MX2020005939A - Mejoramiento de la productividad de lipidos de algas a traves de la modificacion genetica de una proteina que contiene un dominio tpr. - Google Patents
Mejoramiento de la productividad de lipidos de algas a traves de la modificacion genetica de una proteina que contiene un dominio tpr.Info
- Publication number
- MX2020005939A MX2020005939A MX2020005939A MX2020005939A MX2020005939A MX 2020005939 A MX2020005939 A MX 2020005939A MX 2020005939 A MX2020005939 A MX 2020005939A MX 2020005939 A MX2020005939 A MX 2020005939A MX 2020005939 A MX2020005939 A MX 2020005939A
- Authority
- MX
- Mexico
- Prior art keywords
- genetic modification
- containing protein
- domain containing
- tpr domain
- lipid productivity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención proporciona microorganismos mutantes que tienen expresión atenuada de un gen que codifica un polipéptido que incluye un dominio TPR, en donde los microorganismos mutantes tienen una más alta productividad de lípidos y/o exhiben una mayor partición de carbono a lípido en comparación con los microorganismos de tipo salvaje de los que ellos se derivan. Además, se proporcionan métodos para producir lípidos mediante el uso de microorganismos mutantes, ARN guía y constructos de ácido nucleico usados para.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762596671P | 2017-12-08 | 2017-12-08 | |
PCT/US2018/064505 WO2019113463A1 (en) | 2017-12-08 | 2018-12-07 | Improving algal lipid productivity via genetic modification of a tpr domain containing protein |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020005939A true MX2020005939A (es) | 2020-08-24 |
Family
ID=66734597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020005939A MX2020005939A (es) | 2017-12-08 | 2018-12-07 | Mejoramiento de la productividad de lipidos de algas a traves de la modificacion genetica de una proteina que contiene un dominio tpr. |
Country Status (9)
Country | Link |
---|---|
US (1) | US11124798B2 (es) |
EP (1) | EP3720869A4 (es) |
JP (1) | JP2021505158A (es) |
CN (1) | CN111433220A (es) |
AU (1) | AU2018378833A1 (es) |
BR (1) | BR112020011350A2 (es) |
CA (1) | CA3082956A1 (es) |
MX (1) | MX2020005939A (es) |
WO (1) | WO2019113463A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016293527B2 (en) * | 2015-07-14 | 2022-01-13 | Synthetic Genomics, Inc | Microorganisms having increased lipid productivity |
AU2018378833A1 (en) * | 2017-12-08 | 2020-07-09 | Synthetic Genomics, Inc. | Improving algal lipid productivity via genetic modification of a TPR domain containing protein |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
AU5623801A (en) | 2000-03-29 | 2001-10-08 | Max Planck Gesellschaft | 3d structure of polypeptides containing a tpr-structure motif with chaperone-binding function, crystals thereof and compounds for inhibition of said peptides |
JP2005185101A (ja) | 2002-05-30 | 2005-07-14 | National Institute Of Agrobiological Sciences | 植物の全長cDNAおよびその利用 |
WO2005054439A2 (en) | 2003-12-01 | 2005-06-16 | North Carolina State University | Small interfering rna (sirna)-mediated heritable gene manipulation in plants |
WO2008061153A2 (en) * | 2006-11-15 | 2008-05-22 | Agrigenetics, Inc. | Generation of plants with altered protein, fiber, or oil content |
WO2009149470A1 (en) | 2008-06-06 | 2009-12-10 | Aurora Biofuels, Inc. | Vcp-based vectors for algal cell transformation |
US20100255550A1 (en) | 2008-09-15 | 2010-10-07 | Board Of Trustees Of Michigan State University | Regulatory Factors Controlling Oil Biosynthesis In Microalgae And Their Use |
US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
CA2781835A1 (en) | 2009-11-27 | 2011-06-03 | Basf Plant Science Company Gmbh | Chimeric endonucleases and uses thereof |
AU2011213006B2 (en) | 2010-02-03 | 2015-02-19 | Renew Biopharma, Inc. | Stress-induced lipid trigger |
WO2011127118A1 (en) | 2010-04-06 | 2011-10-13 | Algenetix, Inc. | Methods of producing oil in non-plant organisms |
WO2012005898A2 (en) * | 2010-06-15 | 2012-01-12 | Alnylam Pharmaceuticals, Inc. | Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof |
SG187680A1 (en) | 2010-08-02 | 2013-03-28 | Cellectis | Method for targeted genomic events in algae |
US9868959B2 (en) | 2010-12-13 | 2018-01-16 | J. Craig Venter Institute | Engineered microalgae with enhanced lipid production |
WO2012092033A1 (en) | 2010-12-31 | 2012-07-05 | Exxonmobil Research And Engineering Company | Enhancement of biomass production by disruption of light energy dissipation pathways |
MX2013015327A (es) | 2011-06-30 | 2014-01-31 | Exxonmobil Res & Eng Co | Regulacion de genes toxina y antitoxina para contencion biologica. |
WO2013016267A2 (en) | 2011-07-22 | 2013-01-31 | Donald Danforth Plant Science Center | Plants and algae capable of modulating antenna size based on light intensity |
MX356163B (es) | 2011-12-01 | 2018-05-16 | Chemocentryx Inc | Anilinas sustituidas como antagonistas de ccr(4). |
US9243207B2 (en) | 2012-02-29 | 2016-01-26 | Exxonmobil Research And Engineering Company | Solvent extraction of products from algae |
PE20150336A1 (es) | 2012-05-25 | 2015-03-25 | Univ California | Metodos y composiciones para la modificacion de adn objetivo dirigida por arn y para la modulacion de la transcripcion dirigida por arn |
US10612034B2 (en) | 2012-06-01 | 2020-04-07 | Exxonmobil Research And Engineering Company | Promoters and terminators for use in eukaryotic cells |
WO2013188462A2 (en) | 2012-06-12 | 2013-12-19 | Synthetic Genomics, Inc. | Regulatory elements and uses thereof |
IN2015DN04148A (es) | 2012-11-16 | 2015-10-16 | Total Marketing Services | |
WO2014088560A1 (en) | 2012-12-04 | 2014-06-12 | Exxonmobil Research And Engineering Company | Tetraselmis promoters and terminators for use in eukaryotic cells |
EP3401388B1 (en) | 2012-12-06 | 2019-07-10 | Synthetic Genomics, Inc. | Algal mutants having a locked-in high light acclimated phenotype |
EP2929040A4 (en) | 2012-12-06 | 2016-11-09 | Exxonmobil Res & Eng Co | DGAT GENES WITH PLECKSTRIN HOMOLOGY DOMAINS AND USE IN RECOMBINANT MICROORGANISMS |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
EP3252160B1 (en) | 2012-12-12 | 2020-10-28 | The Broad Institute, Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
US10087453B2 (en) | 2013-06-25 | 2018-10-02 | Cellectis | Modified diatoms for biofuel production |
CN105745324A (zh) * | 2013-10-04 | 2016-07-06 | 合成基因组股份有限公司 | 用于调节生物质生产率的组合物和方法 |
AU2014363476A1 (en) | 2013-12-13 | 2016-06-23 | Cellectis | Cas9 nuclease platform for microalgae genome engineering |
US20160090603A1 (en) | 2014-09-30 | 2016-03-31 | Sandia Corporation | Delivery platforms for the domestication of algae and plants |
JP2018500037A (ja) | 2014-12-31 | 2018-01-11 | シンセティック ジェノミクス インコーポレーテッド | 高効率なインビボゲノム編集のための組成物及び方法 |
WO2016134311A1 (en) | 2015-02-19 | 2016-08-25 | Synthetic Genomics, Inc. | High efficiency method for algal transformation |
US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
US9875374B2 (en) | 2015-07-01 | 2018-01-23 | Michael L. Brownewell | System and method for collecting, storing, and securing data |
AU2016293527B2 (en) * | 2015-07-14 | 2022-01-13 | Synthetic Genomics, Inc | Microorganisms having increased lipid productivity |
EP3344776B1 (en) * | 2015-09-04 | 2021-06-16 | Synthetic Genomics, Inc. | Rekombinant algal microorganism with increased productivity |
US10174087B2 (en) | 2015-10-20 | 2019-01-08 | Synthetic Genomics, Inc. | Enhanced productivity by attenuation of chlorophyll binding protein genes |
CN108368491B (zh) * | 2015-11-02 | 2022-12-02 | 合成基因组股份有限公司 | 具有提高的脂质生产率的藻类突变体 |
US10041079B2 (en) | 2015-11-30 | 2018-08-07 | Synthetic Genomics, Inc. | Compositions and methods for expressing genes in algae |
US9896696B2 (en) | 2016-02-15 | 2018-02-20 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
AU2018378833A1 (en) * | 2017-12-08 | 2020-07-09 | Synthetic Genomics, Inc. | Improving algal lipid productivity via genetic modification of a TPR domain containing protein |
-
2018
- 2018-12-07 AU AU2018378833A patent/AU2018378833A1/en active Pending
- 2018-12-07 BR BR112020011350-6A patent/BR112020011350A2/pt unknown
- 2018-12-07 WO PCT/US2018/064505 patent/WO2019113463A1/en unknown
- 2018-12-07 JP JP2020531053A patent/JP2021505158A/ja active Pending
- 2018-12-07 MX MX2020005939A patent/MX2020005939A/es unknown
- 2018-12-07 US US16/213,928 patent/US11124798B2/en active Active
- 2018-12-07 EP EP18886490.4A patent/EP3720869A4/en not_active Withdrawn
- 2018-12-07 CN CN201880079254.3A patent/CN111433220A/zh active Pending
- 2018-12-07 CA CA3082956A patent/CA3082956A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019113463A1 (en) | 2019-06-13 |
EP3720869A4 (en) | 2021-11-24 |
US20190177738A1 (en) | 2019-06-13 |
JP2021505158A (ja) | 2021-02-18 |
CN111433220A (zh) | 2020-07-17 |
US11124798B2 (en) | 2021-09-21 |
BR112020011350A2 (pt) | 2020-11-17 |
CA3082956A1 (en) | 2019-06-13 |
EP3720869A1 (en) | 2020-10-14 |
AU2018378833A1 (en) | 2020-07-09 |
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