Bio, Inc. |
Genetically-engineered bacterial strains for improved fixation of nitrogen
|
|
EP4367242A2
(en)
|
2021-07-07 |
2024-05-15 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
CA3226111A1
(en)
|
2021-07-22 |
2023-01-26 |
Iovance Biotherapeutics, Inc. |
Method for cryopreservation of solid tumor fragments
|
|
TW202327631A
(zh)
|
2021-07-28 |
2023-07-16 |
美商艾歐凡斯生物治療公司 |
利用腫瘤浸潤性淋巴球療法與ｋｒａｓ抑制劑組合治療癌症患者
|
|
AU2022318574B2
(en)
|
2021-07-30 |
2024-03-21 |
Helaina, Inc. |
Methods and compositions for protein synthesis and secretion
|
|
CN118368974A
(zh)
|
2021-07-30 |
2024-07-19 |
科沃施种子欧洲股份两合公司 |
具有提高的消化率和标记单倍型的植物
|
|
WO2023012325A1
(en)
|
2021-08-06 |
2023-02-09 |
Vilmorin & Cie |
Resistance to leveillula taurica in pepper
|
|
EP4396357A1
(en)
|
2021-09-02 |
2024-07-10 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
|
KR20240055811A
(ko)
|
2021-09-10 |
2024-04-29 |
애질런트 테크놀로지스, 인크. |
프라임 편집을 위한 화학적 변형을 갖는 가이드 rna
|
|
EP4596696A3
(en)
|
2021-09-28 |
2025-08-27 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
US20240342314A1
(en)
|
2021-09-30 |
2024-10-17 |
The Board Of Regents Of The University Of Texas System |
Slc13a5 gene therapy vectors and uses thereof
|
|
WO2023059846A1
(en)
|
2021-10-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
|
PE20241173A1
(es)
|
2021-10-14 |
2024-05-28 |
Arsenal Biosciences Inc |
Celulas inmunitarias que tienen arnhc coexpresados y sistemas de compuerta logica
|
|
JP2023059858A
(ja)
|
2021-10-15 |
2023-04-27 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
自己相補的アデノ随伴ウイルスベクター及び筋ジストロフィーの治療におけるその使用
|
|
WO2023077015A2
(en)
|
2021-10-27 |
2023-05-04 |
Iovance Biotherapeutics, Inc. |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
|
CA3237300A1
(en)
|
2021-11-01 |
2023-05-04 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
EP4426832A1
(en)
|
2021-11-03 |
2024-09-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Precise genome editing using retrons
|
|
EP4427229A4
(en)
*
|
2021-11-03 |
2025-11-12 |
The Regents Of Univ Of California |
SErine RECOMBINASES
|
|
WO2023086803A1
(en)
|
2021-11-10 |
2023-05-19 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
|
US20250011781A1
(en)
*
|
2021-11-22 |
2025-01-09 |
The Texas A&M University System |
Methods and compositions targeting nucleus accumbens-associated protein-1 for treatment of autoimmune disorders and cancers
|
|
WO2023096996A2
(en)
|
2021-11-24 |
2023-06-01 |
Research Institute At Nationwide Children's Hospital |
Chimeric hsv expressing hil21 to boost anti-tumor immune activity
|
|
US20240408236A1
(en)
|
2021-11-26 |
2024-12-12 |
Epigenic Therapeutics, Inc. |
Method of modulating pcsk9 and uses thereof
|
|
WO2023102406A1
(en)
|
2021-12-01 |
2023-06-08 |
The Board Of Regents Of The Univesity Of Texas System |
Vector genome design to express optimized cln7 transgene
|
|
WO2023102518A1
(en)
|
2021-12-03 |
2023-06-08 |
The Board Of Regents Of The University Of Texas System |
Gnao1 gene therapy vectors and uses thereof
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
TW202342498A
(zh)
|
2021-12-17 |
2023-11-01 |
美商薩那生物科技公司 |
經修飾副黏液病毒科融合醣蛋白
|
|
EP4448775A1
(en)
|
2021-12-17 |
2024-10-23 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
WO2023122805A1
(en)
|
2021-12-20 |
2023-06-29 |
Vestaron Corporation |
Sorbitol driven selection pressure method
|
|
WO2023122764A1
(en)
|
2021-12-22 |
2023-06-29 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
KR20240133725A
(ko)
|
2021-12-23 |
2024-09-04 |
유니버시티 오브 매사추세츠 |
취약 x 관련 장애의 치료용 치료제
|
|
EP4463135A2
(en)
|
2022-01-10 |
2024-11-20 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
US20250082782A1
(en)
|
2022-01-28 |
2025-03-13 |
The Board Of Regents Of The University Of Texas System |
Transgene cassettes designed to express the human codon-optimized gene fmr1
|
|
US20250099588A1
(en)
|
2022-01-28 |
2025-03-27 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
|
EP4472646A1
(en)
|
2022-02-01 |
2024-12-11 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
EP4473097A1
(en)
|
2022-02-02 |
2024-12-11 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
US20250099584A1
(en)
|
2022-02-18 |
2025-03-27 |
Institut National de la Santé et de la Recherche Médicale |
Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
|
|
EP4504925A1
(en)
|
2022-04-04 |
2025-02-12 |
The Broad Institute, Inc. |
Cas9 variants having non-canonical pam specificities and uses thereof
|
|
EP4256950A1
(en)
|
2022-04-06 |
2023-10-11 |
Vilmorin et Cie |
Tolerance to cgmmv in cucumber
|
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023212715A1
(en)
|
2022-04-28 |
2023-11-02 |
The Broad Institute, Inc. |
Aav vectors encoding base editors and uses thereof
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
WO2023220043A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified genome for gene therapy
|
|
EP4522221A1
(en)
|
2022-05-09 |
2025-03-19 |
Entrada Therapeutics, Inc. |
Compositions and methods for delivery of nucleic acid therapeutics
|
|
EP4522201A1
(en)
|
2022-05-09 |
2025-03-19 |
Synteny Therapeutics, Inc. |
Erythroparvovirus compositions and methods for gene therapy
|
|
US20250295810A1
(en)
|
2022-05-09 |
2025-09-25 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified capsid for gene therapy
|
|
CA3251533A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
TREATMENT OF CANCER PATIENTS WITH TUMOR-INFILTRATING LYMPHOCYTE THERAPIES IN COMBINATION WITH AN IL-15R AGONIST
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
KR20250019772A
(ko)
|
2022-05-25 |
2025-02-11 |
플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 |
종양 억제인자 및 발암유전자를 조절하기 위한 조성물 및 방법
|
|
WO2023230570A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
|
CA3253436A1
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
IMMUNE RESPONSE COMPOSITIONS AND METHODS
|
|
EP4532767A2
(en)
|
2022-05-25 |
2025-04-09 |
Flagship Pioneering Innovations VII, LLC |
Compositions and methods for modulating cytokines
|
|
AU2023276715A1
(en)
|
2022-05-25 |
2025-01-09 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating circulating factors
|
|
JP2025524469A
(ja)
|
2022-06-24 |
2025-07-30 |
チューン セラピューティクス インコーポレイテッド |
標的を定めた遺伝子抑制を介して低密度リポタンパク質を低減するための組成物、系、及び方法
|
|
GB202209518D0
(en)
|
2022-06-29 |
2022-08-10 |
Snipr Biome Aps |
Treating & preventing E coli infections
|
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4548351A1
(en)
|
2022-06-30 |
2025-05-07 |
Pioneer Hi-Bred International, Inc. |
Artificial intelligence-mediated methods and systems for genome editing
|
|
AU2023311964A1
(en)
|
2022-07-18 |
2025-01-30 |
Renagade Therapeutics Management Inc. |
Gene editing components, systems, and methods of use
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
WO2024023578A1
(en)
|
2022-07-28 |
2024-02-01 |
Institut Pasteur |
Hsc70-4 in host-induced and spray-induced gene silencing
|
|
WO2024026406A2
(en)
|
2022-07-29 |
2024-02-01 |
Vestaron Corporation |
Next Generation ACTX Peptides
|
|
EP4569122A2
(en)
|
2022-08-09 |
2025-06-18 |
Pioneer Hi-Bred International, Inc. |
Guide polynucleotide multiplexing
|
|
EP4573191A1
(en)
|
2022-08-16 |
2025-06-25 |
The Broad Institute, Inc. |
Evolved cytosine deaminases and methods of editing dna using same
|
|
WO2024040222A1
(en)
|
2022-08-19 |
2024-02-22 |
Generation Bio Co. |
Cleavable closed-ended dna (cedna) and methods of use thereof
|
|
WO2024044655A1
(en)
|
2022-08-24 |
2024-02-29 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
EP4577660A1
(en)
|
2022-08-26 |
2025-07-02 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
|
WO2024050544A2
(en)
|
2022-09-01 |
2024-03-07 |
J.R. Simplot Company |
Enhanced targeted knock-in frequency in host genomes through crispr exonuclease processing
|
|
WO2024047605A1
(en)
|
2022-09-01 |
2024-03-07 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
|
EP4583905A1
(en)
|
2022-09-06 |
2025-07-16 |
Institut National de la Santé et de la Recherche Médicale |
Novel dual split car-t cells for the treatment of cd38-positive hematological malignancies
|
|
EP4590688A1
(en)
|
2022-09-21 |
2025-07-30 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024064824A2
(en)
|
2022-09-21 |
2024-03-28 |
Yale University |
Compositions and methods for identification of membrane targets for enhancement of nk cell therapy
|
|
EP4602174A1
(en)
|
2022-10-13 |
2025-08-20 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
JP7353602B1
(ja)
|
2022-10-14 |
2023-10-02 |
株式会社インプランタイノベーションズ |
ゲノム編集方法およびゲノム編集用組成物
|
|
WO2024083579A1
(en)
|
2022-10-20 |
2024-04-25 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
JP2025537155A
(ja)
|
2022-11-04 |
2025-11-14 |
アイオバンス バイオセラピューティクス，インコーポレイテッド |
Ｃｄ３９／ｃｄ１０３選択に関連した腫瘍浸潤リンパ球（ｔｉｌ）拡張のための方法
|
|
CN120359023A
(zh)
|
2022-11-10 |
2025-07-22 |
赛欧生物医药股份有限公司 |
包含脂质纳米颗粒或脂质重构的天然信使包的rna组合物
|
|
EP4623072A2
(en)
|
2022-11-21 |
2025-10-01 |
Iovance Biotherapeutics, Inc. |
Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
|
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
EP4630543A1
(en)
|
2022-12-06 |
2025-10-15 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for co-delivery of t-dnas expressing multiple guide polynucleotides into plants
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
CN120583887A
(zh)
|
2022-12-23 |
2025-09-02 |
皮沃特生物股份有限公司 |
各种固氮细菌与各种生物产品的组合用于实现协同效应
|
|
WO2024141599A1
(en)
|
2022-12-29 |
2024-07-04 |
Vilmorin & Cie |
Tomato plants resistant to resistance-breaking tswv strains and corresponding resistance genes
|
|
EP4652271A1
(en)
|
2023-01-18 |
2025-11-26 |
The Broad Institute, Inc. |
Base editing-mediated readthrough of premature termination codons (bert)
|
|
WO2024161358A1
(en)
|
2023-02-01 |
2024-08-08 |
Dlf Seeds A/S |
Beet yellows virus resistance
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
EP4665849A1
(en)
|
2023-02-15 |
2025-12-24 |
Arbor Biotechnologies, Inc. |
Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript
|
|
KR20250160500A
(ko)
|
2023-03-20 |
2025-11-13 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
변경된 pam 인식을 갖는 cas 폴리펩티드
|
|
WO2024197242A1
(en)
|
2023-03-23 |
2024-09-26 |
Carbon Biosciences, Inc. |
Protoparvovirus compositions comprising a protoparvovirus variant vp1 capsid polypeptide and related methods
|
|
US12419265B2
(en)
|
2023-03-27 |
2025-09-23 |
Redsea Science And Technology Inc. |
Tomato plant designated ‘X21-02’
|
|
WO2024206687A1
(en)
*
|
2023-03-29 |
2024-10-03 |
William Marsh Rice University |
Methods and compostions for engineered mitochondrial biogenesis
|
|
WO2024206911A2
(en)
|
2023-03-30 |
2024-10-03 |
Children's Hospital Medical Center |
Clinical-grade organoids
|
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
|
WO2024220574A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
WO2024220719A1
(en)
|
2023-04-18 |
2024-10-24 |
Crystal Ronald G |
Modified aav capsids for gene delivery
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
US20240352485A1
(en)
|
2023-04-19 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for the production of libraries
|
|
WO2024218295A1
(en)
|
2023-04-21 |
2024-10-24 |
Vib Vzw |
Allelic combinations in crops for yield increase
|
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
|
AU2024261681A1
(en)
|
2023-04-28 |
2025-11-13 |
Vilmorin & Cie |
Genetic determinants conferring improved tobrfv resistance
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024238977A2
(en)
|
2023-05-18 |
2024-11-21 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
WO2024243340A1
(en)
|
2023-05-23 |
2024-11-28 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
WO2024263961A2
(en)
|
2023-06-23 |
2024-12-26 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
|
WO2025006419A1
(en)
|
2023-06-26 |
2025-01-02 |
Flagship Pioneering Innovations Vii, Llc |
Engineered plasmodia and related methods
|
|
WO2025003305A1
(en)
|
2023-06-28 |
2025-01-02 |
Vilmorin & Cie |
Pepper resistance to meloidogyne enterolobii
|
|
WO2025021893A1
(en)
|
2023-07-24 |
2025-01-30 |
Vilmorin & Cie |
Resistance to cysdv in melons
|
|
WO2025027166A1
(en)
|
2023-08-01 |
2025-02-06 |
Basf Plant Science Company Gmbh |
Increased resistance by expression of msbp1 protein
|
|
WO2025027165A1
(en)
|
2023-08-01 |
2025-02-06 |
Basf Plant Science Company Gmbh |
Increased resistance by expression of an ics protein
|
|
US20250043304A1
(en)
|
2023-08-03 |
2025-02-06 |
J.R. Simplot Company |
Fusarium wilt resistance genes
|
|
US20250059551A1
(en)
|
2023-08-14 |
2025-02-20 |
The Texas A&M University System |
Corn endotype-derived polypeptides capable of metabolizing fumonisin
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025049959A2
(en)
|
2023-09-01 |
2025-03-06 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025054540A1
(en)
|
2023-09-08 |
2025-03-13 |
Iovance Biotherapeutics, Inc. |
Methods of gene-editing using programmable nucleases
|
|
WO2025064408A1
(en)
|
2023-09-18 |
2025-03-27 |
The Broad Institute, Inc. |
Compositions and methods for treating cardiovascular disease
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025072803A1
(en)
|
2023-09-29 |
2025-04-03 |
Children's Hospital Medical Center |
Ntrk2 signaling-mediated alveolar capillary injury and repair
|
|
EP4554371A1
(en)
|
2023-10-03 |
2025-05-21 |
Inari Agriculture Technology, Inc. |
Viral delivery of grna to the scion
|
|
WO2025081042A1
(en)
|
2023-10-12 |
2025-04-17 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
WO2025101484A1
(en)
|
2023-11-06 |
2025-05-15 |
Iovance Biotherapeutics, Inc. |
Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
|
|
WO2025111526A1
(en)
|
2023-11-22 |
2025-05-30 |
Flagship Pioneering Innovations Vii, Llc |
Methods and compositions for treating non-alcoholic fatty liver disease
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025155753A2
(en)
|
2024-01-17 |
2025-07-24 |
Renagade Therapeutics Management Inc. |
Improved gene editing system, guides, and methods
|
|
WO2025155521A1
(en)
|
2024-01-18 |
2025-07-24 |
Pivot Bio, Inc. |
Host cells for enhanced plant growth
|
|
WO2025155518A1
(en)
|
2024-01-18 |
2025-07-24 |
Pivot Bio, Inc. |
Host cells for enhanced plant growth
|
|
WO2025158400A1
(en)
|
2024-01-24 |
2025-07-31 |
Yale University |
Compositions and methods of natural killer cell hyperboosts for enhancement of nk cell therapy
|
|
WO2025162985A1
(en)
|
2024-01-30 |
2025-08-07 |
Basf Plant Science Company Gmbh |
Increased plant disease resistance by expression of a glycine-rich protein
|
|
WO2025168705A1
(en)
|
2024-02-08 |
2025-08-14 |
Vib Vzw |
Means and methods for the production of saponins with endosomal escape-enhancing properties
|
|
WO2025171210A1
(en)
|
2024-02-09 |
2025-08-14 |
Arbor Biotechnologies, Inc. |
Compositions and methods for gene editing via homology-mediated end joining
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
WO2025184759A1
(en)
|
2024-03-04 |
2025-09-12 |
Pioneer Hi-Bred International, Inc. |
Maize plants comprising resistance to gray leaf spot and compositions and methods for selecting and producing the same
|
|
WO2025186284A1
(en)
|
2024-03-05 |
2025-09-12 |
Vilmorin & Cie |
Increased yield in cucumber
|
|
WO2025194019A1
(en)
|
2024-03-14 |
2025-09-18 |
Flagship Pioneering Innovations Vii, Llc |
Methods for treating liver fibrosis and non-alcoholic fatty liver disease
|
|
WO2025202473A1
(en)
|
2024-03-28 |
2025-10-02 |
Revvity Discovery Limited |
A nucleic acid deaminase, a base editor and uses thereof
|
|
WO2025212920A1
(en)
|
2024-04-03 |
2025-10-09 |
Children's Hospital Medical Center |
Multi-zonal liver organoids
|
|
WO2025217202A1
(en)
|
2024-04-08 |
2025-10-16 |
Children's Hospital Medical Center |
Bile duct organoid
|
|
WO2025224107A1
(en)
|
2024-04-22 |
2025-10-30 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025232898A1
(en)
|
2024-05-10 |
2025-11-13 |
Yoltech Therapeutics Co., Ltd |
Lipid compounds and lipid nanoparticle compositions
|
|
WO2025240947A1
(en)
|
2024-05-17 |
2025-11-20 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
WO2025245188A2
(en)
|
2024-05-21 |
2025-11-27 |
Flagship Pioneering Innovations Vii, Llc |
Methods of treating liver steatosis and non-alcoholic fatty liver disease
|
|
US20250382627A1
(en)
|
2024-06-13 |
2025-12-18 |
J.R. Simplot Company |
Engineering remontant flowering in rosaceae
|
|
CN119601083A
(zh)
*
|
2024-11-16 |
2025-03-11 |
大连易康生物科技有限公司 |
一种基因测序数据处理方法及系统
|
|
CN119874861B
(zh)
*
|
2025-01-10 |
2025-11-25 |
中国科学院遗传与发育生物学研究所 |
SlABCG45基因在提高番茄的列当抗性和产量中的应用
|