JP2025170240A5 - - Google Patents
Info
- Publication number
- JP2025170240A5 JP2025170240A5 JP2025122950A JP2025122950A JP2025170240A5 JP 2025170240 A5 JP2025170240 A5 JP 2025170240A5 JP 2025122950 A JP2025122950 A JP 2025122950A JP 2025122950 A JP2025122950 A JP 2025122950A JP 2025170240 A5 JP2025170240 A5 JP 2025170240A5
- Authority
- JP
- Japan
- Prior art keywords
- adenosine deaminase
- fusion protein
- base editor
- domain
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962897777P | 2019-09-09 | 2019-09-09 | |
| US62/897,777 | 2019-09-09 | ||
| USPCT/US2020/018195 | 2020-02-13 | ||
| PCT/US2020/018195 WO2020168135A1 (en) | 2019-02-13 | 2020-02-13 | Compositions and methods for treating alpha-1 antitrypsin deficiency |
| JP2022514994A JP7717684B2 (ja) | 2019-09-09 | 2020-09-09 | 新規核酸塩基エディター及びその使用方法 |
| PCT/US2020/049975 WO2021050571A1 (en) | 2019-09-09 | 2020-09-09 | Novel nucleobase editors and methods of using same |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022514994A Division JP7717684B2 (ja) | 2019-09-09 | 2020-09-09 | 新規核酸塩基エディター及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025170240A JP2025170240A (ja) | 2025-11-18 |
| JP2025170240A5 true JP2025170240A5 (enExample) | 2026-03-09 |
Family
ID=74867196
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022514994A Active JP7717684B2 (ja) | 2019-09-09 | 2020-09-09 | 新規核酸塩基エディター及びその使用方法 |
| JP2025122950A Pending JP2025170240A (ja) | 2019-09-09 | 2025-07-23 | 新規核酸塩基エディター及びその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022514994A Active JP7717684B2 (ja) | 2019-09-09 | 2020-09-09 | 新規核酸塩基エディター及びその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230075877A1 (enExample) |
| EP (1) | EP4028026A4 (enExample) |
| JP (2) | JP7717684B2 (enExample) |
| KR (1) | KR20220076467A (enExample) |
| CN (1) | CN114667149A (enExample) |
| AU (1) | AU2020344547A1 (enExample) |
| CA (1) | CA3153624A1 (enExample) |
| WO (1) | WO2021050571A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250134703A (ko) | 2018-05-11 | 2025-09-11 | 빔 테라퓨틱스, 인크. | 프로그래밍가능한 염기 편집기 시스템을 이용하여 병원성 아미노산을 치환하는 방법 |
| US12454694B2 (en) | 2018-09-07 | 2025-10-28 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| US12529041B2 (en) | 2018-09-07 | 2026-01-20 | Beam Therapeutics Inc. | Compositions and methods for delivering a nucleobase editing system |
| WO2020168135A1 (en) * | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Compositions and methods for treating alpha-1 antitrypsin deficiency |
| US20220235347A1 (en) | 2019-02-13 | 2022-07-28 | Beam Therapeutics Inc. | Compositions and methods for treating hemoglobinopathies |
| WO2022067089A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| EP4313118A4 (en) * | 2021-03-26 | 2025-06-18 | Beam Therapeutics Inc. | ADENOSINE DEAMINASE VARIANTS AND THEIR USES |
| WO2022240858A1 (en) | 2021-05-10 | 2022-11-17 | Mammoth Biosciences, Inc. | Effector proteins and methods of use |
| EP4363568A4 (en) * | 2021-06-29 | 2025-12-03 | Council Scient Ind Res | MODIFIED FNCAS9 AND ITS USES |
| US20240352439A1 (en) * | 2021-09-03 | 2024-10-24 | The University Of Chicago | Polypeptides and methods for modifying nucleic acids |
| JP2024533313A (ja) * | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | Ｈｂｂを調節する組成物及び方法 |
| EP4409000A1 (en) | 2021-09-28 | 2024-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Base editing approaches for the treatment of beta-hemoglobinopathies |
| WO2023099591A1 (en) | 2021-12-01 | 2023-06-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for increasing fetal hemoglobin content by editing the +55-kb region of the erythroid-specific bcl11a enhancer |
| WO2023141590A2 (en) | 2022-01-21 | 2023-07-27 | Mammoth Biosciences, Inc. | Effector proteins and methods of use |
| WO2023144104A1 (en) | 2022-01-25 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Base editing approaches for the treatment of βeta-thalassemia |
| AU2023248451A1 (en) | 2022-04-04 | 2024-10-17 | President And Fellows Of Harvard College | Cas9 variants having non-canonical pam specificities and uses thereof |
| CN120456933A (zh) | 2022-04-28 | 2025-08-08 | 布罗德研究所股份有限公司 | 编码碱基编辑器的aav载体及其用途 |
| WO2023217888A1 (en) | 2022-05-10 | 2023-11-16 | Institut National de la Santé et de la Recherche Médicale | Base editing approaches for correcting the cd39 (cag>tag) mutation in patients suffering from βeta-thalassemia |
| JP2025517657A (ja) | 2022-05-10 | 2025-06-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | シンシチン－１融合タンパク質及び標的細胞へのカーゴ送達のためのその使用 |
| EP4558633A1 (en) | 2022-07-22 | 2025-05-28 | Institut National de la Santé et de la Recherche Médicale | Base editing approaches for correcting the ivs2-1 (g>a) mutation in patients suffering from beta-thalassemia |
| CN115820691B (zh) * | 2022-07-25 | 2023-08-22 | 安徽农业大学 | 一种基于LbCpf1变体的水稻碱基编辑系统和应用 |
| CA3263821A1 (en) | 2022-08-16 | 2024-02-22 | The Broad Institute, Inc. | ADVANCED CYTOSIN DESAMINASE AND DNA EDITING METHODS USING IT |
| CN115975986B (zh) * | 2022-08-22 | 2023-08-08 | 山东舜丰生物科技有限公司 | 突变的Cas12j蛋白及其应用 |
| CN119998447A (zh) * | 2022-09-23 | 2025-05-13 | 基础科学研究院 | 新型腺嘌呤脱氨酶变体及使用其进行碱基编辑的方法 |
| EP4662313A1 (en) | 2023-02-06 | 2025-12-17 | Institut National de la Santé et de la Recherche Médicale | Enrichment of genetically modified hematopoietic stem cells through multiplex base editing |
| WO2024230760A1 (zh) * | 2023-05-09 | 2024-11-14 | 北京齐禾生科生物科技有限公司 | 一种可作用于dna的腺苷脱氨酶及其应用 |
| CN117965505A (zh) * | 2023-06-28 | 2024-05-03 | 微光基因(苏州)有限公司 | 工程化的腺苷脱氨酶及碱基编辑器 |
| AU2024299627A1 (en) | 2023-07-25 | 2026-01-22 | Flagship Pioneering Innovations Vii, Llc | Cas endonucleases and related methods |
| WO2025059520A1 (en) * | 2023-09-15 | 2025-03-20 | Beam Therapeutics Inc. | Compositions and methods for base editing a phenylalanine hydroxylase polynucleotide |
| WO2025072331A1 (en) | 2023-09-26 | 2025-04-03 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| WO2025117877A2 (en) | 2023-12-01 | 2025-06-05 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| CN120536418A (zh) * | 2024-02-26 | 2025-08-26 | 尧唐(上海)生物科技有限公司 | 一种脱氨酶变体、包含其的碱基编辑器及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108064282A (zh) * | 2014-10-14 | 2018-05-22 | 哈洛齐梅公司 | 腺苷脱氨酶-2(ada2)、其变体的组合物及使用其的方法 |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| US11242542B2 (en) * | 2016-10-07 | 2022-02-08 | Integrated Dna Technologies, Inc. | S. pyogenes Cas9 mutant genes and polypeptides encoded by same |
| AU2017342543B2 (en) * | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| EP3538561A4 (en) * | 2016-11-11 | 2020-10-21 | The Regents of The University of California | RNA-GUIDED VARIANT POLYPEPTIDES AND THEIR METHODS OF USE |
| KR20200121782A (ko) * | 2017-10-16 | 2020-10-26 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| CN109957569B (zh) * | 2017-12-22 | 2022-10-25 | 苏州齐禾生科生物科技有限公司 | 基于cpf1蛋白的碱基编辑系统和方法 |
| CN109295186B (zh) * | 2018-09-30 | 2023-10-03 | 中山大学 | 一种基于全基因组测序检测腺嘌呤单碱基编辑系统脱靶效应的方法及其在基因编辑中的应用 |
-
2020
- 2020-09-09 AU AU2020344547A patent/AU2020344547A1/en active Pending
- 2020-09-09 US US17/641,343 patent/US20230075877A1/en active Pending
- 2020-09-09 WO PCT/US2020/049975 patent/WO2021050571A1/en not_active Ceased
- 2020-09-09 CA CA3153624A patent/CA3153624A1/en active Pending
- 2020-09-09 JP JP2022514994A patent/JP7717684B2/ja active Active
- 2020-09-09 EP EP20863422.0A patent/EP4028026A4/en active Pending
- 2020-09-09 KR KR1020227011386A patent/KR20220076467A/ko active Pending
- 2020-09-09 CN CN202080077983.2A patent/CN114667149A/zh active Pending
-
2025
- 2025-07-23 JP JP2025122950A patent/JP2025170240A/ja active Pending
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