MX2020005784A - Mejoramiento de la productividad de lipidos de algas a traves de la modificacion genetica de una proteina de se?alizacion. - Google Patents

Mejoramiento de la productividad de lipidos de algas a traves de la modificacion genetica de una proteina de se?alizacion.

Info

Publication number
MX2020005784A
MX2020005784A MX2020005784A MX2020005784A MX2020005784A MX 2020005784 A MX2020005784 A MX 2020005784A MX 2020005784 A MX2020005784 A MX 2020005784A MX 2020005784 A MX2020005784 A MX 2020005784A MX 2020005784 A MX2020005784 A MX 2020005784A
Authority
MX
Mexico
Prior art keywords
genetic modification
lipid productivity
signaling protein
via genetic
microorganisms
Prior art date
Application number
MX2020005784A
Other languages
English (en)
Inventor
Imad Ajjawi
Original Assignee
Synthetic Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthetic Genomics Inc filed Critical Synthetic Genomics Inc
Publication of MX2020005784A publication Critical patent/MX2020005784A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención proporciona microorganismos mutantes que tienen expresión atenuada de un gen que codifica un polipéptido que incluye un dominio GAF en donde los microorganismos mutantes tienen una más alta productividad de lípidos y/o exhiben un mayor reparto de carbono a lípido en comparación con los microorganismos de tipo salvaje de los que ellos se derivan. Además, se proporcionan métodos para producir lípidos mediante el uso de microorganismos mutantes, ARN guía y constructos de ácido nucleico que se usan para producir microorganismos mutantes.
MX2020005784A 2017-12-05 2018-12-04 Mejoramiento de la productividad de lipidos de algas a traves de la modificacion genetica de una proteina de se?alizacion. MX2020005784A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762594930P 2017-12-05 2017-12-05
PCT/US2018/063717 WO2019112982A1 (en) 2017-12-05 2018-12-04 Improving algal lipid productivity via genetic modification of a signaling protein

Publications (1)

Publication Number Publication Date
MX2020005784A true MX2020005784A (es) 2020-08-20

Family

ID=66657878

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005784A MX2020005784A (es) 2017-12-05 2018-12-04 Mejoramiento de la productividad de lipidos de algas a traves de la modificacion genetica de una proteina de se?alizacion.

Country Status (9)

Country Link
US (1) US11098328B2 (es)
EP (1) EP3720868A4 (es)
JP (1) JP2021505144A (es)
CN (1) CN111433219A (es)
AU (1) AU2018381232A1 (es)
BR (1) BR112020010326A2 (es)
CA (1) CA3093227A1 (es)
MX (1) MX2020005784A (es)
WO (1) WO2019112982A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017011707A1 (en) * 2015-07-14 2017-01-19 Synthetic Genomics, Inc Microorganisms having increased lipid productivity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
US8822162B2 (en) * 2009-05-27 2014-09-02 Wisconsin Alumni Research Foundation Cyanochrome fluorophores
WO2012082731A2 (en) * 2010-12-13 2012-06-21 J. Craig Venter Institute Engineered microalgae with enhanced lipid production
WO2013005152A1 (en) 2011-07-05 2013-01-10 Basf Plant Science Company Gmbh Regulatory nucleic acid molecules for enhancing constitutive gene expression in plants
WO2013151664A1 (en) * 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
EP4286402A3 (en) * 2012-12-12 2024-02-14 The Broad Institute, Inc. Crispr-cas component systems, methods and compositions for sequence manipulation
US9765126B2 (en) * 2013-10-04 2017-09-19 Synthetic Genomics, Inc. Compositions and methods for modulating biomass productivity
PT3344776T (pt) 2015-09-04 2021-08-03 Synthetic Genomics Inc Microorganismos recombinantes de algas com aumento de produtividade

Also Published As

Publication number Publication date
EP3720868A4 (en) 2021-12-22
EP3720868A1 (en) 2020-10-14
WO2019112982A1 (en) 2019-06-13
AU2018381232A1 (en) 2020-07-09
WO2019112982A4 (en) 2019-08-01
JP2021505144A (ja) 2021-02-18
BR112020010326A2 (pt) 2020-10-20
US20190169627A1 (en) 2019-06-06
CN111433219A (zh) 2020-07-17
US11098328B2 (en) 2021-08-24
CA3093227A1 (en) 2019-06-13

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