CA2729124A1 - New i-crei derived single-chain meganuclease and uses thereof - Google Patents

New i-crei derived single-chain meganuclease and uses thereof Download PDF

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Publication number
CA2729124A1
CA2729124A1 CA2729124A CA2729124A CA2729124A1 CA 2729124 A1 CA2729124 A1 CA 2729124A1 CA 2729124 A CA2729124 A CA 2729124A CA 2729124 A CA2729124 A CA 2729124A CA 2729124 A1 CA2729124 A1 CA 2729124A1
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CA
Canada
Prior art keywords
crei
anyone
chain
meganuclease
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA2729124A
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English (en)
French (fr)
Inventor
Sylvestre Grizot
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Cellectis SA
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Cellectis SA
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Filing date
Publication date
Application filed by Cellectis SA filed Critical Cellectis SA
Publication of CA2729124A1 publication Critical patent/CA2729124A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2729124A 2008-01-31 2009-02-02 New i-crei derived single-chain meganuclease and uses thereof Abandoned CA2729124A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2008/001331 2008-01-31
PCT/IB2008/001331 WO2009095742A1 (en) 2008-01-31 2008-01-31 New i-crei derived single-chain meganuclease and uses thereof
PCT/IB2009/000439 WO2009095793A1 (en) 2008-01-31 2009-02-02 New i-crei derived single-chain meganuclease and uses thereof

Publications (1)

Publication Number Publication Date
CA2729124A1 true CA2729124A1 (en) 2009-08-06

Family

ID=39884323

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2729124A Abandoned CA2729124A1 (en) 2008-01-31 2009-02-02 New i-crei derived single-chain meganuclease and uses thereof

Country Status (7)

Country Link
US (1) US8927247B2 (enExample)
EP (1) EP2245147A1 (enExample)
JP (1) JP2011514144A (enExample)
CN (1) CN101970649B (enExample)
AU (1) AU2009208732A1 (enExample)
CA (1) CA2729124A1 (enExample)
WO (2) WO2009095742A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025101946A1 (en) * 2023-11-08 2025-05-15 Precision Biosciences, Inc. Polypeptide linkers for use in engineered meganucleases

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WO2009095742A1 (en) 2008-01-31 2009-08-06 Cellectis New i-crei derived single-chain meganuclease and uses thereof
WO2003078619A1 (en) † 2002-03-15 2003-09-25 Cellectis Hybrid and single chain meganucleases and use thereof
WO2006097854A1 (en) 2005-03-15 2006-09-21 Cellectis Heterodimeric meganucleases and use thereof
WO2007060495A1 (en) * 2005-10-25 2007-05-31 Cellectis I-crei homing endonuclease variants having novel cleavage specificity and use thereof
WO2009019528A1 (en) * 2007-08-03 2009-02-12 Cellectis Meganuclease variants cleaving a dna target sequence from the human interleukin-2 receptor gamma chain gene and uses thereof
EP2660317B1 (en) 2007-10-31 2016-04-06 Precision Biosciences, Inc. Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
WO2009074842A1 (en) * 2007-12-13 2009-06-18 Cellectis Improved chimeric meganuclease enzymes and uses thereof
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US20150225734A1 (en) 2012-06-19 2015-08-13 Regents Of The University Of Minnesota Gene targeting in plants using dna viruses
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Cited By (1)

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Also Published As

Publication number Publication date
EP2245147A1 (en) 2010-11-03
CN101970649A (zh) 2011-02-09
JP2011514144A (ja) 2011-05-06
US8927247B2 (en) 2015-01-06
US20110179506A1 (en) 2011-07-21
WO2009095793A1 (en) 2009-08-06
CN101970649B (zh) 2014-02-12
WO2009095742A1 (en) 2009-08-06
AU2009208732A1 (en) 2009-08-06

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