JP2011514144A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011514144A5 JP2011514144A5 JP2010544817A JP2010544817A JP2011514144A5 JP 2011514144 A5 JP2011514144 A5 JP 2011514144A5 JP 2010544817 A JP2010544817 A JP 2010544817A JP 2010544817 A JP2010544817 A JP 2010544817A JP 2011514144 A5 JP2011514144 A5 JP 2011514144A5
- Authority
- JP
- Japan
- Prior art keywords
- crei
- chain
- meganuclease
- crei meganuclease
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010050663 endodeoxyribonuclease CreI Proteins 0.000 claims 28
- 230000035772 mutation Effects 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 210000004899 c-terminal region Anatomy 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 101100467529 Homo sapiens RAG1 gene Proteins 0.000 claims 1
- 102220527183 Immunoglobulin heavy joining 1_R51E_mutation Human genes 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102220602177 Synaptotagmin-3_F54A_mutation Human genes 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 102220223852 rs1060502978 Human genes 0.000 claims 1
- 102200081526 rs121913583 Human genes 0.000 claims 1
- 102200155456 rs35947557 Human genes 0.000 claims 1
- 102220122845 rs767335346 Human genes 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2008/001331 WO2009095742A1 (en) | 2008-01-31 | 2008-01-31 | New i-crei derived single-chain meganuclease and uses thereof |
| PCT/IB2009/000439 WO2009095793A1 (en) | 2008-01-31 | 2009-02-02 | New i-crei derived single-chain meganuclease and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011514144A JP2011514144A (ja) | 2011-05-06 |
| JP2011514144A5 true JP2011514144A5 (enExample) | 2012-03-08 |
Family
ID=39884323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544817A Pending JP2011514144A (ja) | 2008-01-31 | 2009-02-02 | 新しいＩ−ＣｒｅＩ由来単鎖メガヌクレアーゼ及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8927247B2 (enExample) |
| EP (1) | EP2245147A1 (enExample) |
| JP (1) | JP2011514144A (enExample) |
| CN (1) | CN101970649B (enExample) |
| AU (1) | AU2009208732A1 (enExample) |
| CA (1) | CA2729124A1 (enExample) |
| WO (2) | WO2009095742A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009095742A1 (en) | 2008-01-31 | 2009-08-06 | Cellectis | New i-crei derived single-chain meganuclease and uses thereof |
| WO2003078619A1 (en) † | 2002-03-15 | 2003-09-25 | Cellectis | Hybrid and single chain meganucleases and use thereof |
| WO2006097854A1 (en) | 2005-03-15 | 2006-09-21 | Cellectis | Heterodimeric meganucleases and use thereof |
| WO2007060495A1 (en) * | 2005-10-25 | 2007-05-31 | Cellectis | I-crei homing endonuclease variants having novel cleavage specificity and use thereof |
| WO2009019528A1 (en) * | 2007-08-03 | 2009-02-12 | Cellectis | Meganuclease variants cleaving a dna target sequence from the human interleukin-2 receptor gamma chain gene and uses thereof |
| EP2660317B1 (en) | 2007-10-31 | 2016-04-06 | Precision Biosciences, Inc. | Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
| WO2009074842A1 (en) * | 2007-12-13 | 2009-06-18 | Cellectis | Improved chimeric meganuclease enzymes and uses thereof |
| CN102177235A (zh) * | 2008-09-08 | 2011-09-07 | 赛莱克蒂斯公司 | 切割来自谷氨酰胺合成酶基因的dna靶序列的大范围核酸酶变体及其用途 |
| EP2180058A1 (en) | 2008-10-23 | 2010-04-28 | Cellectis | Meganuclease recombination system |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
| US20120171191A1 (en) | 2009-05-26 | 2012-07-05 | Cellectis | Meganuclease variants cleaving the genome of a pathogenic non-integrating virus and uses thereof |
| WO2011021062A1 (en) * | 2009-08-21 | 2011-02-24 | Cellectis | Meganuclease variants cleaving a dna target sequence from the human lysosomal acid alpha-glucosidase gene and uses thereof |
| WO2011036640A2 (en) | 2009-09-24 | 2011-03-31 | Cellectis | Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations |
| CA2783351C (en) | 2009-12-10 | 2021-09-07 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| CN103097527A (zh) | 2010-02-26 | 2013-05-08 | 塞勒克提斯公司 | 用于将转基因插入安全港座位的内切核酸酶的用途 |
| US20130145487A1 (en) | 2010-05-12 | 2013-06-06 | Cellectis | Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof |
| WO2011141825A1 (en) | 2010-05-12 | 2011-11-17 | Cellectis | Meganuclease variants cleaving a dna target sequence from the rhodopsin gene and uses thereof |
| CA2798988C (en) | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
| SG186932A1 (en) * | 2010-07-07 | 2013-02-28 | Cellectis | Meganucleases variants cleaving a dna target sequence in the nanog gene and uses thereof |
| WO2012010976A2 (en) | 2010-07-15 | 2012-01-26 | Cellectis | Meganuclease variants cleaving a dna target sequence in the tert gene and uses thereof |
| WO2012007848A2 (en) | 2010-07-16 | 2012-01-19 | Cellectis | Meganuclease variants cleaving a dna target sequence in the was gene and uses thereof |
| CA2807270A1 (en) | 2010-08-02 | 2012-02-09 | Cellectis | Method for targeted genomic events in diatoms |
| JP2013544082A (ja) * | 2010-10-27 | 2013-12-12 | セレクティス | 二本鎖破断−誘導変異誘発の効率を増大させる方法 |
| US9044492B2 (en) | 2011-02-04 | 2015-06-02 | Cellectis Sa | Method for modulating the efficiency of double-strand break-induced mutagenesis |
| EP2694091B1 (en) * | 2011-04-05 | 2019-03-13 | Cellectis | Method for the generation of compact tale-nucleases and uses thereof |
| WO2012138901A1 (en) | 2011-04-05 | 2012-10-11 | Cellectis Sa | Method for enhancing rare-cutting endonuclease efficiency and uses thereof |
| PT2702160T (pt) | 2011-04-27 | 2020-07-30 | Amyris Inc | Métodos para modificação genómica |
| WO2012158778A1 (en) * | 2011-05-16 | 2012-11-22 | Cellectis S.A. | Doubly secure transgenic algae or cyanobacteria strains to prevent their establishment and spread in natural ecosystems |
| DK3489366T3 (da) | 2011-06-01 | 2020-02-24 | Prec Biosciences Inc | Fremgangsmåder og produkter til produktion af manipulerede mammale cellelinier med forstærkede transgener |
| US20150225734A1 (en) | 2012-06-19 | 2015-08-13 | Regents Of The University Of Minnesota | Gene targeting in plants using dna viruses |
| WO2014018601A2 (en) | 2012-07-24 | 2014-01-30 | Cellectis | New modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins |
| MX367031B (es) | 2012-11-01 | 2019-08-02 | Cellectis | Plantas para la produccion de proteinas terapeuticas. |
| CN105051204B (zh) | 2012-11-16 | 2023-07-21 | 波赛伊达治疗学股份有限公司 | 位点特异性酶和使用方法 |
| AU2013346504A1 (en) | 2012-11-16 | 2015-06-18 | Cellectis | Method for targeted modification of algae genomes |
| US20140178561A1 (en) | 2012-12-21 | 2014-06-26 | Cellectis | Potatoes with reduced cold-induced sweetening |
| WO2014102688A1 (en) | 2012-12-27 | 2014-07-03 | Cellectis | New design matrix for improvement of homology-directed gene targeting |
| US10113162B2 (en) | 2013-03-15 | 2018-10-30 | Cellectis | Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes |
| AU2014368982B2 (en) | 2013-12-19 | 2021-03-25 | Amyris, Inc. | Methods for genomic integration |
| WO2015164748A1 (en) | 2014-04-24 | 2015-10-29 | Sangamo Biosciences, Inc. | Engineered transcription activator like effector (tale) proteins |
| CA2952906A1 (en) | 2014-06-20 | 2015-12-23 | Cellectis | Potatoes with reduced granule-bound starch synthase |
| DK3310909T3 (da) | 2015-06-17 | 2021-09-13 | Poseida Therapeutics Inc | Sammensætninger og fremgangsmåder til at føre proteiner til specifikke loci i genomet |
| US10837024B2 (en) | 2015-09-17 | 2020-11-17 | Cellectis | Modifying messenger RNA stability in plant transformations |
| EP4646936A3 (en) | 2016-02-02 | 2025-11-19 | Cellectis | Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes |
| AU2017258304B2 (en) | 2016-04-27 | 2019-07-04 | University Of Puerto Rico | 1,5-disubstituted 1,2,3-triazoles are inhibitors of Rac/Cdc42 GTPases |
| WO2017192741A1 (en) * | 2016-05-03 | 2017-11-09 | Precision Biosciences, Inc. | Engineered nucleases useful for treatment of hemophilia a |
| US11293033B2 (en) | 2016-05-18 | 2022-04-05 | Amyris, Inc. | Compositions and methods for genomic integration of nucleic acids into exogenous landing pads |
| CN109689865A (zh) * | 2016-07-25 | 2019-04-26 | 蓝鸟生物公司 | Bcl11a归巢核酸内切酶变体、组合物和使用方法 |
| UY37482A (es) | 2016-11-16 | 2018-05-31 | Cellectis | Métodos para alterar el contenido de aminoácidos en plantas mediante mutaciones de desplazamiento de marco |
| EP3615668B1 (en) | 2017-04-25 | 2024-02-28 | Cellectis | Alfalfa with reduced lignin composition |
| KR102590466B1 (ko) | 2017-05-25 | 2023-10-19 | 2세븐티 바이오, 인코포레이티드 | Cblb 엔도뉴클레아제 변이체, 조성물 및 사용 방법 |
| WO2019126558A1 (en) * | 2017-12-20 | 2019-06-27 | Bluebird Bio, Inc. | Ahr homing endonuclease variants, compositions, and methods of use |
| WO2019126578A1 (en) | 2017-12-20 | 2019-06-27 | Poseida Therapeutics, Inc. | Compositions and methods for directing proteins to specific loci in the genome |
| BR112020025439A2 (pt) | 2018-06-14 | 2021-03-16 | Bluebird Bio, Inc. | Receptores de antígenos quiméricos cd79a |
| WO2020072059A1 (en) | 2018-10-04 | 2020-04-09 | Bluebird Bio, Inc. | Cblb endonuclease variants, compositions, and methods of use |
| NL2022714B1 (en) * | 2019-03-11 | 2020-09-18 | Academisch Ziekenhuis Leiden | Optimised RAG1 deficient SCID Gene Therapy |
| WO2024236547A1 (en) | 2023-05-18 | 2024-11-21 | Inceptor Bio, Llc | Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof |
| WO2025046513A1 (en) | 2023-08-29 | 2025-03-06 | Inceptor Bio, Llc | Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof |
| WO2025101946A1 (en) * | 2023-11-08 | 2025-05-15 | Precision Biosciences, Inc. | Polypeptide linkers for use in engineered meganucleases |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US5006333A (en) * | 1987-08-03 | 1991-04-09 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| FR2646438B1 (fr) * | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5272071A (en) * | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| AU8081491A (en) | 1990-06-01 | 1991-12-31 | Cetus Corporation | Compositions and methods for identifying biologically active molecules |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6063630A (en) * | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US20040019916A1 (en) * | 1992-04-24 | 2004-01-29 | Zarling David A. | In vivo homologous sequence targeting in eukaryotic cells |
| US6395959B1 (en) * | 1992-05-05 | 2002-05-28 | Institut Pasteur | Nucleotide sequence encoding the enzyme I SceI and the use thereof |
| US5792632A (en) * | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5474896A (en) * | 1992-05-05 | 1995-12-12 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| ATE513037T1 (de) | 1993-02-12 | 2011-07-15 | Univ Johns Hopkins | Funktionelle domänen der restriktionsendonukleasen aus flavobakterium okeanokoites (foki) |
| US5801030A (en) * | 1995-09-01 | 1998-09-01 | Genvec, Inc. | Methods and vectors for site-specific recombination |
| JP3535177B2 (ja) * | 1995-09-22 | 2004-06-07 | バイオイメージ・アクティーゼルスカブ | 緑色蛍光性タンパクであるｇｆｐの新規な変種 |
| US5830729A (en) * | 1996-04-18 | 1998-11-03 | Institut Pasteur | I Sce I-induced gene replacement and gene conversion in embryonic stem cells |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| IL120241A0 (en) * | 1997-02-17 | 1997-06-10 | B G Negev Technologies And App | DNA segments encoding a domain of ho-endonuclease |
| US6232112B1 (en) * | 1997-11-24 | 2001-05-15 | Flinders Technologies Pty Ltd Of Flinders University | Reagents and methods for diversification of DNA |
| CA2360878A1 (en) | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving excision of targeting dna |
| WO2000046386A2 (en) | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site |
| WO2001070946A2 (en) | 2000-03-21 | 2001-09-27 | Neugenesis Corporation | Methods for in vivo diversification of single genes |
| US20020187484A1 (en) | 2000-11-27 | 2002-12-12 | Jon Thorson | Molecular break lights probes for detecting nucleotide cleavage |
| AU2001297625A1 (en) * | 2000-12-21 | 2002-09-12 | Bristol-Myers Squibb Company | Nucleic acid molecules and polypeptides for a human cation channel polypeptide |
| AU2002317771A1 (en) | 2001-06-05 | 2002-12-16 | Cellectis | Methods for modifying the cpg content of polynucleotides |
| DE10131786A1 (de) * | 2001-07-04 | 2003-01-16 | Sungene Gmbh & Co Kgaa | Rekombinationssysteme und Verfahren zum Entfernen von Nukleinsäuresequenzen aus dem Genom eukaryotischer Organismen |
| AU2002353934A1 (en) * | 2001-10-31 | 2003-05-12 | Oxford Glycosciences (Uk) Ltd. | Biomarkers of liver function |
| US7462758B2 (en) * | 2001-12-20 | 2008-12-09 | Sungene Gmbh & Co. Kgaa | Methods for the transformation of vegetal plastids |
| WO2003078619A1 (en) * | 2002-03-15 | 2003-09-25 | Cellectis | Hybrid and single chain meganucleases and use thereof |
| WO2009095742A1 (en) | 2008-01-31 | 2009-08-06 | Cellectis | New i-crei derived single-chain meganuclease and uses thereof |
| WO2004031346A2 (en) | 2002-09-06 | 2004-04-15 | Fred Hutchinson Cancer Research Center | Methods and compositions concerning designed highly-specific nucleic acid binding proteins |
| EP1590468A2 (en) * | 2003-01-28 | 2005-11-02 | Cellectis | Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof |
| US7888121B2 (en) * | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| WO2006097784A1 (en) * | 2005-03-15 | 2006-09-21 | Cellectis | I-crei meganuclease variants with modified specificity, method of preparation and uses thereof |
| WO2006097854A1 (en) * | 2005-03-15 | 2006-09-21 | Cellectis | Heterodimeric meganucleases and use thereof |
| WO2007034262A1 (en) | 2005-09-19 | 2007-03-29 | Cellectis | Heterodimeric meganucleases and use thereof |
| ES2626025T3 (es) | 2005-10-18 | 2017-07-21 | Precision Biosciences | Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas |
| WO2007060495A1 (en) | 2005-10-25 | 2007-05-31 | Cellectis | I-crei homing endonuclease variants having novel cleavage specificity and use thereof |
| WO2007049095A1 (en) | 2005-10-25 | 2007-05-03 | Cellectis | Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof |
| WO2007093836A1 (en) * | 2006-02-13 | 2007-08-23 | Cellectis | Meganuclease variants cleaving a dna target sequence from a xp gene and uses thereof |
| RU2318466C1 (ru) | 2006-06-23 | 2008-03-10 | Давид Георгиевич Кочиев | Лазерная установка для абляции тканей и литотрипсии |
| WO2008002199A2 (en) | 2006-06-23 | 2008-01-03 | Aichinger, Elena | Biocidal and virulicidal agent-clathrate 1,6,3,8-dimethan-tetra-aza-cyclodecane-sodium carbonate |
| WO2008002274A1 (en) | 2006-06-27 | 2008-01-03 | Inventys Pte Ltd | Method and system for client-side user interface enhancement to enable application integration and portalisation |
| WO2008010009A1 (en) | 2006-07-18 | 2008-01-24 | Cellectis | Meganuclease variants cleaving a dna target sequence from a rag gene and uses thereof |
| EP1884516A1 (en) | 2006-08-04 | 2008-02-06 | Ferrer Internacional, S.A. | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions |
| WO2008059317A1 (en) | 2006-11-14 | 2008-05-22 | Cellectis | Meganuclease variants cleaving a dna target sequence from the hprt gene and uses thereof |
| BRPI0718747A2 (pt) | 2006-11-14 | 2013-12-03 | Cellectis | Variantes meganuclease que clavam uma ou sequência alvo de dna a partir do gene hprt e usos das mesmas. |
| WO2008093152A1 (en) | 2007-02-01 | 2008-08-07 | Cellectis | Obligate heterodimer meganucleases and uses thereof |
| US20140112904A9 (en) | 2007-06-06 | 2014-04-24 | Cellectis | Method for enhancing the cleavage activity of i-crei derived meganucleases |
| WO2008149176A1 (en) | 2007-06-06 | 2008-12-11 | Cellectis | Meganuclease variants cleaving a dna target sequence from the mouse rosa26 locus and uses thereof |
| EP2660317B1 (en) | 2007-10-31 | 2016-04-06 | Precision Biosciences, Inc. | Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
| CN102177235A (zh) | 2008-09-08 | 2011-09-07 | 赛莱克蒂斯公司 | 切割来自谷氨酰胺合成酶基因的dna靶序列的大范围核酸酶变体及其用途 |
-
2008
- 2008-01-31 WO PCT/IB2008/001331 patent/WO2009095742A1/en not_active Ceased
-
2009
- 2009-02-02 WO PCT/IB2009/000439 patent/WO2009095793A1/en not_active Ceased
- 2009-02-02 CN CN200980109080.1A patent/CN101970649B/zh not_active Expired - Fee Related
- 2009-02-02 AU AU2009208732A patent/AU2009208732A1/en not_active Abandoned
- 2009-02-02 EP EP09705925A patent/EP2245147A1/en not_active Withdrawn
- 2009-02-02 JP JP2010544817A patent/JP2011514144A/ja active Pending
- 2009-02-02 CA CA2729124A patent/CA2729124A1/en not_active Abandoned
- 2009-02-02 US US12/864,998 patent/US8927247B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011514144A5 (enExample) | ||
| US20230407341A1 (en) | Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing | |
| US20220127667A1 (en) | Method of dna synthesis | |
| KR102254602B1 (ko) | Cas9 변이체 및 그의 용도 | |
| JP4448619B2 (ja) | 組換えポリヌクレオチド配列をＩｎｖｉｔｒｏで得る方法、配列バンク及びかくして得られた配列 | |
| TW202136508A (zh) | 用於編輯目標rna之附加有功能性領域之反義型嚮導rna | |
| JP2013502226A5 (enExample) | ||
| US20180080013A1 (en) | Rna-guided gene editing system and uses thereof | |
| CN105142663B (zh) | 用于癌症靶向治疗的含有结合白蛋白的精氨酸脱亚胺酶的药物组合物 | |
| JPWO2021113270A5 (enExample) | ||
| CN111741977A (zh) | 转铁蛋白受体结合性多肽和其用途 | |
| JP2018527013A (ja) | アレル選択的な遺伝子編集およびその使用 | |
| JP2017018125A5 (enExample) | ||
| HRP20250549T1 (hr) | Postupak i sastavi za modificiranje ciljne dnk s pomoću rnk i za modulaciju transkripcije s pomoću rnk | |
| JP2010517524A5 (enExample) | ||
| CA3109083A1 (en) | Compositions and methods for genome engineering with cas12a proteins | |
| CA3140093A1 (en) | Methods of editing a single nucleotide polymorphism using programmable base editor systems | |
| CN113774085B (zh) | 一种单碱基编辑工具TaC9-ABE及其应用 | |
| CN114144519B (zh) | 单碱基置换蛋白以及包含其的组合物 | |
| Gordeeva et al. | Improved PCR-based gene synthesis method and its application to the Citrobacter freundii phytase gene codon modification | |
| JP2005525128A5 (enExample) | ||
| CN110747191A (zh) | 多肽、嵌合聚合酶及其应用 | |
| DK2718430T3 (en) | Technically designed sequence-specific ribonuclease H AND METHOD FOR ESTABLISHING SEKVENSPREFERENCEN OF DNA-RNA hybrid binding proteins | |
| CN112585266A (zh) | 新型转录激活物 | |
| CN115244068A (zh) | 铁蛋白-ace-2短肽纳米药物 |