MX2022015169A - Constructos de arni para inhibir la expresion de hsd17b13 y metodos de uso de los mismos. - Google Patents

Constructos de arni para inhibir la expresion de hsd17b13 y metodos de uso de los mismos.

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Publication number
MX2022015169A
MX2022015169A MX2022015169A MX2022015169A MX2022015169A MX 2022015169 A MX2022015169 A MX 2022015169A MX 2022015169 A MX2022015169 A MX 2022015169A MX 2022015169 A MX2022015169 A MX 2022015169A MX 2022015169 A MX2022015169 A MX 2022015169A
Authority
MX
Mexico
Prior art keywords
methods
rnai constructs
hsd17b13 expression
inhibiting
expression
Prior art date
Application number
MX2022015169A
Other languages
English (en)
Inventor
Justin K Murray
Bradley J Herberich
Michael Ollmann
Oliver Homann
Daniel C H Lin
Amrita Das
Patrick Collins
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2022015169A publication Critical patent/MX2022015169A/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3523—Allyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a constructos de ARNi para reducir la expresión del gen de HSD17B13. También se describen métodos de uso de tales constructos de ARNi para tratar o prevenir enfermedad hepática, enfermedad por hígado graso no alcohólico (NAFLD).
MX2022015169A 2020-06-01 2021-06-03 Constructos de arni para inhibir la expresion de hsd17b13 y metodos de uso de los mismos. MX2022015169A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063033128P 2020-06-01 2020-06-01
PCT/US2021/035730 WO2021247885A2 (en) 2020-06-01 2021-06-03 Rnai constructs for inhibiting hsd17b13 expression and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2022015169A true MX2022015169A (es) 2023-07-03

Family

ID=76921296

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022015169A MX2022015169A (es) 2020-06-01 2021-06-03 Constructos de arni para inhibir la expresion de hsd17b13 y metodos de uso de los mismos.

Country Status (12)

Country Link
US (1) US20230279399A1 (es)
EP (1) EP4158026A2 (es)
JP (1) JP2023528608A (es)
KR (1) KR20240004092A (es)
CN (1) CN116234907A (es)
AU (1) AU2021284377A1 (es)
BR (1) BR112022024501A2 (es)
CA (1) CA3184345A1 (es)
CL (1) CL2022003369A1 (es)
IL (1) IL298697A (es)
MX (1) MX2022015169A (es)
WO (1) WO2021247885A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202340466A (zh) * 2021-12-16 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其製備方法及應用
CN116515835A (zh) * 2022-04-29 2023-08-01 北京福元医药股份有限公司 用于抑制HSD17B13表达的siRNA、其缀合物和药物组合物及其用途
WO2023213284A1 (zh) * 2022-05-06 2023-11-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2024023256A1 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds
WO2024059165A1 (en) * 2022-09-15 2024-03-21 Alnylam Pharmaceuticals, Inc. 17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof

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Also Published As

Publication number Publication date
CN116234907A (zh) 2023-06-06
US20230279399A1 (en) 2023-09-07
AU2021284377A1 (en) 2022-12-22
BR112022024501A2 (pt) 2023-05-09
CL2022003369A1 (es) 2023-07-21
KR20240004092A (ko) 2024-01-11
IL298697A (en) 2023-02-01
WO2021247885A3 (en) 2022-02-10
CA3184345A1 (en) 2021-12-09
JP2023528608A (ja) 2023-07-05
EP4158026A2 (en) 2023-04-05
WO2021247885A2 (en) 2021-12-09

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