ME02692B - NOVA IMUNOTERAPIJA PROTIV NEKOLIKO TUMORA UKLJUČUJUĆI GASTROINTESTINALNI KARCINOM l KARCINOM ŽELUCA - Google Patents

NOVA IMUNOTERAPIJA PROTIV NEKOLIKO TUMORA UKLJUČUJUĆI GASTROINTESTINALNI KARCINOM l KARCINOM ŽELUCA

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Publication number
ME02692B
ME02692B MEP-2017-87A MEP8717A ME02692B ME 02692 B ME02692 B ME 02692B ME P8717 A MEP8717 A ME P8717A ME 02692 B ME02692 B ME 02692B
Authority
ME
Montenegro
Prior art keywords
peptide
seq
nucleic acid
sfnplwlrl
sfnplwlrf
Prior art date
Application number
MEP-2017-87A
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German (de)
English (en)
French (fr)
Inventor
Toni Weinschenk
Jens Fritsche
Steffen Walter
Peter Lewandrowski
Harpreet Singh
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of ME02692B publication Critical patent/ME02692B/me

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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Claims (15)

1. Peptid koji ima celokupnu dužinu od između lO i 14 aminokiselina koji sadrži sekvencu izabranu iz grupea) sekvenca koja sadrži ID BR. SEKV 2 i b) varijanta ID BR. SEKV 2 koja indukuje unakrsnu reakciju T ćelija sa navedenim peptidom, naznačeno time što je navedena varijanta izabrana iz grupe sekvenci SFNPLWLRI, SFNPLWLRL, SFNPLWLRF, SFNPLWLRL i SFNPLWLRF za upotrebu u medicini.
2.Peptid za upotrebu u skladu sa patentnim zahtevom l, koji ima sposobnost da se vezuje za molekul humanog glavnog kompleksa gena tkivne podudarnosti (MHC) klase I.
3.Peptid za upotrebu u skladu sa patentnim zahtevom l ili 2, naznačeno time što peptid sadrži nepeptidne veze.
4.Fuzioni protein koji obuhvata peptidnu sekvencu kao deo izabran iz grupe a) sekvence koja se sastoji od ID BR. SEKV 2 i b) varijante ID BR. SEKV 2 izabrane iz grupe sekvenci SFNPLWLRI, SFNPLWLRL, SFNPLWLRF, SFNPLWLRL i SFNPLWLRF, koje konkretno sadrže N-terminalne aminokiseline HLA-DR antigen-asociranog nepromenljivog lanca (Ii).
5.Nukleinska kiselina, koja kodira peptid za upotrebu u skladu sa bilo kojim od patentnih zahteva od l do 4, pod uslovom da peptid nije kompletan humani protein, naznačeno time što je navedena nukleinska kiselina poželjno DNK, cDNK, PNK, RNK ili njihova kombinacija, ili vektor ekspresije koji eksprimira navedenu nukelinsku kiselinu.
6.Nukleinska kiselina ili vektor ekspresije u skladu sa patentnim zahtevom 5 za upotrebu u medicini.
7.Ćelija domaćin, koja sadrži nukleinsku kiselinu ili vektor ekspresije u skladu sa patentnim zahtevom 5, koja je antigen-prezentujuća ćelija. • - 134-
8.Metod za proizvodnju peptida za upotrebu u skladu sa bilo kojim od patentnih zahteva od l do 4, pri čemu metod obuhvata kultiviranje ćelije domaćina u skladu sa patentnim zahtevom 7, kao i izolaciju peptida iz ćelije domaćina ili medijuma za njeno kultiviranje.
9.In vitro metod za proizvodnju aktiviranih citotoksičnih T limfocita (CTL), metod koji se sastoji od dovođenja u kontakt in vitro CTL sa humanim MHC molekulima klase I sa ubačenim antigenom eksprimiranim na površini prikladne antigen-prezentujuće ćelije u toku vremenskog perioda koji je dovoljan da se navedeni CTL aktiviraju na antigen specifičan način, naznačeno time što je navedeni antigen peptid u skladu sa patentnim zahtevom l ili 2.
10. Metod u skladu sa patentnim zahtevom 9, naznačeno time što navedena antigen prezentujuća ćelija sadrži vektor ekspresije koji eksprimira navedeni peptid u skladu sa patentnim zahtevom l ili 2.
11. Aktivirani citotoksični T limfocit (CTL), proizveden metodom u skladu sa patentnim zahtevom 9 ili 10, koji selektivno prepoznaje peptid u skladu sa patentnim zahtevom l ili
12.Citotoksični T limfocit (CTL) u skladu sa patentnim zahtevom ll za upotrebu u lečenju malignog tumora, koji ubija ciljne ćelije kod pacijenta, naznačeno time što navedene ciljne ćelije aberantno prezentuju peptid u skladu sa ID BR. SEKV 2.
13.Peptid u skladu sa patentnim zahtevom l ili 2, nukleinska kiselina ili vektor ekspresije u skladu sa patentnim zahtevom 5, ćelija u skladu sa patentnim zahtevom 7, ili aktivirani citotoksični T limfocit u skladu sa patentnim zahtevom 12 za primenu u lečenju raka, kao što su, na primer, karcinom želuca, gastrointestinalni, kolorektalni, karcinom pankreasa, pluća ili bubrega.
14.Peptid, nukleinska kiselina ili vektor ekspresije, ćelija ili aktivirani citotoksični T limfocit za upotrebu u skladu sa patentnim zahtevom 13, naznačeno time što je navedeni Jek vakcina.
15. Neterapijska upotreba peptida koji ima celokupnu dužinu od između 10 14 aminokiselina, koje obuhvataju sekvencu izabranu iz grupe a) sekvence koja sadrži ID BR. SEKV 2 i b) varijante ID BR. SEKV 2 izabrane iz grupe sekvenci SFNPLWLRI, SFNPLWLRL, ' SFNPLWLRF, SFNPLWLRL i SFNPLWLRF za stvaranje i razvoj antitela koja su specifična protiv kompleksa MHC/peptid koji sadrži navedeni peptid.
MEP-2017-87A 2010-03-19 2011-03-15 NOVA IMUNOTERAPIJA PROTIV NEKOLIKO TUMORA UKLJUČUJUĆI GASTROINTESTINALNI KARCINOM l KARCINOM ŽELUCA ME02692B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31570410P 2010-03-19 2010-03-19
GBGB1004551.6A GB201004551D0 (en) 2010-03-19 2010-03-19 NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
EP14184348.2A EP2845604B1 (en) 2010-03-19 2011-03-15 Novel immunotherapy against several tumors including gastrointestinal and gastric cancer

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ME02692B true ME02692B (me) 2017-10-20

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MEP-2015-122A ME02229B (me) 2010-03-19 2011-03-15 NOVA IMUNOTERAPIJA PROTIV NEKOLIKO TUMORA UKLJUČUJUĆI GASTROINTESTINALNI KARCINOM l KARCINOM ŽELUCA
MEP-2019-287A ME03569B (me) 2010-03-19 2011-03-15 Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni karcinom i karcinom želuca
MEP-2017-87A ME02692B (me) 2010-03-19 2011-03-15 NOVA IMUNOTERAPIJA PROTIV NEKOLIKO TUMORA UKLJUČUJUĆI GASTROINTESTINALNI KARCINOM l KARCINOM ŽELUCA

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MEP-2015-122A ME02229B (me) 2010-03-19 2011-03-15 NOVA IMUNOTERAPIJA PROTIV NEKOLIKO TUMORA UKLJUČUJUĆI GASTROINTESTINALNI KARCINOM l KARCINOM ŽELUCA
MEP-2019-287A ME03569B (me) 2010-03-19 2011-03-15 Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni karcinom i karcinom želuca

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US (25) US10064913B2 (me)
EP (9) EP3363456B1 (me)
JP (10) JP5891181B2 (me)
KR (13) KR20230141886A (me)
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GB201004575D0 (en) 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
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