JP2018528237A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018528237A5 JP2018528237A5 JP2018515566A JP2018515566A JP2018528237A5 JP 2018528237 A5 JP2018528237 A5 JP 2018528237A5 JP 2018515566 A JP2018515566 A JP 2018515566A JP 2018515566 A JP2018515566 A JP 2018515566A JP 2018528237 A5 JP2018528237 A5 JP 2018528237A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- epitope
- protein
- cell epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 102000004169 proteins and genes Human genes 0.000 claims 37
- 210000001744 T-lymphocyte Anatomy 0.000 claims 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 102000043131 MHC class II family Human genes 0.000 claims 23
- 108091054438 MHC class II family Proteins 0.000 claims 23
- 210000000581 natural killer T-cell Anatomy 0.000 claims 21
- 230000001225 therapeutic effect Effects 0.000 claims 17
- 102000004316 Oxidoreductases Human genes 0.000 claims 10
- 108090000854 Oxidoreductases Proteins 0.000 claims 10
- 239000013604 expression vector Substances 0.000 claims 10
- 239000013603 viral vector Substances 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 238000012423 maintenance Methods 0.000 claims 3
- 238000001415 gene therapy Methods 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002255 vaccination Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010093013 HLA-DR1 Antigen Proteins 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013519 translation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15186845.2 | 2015-09-25 | ||
| EP15186845 | 2015-09-25 | ||
| PCT/EP2016/072690 WO2017050966A1 (en) | 2015-09-25 | 2016-09-23 | Improved methods and compounds for eliminating immune responses to therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528237A JP2018528237A (ja) | 2018-09-27 |
| JP2018528237A5 true JP2018528237A5 (enExample) | 2019-11-07 |
| JP7090335B2 JP7090335B2 (ja) | 2022-06-24 |
Family
ID=54251983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515566A Active JP7090335B2 (ja) | 2015-09-25 | 2016-09-23 | 治療剤に対する免疫応答を除去するための改善された方法及び化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11787849B2 (enExample) |
| EP (2) | EP3352782B1 (enExample) |
| JP (1) | JP7090335B2 (enExample) |
| CN (1) | CN108289941B (enExample) |
| AU (2) | AU2016328582B2 (enExample) |
| CA (1) | CA2995771A1 (enExample) |
| ES (1) | ES2874077T3 (enExample) |
| WO (1) | WO2017050966A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2657480T3 (es) | 2006-08-11 | 2018-03-05 | Life Sciences Research Partners Vzw | Péptidos inmunogénicos y su uso en trastornos inmunitarios |
| ES2637812T3 (es) | 2008-02-14 | 2017-10-17 | Life Sciences Research Partners Vzw | Inmunoterapia dirigida a patógenos intracelulares |
| US8999346B2 (en) | 2008-02-14 | 2015-04-07 | Life Sciences Research Partners Vzw | Immunogenic control of tumours and tumour cells |
| KR101902029B1 (ko) | 2010-11-25 | 2018-09-27 | 임나트 에스에이알엘 | 감염성 질환, 자가면역 질환, 동종인자에 대한 면역 반응, 알레르기 질환, 종양, 이식편 거부 및 유전자 요법 또는 유전자 백신접종을 위해 사용되는 바이러스 벡터에 대한 면역 반응의 예방 및/또는 치료에 사용하기 위한 면역원성 펩티드 |
| GB201201511D0 (en) | 2012-01-30 | 2012-03-14 | Univ Leuven Kath | Modified epitopes for boosting CD4+ T-cell responses |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
| US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
| ES2874077T3 (es) | 2015-09-25 | 2021-11-04 | Imcyse Sa | Métodos y compuestos mejorados para eliminar respuestas inmunitarias a agentes terapéuticos |
| WO2017182528A1 (en) | 2016-04-19 | 2017-10-26 | Imcyse Sa | Novel immunogenic cd1d binding peptides |
| CN113906046A (zh) * | 2019-05-16 | 2022-01-07 | 易姆赛斯股份公司 | 具有包含经修饰半胱氨酸的氧化还原酶基序的免疫原性肽 |
| EP4146255A1 (en) * | 2020-05-06 | 2023-03-15 | Imcyse SA | Immunogenic peptides with new oxidoreductase motifs |
| JP2023525276A (ja) * | 2020-05-06 | 2023-06-15 | アンシス・エスア | 延長された酸化還元酵素モチーフを有する免疫原性ペプチド |
| PH12022552979A1 (en) * | 2020-05-06 | 2024-02-26 | Imcyse Sa | Peptides and methods for the treatment of multiple sclerosis |
| CN113621030B (zh) * | 2020-07-14 | 2023-05-26 | 上海科技大学 | 一种诱导蛋白质降解的多肽及其应用 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU579148B2 (en) | 1984-03-09 | 1988-11-17 | Scripps Clinic And Research Foundation | Synthetic hepatitis b virus vaccine including both t cell and b cell determinants |
| US4599231A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4886782A (en) | 1987-02-26 | 1989-12-12 | The United States Of America As Represented By The Department Of Health And Human Services | Malarial immunogen |
| US5433948A (en) | 1990-02-13 | 1995-07-18 | Thomas; Wayne R. | Cloning and sequencing of allergens of dermatophagoides (house dust mite) |
| HU9300877D0 (en) | 1990-09-27 | 1993-06-28 | Syntello Vaccine Dev Kb | Method for producing proteines applicables by injection and inducing anti-bodies having neutralizing effect against virus of human immun insufficiency |
| KR100260342B1 (ko) | 1991-10-16 | 2000-07-01 | 스타세이 엘. 첸링 | 더마토파고이드로 부터 유래된 알레르겐의 t세포 에피토프 |
| US7252829B1 (en) | 1998-06-17 | 2007-08-07 | Idm Pharma, Inc. | HLA binding peptides and their uses |
| US5589582A (en) | 1992-10-27 | 1996-12-31 | Biotransplant, Inc. | Polynucleotides en coding porcine cytokines |
| US5633234A (en) | 1993-01-22 | 1997-05-27 | The Johns Hopkins University | Lysosomal targeting of immunogens |
| US5824315A (en) | 1993-10-25 | 1998-10-20 | Anergen, Inc. | Binding affinity of antigenic peptides for MHC molecules |
| US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| US7157089B1 (en) | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| WO1999021979A1 (en) | 1997-10-28 | 1999-05-06 | Maxygen, Inc. | Human papillomavirus vectors |
| NO315238B1 (no) | 1998-05-08 | 2003-08-04 | Gemvax As | Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy |
| AR020102A1 (es) | 1998-07-30 | 2002-04-10 | Ucb Sa | Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento |
| US20030152581A1 (en) | 1998-07-30 | 2003-08-14 | Jean-Marie Saint-Remy | Compound and method for the prevention and/or the treatment of allergy |
| CA2350911A1 (en) | 1998-11-16 | 2000-05-25 | Board Of Regents, The University Of Texas System | Hiv-specific t-cell induction |
| GB0006437D0 (en) | 2000-03-17 | 2000-05-10 | Leuven Res & Dev Vzw | Compounds for the modulation of allergen sensitivity by antigens sharing T cell epitopes with allergens |
| AU2001254620A1 (en) * | 2000-04-28 | 2001-11-12 | Novozymes A/S | Lipolytic enzyme variant |
| JP2004501648A (ja) | 2000-06-26 | 2004-01-22 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | チオレドキシンおよび目的のポリペプチドの間に融合するユビキチンを含む三重融合タンパク質 |
| US7049413B2 (en) | 2001-05-18 | 2006-05-23 | Ludwig Institute For Cancer Research | MAGE-A3 peptides presented by HLA class II molecules |
| DE60210623T2 (de) | 2001-05-30 | 2007-02-15 | Fondazione Téléthon | Ex-vivo isolierte cd25+cd4+ t zellen mit immunsuppressiver aktivität und deren anwendungen |
| CA2458392A1 (en) | 2001-10-03 | 2003-04-17 | Unilever Plc | Carbohydrate binding domain containing fusion proteins for delivery of therapeutic and other agents, and compositions containing them |
| WO2003072731A2 (en) | 2002-02-21 | 2003-09-04 | Apovia, Inc. | STABILIZED HBc CHIMER PARTICLES HAVING MENINGOCCOCAL IMMUNOGENS |
| US20100183652A1 (en) | 2002-02-21 | 2010-07-22 | Mark Page | STABILIZED HBc CHIMER PARTICLES AS THERAPEUTIC VACCINE FOR CHRONIC HEPATITIS |
| TW200413406A (en) | 2002-08-26 | 2004-08-01 | Kirin Brewery | Peptides and drugs containing the same |
| DK1548032T3 (da) | 2002-09-12 | 2009-08-17 | Oncotherapy Science Inc | KDR-peptider og vacciner indeholdende disse |
| JP2004147649A (ja) | 2002-10-11 | 2004-05-27 | Kumamoto Technology & Industry Foundation | 頭頚部癌の抗原 |
| CA2520768A1 (en) | 2003-03-28 | 2005-02-10 | Idm Pharma, Inc. | Methods of identifying optimal variants of peptide epitopes |
| US7651855B2 (en) | 2003-04-17 | 2010-01-26 | The Trustees Of The University Of Pennsylvania | Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses |
| GB0324265D0 (en) | 2003-10-16 | 2003-11-19 | Medical Res Council | Peptide |
| EP1687333A2 (en) | 2003-10-30 | 2006-08-09 | Pharmexa A/S | Method for down-regulation of vegf |
| JP2008044848A (ja) | 2004-11-30 | 2008-02-28 | Univ Kurume | Ｈｌａ−ａ２４拘束性腫瘍抗原ペプチド |
| US8252893B2 (en) | 2005-01-31 | 2012-08-28 | Board Of Trustees Of The University Of Arkansas | CD8 T cell epitopes in HPV 16 E6 and E7 proteins and uses thereof |
| US10183986B2 (en) | 2005-12-15 | 2019-01-22 | Industrial Technology Research Institute | Trimeric collagen scaffold antibodies |
| GB0603081D0 (en) | 2006-02-15 | 2006-03-29 | Dynal Biotech Asa Oslo | Method |
| FR2898275B1 (fr) | 2006-03-10 | 2012-12-14 | Genethon | Cellules t regulatrices cd4+cd25+specifiques pour la greffe de cellules hematopoietiques et la tolerance immunitaire |
| WO2007135684A2 (en) | 2006-05-22 | 2007-11-29 | Hadasit Medical Research Services & Development Limited | Method of treatment of anti-cd4 autoimmunity |
| ES2657480T3 (es) | 2006-08-11 | 2018-03-05 | Life Sciences Research Partners Vzw | Péptidos inmunogénicos y su uso en trastornos inmunitarios |
| ES2602610T3 (es) | 2007-05-31 | 2017-02-21 | Medigene Ag | Proteína estructural mutada de un parvovirus |
| CA2700618A1 (en) | 2007-09-27 | 2009-04-02 | The Board Of Trustees Of The University Of Arkansas | Inhibition of dendritic cell-driven regulatory t cell activation and potentiation of tumor antigen-specific t cell responses by interleukin-15 and map kinase inhibitor |
| WO2009101206A2 (en) * | 2008-02-14 | 2009-08-20 | Life Sciences Research Partners Vzw | Strategies to prevent and/or treat immune responses to soluble allofactors |
| US8999346B2 (en) | 2008-02-14 | 2015-04-07 | Life Sciences Research Partners Vzw | Immunogenic control of tumours and tumour cells |
| ES2637812T3 (es) | 2008-02-14 | 2017-10-17 | Life Sciences Research Partners Vzw | Inmunoterapia dirigida a patógenos intracelulares |
| US20110111395A1 (en) | 2008-02-14 | 2011-05-12 | Jean-Marie Saint-Remy | Cd4+cells with cytolytic properties |
| WO2009101204A2 (en) | 2008-02-14 | 2009-08-20 | Life Sciences Research Partners Vzw | Elimination of immune responses to viral vectors |
| EP2249855B1 (en) | 2008-02-14 | 2017-03-22 | Life Sciences Research Partners VZW | Immunogenic peptides and their use in transplantation |
| EP2254592B1 (en) | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
| KR101022649B1 (ko) | 2008-08-07 | 2011-03-22 | 삼성모바일디스플레이주식회사 | 헤테로고리 화합물 및 이를 이용한 유기 전계 발광 장치 |
| US20110318380A1 (en) | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
| JP5942296B2 (ja) | 2010-03-29 | 2016-06-29 | サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィクＣｅｎｔｒｅ Ｎａｔｉｏｎａｌ Ｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｓｃｉｅｎｔｉｆｉｑｕｅ | 少なくとも１つのｃｘｘｃモチーフを含むポリペプチドと異種抗原とを含む医薬組成物、及びその使用 |
| KR101902029B1 (ko) | 2010-11-25 | 2018-09-27 | 임나트 에스에이알엘 | 감염성 질환, 자가면역 질환, 동종인자에 대한 면역 반응, 알레르기 질환, 종양, 이식편 거부 및 유전자 요법 또는 유전자 백신접종을 위해 사용되는 바이러스 벡터에 대한 면역 반응의 예방 및/또는 치료에 사용하기 위한 면역원성 펩티드 |
| GB201201511D0 (en) | 2012-01-30 | 2012-03-14 | Univ Leuven Kath | Modified epitopes for boosting CD4+ T-cell responses |
| CN104271148A (zh) | 2012-02-15 | 2015-01-07 | 洛桑聚合联合学院 | 红细胞结合性治疗剂 |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| GB201315946D0 (en) | 2013-09-06 | 2013-10-23 | Immune Targeting Systems Its Ltd | Oncology vaccine |
| GB201319160D0 (en) | 2013-10-30 | 2013-12-11 | Imcyse Sa | Methods for induction of antigen-specific regulatory t cells |
| GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
| US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
| ES2874077T3 (es) | 2015-09-25 | 2021-11-04 | Imcyse Sa | Métodos y compuestos mejorados para eliminar respuestas inmunitarias a agentes terapéuticos |
| WO2017182528A1 (en) | 2016-04-19 | 2017-10-26 | Imcyse Sa | Novel immunogenic cd1d binding peptides |
-
2016
- 2016-09-23 ES ES16778714T patent/ES2874077T3/es active Active
- 2016-09-23 JP JP2018515566A patent/JP7090335B2/ja active Active
- 2016-09-23 EP EP16778714.2A patent/EP3352782B1/en active Active
- 2016-09-23 AU AU2016328582A patent/AU2016328582B2/en not_active Ceased
- 2016-09-23 CA CA2995771A patent/CA2995771A1/en active Pending
- 2016-09-23 EP EP21164831.6A patent/EP3939606A3/en not_active Withdrawn
- 2016-09-23 US US15/761,223 patent/US11787849B2/en active Active
- 2016-09-23 CN CN201680068767.5A patent/CN108289941B/zh not_active Expired - Fee Related
- 2016-09-23 WO PCT/EP2016/072690 patent/WO2017050966A1/en not_active Ceased
-
2023
- 2023-02-24 AU AU2023201135A patent/AU2023201135A1/en not_active Abandoned
- 2023-09-06 US US18/462,035 patent/US20240109951A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018528237A5 (enExample) | ||
| Cossart et al. | Interactions of Listeria monocytogenes with mammalian cells during entry and actin‐based movement: bacterial factors, cellular ligands and signaling | |
| MX2018010824A (es) | Proteinas de union inducibles y metodos de uso. | |
| RU2020113032A (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака | |
| IL309801A (en) | Use of protein domains interacting with the nucleosome to enhance targeted genome modification | |
| JP2017018125A5 (enExample) | ||
| MX2018009225A (es) | Inmunoterapia basada en vectores de distribución personalizados y usos de la misma. | |
| IL259120A (en) | Her2-targeted antigen chimeric receptors2 | |
| WO2018191502A3 (en) | Anti-cd137 antibodies and methods of use thereof | |
| MX2025000172A (es) | Polipeptidos que contienen dominios d y sus usos | |
| JP2013507907A5 (enExample) | ||
| JP2017538401A5 (enExample) | ||
| JP2016501829A5 (enExample) | ||
| JP2010506826A5 (enExample) | ||
| CN103160530B (zh) | 一种融合基因及其应用 | |
| WO2020047467A3 (en) | Cardiac cell reprogramming with myocardin and ascl1 | |
| JP2017514522A5 (enExample) | ||
| EP3939606A3 (en) | Improved methods and compounds for eliminating immune responses to therapeutic agents | |
| HRP20192262T1 (hr) | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) | |
| RU2017127024A (ru) | Герпесвирус с измененным спектром мишеней, содержащий гибридный гликопротеин н | |
| JP2019530441A5 (enExample) | ||
| JP2015511599A5 (enExample) | ||
| WO2016130628A8 (en) | Griffithsin mutants | |
| EP4353256A3 (en) | Induction of cross-reactive cellular response against rhinovirus antigens | |
| WO2013052814A3 (en) | E1 enzyme mutants and uses thereof |