HRP20211852T1 - Nova imunoterapija protiv nekoliko tumora, poput raka pluća, uključujući nsclc - Google Patents
Nova imunoterapija protiv nekoliko tumora, poput raka pluća, uključujući nsclc Download PDFInfo
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- HRP20211852T1 HRP20211852T1 HRP20211852TT HRP20211852T HRP20211852T1 HR P20211852 T1 HRP20211852 T1 HR P20211852T1 HR P20211852T T HRP20211852T T HR P20211852TT HR P20211852 T HRP20211852 T HR P20211852T HR P20211852 T1 HRP20211852 T1 HR P20211852T1
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- 206010028980 Neoplasm Diseases 0.000 title claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 201000005202 lung cancer Diseases 0.000 title 1
- 208000020816 lung neoplasm Diseases 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 108091008874 T cell receptors Proteins 0.000 claims 7
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 3
- 102000043129 MHC class I family Human genes 0.000 claims 2
- 108091054437 MHC class I family Proteins 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24065—Macrophage elastase (3.4.24.65), i.e. metalloelastase
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Claims (14)
1. Peptid, a) koji se sastoji od aminokiselinske sekvence odabrane iz skupine koju čine SEQ ID br. 2 ili b) koja se sastoji od aminokiselinske sekvence koja sadrži aminokiselinsku sekvencu prema SEQ ID br. 2 i ima ukupnu duljinu do do 14 aminokiselina ili farmaceutski prihvatljive soli a) ili b).
2. Peptid u skladu s patentnim zahtjevom 1, pri čemu navedeni peptid uključuje nepeptidne veze.
3. Peptid prema zahtjevu 1 ili 2, pri čemu je navedeni peptid dio fuzijskog proteina, koji sadrži N-terminalne aminokiseline HLA-DR invarijantnog lanca vezanog za antigene (Ii) ili je vezan za antitijelo.
4. Nukleinska kiselina, koja kodira peptid u skladu s bilo kojim od patentnih zahtjeva 1 do 3, koji je DNA, cDNA, PNA, RNA ili kombinacija istih, ili ekspresivni vektor koji eksprimira navedenu nukleinsku kiselinu.
5. Peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, nukleinska kiselina ili vektor ekspresije u skladu s patentnim zahtjevom 4 za upotrebu u medicini.
6. Stanica domaćin koja sadrži nukleinske kiseline ili ekspresivni vektor prema zahtjevu 4.
7. Protutijelo ili njegov fragment, ili receptor T-stanica (TCR) ili topljivi receptor T-stanica (sTCR) ili njegov fragment, pri čemu se navedeno antitijelo ili njegov fragment ili TCR, sTCR ili njegov fragment vežu specifično na peptid prema zahtjevu 1 sadržana u kompleksu s molekulom MHC.
8. Farmaceutski pripravak, koji sadrži peptid prema bilo kojem od zahtjeva 1 do 3 ili njegovu farmaceutski prihvatljivu sol, nukleinsku kiselinu ili ekspresijski vektor prema zahtjevu 4, ili izolirano vezivno sredstvo prema zahtjevu 7, i najmanje jednu drugu komponentu odabrani iz skupine farmaceutski prihvatljivih, poželjno vodenih, nosača i/ili pomoćnih tvari.
9. In vitro metoda za proizvodnju aktiviranog citotoksičnog T-limfocita (CTL) ili T-pomoćne stanice (Th stanice), metoda je koja obuhvaća kontaktiranje in vitro CTL-a ili Th stanice humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen u vremenskom razdoblju dovoljnom da se aktivira navedeni CTL na način svojstven antigenu, pri čemu je navedeni antigen peptid u skladu s bilo kojim patentnim zahtjevom od 1 do 3.
10. Postupak u skladu s patentnim zahtjevom 9, naznačen time što se spomenuti antigen učitava na molekule MHC klase I izražene na površini odgovarajuće stanice koja predstavlja antigen dovodeći u vezu dovoljnu količinu navedenog antigena s navedenom stanicom koja predstavlja antigen.
11. Aktivirani citotoksični T-limfocit (CTL) ili pomoćna stanica (Th stanica), proizveden metodom u skladu s patentnim zahtjevom 9 ili 10, pri čemu navedena CTL ili Th selektivno prepoznaje stanicu koja eksprimira polipeptid koji se sastoji od sekvence aminokiselina navedene u patentnom zahtjevu 1 ili 2.
12. Autologna ili alogenska humana citotoksična T stanica (CTL) ili T pomoćna stanica (Th stanica), rekombinantno transficirana receptorom T-stanica prema zahtjevu 7.
13. Peptid prema bilo kojem od zahtjeva 1 do 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 4, stanica prema zahtjevu 6, aktivirani T-limfocit prema zahtjevu 11 ili antitijelo ili TCR ili sTCR prema zahtjevu 7 za upotrebu kao lijek koji je aktivan protiv karcinoma.
14. Peptid prema bilo kojem od zahtjeva 1 do 3, nukleinska kiselina ili ekspresivni vektor prema zahtjevu 4, stanica prema zahtjevu 6, aktivirani citotoksični T-limfocit prema zahtjevu 11, ili antitijelo ili TCR ili sTCR prema zahtjevu 7, za uporabu prema zahtjevu 13, u kojem je lijek naveden kao cjepivo.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361862213P | 2013-08-05 | 2013-08-05 | |
| GBGB1313987.8A GB201313987D0 (en) | 2013-08-05 | 2013-08-05 | Novel immunotherapy against several tumors, such as lung cancer including NSCLC |
| GBGB1403297.3A GB201403297D0 (en) | 2014-02-25 | 2014-02-25 | Novel immunotherapy against several tumors, such as lung cancer, including NSCLC |
| EP18201334.2A EP3456339B1 (en) | 2013-08-05 | 2014-08-04 | Novel immunotherapy against several tumors, such as lung cancer including nsclc |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211852T1 true HRP20211852T1 (hr) | 2022-03-18 |
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ID=60955422
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211852TT HRP20211852T1 (hr) | 2013-08-05 | 2014-08-04 | Nova imunoterapija protiv nekoliko tumora, poput raka pluća, uključujući nsclc |
| HRP20192262TT HRP20192262T1 (hr) | 2013-08-05 | 2019-12-17 | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192262TT HRP20192262T1 (hr) | 2013-08-05 | 2019-12-17 | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) |
Country Status (19)
| Country | Link |
|---|---|
| US (17) | US20170320913A1 (hr) |
| JP (4) | JP6646017B2 (hr) |
| KR (2) | KR20220045085A (hr) |
| CN (3) | CN110041402B (hr) |
| AU (1) | AU2022201167A1 (hr) |
| CL (6) | CL2018002279A1 (hr) |
| CY (2) | CY1122453T1 (hr) |
| ES (1) | ES2900004T3 (hr) |
| HR (2) | HRP20211852T1 (hr) |
| HU (1) | HUE057334T2 (hr) |
| IL (5) | IL300761A (hr) |
| LT (1) | LT3456339T (hr) |
| MX (3) | MX2021001914A (hr) |
| MY (1) | MY191939A (hr) |
| PH (3) | PH12018501901A1 (hr) |
| PL (1) | PL3456339T3 (hr) |
| PT (1) | PT3456339T (hr) |
| RS (1) | RS62602B1 (hr) |
| SI (1) | SI3456339T1 (hr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| RS62602B1 (sr) | 2013-08-05 | 2021-12-31 | Immatics Biotechnologies Gmbh | Nova imunoterapija za lečenje nekoliko tumora, kao što je rak pluća, uključujući nsclc |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| SG11202003907WA (en) | 2017-12-14 | 2020-05-28 | Flodesign Sonics Inc | Acoustic transducer drive and controller |
| CN112521484A (zh) * | 2020-12-03 | 2021-03-19 | 佛山市第一人民医院（中山大学附属佛山医院） | 结肠癌肿瘤特异tcr序列及其应用 |
| CN112691195B (zh) * | 2021-02-02 | 2023-03-14 | 黑龙江省科学院高技术研究院 | Prpf8表达抑制剂在制备治疗肺癌的药物中的应用 |
| CN113881707B (zh) * | 2021-10-25 | 2023-07-14 | 中国人民解放军军事科学院军事医学研究院 | 调控脐带间充质干细胞免疫抑制作用的产品、方法及用途 |
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