SG11202003907WA - Acoustic transducer drive and controller - Google Patents

Acoustic transducer drive and controller

Info

Publication number
SG11202003907WA
SG11202003907WA SG11202003907WA SG11202003907WA SG11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA SG 11202003907W A SG11202003907W A SG 11202003907WA
Authority
SG
Singapore
Prior art keywords
controller
acoustic transducer
transducer drive
drive
acoustic
Prior art date
Application number
SG11202003907WA
Inventor
Bart Lipkens
Ronald Musiak
John Artis
Original Assignee
Flodesign Sonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flodesign Sonics Inc filed Critical Flodesign Sonics Inc
Publication of SG11202003907WA publication Critical patent/SG11202003907WA/en

Links

Classifications

    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R3/00Circuits for transducers, loudspeakers or microphones
    • H04R3/04Circuits for transducers, loudspeakers or microphones for correcting frequency response
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D21/00Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283Settling tanks provided with vibrators
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D17/00Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02Separation of non-miscible liquids
    • B01D17/04Breaking emulsions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D21/00Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D21/00Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30Control equipment
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/0207Driving circuits
    • B06B1/0223Driving circuits for generating signals continuous in time
    • B06B1/0238Driving circuits for generating signals continuous in time of a single frequency, e.g. a sine-wave
    • B06B1/0246Driving circuits for generating signals continuous in time of a single frequency, e.g. a sine-wave with a feedback signal
    • B06B1/0261Driving circuits for generating signals continuous in time of a single frequency, e.g. a sine-wave with a feedback signal taken from a transducer or electrode connected to the driving transducer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/06Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
    • B06B1/0644Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R1/00Details of transducers, loudspeakers or microphones
    • H04R1/20Arrangements for obtaining desired frequency or directional characteristics
    • H04R1/22Arrangements for obtaining desired frequency or directional characteristics for obtaining desired frequency characteristic only 
    • H04R1/24Structural combinations of separate transducers or of two parts of the same transducer and responsive respectively to two or more frequency ranges
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R1/00Details of transducers, loudspeakers or microphones
    • H04R1/20Arrangements for obtaining desired frequency or directional characteristics
    • H04R1/22Arrangements for obtaining desired frequency or directional characteristics for obtaining desired frequency characteristic only 
    • H04R1/28Transducer mountings or enclosures modified by provision of mechanical or acoustic impedances, e.g. resonator, damping means
    • H04R1/2807Enclosures comprising vibrating or resonating arrangements
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R17/00Piezoelectric transducers; Electrostrictive transducers
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R9/00Transducers of moving-coil, moving-strip, or moving-wire type
    • H04R9/06Loudspeakers
    • H04R9/063Loudspeakers using a plurality of acoustic drivers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B2201/00Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
    • B06B2201/70Specific application
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R2201/00Details of transducers, loudspeakers or microphones covered by H04R1/00 but not provided for in any of its subgroups
    • H04R2201/003Mems transducers or their use
SG11202003907WA 2017-12-14 2018-12-14 Acoustic transducer drive and controller SG11202003907WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762599017P 2017-12-14 2017-12-14
US201862614354P 2018-01-05 2018-01-05
PCT/US2018/065839 WO2019118921A1 (en) 2017-12-14 2018-12-14 Acoustic transducer drive and controller

Publications (1)

Publication Number Publication Date
SG11202003907WA true SG11202003907WA (en) 2020-05-28

Family

ID=66816603

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003907WA SG11202003907WA (en) 2017-12-14 2018-12-14 Acoustic transducer drive and controller

Country Status (11)

Country Link
US (2) US10785574B2 (en)
EP (1) EP3725092A4 (en)
JP (1) JP2021507561A (en)
KR (2) KR102439221B1 (en)
CN (2) CN114900773A (en)
AU (1) AU2018385759B2 (en)
BR (1) BR112020009889A2 (en)
CA (1) CA3085784A1 (en)
IL (1) IL274333A (en)
SG (1) SG11202003907WA (en)
WO (1) WO2019118921A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
EP3501619B1 (en) * 2017-12-20 2023-10-18 Nokia Technologies Oy Apparatus for collecting particles within a fluid
CN115917655A (en) * 2020-06-17 2023-04-04 美商亚威科技有限责任公司 Use of ultrasound to destroy airborne pathogens and microorganisms on cereals and dried food
CN114515184B (en) * 2020-11-20 2024-03-15 深圳开立生物医疗科技股份有限公司 Ultrasonic knife system, power driving method and device thereof and host

Family Cites Families (837)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1017524A (en) 1911-05-01 1912-02-13 Robert George Ferguson Flush-tank.
US1016731A (en) 1911-10-11 1912-02-06 Stephen Bennis Tender-scoop.
US2473971A (en) 1944-02-25 1949-06-21 Donald E Ross Underwater transducer
US2667944A (en) 1949-12-10 1954-02-02 Combustion Eng Cyclone separator
US3372370A (en) 1965-09-22 1968-03-05 Aquasonics Engineering Company Electroacoustic transducer
US3555311A (en) 1969-01-23 1971-01-12 Marquardt Corp High pressure piezoelectric transducer
US3948489A (en) 1972-10-30 1976-04-06 Sawyer Harold T In-line mixer for fluids
US4158629A (en) 1974-08-12 1979-06-19 Vernon D. Beehler Dynamic self-cleaning filter for liquids
US4048454A (en) 1974-12-02 1977-09-13 Barcus Lester M Sonic transducer employing rigid radiating member
US4204096A (en) 1974-12-02 1980-05-20 Barcus Lester M Sonic transducer mounting
US4055491A (en) 1976-06-02 1977-10-25 Porath Furedi Asher Apparatus and method for removing fine particles from a liquid medium by ultrasonic waves
SU629496A1 (en) 1976-08-01 1978-10-25 Институт Радиофизики И Электроники Ан Украинской Сср Acousto-electric ultrasound transducer
US4065875A (en) 1976-09-17 1978-01-03 University Of Delaware Selective destruction of certain algae
JPS6034433B2 (en) 1977-03-07 1985-08-08 株式会社豊田中央研究所 ultrasonic transducer
US4118649A (en) 1977-05-25 1978-10-03 Rca Corporation Transducer assembly for megasonic cleaning
US4125789A (en) 1977-06-07 1978-11-14 Sundstrand Corporation Biasing and scaling circuit for transducers
US4165273A (en) 1977-12-20 1979-08-21 Azarov Nikolai N Device for producing deeply desalted water
US4320659A (en) 1978-02-27 1982-03-23 Panametrics, Inc. Ultrasonic system for measuring fluid impedance or liquid level
AU529113B2 (en) 1978-04-19 1983-05-26 Commonwealth Of Australia, The Ultrasonic transducer array
US4211949A (en) 1978-11-08 1980-07-08 General Electric Company Wear plate for piezoelectric ultrasonic transducer arrays
CA1141629A (en) 1979-07-31 1983-02-22 Roger F. Potts Machine for cleaning plastic containers
US4264003A (en) 1979-09-12 1981-04-28 Fruehauf Corporation Foldable unloading machine having full circle swivelling action
FR2485858B1 (en) 1980-06-25 1986-04-11 Commissariat Energie Atomique METHOD FOR MANUFACTURING ULTRASONIC TRANSDUCERS OF COMPLEX SHAPES AND APPLICATION TO OBTAINING ANNULAR TRANSDUCERS
DE3027433A1 (en) 1980-07-19 1982-02-18 Messerschmitt-Bölkow-Blohm GmbH, 8000 München Pressure diffusion sepn. method for mixts. - uses perpendicular identical frequency wave fields with differing phases
US5834871A (en) 1996-08-05 1998-11-10 Puskas; William L. Apparatus and methods for cleaning and/or processing delicate parts
DE3218488A1 (en) 1982-05-15 1983-11-17 Battelle-Institut E.V., 6000 Frankfurt Process and apparatus for sorting particles according to different density ranges
US4552669A (en) 1983-04-18 1985-11-12 Mott Metallurgical Corporation Pneumatic hydro-pulse filter system and method of operation
US4484907A (en) 1983-10-20 1984-11-27 E. I. Du Pont De Nemours And Company Microtube adapter having a holding and uncapping apparatus
JPH0679682B2 (en) 1983-10-31 1994-10-12 ブリティッシュ・テクノロジー・グループ・リミテッド Method and apparatus for separating particulate matter in a liquid medium
GB8417240D0 (en) 1984-07-06 1984-08-08 Unilever Plc Particle separation
EP0278108B1 (en) 1984-07-18 1989-08-16 Schenck Auto-Service-Geräte GmbH Process and device for arresting a turning object
CN85100483B (en) 1985-04-01 1988-10-19 上海灯泡厂 Material for utrasonic transducer
US4666595A (en) 1985-09-16 1987-05-19 Coulter Electronics, Inc. Apparatus for acoustically removing particles from a magnetic separation matrix
US4983189A (en) 1986-02-21 1991-01-08 Technical Research Associates, Inc. Methods and apparatus for moving and separating materials exhibiting different physical properties
US4759775A (en) 1986-02-21 1988-07-26 Utah Bioresearch, Inc. Methods and apparatus for moving and separating materials exhibiting different physical properties
US4699588A (en) 1986-03-06 1987-10-13 Sonotech, Inc. Method and apparatus for conducting a process in a pulsating environment
GB8612759D0 (en) 1986-05-27 1986-07-02 Unilever Plc Manipulating particulate matter
US4823042A (en) * 1986-07-18 1989-04-18 Rich-Mar Corporation Sonic transducer and method for making the same
BE905707A (en) 1986-11-06 1987-03-02 Poppe Willy QUILT.
AT389235B (en) 1987-05-19 1989-11-10 Stuckart Wolfgang METHOD FOR CLEANING LIQUIDS BY MEANS OF ULTRASOUND AND DEVICES FOR CARRYING OUT THIS METHOD
US4821838A (en) 1987-10-30 1989-04-18 Hewlett-Packard Company Acoustic damper
JPH01134216A (en) 1987-11-19 1989-05-26 Agency Of Ind Science & Technol Visualizing method for three-dimensional standing wave sound field
US4860993A (en) 1988-01-14 1989-08-29 Teledyne Industries, Inc. Valve design to reduce cavitation and noise
US4836684A (en) 1988-02-18 1989-06-06 Ultrasonic Power Corporation Ultrasonic cleaning apparatus with phase diversifier
WO1989011899A1 (en) 1988-06-08 1989-12-14 Invitron Corporation Tandem hollow fiber cell culture product harvest system
AT390739B (en) 1988-11-03 1990-06-25 Ewald Dipl Ing Dr Benes METHOD AND DEVICE FOR SEPARATING PARTICLES DISPERSED IN A DISPERSION AGENT
FR2638659B1 (en) 1988-11-07 1992-06-12 Framatome Sa FILTRATION APPARATUS COMPRISING AN ULTRASONIC DECOLMATION DEVICE AND CORRESPONDING DECOLMATION METHOD
JPH02290266A (en) 1989-04-28 1990-11-30 Mitsubishi Heavy Ind Ltd Ultrasonic type crude oil dehydrating and desalting apparatus
GB9005705D0 (en) 1990-03-14 1990-05-09 Health Lab Service Board Particle manipulation
US5085783A (en) 1990-08-16 1992-02-04 Case Western Reserve University Acoustically driven particle separation method and apparatus
US5059811A (en) 1990-08-30 1991-10-22 Great Lakes Instruments, Inc. Turbidimeter having a baffle assembly for removing entrained gas
RU2085933C1 (en) 1991-08-14 1997-07-27 Кирпиченко Борис Иванович Device for ultrasonic inspection of solution density
RU2037327C1 (en) 1991-12-09 1995-06-19 Александр Александрович Ковалев Ultrasonic filter
GB2265004B (en) 1992-03-10 1996-01-10 Univ Cardiff Immuno-agglutination assay using ultrasonic standing wave field
WO1993019873A2 (en) 1992-04-06 1993-10-14 Mountford Norman D G Ultrasonic treatment of liquids in particular metal melts
US6216538B1 (en) 1992-12-02 2001-04-17 Hitachi, Ltd. Particle handling apparatus for handling particles in fluid by acoustic radiation pressure
AT398707B (en) 1993-05-11 1995-01-25 Trampler Felix MULTILAYER PIEZOELECTRIC RESONATOR FOR THE SEPARATION OF SUSPENDED PARTICLES
AU684284B2 (en) 1993-05-11 1997-12-11 Sonosep Biotech, Inc. Multilayered piezoelectric resonator for the separation of suspended particles
US5626767A (en) 1993-07-02 1997-05-06 Sonosep Biotech Inc. Acoustic filter for separating and recycling suspended particles
US5443985A (en) 1993-07-22 1995-08-22 Alberta Research Council Cell culture bioreactor
AU688334B2 (en) 1993-09-07 1998-03-12 Siemens Medical Solutions Usa, Inc. Broadband phased array transducer design with frequency controlled two dimension capability and methods for manufacture thereof
US5415175A (en) 1993-09-07 1995-05-16 Acuson Corporation Broadband phased array transducer design with frequency controlled two dimension capability and methods for manufacture thereof
US5431817A (en) 1993-09-13 1995-07-11 W. R. Grace & Co.-Conn. Bleach resistant polysulfone/polyurethane composite membranes
US5371429A (en) 1993-09-28 1994-12-06 Misonix, Inc. Electromechanical transducer device
US5395592A (en) 1993-10-04 1995-03-07 Bolleman; Brent Acoustic liquid processing device
US5452267A (en) 1994-01-27 1995-09-19 Magnetrol International, Inc. Midrange ultrasonic transducer
US5562823A (en) 1994-04-25 1996-10-08 Reeves; William Combination centrifugal and sonic device for separating components within a solution
EP0764265A4 (en) 1994-06-07 1998-05-20 Univ Boston Acoustic detection of particles
US5560362A (en) 1994-06-13 1996-10-01 Acuson Corporation Active thermal control of ultrasound transducers
US5475486A (en) 1994-10-21 1995-12-12 Hach Company Flow cell system for turbidimeter
JP3487699B2 (en) 1995-11-08 2004-01-19 株式会社日立製作所 Ultrasonic treatment method and apparatus
JP3875736B2 (en) 1995-11-14 2007-01-31 株式会社協和エクシオ Wastewater treatment method and apparatus
JP2700058B2 (en) 1996-01-23 1998-01-19 工業技術院長 Non-contact micromanipulation method using ultrasonic waves
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
US5688405A (en) 1996-02-28 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for separating particulate matter from a fluid
WO1997034643A1 (en) 1996-03-19 1997-09-25 Ozone Sterilization Products, Inc. Ozone sterilizer and generator
NL1003595C2 (en) 1996-04-10 1997-10-14 Tno Method and device for characterizing suspensions.
MX9604952A (en) 1996-10-18 1998-04-30 Servicios Condumex Sa Solid particles hydraulic classifier and reactor with ultrasound application.
GB9621832D0 (en) 1996-10-19 1996-12-11 Univ Cardiff Removing partiles from suspension
DE19648519C2 (en) 1996-11-23 2000-11-16 Preussag Wassertechnik Gmbh Process and system for material separation by means of membrane filtration
GB9708984D0 (en) 1997-05-03 1997-06-25 Univ Cardiff Particle manipulation
US5951456A (en) 1997-05-16 1999-09-14 Scott; Harold W. Ultrasonic methods and apparatus for separating materials in a fluid mixture
DE69810999T2 (en) 1997-06-17 2003-08-28 Konishiroku Photo Ind Method and apparatus for removing bubbles from a liquid using ultrasound
JPH1190110A (en) 1997-09-16 1999-04-06 Konica Corp Ultrasonic deforming method, manufacture of photosensitive material and ultrasonic deforming device
US6029518A (en) 1997-09-17 2000-02-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Manipulation of liquids using phased array generation of acoustic radiation pressure
US6280388B1 (en) 1997-11-19 2001-08-28 Boston Scientific Technology, Inc. Aerogel backed ultrasound transducer
US6326213B1 (en) 1998-02-09 2001-12-04 The Boards Of Govenors For Higher Education, State Of Rhode Island And Providence Plantations Acoustic standing-wave enhancement of a fiber-optic Salmonella biosensor
DE19815882A1 (en) 1998-04-08 1999-10-14 Fuhr Guenther Method and device for manipulating microparticles in fluid flows
DE19820466C2 (en) 1998-05-07 2002-06-13 Fraunhofer Ges Forschung Device and method for the targeted exposure of a biological sample to sound waves
JP2000024431A (en) 1998-07-14 2000-01-25 Hitachi Ltd Fine particle treating device
US6090295A (en) 1998-08-11 2000-07-18 University Technology Corporation Method and apparatus for acoustically demixing aqueous solutions
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
CA2316160A1 (en) 1998-11-20 2000-06-02 Proudo Co., Ltd. Liquid treating process and apparatus, as well as liquid treating system
US6166231A (en) 1998-12-15 2000-12-26 Martek Biosciences Corporation Two phase extraction of oil from biomass
WO2000041794A1 (en) 1999-01-15 2000-07-20 University College Cardiff Consultants Ltd. Particle manipulation
CN1181337C (en) 2000-08-08 2004-12-22 清华大学 Solid molecule operating method in microfluid system
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6314974B1 (en) 1999-06-28 2001-11-13 Fairchild Semiconductor Corporation Potted transducer array with matching network in a multiple pass configuration
GB9916851D0 (en) 1999-07-20 1999-09-22 Univ Wales Bangor Manipulation of particles in liquid media
JP4020559B2 (en) * 2000-02-04 2007-12-12 オリンパス株式会社 Ultrasonic transducer drive
AUPQ629100A0 (en) 2000-03-16 2000-04-15 Btf Pty Ltd Process for preparing controlled samples of particles such as microorganisms and cells
US6599288B2 (en) 2000-05-16 2003-07-29 Atrionix, Inc. Apparatus and method incorporating an ultrasound transducer onto a delivery member
US6395186B1 (en) 2000-06-20 2002-05-28 Delaware Capital Formation, Inc. Pressure liquid filtration with ultrasonic bridging prevention
US7319763B2 (en) * 2001-07-11 2008-01-15 American Technology Corporation Power amplification for parametric loudspeakers
EP1175931A1 (en) 2000-07-25 2002-01-30 Computer Cell Culture Center S.A. Integration of high cell density bioreactor operation with ultra fast on-line downstream processing
WO2002018275A1 (en) 2000-08-28 2002-03-07 Ocean Power Corporation Method for pretreating water for desalination
CN100495030C (en) 2000-09-30 2009-06-03 清华大学 Multi-force operator and use thereof
JP2004516468A (en) 2000-12-18 2004-06-03 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Ultrasonic size measurement method and apparatus for particles in suspension
SE522801C2 (en) 2001-03-09 2004-03-09 Erysave Ab Apparatus for separating suspended particles from an ultrasonic fluid and method for such separation
SE0103013D0 (en) 2001-03-09 2001-09-12 Erysave Ab Ideon System and method of treatment of whole blood
SE0100820D0 (en) 2001-03-09 2001-03-09 Erysave Ab Ideon Particle separation using an acoustic filter
US6467350B1 (en) 2001-03-15 2002-10-22 The Regents Of The University Of California Cylindrical acoustic levitator/concentrator
US6770248B2 (en) 2001-05-04 2004-08-03 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government Flowthrough device for the ultrasonic destruction of microorganisms in fluids
US6763722B2 (en) 2001-07-13 2004-07-20 Transurgical, Inc. Ultrasonic transducers
US6551248B2 (en) 2001-07-31 2003-04-22 Koninklijke Philips Electronics N.V. System for attaching an acoustic element to an integrated circuit
US7431892B2 (en) 2001-09-25 2008-10-07 Piezo Top Ltd. Apparatus for sterilizing a liquid with focused acoustic standing waves
DE10148916A1 (en) 2001-10-04 2003-04-17 Beatrix Christa Meier Ultrasonic head assembly, to break down cells, comprises a piezo element to generate ultrasonic waves which are carried through intermediate elements to a sonotrode for direct delivery into the samples in a micro-titration plate
US6487095B1 (en) 2001-10-31 2002-11-26 International Business Machines Corporation Multiphase zero-volt-switching resonant DC-DC regulator
US7470545B2 (en) 2001-11-05 2008-12-30 Rohm And Haas Company Buccal dissolution of active substances
WO2003046546A1 (en) 2001-11-27 2003-06-05 Euroflow (Uk) Limited Detection systems and methods
US6649069B2 (en) 2002-01-23 2003-11-18 Bae Systems Information And Electronic Systems Integration Inc Active acoustic piping
US7061163B2 (en) 2002-01-28 2006-06-13 Matsushita Electric Industrial Co., Ltd. Ultrasonic transducer and ultrasonic flowmeter
EP1354941A1 (en) 2002-04-19 2003-10-22 Computer Cell Culture Center S.A. Apparatus and method for a cell culture in a bioreactor at high cell concentration
US6749666B2 (en) 2002-04-26 2004-06-15 Board Of Regents, The University Of Texas System Modulated acoustic aggiomeration system and method
KR100571803B1 (en) 2002-05-03 2006-04-17 삼성전자주식회사 Semiconductor carbon nano tube functionalized by hydrogen, electronic device and method of fabrication thereof
GB2408276B (en) 2002-06-03 2006-01-25 Shell Int Research Downhole desalination of aquifer water
WO2003102737A2 (en) 2002-06-04 2003-12-11 Protasis Corporation Method and device for ultrasonically manipulating particles within a fluid
US20040016699A1 (en) 2002-07-29 2004-01-29 Michael Bayevsky Systems and methods for ultrasonic cleaning of cross-flow membrane filters
US6938488B2 (en) 2002-08-21 2005-09-06 Battelle Memorial Institute Acoustic inspection device
GB0221391D0 (en) 2002-09-16 2002-10-23 Secr Defence Apparatus for directing particles in a fluid
US6881389B2 (en) 2002-09-24 2005-04-19 Edg, Inc. Removal of H2S and CO2 from a hydrocarbon fluid stream
GB0222421D0 (en) 2002-09-27 2002-11-06 Ratcliff Henry K Advanced ultrasonic processor
US7108137B2 (en) 2002-10-02 2006-09-19 Wisconsin Alumni Research Foundation Method and apparatus for separating particles by size
WO2004041413A2 (en) 2002-11-01 2004-05-21 Board Of Regents Acoustical stimulation of vapor diffusion system and method
US6878288B2 (en) 2002-12-17 2005-04-12 Harold W. Scott System and apparatus for removing dissolved and suspended solids from a fluid stream
US7191787B1 (en) 2003-02-03 2007-03-20 Lam Research Corporation Method and apparatus for semiconductor wafer cleaning using high-frequency acoustic energy with supercritical fluid
SE0300290D0 (en) 2003-02-05 2003-02-05 Siemens Elema Ab Acoustic meter assembly
EP1599865B1 (en) 2003-03-06 2008-11-19 Jürg Dual Method for positioning small particles in a fluid
US7008540B1 (en) 2003-04-07 2006-03-07 The Ohio State University Ultrasonically cleaned membrane filtration system
DE10319467B3 (en) 2003-04-29 2004-07-22 Miele & Cie. Kg Device for preventing foam or air bubbles in measuring zone of turbidity sensor for dishwasher or laundry machine with turbulence region incorporated in bypass line across main flow line
US6990852B2 (en) 2003-07-28 2006-01-31 Becton Dickinson & Company System and method for detecting particles
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
CN1245231C (en) 2003-08-27 2006-03-15 中国石油化工股份有限公司 Method and device for breaking oil water emulsion using combined action of forward current and countercurrent flow ultrasonic wave
US7541166B2 (en) 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
US7232016B2 (en) 2003-12-08 2007-06-19 General Motors Corporation Fluid damper having continuously variable damping response
WO2005058459A1 (en) * 2003-12-17 2005-06-30 Matsushita Electric Industrial Co., Ltd. Component separating device, method of producing the device, and method of separating component by using the device
US7445716B2 (en) 2004-01-05 2008-11-04 Eaton Lp Crossflow pressure liquid filtration with ultrasonic enhancement
US8012355B2 (en) 2004-01-30 2011-09-06 Pss Acquisitionco Llc Molecular separator
JP2005249267A (en) 2004-03-03 2005-09-15 Sanyo Electric Co Ltd Microwave oven
US7044737B2 (en) 2004-03-05 2006-05-16 Liang Fu Ultrasound oral hygiene and therapeutic device
JP2007534335A (en) 2004-04-27 2007-11-29 バクスター・インターナショナル・インコーポレイテッド Stirred tank reactor system
EP1766608B1 (en) 2004-06-07 2017-08-09 Koninklijke Philips N.V. Acoustic device with variable focal length
JP2005349267A (en) 2004-06-09 2005-12-22 Enomoto Bea Co Ltd Suspension separation apparatus and suspension separating method
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US20080272034A1 (en) 2004-08-16 2008-11-06 Searete Llc, Separation of particles from a fluid by wave action
AT413655B (en) 2004-08-19 2006-04-15 Felix Dipl Ing Dr Trampler DEVICE FOR DISPERSING DISPERSED PARTICLES
US7230882B2 (en) 2004-09-03 2007-06-12 Lowrance Electronics, Inc. Transducer support and associated lock
SE528313C2 (en) 2004-09-24 2006-10-17 Spectronic Ab Method and apparatus for separating particles using ultrasonic waves
GB2420510B (en) 2004-11-25 2010-10-06 Cyclotech Ltd Methods and apparatus for conditioning and degassing liquids and gases in suspension
BRPI0519737A2 (en) 2004-12-21 2009-01-27 Musc Found For Res Dev compositions and methods to promote wound healing and tissue regeneration
EP1844138A2 (en) 2004-12-29 2007-10-17 Biogen Idec MA Inc. Bioreactor process control system and method
FR2882939B1 (en) 2005-03-11 2007-06-08 Centre Nat Rech Scient FLUIDIC SEPARATION DEVICE
EA015584B1 (en) 2005-03-23 2011-10-31 Генмаб А/С Antibody to human cd38 and use thereof
US7704743B2 (en) 2005-03-30 2010-04-27 Georgia Tech Research Corporation Electrosonic cell manipulation device and method of use thereof
JP4770251B2 (en) 2005-04-25 2011-09-14 パナソニック株式会社 Component separation device and component separation method using the same
US20090226994A1 (en) 2005-07-07 2009-09-10 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Method and Device for Acoustic Manipulation of Particles, Cells and Viruses
US7757561B2 (en) 2005-08-01 2010-07-20 Covaris, Inc. Methods and systems for processing samples using acoustic energy
JP4572789B2 (en) * 2005-09-27 2010-11-04 パナソニック電工株式会社 Ultrasonic generator and ultrasonic beauty device
DE102005050167B4 (en) 2005-10-19 2009-02-19 Advalytix Ag Concentration method, concentration apparatus and reaction method
US7766121B2 (en) 2005-12-20 2010-08-03 Cyclotech Limited Methods and apparatus for conditioning and degassing liquids and gases in suspension
WO2007083295A2 (en) 2006-01-19 2007-07-26 Yeda Research And Development Co. Ltd. Device and method for particle manipulation in fluid
BRPI0708470A2 (en) 2006-03-14 2011-05-31 Merck & Co Inc process for the production of crystalline particles of an organic active compound, and, pharmaceutical composition
US20070224676A1 (en) 2006-03-21 2007-09-27 Becton, Dickinson And Company Expandable culture roller bottle
CN1843945A (en) 2006-05-16 2006-10-11 徐小宁 Seawater desalination treatment system utilizing jet-flow technology
US20070267351A1 (en) 2006-05-22 2007-11-22 Traceguard Technologies Inc. Low-frequency acoustic waves for collecting and/or moving particles inside articles
US20080011693A1 (en) 2006-07-12 2008-01-17 Ming Li Self-cleaning waste-water device and method
US8075786B2 (en) 2006-09-05 2011-12-13 The Board Of Regents Of The University Of Oklahoma Acoustic/pressure wave-driven separation device
US7763177B2 (en) 2006-10-26 2010-07-27 Atlantium Technologies Ltd. System and method for ultrasonic cleaning of ultraviolet disinfection system
JP4984849B2 (en) 2006-11-27 2012-07-25 パナソニック株式会社 Component separation device and chemical analysis device using the component separation device
US7673516B2 (en) 2006-12-28 2010-03-09 Kimberly-Clark Worldwide, Inc. Ultrasonic liquid treatment system
US20080181828A1 (en) 2007-01-25 2008-07-31 Kluck William P Ultrasound one-quarter wave separator integrates with sterile tubing kit - optical sensing / valves manage purity - lowers apheresis extra corporeal blood volume - replacement for centrifuge
WO2008106403A2 (en) 2007-02-26 2008-09-04 Trustees Of Princeton University Turnable acoustic gradient index of refraction lens and system
KR20090121297A (en) 2007-03-02 2009-11-25 스미쓰 앤드 네퓨 피엘씨 Apparatus and method for filter cleaning by ultrasound, backwashing and filter movement during the filtration of biological samples
DE102008006501B4 (en) 2007-03-19 2013-05-16 Sonja Lauterborn Combined ultrasonic air backwashing process for the chemical-free in-situ cleaning of submerged membranes during backwashing during operation
US8911460B2 (en) 2007-03-22 2014-12-16 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
EP2479552B1 (en) 2007-04-02 2015-09-02 Acoustic Cytometry Systems, Inc. Methods for enhanced analysis of acoustic field focused cells and particles
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
WO2008142850A1 (en) 2007-05-15 2008-11-27 Panasonic Corporation Component separation device and method of component separation therewith
US7889601B2 (en) 2007-06-19 2011-02-15 Lockheed Martin Corporation Lightweight acoustic array
DE102007030904A1 (en) 2007-07-03 2009-02-05 Pharis Biotec Gmbh Human circulating antiviral albumin fragment (ALB-408) and its use
US8882791B2 (en) 2007-07-27 2014-11-11 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US8808319B2 (en) 2007-07-27 2014-08-19 Ethicon Endo-Surgery, Inc. Surgical instruments
US8430898B2 (en) 2007-07-31 2013-04-30 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
WO2009023562A2 (en) 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
GB0716047D0 (en) 2007-08-16 2007-09-26 Welding Inst Acoustic transducer assembley
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
US8623027B2 (en) 2007-10-05 2014-01-07 Ethicon Endo-Surgery, Inc. Ergonomic surgical instruments
JP5119848B2 (en) 2007-10-12 2013-01-16 富士ゼロックス株式会社 Microreactor device
US8528406B2 (en) 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US20100255573A1 (en) 2007-11-14 2010-10-07 Damian Joseph Peter Bond Extraction and purification of biologigal cells using ultrasound
US8096177B2 (en) 2007-11-19 2012-01-17 Petroleum Recovery Services Llc Fuel inventory monitoring system
ES2326109B1 (en) 2007-12-05 2010-06-25 Consejo Superior De Investigaciones Cientificas SELECTIVE AND NON INVASIVE SEPARATION AND EXTRACTION MICRODISPOSITIVE OF PARTICLES IN POLIDISPERSE SUSPENSIONS, MANUFACTURING PROCEDURE AND ITS APPLICATIONS.
US8030290B2 (en) 2007-12-07 2011-10-04 City Of Hope Cell-type specific aptamer-siRNA delivery system for HIV-1 Therapy
US8266950B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8714014B2 (en) 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US9480935B2 (en) 2008-02-01 2016-11-01 Lawrence Livermore National Security, Llc Systems and methods for separating particles and/or substances from a sample fluid
EP2266111A1 (en) 2008-03-03 2010-12-29 3M Innovative Properties Company Process for audible acoustic frequency management in gas flow systems
WO2009146140A2 (en) 2008-04-04 2009-12-03 Microsonic Systems Inc. Methods and systems to form high efficiency and uniform fresnel lens arrays for ultrasonic liquid manipulation
US8054145B2 (en) 2008-04-30 2011-11-08 Georgia Tech Research Corporation Phononic crystal wave structures
EP2285744A1 (en) 2008-05-27 2011-02-23 Kolmir Water Technologies Ltd. Apparatus and method for treatment of a contaminated water-based fluid
DE102008002210A1 (en) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Process for the fermentative production of erythropoietin
CA2893175C (en) 2008-06-10 2016-09-06 Sangamo Biosciences, Inc. Methods and compositions for generation of bax- and bak-deficient cell lines
WO2009149519A1 (en) 2008-06-12 2009-12-17 Winwick Business Solutions Pty Ltd System for cultivation and processing of microorganisms and products therefrom
US7935259B2 (en) 2008-07-03 2011-05-03 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Filtering apparatus and method of use
SG192529A1 (en) 2008-07-16 2013-08-30 Kbi Biopharma Inc Methods and systems for manipulating particles using a fluidized bed
CN102149437B (en) 2008-07-18 2017-02-15 普罗索尼克斯有限公司 Process for improving crystallinity of fluticasone particles
US8387803B2 (en) 2008-08-26 2013-03-05 Ge Healthcare Bio-Sciences Ab Particle sorting
AU2009288234B2 (en) 2008-09-02 2014-08-21 Merck Millipore Ltd. Chromatography membranes, devices containing them, and methods of use thereof
WO2010030589A2 (en) 2008-09-11 2010-03-18 Luna Innovations Incorporation Method and apparatus for acoustically enhanced removal of bubbles from a fluid
US8865003B2 (en) 2008-09-26 2014-10-21 Abbott Laboratories Apparatus and method for separation of particles suspended in a liquid from the liquid in which they are suspended
SI2172211T1 (en) 2008-10-01 2015-03-31 Immatics Biotechnologies Gmbh Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers
WO2010040394A1 (en) 2008-10-08 2010-04-15 Foss Analytical A/S Separation of particles in liquids by use of a standing ultrasonic wave
US20100140185A1 (en) 2008-12-05 2010-06-10 John Hill Wastewater treatment
FR2941385B1 (en) 2009-01-23 2011-04-01 Millipore Corp METHOD FOR PROVIDING A CIRCUIT FOR BIOLOGICAL LIQUID AND CIRCUIT OBTAINED
US20100206818A1 (en) 2009-02-19 2010-08-19 Chartered Semiconductor Manufacturing, Ltd. Ultrasonic filtration for cmp slurry
JP2010252785A (en) 2009-03-31 2010-11-11 Kanagawa Acad Of Sci & Technol Device for concentrating and separating cell
JP6215533B2 (en) 2009-04-09 2017-10-18 サンガモ セラピューティクス, インコーポレイテッド Targeted integration into stem cells
US8476060B2 (en) 2009-04-13 2013-07-02 Board Of Regents, The University Of Texas System Process for separating lipids from a biomass
US20110095225A1 (en) 2009-04-20 2011-04-28 Origin Oil, Inc. Systems, apparatuses, and methods for extracting non-polar lipids from an aqueous algae slurry and lipids produced therefrom
IT1396003B1 (en) 2009-05-14 2012-11-09 Fidia Farmaceutici EXTRACELLULAR IALURONIDASE FROM STREPTOMYCES KOGANEIENSIS
JP5645816B2 (en) 2009-05-25 2014-12-24 国立大学法人東京工業大学 Pharmaceutical composition comprising core factor related to proliferation and differentiation of central nerve cell
US8865452B2 (en) 2009-06-15 2014-10-21 Aurora Algae, Inc. Systems and methods for extracting lipids from wet algal biomass
US8319400B2 (en) 2009-06-24 2012-11-27 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US8772004B2 (en) 2009-06-25 2014-07-08 Old Dominion University Research Foundation System and method for high-voltage pulse assisted aggregation of algae
CA2804912A1 (en) 2009-06-26 2012-12-29 Cobalt Technologies, Inc. Integrated system and process for bioproduct production
DE102009032840B4 (en) 2009-07-13 2015-02-05 Epcos Ag SAW filter circuit with improved ESD resistance
GB0914762D0 (en) 2009-08-24 2009-09-30 Univ Glasgow Fluidics apparatus and fluidics substrate
CA2772070A1 (en) 2009-08-26 2011-03-03 Xcellerex, Inc. Continuous recovery harvest bag
GB0915072D0 (en) 2009-09-01 2009-09-30 Prokyma Technologies Ltd Ultrasound & magnetic method
CA2773181C (en) 2009-09-04 2018-02-27 The University Of North Carolina At Chapel Hill Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics
DE102009046145A1 (en) 2009-10-29 2011-05-12 Robert Bosch Gmbh Ultrasonic transducer for use in a fluid medium
US9588121B2 (en) 2009-11-06 2017-03-07 Go Therapeutics, Inc. Method for early detection of cancer
US20180223439A1 (en) 2009-11-16 2018-08-09 Flodesign Sonics, Inc. Particle-particle interaction using acoustic waves
US8691145B2 (en) 2009-11-16 2014-04-08 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for water purification
LT2501822T (en) 2009-11-17 2017-10-25 E. R. Squibb & Sons, L.L.C. Methods for enhanced protein production
EP2504706B1 (en) 2009-11-25 2018-05-23 Hologic Inc. Detection of intraamniotic infection
CA2819583A1 (en) 2009-12-03 2011-06-09 Bard Holding, Inc. Process and system for producing algal oil
US8518681B2 (en) 2009-12-04 2013-08-27 Sound Surgical Technologies Llc Selective lysing of cells using ultrasound
US20110134426A1 (en) 2009-12-04 2011-06-09 Life Technologies Corporation Apparatuses, systems, methods, and computer readable media for acoustic flow cytometry.
US8591459B2 (en) 2009-12-21 2013-11-26 Ethicon Endo-Surgery, Inc. Use of biomarkers and therapeutic agents with surgical devices
CN103124737A (en) 2010-03-11 2013-05-29 葛兰素史密丝克莱恩生物有限公司 Immunogenic composition or vaccine against Gram-negative bacterial, for example neiserial, infrection or disease
US9199217B2 (en) 2010-03-12 2015-12-01 Los Alamos National Security, Llc Material fabrication using acoustic radiation forces
GB201004551D0 (en) 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
EP2558179B1 (en) * 2010-04-12 2020-08-05 Flodesign Sonics Inc. Use of ultrasound and acoustophoresis technology for separation of particulates from a host medium
US8889388B2 (en) 2010-04-21 2014-11-18 Zhaowei Wang Acoustic device and methods thereof for separation and concentration
PT105058B (en) 2010-04-21 2013-04-17 Hovione Farmaciencia S A PROCESS FOR PROCESSING OF PARTICLES OF PHARMACEUTICAL ACTIVE INGREDIENTS
US8714360B2 (en) 2010-05-12 2014-05-06 Ethicon Endo-Surgery, Inc. Tissue processing device with ultrasonic tissue particle separator
US9079127B2 (en) 2010-06-04 2015-07-14 Empire Technology Development Llc Acoustically driven nanoparticle concentrator
EP2582631A4 (en) 2010-06-16 2016-05-25 Flodesign Sonics Inc Phononic crystal desalination system and method of use
GB201010724D0 (en) 2010-06-25 2010-08-11 Isis Innovation Acoustic separators
US20130217113A1 (en) 2010-07-15 2013-08-22 Advanced Liquid Logic Inc. System for and methods of promoting cell lysis in droplet actuators
WO2012012667A2 (en) 2010-07-21 2012-01-26 Sangamo Biosciences, Inc. Methods and compositions for modification of a hla locus
WO2012012750A1 (en) 2010-07-23 2012-01-26 Trustees Of Boston University ANTI-DEsupR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY
CA2902942C (en) 2010-07-28 2020-12-22 David S. Block Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions
SG186915A1 (en) 2010-07-30 2013-02-28 Emd Millipore Corp Chromatography media and method
EP2606064B1 (en) 2010-08-16 2015-02-25 NovImmune S.A. Methods for the generation of multispecific and multivalent antibodies
US8679338B2 (en) 2010-08-23 2014-03-25 Flodesign Sonics, Inc. Combined acoustic micro filtration and phononic crystal membrane particle separation
US8592204B2 (en) 2010-08-23 2013-11-26 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for collection and processing of oleaginous microorganisms
US9011699B2 (en) 2010-08-23 2015-04-21 Flodesign Sonics, Inc. Ultrasonic agglomeration of microalgae
US9421553B2 (en) 2010-08-23 2016-08-23 Flodesign Sonics, Inc. High-volume fast separation of multi-phase components in fluid suspensions
CA2811364C (en) 2010-09-27 2022-01-04 Sangamo Biosciences, Inc. Methods and compositions for inhibiting viral entry into cells
US20170233798A1 (en) 2010-10-22 2017-08-17 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
WO2012070160A1 (en) 2010-11-26 2012-05-31 Empire Technology Development Llc Air purification system and method using an ultrasonic wave
CA2817773A1 (en) 2010-11-30 2012-06-07 Orphazyme Aps Methods for increasing intracellular activity of hsp70
US8895279B2 (en) 2010-12-02 2014-11-25 Dennis A. Burke Applications of the rotating photobioreactor
CN103221105B (en) 2010-12-03 2015-11-25 通用电气健康护理生物科学股份公司 The system of biopolymer chromatography and technique
US20120145633A1 (en) 2010-12-09 2012-06-14 General Electric Company Ultra-sound enhanced centrifugal separation of oil from oily solids in water and wastewater
WO2012081931A2 (en) 2010-12-17 2012-06-21 Kim Sung-Chun Method and apparatus for producing cells and fat soluble materials by cell culture
GB2486680A (en) 2010-12-22 2012-06-27 Morgan Electro Ceramics Ltd Ultrasonic or acoustic transducer that supports two or more frequencies
US9314751B2 (en) 2011-01-07 2016-04-19 Life Technologies Corporation Methods and apparatus for mixing and shipping fluids
US9428565B2 (en) 2011-01-31 2016-08-30 The General Hospital Corporation Treatment and bioluminescent visualization using multimodal TRAIL molecules
CA2826652C (en) 2011-02-04 2018-07-31 Cidra Corporate Services Inc. Optimizing acoustic efficiency of a sonic filter or separator
WO2012154238A1 (en) 2011-02-04 2012-11-15 Cidra Corporate Services Inc. Sonic filter for measuring and capturing particles having a particular particle size in a fluid, mixture or process flow
US9480375B2 (en) 2011-02-09 2016-11-01 The University Of Vermont & State Agricultural College Aeroacoustic duster
CA2827348C (en) 2011-02-14 2021-02-23 Revivicor, Inc. Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
WO2012118717A2 (en) 2011-02-28 2012-09-07 Seattle Children's Research Institute Coupling endonucleases with end-processing enzymes drive high efficiency gene disruption
ES2716010T3 (en) 2011-03-29 2019-06-07 Uab Research Foundation Methods and compositions for cytomegalovirus IL-10 protein
EP3320910A1 (en) 2011-04-05 2018-05-16 Cellectis Method for the generation of compact tale-nucleases and uses thereof
US10254401B2 (en) 2011-04-20 2019-04-09 Nissan Motor Co., Ltd. Mounting structure for sonar sensor
US8668886B2 (en) 2011-04-24 2014-03-11 Therapeutic Proteins International, LLC Separative bioreactor
EP3427815B1 (en) 2011-05-17 2023-12-06 Merck Millipore Ltd. Device with layered tubular membranes for chromatography
EP2944653A1 (en) 2011-06-23 2015-11-18 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
IL293163A (en) 2011-06-23 2022-07-01 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
CN103958697B (en) 2011-06-27 2016-10-12 红外检测公司 From mixing nucleic acid samples separation target nucleic acid
DE102011107533A1 (en) 2011-07-14 2013-01-17 Airbus Operations Gmbh Door for a stay module, stay module and aircraft
FR2979256B1 (en) 2011-08-30 2014-09-26 Centre Nat Rech Scient DEVICE FOR HANDLING OBJECTS BY ACOUSTIC FORCE FIELDS
US8932586B2 (en) 2011-09-06 2015-01-13 Intrexon Corporation Modified forms of Pseudomonas exotoxin A
NL1039052C2 (en) 2011-09-19 2013-03-21 Stichting Wetsus Ct Excellence Sustainable Water Technology Device and method for a heterogeneous waste water treatment reactor.
NL1039053C2 (en) 2011-09-19 2013-03-21 Stichting Wetsus Ct Excellence Sustainable Water Technology Device and method for a bioreactor, catalysis reactor or crystallizer without internals.
EP2761291B1 (en) 2011-09-28 2016-06-29 Acousort AB System and method to separate cells and/or particles
US9175535B2 (en) 2011-09-29 2015-11-03 Coil Solutions, Inc. Propulsion generator and method
US9376655B2 (en) 2011-09-29 2016-06-28 Life Technologies Corporation Filter systems for separating microcarriers from cell culture solutions
WO2013049623A1 (en) 2011-09-30 2013-04-04 Brian David Warner Fluid exchange methods and devices
RS57350B1 (en) 2011-10-03 2018-08-31 Mx Adjuvac Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
AU2012351751B2 (en) 2011-10-19 2017-09-07 Novimmune S.A. Methods of purifying antibodies
FR2982082B1 (en) 2011-11-02 2013-11-22 Fabien Gaben PROCESS FOR PRODUCING THIN-FILT THIN-FILTER BATTERIES
GB201119192D0 (en) 2011-11-07 2011-12-21 Ucl Business Plc Chromatography medium
JP6057251B2 (en) 2011-11-11 2017-01-11 国立研究開発法人産業技術総合研究所 Particle sorting apparatus and particle sorting method
US8256076B1 (en) 2011-11-19 2012-09-04 Murray F Feller Method of making an ultrasonic transducer
GB201120143D0 (en) 2011-11-22 2012-01-04 Micromass Ltd Droplet manipulation using gas-phase standing-wave ultrasound fields in MS sources
WO2013075740A1 (en) 2011-11-23 2013-05-30 Sanofi Antibody purification method
JP6385277B2 (en) 2011-12-01 2018-09-05 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. Anti-CEACAM1 recombinant antibody for cancer treatment
GB201120887D0 (en) 2011-12-06 2012-01-18 The Technology Partnership Plc Acoustic sensor
US9943599B2 (en) 2011-12-22 2018-04-17 Herlev Hospital Therapeutic applications of calcium electroporation to effectively induce tumor necrosis
JP2015512766A (en) 2012-01-31 2015-04-30 ザ・ペン・ステート・リサーチ・ファンデーション Microfluidic manipulation and particle classification using variable stationary surface acoustic waves
JP6188728B2 (en) 2012-02-07 2017-08-30 グローバル・バイオ・セラピューティクス・インコーポレイテッドGlobal Bio Therapeutics,Inc. Method for compartmentalization of nucleic acid delivery and compositions and uses thereof
GB2499251A (en) 2012-02-13 2013-08-14 Univ United Arab Emirates Treatment of industrial and petroleum refinery wastewater
EP2820393B1 (en) 2012-02-27 2017-12-06 Centre National De La Recherche Scientifique Method of forming an aggregate of cells
EP2820385A1 (en) 2012-02-29 2015-01-07 KCI Licensing, Inc. Systems and methods for supplying reduced pressure and measuring flow using a disc pump system
JP6183862B2 (en) 2012-03-07 2017-08-23 ケーシーアイ ライセンシング インコーポレイテッド Disc pump with improved actuator
AU2013232101B2 (en) 2012-03-13 2018-01-04 Salk Institute For Biological Studies Selective cell targeting using adenovirus and chemical dimers
CN107267554A (en) 2012-03-14 2017-10-20 萨克生物研究学院 Adenovirus diagnosing tumor method
US9340435B2 (en) 2012-03-15 2016-05-17 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9512395B2 (en) 2013-11-05 2016-12-06 Flodesign Sonics, Inc. Acoustophoresis device with modular components
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US10040011B2 (en) 2012-03-15 2018-08-07 Flodesign Sonics, Inc. Acoustophoretic multi-component separation technology platform
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9950282B2 (en) * 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9416344B2 (en) 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US9422328B2 (en) 2012-03-15 2016-08-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
CN104363996B (en) * 2012-03-15 2017-07-07 弗洛设计声能学公司 Sound swimming multicomponent separation technology platform
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US9623348B2 (en) 2012-03-15 2017-04-18 Flodesign Sonics, Inc. Reflector for an acoustophoretic device
US9738866B2 (en) 2012-03-15 2017-08-22 Flodesign Sonics, Inc. Acoustic perfusion devices
US9822333B2 (en) 2012-03-15 2017-11-21 Flodesign Sonics, Inc. Acoustic perfusion devices
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US20170191022A1 (en) 2012-03-15 2017-07-06 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9797897B2 (en) 2012-03-26 2017-10-24 Duke University Acoustically responsive particles
PT106237B (en) 2012-03-30 2015-03-19 Hovione Farmaci Ncia S A PRODUCTION OF SUBSTANCIALLY MONO-BUILT PARTICLES USING GRINDING AND MEMBRANE SEPARATION
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
AU2013243950A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US11324873B2 (en) 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
CA2870016A1 (en) 2012-04-20 2013-10-24 Flodesign Sonics Inc. Acoustophoretic separation of lipid particles from red blood cells
CA2870018A1 (en) 2012-04-20 2013-10-24 Nicholas M. LORICCO Acoustophoretic enhanced system for use in tanks
US9357293B2 (en) 2012-05-16 2016-05-31 Siemens Aktiengesellschaft Methods and systems for Doppler recognition aided method (DREAM) for source localization and separation
US9517474B2 (en) 2012-05-18 2016-12-13 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
EA029944B1 (en) 2012-05-23 2018-06-29 Ланцатек Нью Зилэнд Лимитед Fermentation and simulated moving bed process
SG11201407802WA (en) 2012-05-25 2015-01-29 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
EP2861918B1 (en) 2012-06-14 2019-11-06 Yan Beliavsky Method and device for transfer of energy
US9820768B2 (en) 2012-06-29 2017-11-21 Ethicon Llc Ultrasonic surgical instruments with control mechanisms
US9689802B2 (en) 2012-06-29 2017-06-27 Southwest Research Institute Systems, methods and apparatus for analysis of multiphase fluid mixture in pipelines
US9657290B2 (en) 2012-07-03 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Scalable bio-element analysis
US8709250B2 (en) 2012-07-12 2014-04-29 Heliae Development, Llc Tubular electro-acoustic aggregation device
WO2014014941A1 (en) 2012-07-16 2014-01-23 Flodesign Sonics, Inc. Improved separation of multi-component fluid through ultrasonic acoustophoresis
EP2877213B1 (en) 2012-07-25 2020-12-02 The Broad Institute, Inc. Inducible dna binding proteins and genome perturbation tools and applications thereof
JP6025982B2 (en) 2012-08-01 2016-11-16 ザ・ペン・ステート・リサーチ・ファンデーション Efficient separation and manipulation of particles and cells
WO2014029505A1 (en) 2012-08-22 2014-02-27 Eth Zurich Acoustophoretic contactless transport and handling of matter in air
CA2883227A1 (en) 2012-08-29 2014-03-06 Nature Technology Corporation Dna plasmids with improved expression
US9605074B2 (en) 2012-08-30 2017-03-28 The General Hospital Corporation Multifunctional nanobodies for treating cancer
US20150253226A1 (en) 2012-09-21 2015-09-10 Acousort Ab Method for separating cells-bead complexes
JP2014079748A (en) 2012-09-26 2014-05-08 Hitachi Ltd Suspension treating apparatus using ultrasonic wave
ES2809878T3 (en) 2012-10-02 2021-03-08 Flodesign Sonics Inc Acoustophoretic separation technology using multidimensional standing waves
EP3763810A3 (en) 2012-10-10 2021-07-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
US9480991B2 (en) 2012-10-12 2016-11-01 Elwha Llc Radiofrequency particle separator
US10201365B2 (en) 2012-10-22 2019-02-12 Ethicon Llc Surgeon feedback sensing and display methods
US9095367B2 (en) 2012-10-22 2015-08-04 Ethicon Endo-Surgery, Inc. Flexible harmonic waveguides/blades for surgical instruments
WO2014066553A1 (en) 2012-10-26 2014-05-01 Becton, Dickinson And Company Devices and methods for manipulating components in a fluid sample
DE102012022146A1 (en) 2012-11-12 2014-05-15 Physik Instrumente (Pi) Gmbh & Co. Kg Ultrasonic actuator for a linear ultrasonic motor and linear ultrasonic motor with an ultrasonic actuator
US8900532B2 (en) 2012-11-16 2014-12-02 The Charles Stark Draper Laboratory, Inc. Apparatus and method for separating plasma from blood and delayed wetting
US9080167B2 (en) 2012-11-16 2015-07-14 Covaris, Inc. System and method for processing paraffin embedded samples
WO2014077863A1 (en) 2012-11-19 2014-05-22 Nature Technology Corporation Replicative minicircle vectors with improved expression
PT2922554T (en) 2012-11-26 2022-06-28 Modernatx Inc Terminally modified rna
ES2626754T3 (en) 2012-11-26 2017-07-25 Gambro Lundia Ab Adsorption device that combines beads and hollow fiber membranes
EP2922902B1 (en) 2012-11-26 2019-01-02 ETH Zurich Method for the preparation of macroporous particles and macroporous particles obtained using such a method
FR2998891B1 (en) 2012-11-30 2015-04-10 Commissariat Energie Atomique PROCESS FOR PREPARING A GLASS WITH BIMODAL POROSITY, POSSIBLY FUNCTIONALIZED, AND SAID GLASS
US10272163B2 (en) 2012-12-07 2019-04-30 The Regents Of The University Of California Factor VIII mutation repair and tolerance induction
US20140179770A1 (en) 2012-12-12 2014-06-26 Massachusetts Institute Of Technology Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
DK2921557T3 (en) 2012-12-12 2016-11-07 Broad Inst Inc Design of systems, methods and optimized sequence manipulation guide compositions
EP3434776A1 (en) 2012-12-12 2019-01-30 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
EP3434774A1 (en) 2013-01-17 2019-01-30 ModernaTX, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
US9504780B2 (en) 2013-01-30 2016-11-29 The Charles Stark Draper Laboratory, Inc. Extracorporeal clearance of organophosphates from blood on an acoustic separation device
CA2900277C (en) 2013-02-07 2019-03-26 Bart Lipkens Bioreactor using acoustic standing waves
WO2014126548A1 (en) 2013-02-12 2014-08-21 Faurecia Emissions Control Technologies Vehicle exhaust system with resonance damping
HUE038959T2 (en) 2013-02-14 2018-12-28 Faron Pharmaceuticals Oy A method for determining acute respiratory distress syndrome (ards) related biomarkers, a method to monitor the development and treatment of ards in a patient
BR112015021098B1 (en) 2013-03-01 2022-02-15 Ethicon Endo-Surgery, Inc COVERAGE FOR A JOINT JOINT AND SURGICAL INSTRUMENT
US20140246475A1 (en) 2013-03-01 2014-09-04 Ethicon Endo-Surgery, Inc. Control methods for surgical instruments with removable implement portions
WO2014138203A2 (en) 2013-03-05 2014-09-12 Board Of Regents, The University Of Texas System Microfluidic devices for the rapid and automated processing of sample populations
JP5817762B2 (en) * 2013-03-07 2015-11-18 ヤマハ株式会社 Sound equipment
US10166323B2 (en) 2013-03-08 2019-01-01 The Charles Stark Draper Laboratories, Inc. Blood separation by microfluidic acoustic focusing
CN105283539A (en) 2013-03-12 2016-01-27 桑格摩生物科学股份有限公司 Methods and compositions for modification of HLA
US9725709B2 (en) 2013-03-12 2017-08-08 OpenCell Technologies, Inc. Intracellular delivery and transfection methods and devices
US20140261535A1 (en) * 2013-03-13 2014-09-18 Lam Research Corporation Standing Wave Generation in Holes to Enhance Cleaning in the Holes in Liquid Sonification Cleaning Systems
US10258698B2 (en) 2013-03-14 2019-04-16 Modernatx, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US9388363B2 (en) 2013-03-15 2016-07-12 Megasonic Sweeping, Incorporated Ultrasonic and megasonic method for extracting palm oil
US9937207B2 (en) 2013-03-21 2018-04-10 Sangamo Therapeutics, Inc. Targeted disruption of T cell receptor genes using talens
EP2978855B1 (en) 2013-03-28 2021-01-13 The University of British Columbia Microfluidic devices and methods for use thereof in multicellular assays of secretion
AR095962A1 (en) 2013-04-01 2015-11-25 Moreinx Ab NANOPARTICLES, STEROL AND SAPONINE COMPOUNDS OF QUILLAJA SAPONARIA MOLINA, PROCESS FOR PREPARATION AND USE OF THE SAME AS CARRIERS FOR AMPHIPATHIC OR HYDROPHOBLE MOLECULES IN THE FIELD OF THE MEDICINE INCLUDING CANCER TREATMENT AND COMPOUNDING
CA2909950A1 (en) 2013-04-25 2014-10-30 Flodesign Sonics, Inc. Excipient removal from pharmacological samples
EP2981822B1 (en) 2013-05-06 2020-09-02 Scholar Rock, Inc. Compositions and methods for growth factor modulation
AU2014264697B2 (en) 2013-05-06 2019-08-22 Sanofi Continuous multistep process for purifying antibodies
WO2014186469A2 (en) 2013-05-14 2014-11-20 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
EP2997146A4 (en) 2013-05-15 2017-04-26 Sangamo BioSciences, Inc. Methods and compositions for treatment of a genetic condition
ES2883131T3 (en) 2013-05-29 2021-12-07 Cellectis Methods for modifying T cells for immunotherapy using the RNA-guided CAS nuclease system
AU2014273089B2 (en) 2013-05-31 2018-02-22 Cellectis A LAGLIDADG homing endonuclease cleaving the C-C Chemokine Receptor Type-5 (CCR5) gene and uses thereof
ES2716867T3 (en) 2013-05-31 2019-06-17 Cellectis Sa LAGLIDADG settlement endonuclease that cleaves the alpha T cell receptor gene and uses thereof
KR101442486B1 (en) 2013-06-07 2014-09-24 아이에스테크놀로지 주식회사 Apparatus and method for separating impurities from fluid using ultrasound
WO2014204723A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
WO2014210046A1 (en) 2013-06-24 2014-12-31 Flodesign Sonics, Inc. Fluid dynamic sonic separator
US10214718B2 (en) 2013-07-01 2019-02-26 University Of Massachusetts Distributed perfusion bioreactor system for continuous culture of biological cells
EP3019606B1 (en) 2013-07-12 2018-09-05 Flodesign Sonics, Inc. Acoustic bioreactor processes
TWI777196B (en) 2013-08-05 2022-09-11 德商伊瑪提克斯生物科技有限公司 Novel peptides, cells, and their use against several tumors, methods for production thereof and pharmaceutical composition comprising the same
IL300761A (en) 2013-08-05 2023-04-01 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors, such as lung cancer, including NSCLC
US11092521B2 (en) 2013-08-21 2021-08-17 Covaris, Inc. Method and system for acoustically treating material
US9567609B2 (en) 2013-08-28 2017-02-14 Sangamo Biosciences, Inc. Compositions for linking DNA-binding domains and cleavage domains
EP3043826A4 (en) 2013-09-13 2017-05-24 Moderna Therapeutics, Inc. Polynucleotide compositions containing amino acids
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EP3058072B1 (en) 2013-10-17 2021-05-19 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
DK3060237T3 (en) 2013-10-25 2021-10-25 Univ Wayne State MODIFIED PROGRAMMING PROTEIN FOR USE IN CANCER TREATMENT
GB201319446D0 (en) 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
KR102380245B1 (en) 2013-11-07 2022-03-30 에디타스 메디신, 인코포레이티드 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS
ES2908268T3 (en) 2013-11-12 2022-04-28 Univ Brussel Vrije RNA transcription vector and its uses
FR3012972A1 (en) 2013-11-14 2015-05-15 Biomerieux Sa NOVEL FILTER MEDIA FOR OBTAINING PLASMA, APPARATUS AND FILTRATION METHOD THEREOF
CA2930665A1 (en) 2013-11-18 2015-05-21 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
AU2014355072A1 (en) * 2013-11-26 2016-06-02 Alliqua Biomedical, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
DE102013224569B3 (en) 2013-11-29 2014-06-26 Physik Instrumente (Pi) Gmbh & Co. Kg Ultrasonic motor used for automatic balancing of e.g. grinding disc, has first group friction elements that are arranged offset with respect to second group friction elements at specific circumferential angle
US20170173128A1 (en) 2013-12-06 2017-06-22 Moderna TX, Inc. Targeted adaptive vaccines
WO2015089427A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
CN106536729A (en) 2013-12-12 2017-03-22 布罗德研究所有限公司 Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
GB201322103D0 (en) 2013-12-13 2014-01-29 The Technology Partnership Plc Fluid pump
DE102013226418B3 (en) 2013-12-18 2015-04-02 Physik Instrumente (Pi) Gmbh & Co. Kg ultrasonic motor
JP2017504601A (en) 2013-12-20 2017-02-09 セレクティスCellectis Method for manipulating multi-input signal sensitive T cells for immunotherapy
WO2015102528A1 (en) 2013-12-30 2015-07-09 Ge Healthcare Bio-Sciences Corp. Apparatus for cell cultivation
US20170002060A1 (en) 2014-01-08 2017-01-05 Moderna Therapeutics, Inc. Polynucleotides for the in vivo production of antibodies
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US9567846B2 (en) * 2014-01-09 2017-02-14 Baker Hughes Incorporated Devices and methods for downhole acoustic imaging
US20160332159A1 (en) 2014-01-15 2016-11-17 Eth Zurich Acoustophoretic droplet handling in bulk acoustic wave devices
WO2015110600A1 (en) 2014-01-24 2015-07-30 Eth Zurich Acoustophoretic printing apparatus and method
CA2939711C (en) 2014-02-21 2020-09-29 Cellectis Method for in situ inhibition of regulatory t cells
RU2016139366A (en) 2014-03-10 2018-04-13 Флоудизайн Соникс, Инк. DISPOSABLE BIOREACTOR WITH ACOUSTOPHORETIC DEVICE
HUE048558T2 (en) 2014-03-11 2020-07-28 Cellectis Method for generating t-cells compatible for allogenic transplantation
US8820538B1 (en) 2014-03-17 2014-09-02 Namocell LLC Method and apparatus for particle sorting
DK3569619T3 (en) 2014-03-19 2021-06-14 Cellectis Method for producing CD123-specific CAR T cells for cancer immunotherapy
US9884895B2 (en) 2014-03-20 2018-02-06 The University Of North Carolina At Chapel Hill Methods and compositions for chimeric coronavirus spike proteins
CA2943622A1 (en) 2014-03-25 2015-10-01 Editas Medicine Inc. Crispr/cas-related methods and compositions for treating hiv infection and aids
DE102014205577B4 (en) 2014-03-26 2021-05-12 Physik Instrumente (Pi) Gmbh & Co. Kg Ultrasonic motor
US9982265B2 (en) 2014-03-28 2018-05-29 Board Of Regents, The University Of Texas System Inhibition of Bruton's tyrosine kinase (Btk) in the lung to treat severe lung inflammation and lung injury
JP6839073B2 (en) 2014-03-28 2021-03-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California Efficient delivery of large cargo to cells on a porous support
WO2015152858A1 (en) 2014-03-31 2015-10-08 Faurecia Emissions Control Technologies Vehicle exhaust system with resistive patch
EP3498845B1 (en) 2014-04-01 2022-06-22 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
MA39819A (en) 2014-04-01 2017-02-08 Rubius Therapeutics Inc Methods and compositions for immunomodulation
CA2944528C (en) 2014-04-03 2021-08-10 Cellectis Cd33 specific chimeric antigen receptors for cancer immunotherapy
DE102014206823A1 (en) 2014-04-09 2015-10-15 Siemens Aktiengesellschaft Device for separating an emulsion and / or a suspension
AU2015245469B2 (en) 2014-04-11 2020-11-12 Cellectis Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
EP3131927B8 (en) 2014-04-14 2020-12-23 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
HRP20220070T1 (en) 2014-04-23 2022-04-01 Modernatx, Inc. Nucleic acid vaccines
AU2015249655B2 (en) 2014-04-23 2021-01-07 Board Of Regents, The University Of Texas System Chimeric antigen receptors (CAR) for use in therapy and methods for making the same
US10202762B2 (en) 2014-04-24 2019-02-12 New Jersey Institute Of Technology Concealed fastener window or curtain wall assemblies
US20170073406A1 (en) 2014-05-06 2017-03-16 Scholar Rock, Inc. Compositions and methods for growth factor modulation
CA2948355A1 (en) * 2014-05-08 2015-11-12 Bart Lipkens Acoustophoretic device with piezoelectric transducer array
EP3143134B1 (en) 2014-05-15 2020-10-28 National University of Singapore Modified natural killer cells and uses thereof
EP3151967A2 (en) 2014-06-09 2017-04-12 Ascent Bio-Nano Technologies, Inc. System for manipulation and sorting of particles
GB201410262D0 (en) 2014-06-10 2014-07-23 Cambridge Entpr Ltd Novel method
US9683968B2 (en) * 2014-06-17 2017-06-20 Nxp B.V. Combination sensor
US10000533B2 (en) 2014-06-20 2018-06-19 Immatics Biotechnologies Gmbh Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL)
US9827511B2 (en) * 2014-07-02 2017-11-28 Flodesign Sonics, Inc. Acoustophoretic device with uniform fluid flow
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
EP3170185B1 (en) 2014-07-14 2019-02-27 Westinghouse Electric Company Llc Thermo-acoustic nuclear power distribution measurement assembly
US9605266B2 (en) 2014-07-16 2017-03-28 City Of Hope Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore
EP3172826B1 (en) 2014-07-23 2019-04-17 Physik Instrumente (PI) GmbH & Co. Kg Ultrasonic motor
AU2015295349B2 (en) 2014-07-29 2020-09-24 Cellectis ROR1(NTRKR1)specific chimeric antigen receptors for cancer immunotherapy
US9908288B2 (en) 2014-07-29 2018-03-06 The Boeing Company Free-form spatial 3-D printing using part levitation
US9616090B2 (en) 2014-07-30 2017-04-11 Sangamo Biosciences, Inc. Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
WO2016022851A1 (en) 2014-08-06 2016-02-11 Children's Medical Center Corporation Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereof
WO2016025518A1 (en) 2014-08-11 2016-02-18 Carnegie Mellon University Separation of low-abundance cells from fluid using surface acoustic waves
EP3686279B1 (en) 2014-08-17 2023-01-04 The Broad Institute, Inc. Genome editing using cas9 nickases
TR201907471T4 (en) 2014-08-28 2019-06-21 Halozyme Inc Combination therapy with a hyaluronan degrading enzyme and an immune checkpoint inhibitor.
US20160060615A1 (en) 2014-09-03 2016-03-03 Thomas Walther Device for the identification, separation and / or cell type-specific manipulation of at least one cell of a cellular system
WO2017039709A1 (en) * 2015-09-04 2017-03-09 Edison Industrial Innovation, Llc Closed-loop metalworking system
WO2016049251A1 (en) 2014-09-24 2016-03-31 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
US20160082129A1 (en) 2014-09-24 2016-03-24 Aerpio Therapeutics, Inc. VE-PTP Extracellular Domain Antibodies Delivered by a Gene Therapy Vector
WO2016049258A2 (en) 2014-09-25 2016-03-31 The Broad Institute Inc. Functional screening with optimized functional crispr-cas systems
EP3200892B1 (en) 2014-09-30 2022-08-03 Flodesign Sonics, Inc. Acoustophoretic clarification of particle-laden non-flowing fluids
US10238741B2 (en) 2014-10-10 2019-03-26 The Trustees Of Columbia University In The City Of New York Nucleic acid constructs for presentation of CD4 and CD8 epitopes, cellular transfection and uses thereof
CA2963693A1 (en) 2014-10-10 2016-04-14 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
BR112017007765B1 (en) 2014-10-14 2023-10-03 Halozyme, Inc COMPOSITIONS OF ADENOSINE DEAMINASE-2 (ADA2), VARIANTS THEREOF AND METHODS OF USING THE SAME
BR112017008429B1 (en) 2014-10-24 2022-08-09 Life Technologies Corporation METHOD TO PURIFY A SAMPLE IN A TWO-PHASE SYSTEM AND SAMPLE PURIFICATION SYSTEM
JP6649377B2 (en) 2014-11-03 2020-02-19 ザ ジェネラル ホスピタル コーポレイション Combined classification and enrichment of particles with microfluidic devices
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US20160142832A1 (en) * 2014-11-19 2016-05-19 Martin Evert Gustaf Hillbratt Signal Amplifier
US20160153249A1 (en) 2014-12-02 2016-06-02 Chevron U.S.A. Inc. Systems and Methods for Reducing Pipeline Erosion Using Acoustic Radiation
EP3229586A4 (en) 2014-12-10 2018-10-24 Regents of the University of Minnesota Genetically modified cells, tissues, and organs for treating disease
EP3035519B1 (en) 2014-12-19 2018-02-21 Attocube Systems AG Electromechanical actuator
GB201501017D0 (en) 2014-12-23 2015-03-04 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers
WO2016115014A1 (en) 2015-01-12 2016-07-21 Instrumentation Laboratory Company Spatial separation of particles in a particle containing solution for biomedical sensing and detection
US10343187B2 (en) 2015-01-21 2019-07-09 Utah Valley University Foundation, Inc. System and method for harmonic modulation of standing wavefields for spatial focusing, manipulation, and patterning
JP2018504144A (en) 2015-01-26 2018-02-15 セレクティスCellectis CLL1-specific multi-chain chimeric antigen receptor
DE102015101542A1 (en) 2015-02-03 2016-08-18 ACO Severin Ahlmann GmbH & Co Kommanditgesellschaft Method and device for the separation of substances
CN104785429B (en) * 2015-02-03 2017-01-11 浙江工业大学 Piezoelectric ultrasonic transducer with acoustic feedback function
CA2976298A1 (en) 2015-02-13 2016-08-18 Sanofi Stable liquid formulation for monoclonal antibodies
CA2978906A1 (en) 2015-02-16 2016-08-25 Flodesign Sonics Inc. Acoustic microreactor and methods of use thereof
US20180246103A1 (en) 2015-02-16 2018-08-30 Flodesign Sonics, Inc. Acoustic microreactor and methods of use thereof
US10568970B2 (en) 2015-02-20 2020-02-25 Trustees Of Boston University Theranostic compositions and uses thereof
US10324082B2 (en) 2015-03-03 2019-06-18 Quest Diagnostics Investments Llc Methods for quantitation of insulin levels by mass spectrometry
MX2021000153A (en) 2015-03-06 2021-10-28 Genentech Inc Ultrapurified dsba and dsbc and methods of making and using the same.
NL2014433B1 (en) 2015-03-10 2016-10-13 Exsilent Res Bv Personal hearing device, in particular a hearing aid.
KR102615825B1 (en) 2015-03-11 2023-12-21 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Transposase polypeptides and uses thereof
US9533241B2 (en) 2015-03-24 2017-01-03 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
US10444138B2 (en) 2015-03-25 2019-10-15 Bennubio, Inc. Optical cell constructed by anodically bonding a thin metal layer between two optically clear glass windows
CN104722106B (en) 2015-03-25 2016-04-06 陕西师范大学 A kind of ultrasonic separation means of fine particle
WO2016154596A1 (en) 2015-03-25 2016-09-29 Editas Medicine, Inc. Crispr/cas-related methods, compositions and components
WO2016154579A2 (en) 2015-03-26 2016-09-29 Editas Medicine, Inc. Crispr/cas-mediated gene conversion
US10737012B2 (en) 2015-03-31 2020-08-11 Biomet Biologics, Inc. Cell washing using acoustic waves
US9855382B2 (en) 2015-03-31 2018-01-02 Biomet Biologics, Llc Cell washing device using standing acoustic waves and a phantom material
WO2016161109A1 (en) 2015-03-31 2016-10-06 The Regents Of The University Of California System and method for tunable patterning and assembly of particles via acoustophoresis
WO2016161358A1 (en) 2015-04-01 2016-10-06 Los Alamos National Security, Llc Ultrasonic in-situ water-cut measurement using ultrasonic oil-water separation for affecting sound speed calibration
US20180095067A1 (en) 2015-04-03 2018-04-05 Abbott Laboratories Devices and methods for sample analysis
US20180066223A1 (en) 2015-04-17 2018-03-08 Xcell Biosciences, Inc. Cancer cell enrichment system
WO2016168687A1 (en) 2015-04-17 2016-10-20 Xcell Biosciences, Inc. Cancer cell enrichment system
US10900902B2 (en) 2015-04-20 2021-01-26 Unm Rainforest Innovations Method for simultaneous spectrally resolved detection or imaging of items in multiple flowing streams
US9947431B2 (en) 2015-04-21 2018-04-17 The Florida International University Board Of Trustees Anisotropic films templated using ultrasonic focusing
WO2016172726A1 (en) 2015-04-24 2016-10-27 The Regents Of The University Of California Modulators of ror1-ror2 binding
CA2984492A1 (en) 2015-04-29 2016-11-03 Flodesign Sonics, Inc. Acoustophoretic device for angled wave particle deflection
PT3289362T (en) 2015-04-30 2022-06-21 European Molecular Biology Laboratory Microfluidic droplet detection and sorting
WO2016176611A2 (en) 2015-04-30 2016-11-03 Wilsa Holding, Llc Method and apparatus for conditioning fluids
CN107849111B (en) 2015-05-04 2022-02-22 Vcn生物科学有限公司 Oncolytic adenoviruses having mutations in immunodominant adenoviral epitopes and their use in cancer therapy
US20160325206A1 (en) 2015-05-06 2016-11-10 Flodesign Sonics, Inc. Acoustic pre-conditioner
US10414810B2 (en) 2015-05-07 2019-09-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Double mutant survivin vaccine
WO2017191289A1 (en) 2016-05-04 2017-11-09 Aenitis Technologies Multiple blood bag system
CA2985151C (en) 2015-05-07 2023-06-13 Aenitis Technologies Multiple blood bag system
EP3015542A1 (en) 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modular system and method for continuous, germ reduced production and/or processing of a product
CA2986310A1 (en) 2015-05-11 2016-11-17 Editas Medicine, Inc. Optimized crispr/cas9 systems and methods for gene editing in stem cells
AU2016262521A1 (en) 2015-05-11 2017-12-14 Editas Medicine, Inc. CRISPR/CAS-related methods and compositions for treating HIV infection and AIDS
JP6883173B2 (en) 2015-05-12 2021-06-09 ヘモストッド エスエー Combination of pharmacological and microfluidic features for improved platelet production
EP3037513A1 (en) 2015-05-13 2016-06-29 Bayer Technology Services GmbH Method for the continuous elution of a product from chromatography columns
US20180119174A1 (en) 2015-05-13 2018-05-03 Seattle Children's Hospita (dba Seattle Children's Research Institute Enhancing endonuclease based gene editing in primary cells
CN104892672B (en) 2015-05-15 2018-09-21 浙江九洲药业股份有限公司 Chiral spiro phosphine-nitrogen-sulphur tridentate ligand and its preparation method and application
CN107849102B (en) 2015-05-15 2022-05-13 希望之城 Chimeric antigen receptor compositions
US9686096B2 (en) 2015-05-20 2017-06-20 Flodesign Sonics, Inc. Acoustic manipulation of particles in standing wave fields
WO2016187596A1 (en) 2015-05-20 2016-11-24 Flodesign Sonics, Inc. Acoustic manipulation of particles in standing wave fields
EP3298046A1 (en) 2015-05-20 2018-03-28 Cellectis Anti-gd3 specific chimeric antigen receptors for cancer immunotherapy
SG11201708512WA (en) 2015-05-27 2017-12-28 Commw Scient Ind Res Org Separation of metal-organic frameworks
CA2929293C (en) 2015-05-27 2023-01-24 Commonwealth Scientific And Industrial Research Organisation Production of metal-organic frameworks
CA2985702A1 (en) 2015-05-29 2016-12-08 Boehringer Ingelheim International Gmbh Cell-controlled perfusion in continuous culture
SG11201709908QA (en) 2015-06-01 2017-12-28 Shimadzu Corp Method for quantifying monoclonal antibody
US10613085B2 (en) 2015-06-09 2020-04-07 Institut Pasteur Monoclonal antibodies specific for serogroup X of N. meningitidis and uses thereof in diagnosis
US10161926B2 (en) 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
EP3311173A2 (en) 2015-06-18 2018-04-25 Thomas Mole Herd Methods of characterising cancer
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
US10648020B2 (en) 2015-06-18 2020-05-12 The Broad Institute, Inc. CRISPR enzymes and systems
WO2016205764A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
KR102575342B1 (en) 2015-06-18 2023-09-05 더 브로드 인스티튜트, 인코퍼레이티드 CRISPR enzyme mutations that reduce off-target effects
WO2016205749A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
US9663756B1 (en) 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells
EP3310848A1 (en) 2015-06-22 2018-04-25 Proxonix AS Method for making a body with arranged particles using acoustic waves
US9613615B2 (en) 2015-06-22 2017-04-04 Sony Corporation Noise cancellation system, headset and electronic device
US11129669B2 (en) 2015-06-30 2021-09-28 Cilag Gmbh International Surgical system with user adaptable techniques based on tissue type
US9368110B1 (en) 2015-07-07 2016-06-14 Mitsubishi Electric Research Laboratories, Inc. Method for distinguishing components of an acoustic signal
JP5923205B1 (en) 2015-07-07 2016-05-24 日立アロカメディカル株式会社 Ultrasonic probe
CN108025333B (en) 2015-07-09 2020-10-02 弗洛设计声能学公司 Non-planar and asymmetric piezoelectric crystals and reflectors
CA2991301A1 (en) 2015-07-13 2017-01-19 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
AU2016297248A1 (en) 2015-07-22 2018-02-15 Scholar Rock, Inc. GDF11 binding proteins and uses thereof
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US20170029802A1 (en) 2015-07-28 2017-02-02 Flodesign Sonics, Inc. Acoustic affinity separation
EP3328399B1 (en) 2015-07-31 2023-12-27 Regents of the University of Minnesota Modified cells and methods of therapy
CN105087788B (en) 2015-08-03 2018-11-23 上海白泽医疗器械有限公司 It is a kind of sort people's cell immunomagnetic beads, its preparation and cutting method
WO2017020078A1 (en) 2015-08-03 2017-02-09 Arlenko Pty Ltd Fire collar
US20180230433A1 (en) 2015-08-05 2018-08-16 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Use of dermatopontin for maintaining hematopoietic stem and/or progenitor cells in culture
US20180231555A1 (en) 2015-08-11 2018-08-16 Apocell, Inc. Systems and methods for isolating target particles and their use in diagnostic, prognostic, and therapeutic methods
CN105384825B (en) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 A kind of bispecific chimeric antigen receptor and its application based on single domain antibody
US10261078B2 (en) 2015-08-17 2019-04-16 National Technology & Engineering Solutions Of Sandia, Llc Shear horizontal surface acoustic wave (SH-SAW) resonators and arrays thereof
JP7091238B2 (en) 2015-08-20 2022-06-27 ジェネンテック, インコーポレイテッド Purification of FKPA and its use for the production of recombinant polypeptides
BR112018002189A2 (en) 2015-08-24 2018-09-18 Cellectis chimeric antigenic receptors with integrated controllable functions
CA2995716A1 (en) 2015-08-24 2017-03-02 Trustees Of Boston University Anti-despr monoclonal antibody targeted therapy and imaging for cancer and stroke
DK3341116T3 (en) 2015-08-27 2022-05-02 Harvard College SORTING PROCEDURE USING ACOUSTIC WAVES
GB201515339D0 (en) 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
US9947514B2 (en) * 2015-09-01 2018-04-17 Mks Instruments, Inc. Plasma RF bias cancellation system
WO2017040670A1 (en) 2015-09-01 2017-03-09 Ifm Therapeutics, Inc Immune cells having increased immunity or resistance to an immunosuppressive cytokine and use of the same
WO2017041102A1 (en) 2015-09-04 2017-03-09 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
EP3347458A4 (en) 2015-09-09 2019-08-07 Revivicor Inc. Multi-transgenic pig for xenotransplantation
WO2017044709A1 (en) 2015-09-09 2017-03-16 Virginia Commonwealth University Targeting mda-5 activation for cancer immunotherapy
US10155222B2 (en) 2015-09-17 2018-12-18 Carnegie Mellon University Device for the separation of particles using a bulk acoustic wave field
US20190054112A1 (en) 2015-09-18 2019-02-21 Moderna Therapeutics, Inc. Polynucleotide formulations for use in the treatment of renal diseases
CN106554010A (en) 2015-09-25 2017-04-05 苏州烯时代石墨烯科技有限公司 The method of preparation of industrialization big size graphene
USD787630S1 (en) 2015-10-06 2017-05-23 Flodesign Sonics, Inc. U-turn acoustic separation device
KR102549704B1 (en) 2015-10-07 2023-06-30 후지레비오 가부시키가이샤 Method for measuring PIVKA-II, and method for preparing PIVKA-II immunoassay reagent or kit
US10224015B2 (en) 2015-10-09 2019-03-05 Jeffrey James Hsu Stringless bowed musical instrument
EP3386652B1 (en) 2015-10-14 2022-06-22 Sonosep Technologies Inc. Methods, systems, and apparatuses for acoustically separating and washing particles
CN108367081A (en) 2015-10-14 2018-08-03 生命技术公司 Ribonucleoprotein transfection agents
EP3365062A4 (en) 2015-10-19 2019-07-17 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
CA3001351A1 (en) 2015-10-21 2017-04-27 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating hepatitis b virus
CN109153980B (en) 2015-10-22 2023-04-14 布罗德研究所有限公司 CRISPR enzymes and systems of type VI-B
EP3365095A1 (en) 2015-10-23 2018-08-29 3M Innovative Properties Company Filtration medium sequence for biomaterial purification
TW201729810A (en) 2015-10-26 2017-09-01 札爾科製藥公司 Pyrimidine compositions, ultra-pure compositions and salts thereof, methods of making the same, and methods of using the same for treating histamine H4 receptor (H4) mediated diseases and conditions
AU2016343991B2 (en) 2015-10-30 2022-12-01 Editas Medicine, Inc. CRISPR/CAS-related methods and compositions for treating herpes simplex virus
WO2017079674A1 (en) 2015-11-04 2017-05-11 Northeastern University Systems for producing cellular immunotherapeutics and methods of use thereof
SG10201509280YA (en) 2015-11-11 2017-06-29 Singapore Univ Of Tech And Design Microfluidic particle manipulation
CN105307099B (en) * 2015-11-11 2018-10-02 西安工程大学 A kind of test method of Loudspeaker Power Test System and power and low-frequency parameter
US9910074B2 (en) * 2015-11-12 2018-03-06 National Instruments Corporation Digital approach to the removal of AC parasitics for impedance measurements
WO2017083681A1 (en) 2015-11-13 2017-05-18 The University Or North Carolina At Chapel Hill Optimized crosslinkers for trapping a target on a substrate
ES2870907T3 (en) 2015-12-14 2021-10-28 Genomefrontier Therapeutics Inc Transposon system, kit that includes it and its uses
EP3390434A2 (en) 2015-12-14 2018-10-24 Bellicum Pharmaceuticals, Inc. Dual controls for therapeutic cell activation or elimination
US11053788B2 (en) 2015-12-16 2021-07-06 Saudi Arabian Oil Company Acoustic downhole oil-water separation
US10648460B2 (en) 2015-12-16 2020-05-12 The University Of Hong Kong Nanomotor propulsion
CA3007108A1 (en) 2015-12-17 2017-06-22 Modernatx, Inc. Polynucleotides encoding methylmalonyl-coa mutase
KR20180088911A (en) 2015-12-18 2018-08-07 상가모 테라퓨틱스, 인코포레이티드 Targeted Collapse of MHC Cell Receptors
JP7065772B2 (en) 2015-12-22 2022-05-12 エクスエル‐プロテイン ゲーエムベーハー Nucleic acid encoding a repetitive amino acid sequence rich in proline and alanine residues with a low repetitive nucleotide sequence
US10648900B2 (en) 2015-12-23 2020-05-12 Becton, Dickinson And Company Multi-color flow cytometric analysis of samples with low cell numbers
JP2019500043A (en) 2015-12-28 2019-01-10 ノバルティス アーゲー Compositions and methods for the treatment of abnormal hemoglobinosis
US10428324B1 (en) 2016-01-08 2019-10-01 Triad National Security, Llc Acoustic manipulation of fluids based on eigenfrequency
GB201600328D0 (en) 2016-01-08 2016-02-24 Univ Oslo Hf Anti-CD37 chimeric antigen receptors and immune cells expressing them
CA3010612A1 (en) 2016-01-08 2017-07-13 Oncobiologics, Inc. Methods for separating isoforms of monoclonal antibodies
KR20180096793A (en) 2016-01-14 2018-08-29 안톤 바우어 How to make a production cell line
CA3010869A1 (en) 2016-01-15 2017-07-20 Etubics Corporation Methods and compositions for t-cell immunotherapy
US11229450B2 (en) 2016-01-15 2022-01-25 Cilag Gmbh International Modular battery powered handheld surgical instrument with motor drive
WO2017127686A1 (en) 2016-01-22 2017-07-27 Carnegie Mellon University Three-dimensional acoustic manipulation of cells
WO2017132202A1 (en) 2016-01-25 2017-08-03 Nant Holdings Ip, Llc Nk cells with altered cxcl12/cxcr4 signaling
WO2017132486A1 (en) 2016-01-27 2017-08-03 Siamab Therapeutics, Inc. Compositions and methods for targeting cancer stem cells
WO2017133175A1 (en) 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Engineered mammalian cells for cancer therapy
CA3009115A1 (en) 2016-03-01 2017-09-08 Wolfgang Hammerschmidt Means and methods for treating herpesvirus infection
CA3016331A1 (en) 2016-03-04 2017-09-08 Editas Medicine, Inc. Crispr-cpf1-related methods, compositions and components for cancer immunotherapy
CA3016841A1 (en) 2016-03-06 2017-09-14 WindplusSonne GmbH Method and device for separating and/or cleaning aerosols and solid material particles and fibers from gases as well as solid material particles and fibers from liquid materials by acoustophoresis
WO2017156349A1 (en) 2016-03-10 2017-09-14 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
EP3426690A4 (en) 2016-03-11 2019-10-09 Bluebird Bio, Inc. Genome edited immune effector cells
EP3426372A1 (en) 2016-03-12 2019-01-16 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
JP2019511224A (en) 2016-03-15 2019-04-25 キャンサー・リサーチ・テクノロジー・リミテッドCancer Research Technology Limited Antibodies and related molecules and uses thereof
WO2017160964A1 (en) 2016-03-15 2017-09-21 Washington University High throughput acoustic particle separation methods and devices
ES2841528T3 (en) 2016-03-15 2021-07-08 Centre Nat Rech Scient Acoustic Tweezers
EP3219800A1 (en) 2016-03-15 2017-09-20 Max-Delbrück-Centrum Für Molekulare Medizin A transposon-based transfection system for primary cells
EP3429753A4 (en) 2016-03-16 2019-11-06 Berkeley Lights, Inc. Methods, systems and devices for selection and generation of genome edited clones
EP3433363A1 (en) 2016-03-25 2019-01-30 Editas Medicine, Inc. Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
WO2017161553A1 (en) 2016-03-25 2017-09-28 Wu Sareina Chiung-Yuan Kit for constructing transposon and use thereof
AU2017241592A1 (en) 2016-03-28 2018-10-18 The Charles Stark Draper Laboratory, Inc. Bacteriophage engineering methods
EP3436579A4 (en) 2016-03-30 2020-01-01 Renew Biopharma, Inc. Modified rubisco large subunit proteins
CA3177398A1 (en) 2016-04-01 2017-10-05 Kite Pharma, Inc. Chimeric receptors and methods of use thereof
KR20180131557A (en) 2016-04-05 2018-12-10 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Inhibition of TGF beta in immunotherapy
WO2017176211A1 (en) 2016-04-06 2017-10-12 Singapore University Of Technology And Design Particle manipulation
US20190161530A1 (en) 2016-04-07 2019-05-30 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
EP3442598A4 (en) 2016-04-12 2019-11-20 SynPloid Biotek, LLC Methods for creating synthetic chromosomes expressing biosynthetic pathways and uses thereof
JP2019513396A (en) 2016-04-12 2019-05-30 シンプロイド バイオテック エルエルシーSynploid Biotek,Llc Method of making synthetic chromosomes with gene regulatory system and use thereof
AU2017251120B2 (en) 2016-04-14 2022-01-27 Orthoxel Dac An intramedullary nail system
AU2017250773A1 (en) 2016-04-14 2018-11-08 2Seventy Bio, Inc. Salvage chimeric antigen receptor systems
WO2017189308A1 (en) 2016-04-19 2017-11-02 The Broad Institute Inc. Novel crispr enzymes and systems
WO2017184786A1 (en) 2016-04-19 2017-10-26 The Broad Institute Inc. Cpf1 complexes with reduced indel activity
AU2017253089B2 (en) 2016-04-19 2023-07-20 Massachusetts Institute Of Technology Novel CRISPR enzymes and systems
WO2018018958A1 (en) 2016-04-22 2018-02-01 Carsgen Therapeutics Co., Ltd. Compositions and methods of cellular immunotherapy
CN116254231A (en) 2016-04-25 2023-06-13 巴塞尔大学 Allele editing and uses thereof
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
CN109715124B (en) 2016-05-03 2022-04-22 弗洛设计声能学公司 Therapeutic cell washing, concentration and separation using acoustophoresis
JP2019517788A (en) 2016-05-06 2019-06-27 ジュノー セラピューティクス インコーポレイテッド Genetically engineered cells and methods of making same
CA3024470A1 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding interleukin-12 (il12) and uses thereof
WO2017201346A1 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria
JP7114485B2 (en) 2016-05-18 2022-08-08 モデルナティエックス インコーポレイテッド Polynucleotides encoding α-galactosidase A for the treatment of Fabry disease
US20190275170A1 (en) 2016-05-18 2019-09-12 Modernatx, Inc. Polynucleotides encoding jagged1 for the treatment of alagille syndrome
WO2017201348A1 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1
WO2017201347A1 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
AU2017268396B2 (en) 2016-05-18 2023-05-18 Modernatx, Inc. Polynucleotides encoding citrin for the treatment of citrullinemia type 2
CN109562375A (en) 2016-05-24 2019-04-02 法国国家科研中心 Acoustic tweezers
BR112018074192A8 (en) 2016-05-25 2022-11-22 Inst Nat Sante Rech Med METHOD FOR TREATMENT OF A SUBJECT, METHOD FOR PRODUCING A CELL COMPOSITION, CELL COMPOSITION, VACCINE COMPOSITION AND KIT
CN109642232A (en) 2016-06-01 2019-04-16 Kws种子欧洲股份公司 Heterologous nucleic acid sequences for genome manipulation
WO2017214216A1 (en) 2016-06-07 2017-12-14 Evoqua Water Technologies Llc Ballasted solids treatment system and method
US10212514B2 (en) * 2016-06-10 2019-02-19 Cirrus Logic, Inc. Method for limiting amplifier input current to avoid low voltage conditions
EP3468351B1 (en) 2016-06-13 2020-09-09 Lic Automation Limited A livestock management system and method of operation
US20220323612A1 (en) 2016-06-13 2022-10-13 Bluebird Bio, Inc. Gene therapy of neuronal ceroid lipofuscinoses
KR20190017985A (en) 2016-06-14 2019-02-20 리전츠 오브 더 유니버스티 오브 미네소타 Genetically modified cells, tissues, and organs for treating diseases
EP3257600A1 (en) 2016-06-15 2017-12-20 Maquinaria GEKA, S.A. Notching tool, use and method
US20170363522A1 (en) 2016-06-21 2017-12-21 Becton, Dickinson And Company Devices and methods for acoustic particle separation
US10800899B2 (en) 2016-06-22 2020-10-13 Yunuen Montelongo Reversible optical assembly of composites
JP7176958B2 (en) 2016-06-24 2022-11-22 サイエンコンス アクスイェ セルスカプ Preparation of 212Pb-labeled monoclonal antibody
US20190225694A1 (en) 2016-06-28 2019-07-25 Zaklady Farmaceutyczne Polpharma Sa Recombinant production of monoclonal antibodies
WO2018005873A1 (en) 2016-06-29 2018-01-04 The Broad Institute Inc. Crispr-cas systems having destabilization domain
US20180000870A1 (en) 2016-06-29 2018-01-04 Applied Biologics, Llc Methods of forming amniotic fluid-derived preparations
US20180015128A1 (en) 2016-06-29 2018-01-18 Applied Biologics, Llc Amniotic Fluid-Derived Preparation with a Standardized Biologic Activity
KR102496333B1 (en) 2016-06-30 2023-02-07 삼성전자주식회사 Dish washer and method for controlling the same
US20180003110A1 (en) 2016-07-01 2018-01-04 Flodesign Sonics, Inc. Acoustically-Enhanced Separators for Aircraft Engines
CA3030156A1 (en) 2016-07-07 2018-01-11 Iovance Biotherapeutics, Inc. Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof
US20180010117A1 (en) 2016-07-07 2018-01-11 Sangamo Therapeutics, Inc. Targeted treatment of leber congenital amourosis
US10245064B2 (en) 2016-07-12 2019-04-02 Ethicon Llc Ultrasonic surgical instrument with piezoelectric central lumen transducer
EP3485032B1 (en) 2016-07-12 2021-02-17 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
WO2018013840A1 (en) 2016-07-13 2018-01-18 Vertex Pharmaceuticals Incorporated Methods, compositions and kits for increasing genome editing efficiency
US11134864B2 (en) 2016-07-13 2021-10-05 Alexei L. Vyssotski Tracking method and system for small animal research
CN114700057A (en) 2016-07-14 2022-07-05 纯化迪发有限公司 Functionalized chromatography media comprising polymeric nanofibers and methods of making the same
WO2018014174A1 (en) 2016-07-19 2018-01-25 General Electric Company Ultrasonic separation of a production stream
JP2019521715A (en) 2016-07-21 2019-08-08 セリアドCelyad Method and apparatus for automatically and independently batch processing cells in parallel
CN113853051A (en) * 2016-07-22 2021-12-28 路创技术有限责任公司 Electrical control panel and system for controlling a plurality of electrical loads
US20190184035A1 (en) 2016-07-25 2019-06-20 Bluebird Bio, Inc. Bcl11a homing endonuclease variants, compositions, and methods of use
AU2017301681A1 (en) 2016-07-25 2019-03-07 Cellular Approaches, Inc. Autologous and allogenic macrophages and monocytes for use in therapeutic methods
CN112810319A (en) 2016-07-27 2021-05-18 哈佛学院院长及董事 Acoustophoretic printed droplets
JP7179715B2 (en) 2016-07-27 2022-11-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Collapsible cell-permeable complexes for nucleic acid delivery
WO2018021920A1 (en) 2016-07-27 2018-02-01 The University Of Canterbury Maskless speech airflow measurement system
JP2019527536A (en) 2016-07-28 2019-10-03 ザ・チャールズ・スターク・ドレイパ・ラボラトリー・インコーポレイテッド Acoustic separation for bioprocessing
CA3032412A1 (en) 2016-07-29 2018-02-01 Ohio State Innovation Foundation Expression of pten-long with ocolytic viruses
WO2018026644A1 (en) 2016-08-01 2018-02-08 Academia Sinica Internally fixed lipid vesicle
US11207683B2 (en) 2016-08-02 2021-12-28 Imec Vzw Method and arrangement for focusing objects in a flow
KR102561368B1 (en) 2016-08-03 2023-08-01 론자 워커스빌 아이엔씨. Endotoxin Detection Method Using Limulus Amebocyte Lysate Substantially Free of Coagulogen
US10160061B2 (en) 2016-08-15 2018-12-25 The Aerospace Corporation Systems and methods for modifying acoustic waves based on selective heating
WO2018034655A1 (en) 2016-08-16 2018-02-22 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
MY196321A (en) 2016-08-16 2023-03-24 Regeneron Pharma Methods for Quantitating Individual Antibodies From a Mixture
WO2018035141A1 (en) 2016-08-16 2018-02-22 Bluebird Bio, Inc. Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use
CA3034101A1 (en) 2016-08-19 2018-02-22 Bluebird Bio, Inc. Genome editing enhancers
CN109642868B (en) 2016-08-19 2022-03-15 国立大学法人香川大学 Optical characteristic measuring device and optical characteristic measuring method
EP3500244A4 (en) 2016-08-22 2020-05-13 Codiak BioSciences, Inc. Methods of suppressing delivery of exosomes to liver and spleen
CA3034801A1 (en) 2016-08-23 2018-03-01 Flodesign Sonics, Inc. Acoustic bioreactor processes
US10952759B2 (en) 2016-08-25 2021-03-23 Ethicon Llc Tissue loading of a surgical instrument
US10420580B2 (en) 2016-08-25 2019-09-24 Ethicon Llc Ultrasonic transducer for surgical instrument
US11801374B2 (en) 2016-09-02 2023-10-31 The General Hospital Corporation Methods and systems for non-contact construction of an internal structure
EP3510157B1 (en) 2016-09-08 2023-05-31 2seventy bio, Inc. Pd-1 homing endonuclease variants, compositions, and methods of use
CN109937050A (en) 2016-09-14 2019-06-25 鲁汶大学 The VSV-G and its vaccine of modification
WO2018057825A1 (en) 2016-09-23 2018-03-29 The Curators Of The University Of Missouri Antigen-specific immune modulation
WO2018058275A1 (en) 2016-09-27 2018-04-05 深圳智乐信息科技有限公司 Smart driving method and system employing mobile terminal
WO2018063291A1 (en) 2016-09-30 2018-04-05 Intel Corporation Single-flipped resonator devices with 2deg bottom electrode
WO2018067614A1 (en) 2016-10-04 2018-04-12 Massachusetts Institute Of Technology Fiber microfluidics
GB2607227B (en) 2016-10-27 2023-05-10 Intima Bioscience Inc Viral methods of T cell therapy
WO2018081701A1 (en) 2016-10-28 2018-05-03 Indiggo Associates, Inc. System and method for transforming a digital calendar into a strategic tool
GB201618508D0 (en) 2016-11-02 2016-12-14 Imp Innovations Ltd Implantable device
US10830738B2 (en) 2016-11-14 2020-11-10 University Of Alberta Ultrasensitive high Q-factor AT-cut-quartz crystal microbalance femtogram mass sensor
US20180136167A1 (en) 2016-11-16 2018-05-17 Battelle Energy Alliance, Llc Acoustic measurement infrastructure method and system for process monitoring, diagnostics, and prognostics
FR3058644B1 (en) 2016-11-17 2022-04-22 Commissariat Energie Atomique METHOD AND DEVICE FOR THE CONCENTRATION OF PARTICLES BY ACOUSTOPHORESIS
CA3043888A1 (en) 2016-11-17 2018-05-24 Bluebird Bio, Inc. Tgf.beta. signal convertor
GB201619559D0 (en) 2016-11-18 2017-01-04 Univ Oxford Innovation Ltd Acoustic excitation and detection of spin waves
CN110402305B (en) 2016-11-30 2023-07-21 北京复昇生物科技有限公司 CRISPR library screening method
AU2017368320A1 (en) 2016-12-02 2019-05-02 Cartesian Therapeutics, Inc. Cancer immuno therapy with highly enriched CD8+ chimeric antigen receptor T cells
JP6414994B2 (en) 2016-12-06 2018-10-31 学校法人同志社 Liquid crystal variable focus lens and focal length control method
US11246000B2 (en) 2016-12-07 2022-02-08 Dirac Research Ab Audio precompensation filter optimized with respect to bright and dark zones
EP3554668A1 (en) 2016-12-15 2019-10-23 Beckman Coulter, Inc. Cell washing device and method
WO2018112335A1 (en) 2016-12-16 2018-06-21 Dolby Laboratories Licensing Corporation Audio speaker with full-range upward firing driver for reflected sound projection
US10212526B2 (en) * 2017-01-13 2019-02-19 Bose Corporation Acoustic pressure reducer and engineered leak
US9909313B1 (en) 2017-01-19 2018-03-06 Austin M. Grubbs Composite materials, methods of making composite materials, and enclosures constructed from composite materials
JP2020505044A (en) 2017-01-26 2020-02-20 サンガモ セラピューティクス, インコーポレイテッド B cell manipulation
WO2018140845A2 (en) 2017-01-27 2018-08-02 Duke University Bi-specific antibodies to cd64 and a disease antigen
KR20190112771A (en) 2017-01-30 2019-10-07 케이더블유에스 에스에이에이티 에스이 운트 코. 카게아아 Repair template linkage to endonucleases for genome engineering
TW201839136A (en) 2017-02-06 2018-11-01 瑞士商諾華公司 Compositions and methods for the treatment of hemoglobinopathies
US20180223256A1 (en) 2017-02-09 2018-08-09 University Of Rochester Modified t cells and their uses in treating cancer
CA2994643A1 (en) 2017-02-14 2018-08-14 Bart Lipkens Bioreactor using acoustic standing waves
AU2018221221B2 (en) 2017-02-16 2022-03-24 Xequel Bio, Inc. Composition and methods for preventing radiation injury and promoting tissue regeneration
EP3583113A4 (en) 2017-02-17 2020-08-26 George Todaro Use of tgf alpha for the treatment of diseases and disorders
GB201703116D0 (en) 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
WO2018160548A1 (en) 2017-02-28 2018-09-07 Cardiodx, Inc. Markers for coronary artery disease and uses thereof
WO2018161026A1 (en) 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Il15 compositions and methods for immunotherapy
WO2018160909A1 (en) 2017-03-03 2018-09-07 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
WO2018161038A1 (en) 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Il12 compositions and methods for immunotherapy
WO2018161017A1 (en) 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Cd19 compositions and methods for immunotherapy
US11229809B2 (en) 2017-03-03 2022-01-25 California Institute Of Technology Selective disruption of neoplastic cells via resonant harmonic excitation
CN110913954A (en) 2017-03-03 2020-03-24 黑曜石疗法公司 Compositions and methods for immunotherapy
US10428765B2 (en) 2017-03-07 2019-10-01 United Technologies Corporation Asymmetric multi degree of freedom flutter damper
EP3372813B8 (en) 2017-03-07 2021-04-07 Raytheon Technologies Corporation Multi degree of freedom flutter damper
EP3372814B1 (en) 2017-03-07 2022-05-04 Raytheon Technologies Corporation Asymmetric multi degree of freedom flutter damper
CN106932370B (en) 2017-03-07 2019-08-13 中国农业科学院油料作物研究所 The synchronous chromatography time-resolved fluorescence kit for detecting five kinds of mycotoxins and application
US10415506B2 (en) 2017-03-07 2019-09-17 United Technologies Corporation Multi degree of freedom flutter damper
WO2018163183A1 (en) 2017-03-09 2018-09-13 B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University Process and apparatus for purifying liquid
FR3064311B1 (en) * 2017-03-22 2019-04-12 IFP Energies Nouvelles METHOD FOR CONTROLLING A HOOM SYSTEM USING AN INTEGRATED PROPORTIONAL CONTROL LAW
BR112019020473A2 (en) 2017-03-31 2020-04-28 Quest Diagnostics Invest Llc methods for quantification of insulin and c-peptide
WO2018202691A1 (en) 2017-05-02 2018-11-08 Linnaeus University Method for performing a bioleaching process of chalcopyrite
US11358140B2 (en) 2017-05-16 2022-06-14 Autonomous Medical Devices Inc. Apparatus for automatic sampling of biological species employing an amplification with a magnetic nanoparticle and propulsion method
US20180334697A1 (en) 2017-05-16 2018-11-22 Sensor Kinesis Corporation Method for isothermal dna detection using a modified crispr/cas system and the apparatus for detection by surface acoustic waves for gene editing
UY37758A (en) 2017-06-12 2019-01-31 Novartis Ag METHOD OF MANUFACTURING OF BIESPECTIFIC ANTIBODIES, BISPECTIFIC ANTIBODIES AND THERAPEUTIC USE OF SUCH ANTIBODIES
GB2588249B (en) 2017-06-12 2023-01-04 Sinai Health Sys Allograft tolerance without the need for systemic immune suppression
MA49403A (en) 2017-06-12 2021-03-24 Obsidian Therapeutics Inc PDE5 COMPOSITIONS AND IMMUNOTHERAPY METHODS
CN111373253A (en) 2017-06-13 2020-07-03 弗洛设计声能学公司 Driver and control for variable impedance loads
WO2018232131A1 (en) 2017-06-14 2018-12-20 The Charles Stark Draper Laboratory Inc. Acoustophoresis device having improved dimensions
US20200131498A1 (en) 2017-06-14 2020-04-30 Modernatx, Inc. Polynucleotides encoding methylmalonyl-coa mutase
US11754486B2 (en) 2017-06-19 2023-09-12 Massachusetts Institute Of Technology Systems and methods for measuring properties of particles
GB201709838D0 (en) 2017-06-20 2017-08-02 Univ Oslo Hf Method of modulating immune cells
SG11201912071QA (en) 2017-06-22 2020-01-30 Catalyst Biosciences Inc Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
WO2018235228A1 (en) 2017-06-22 2018-12-27 株式会社島津製作所 Method for quantifying monoclonal antibody having antigen or anti-antibody bonded thereto
CN107071684B (en) * 2017-06-23 2023-03-17 深圳精拓创新科技有限公司 Method and device for testing T/S parameters of loudspeaker
US11092532B2 (en) 2017-06-23 2021-08-17 Texas Tech University System Method and device for label-free, high throughput holographic screening and enumeration of tumor cells in blood
TWI704923B (en) 2017-06-26 2020-09-21 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 Formulation comprising extracellular vesicles, method for producing the same, and uses thereof
WO2019005866A1 (en) 2017-06-26 2019-01-03 The Broad Institute, Inc. Novel type vi crispr orthologs and systems
US20210355448A1 (en) 2017-06-26 2021-11-18 City Of Hope Methods of islet cell culture
CA3068306A1 (en) 2017-06-28 2019-01-03 Perceptimed, Inc. Inventory management
US11516354B2 (en) 2017-06-30 2022-11-29 Hewlett-Packard Development Company, L.P. Imaging device with audio portion
WO2019002633A1 (en) 2017-06-30 2019-01-03 Cellectis Cellular immunotherapy for repetitive administration
EP3645021A4 (en) 2017-06-30 2021-04-21 Intima Bioscience, Inc. Adeno-associated viral vectors for gene therapy
EP3421975A1 (en) 2017-06-30 2019-01-02 Centre National De La Recherche Scientifique Methods and device for manipulating objects
GB201710620D0 (en) 2017-07-03 2017-08-16 Glaxosmithkline Intellectual Property Ltd Targeted protein degradation
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
EP3425386B1 (en) 2017-07-07 2022-04-13 Université de Strasbourg Online apparatus for in-depth characterization of antibody drug conjugates
US20200165594A1 (en) 2017-07-07 2020-05-28 The Broad Institute, Inc. Crispr system based antiviral therapy
WO2019018423A1 (en) 2017-07-17 2019-01-24 The Broad Institute, Inc. Novel type vi crispr orthologs and systems
SG11202000428PA (en) 2017-07-18 2020-02-27 Calimmune Inc A modulatable switch for selection of donor modified cells
WO2019018796A1 (en) 2017-07-21 2019-01-24 Fred Hutchinson Cancer Research Center Herpes simplex virus vaccine epitopes specifically recognized by tissue resident memory t cells
JP7198280B2 (en) 2017-07-26 2022-12-28 フロデザイン ソニックス, インク. Acoustic transducer with automated start-up and operation
US20210085615A1 (en) 2017-07-28 2021-03-25 National University Of Singapore Biomolecular composites comprising modified cell ghosts
AU2018311504A1 (en) 2017-07-31 2020-03-12 Reflection Biotechnologies Limited Cellular models of and therapies for ocular diseases
JP2020529605A (en) 2017-08-01 2020-10-08 コンパス セラピューティクス リミテッド ライアビリティ カンパニー Filtration and chromatography pods and how to use them
US11266984B2 (en) 2017-08-03 2022-03-08 The Board Of Trustees Of The Leland Stanford Junior University Massive microfluidics for multiplexed counting
EP3437740A1 (en) 2017-08-04 2019-02-06 Nokia Technologies Oy Apparatus and method for positioning particles inside a channel
WO2019032675A1 (en) 2017-08-08 2019-02-14 Sangamo Therapeutics, Inc. Chimeric antigen receptor mediated cell targeting
CN111225686A (en) 2017-08-15 2020-06-02 普罗根尼蒂公司 Treatment of inflammatory diseases using ingestible devices to release immunomodulators
US10969324B2 (en) 2017-08-16 2021-04-06 Washington University Synthesis, post-modification and separation of biologics using acoustically confined substrates
WO2019046304A1 (en) 2017-08-28 2019-03-07 Matthias Wagner Microfluidic laser-activated intracellular delivery systems and methods
US11085902B2 (en) 2017-08-29 2021-08-10 Massachusetts Institute Of Technology Optical breakdown acoustic transducer
WO2019041344A1 (en) 2017-09-04 2019-03-07 Hebei University Of Science And Technology Methods and compositions for single-stranded dna transfection
WO2019051278A1 (en) 2017-09-07 2019-03-14 The Board Of Trustees Of The Leland Stanford Junior University Nuclease systems for genetic engineering
WO2019051355A1 (en) 2017-09-08 2019-03-14 Ohio State Innovation Foundation Novel microrna inhibitor therapy in systemic lupus erythematosus
WO2019051255A1 (en) 2017-09-08 2019-03-14 Generation Bio Co. Modified closed-ended dna (cedna)
JP2020534813A (en) 2017-09-08 2020-12-03 ライフ テクノロジーズ コーポレイション Methods for improved homologous recombination and compositions thereof
WO2019051237A1 (en) 2017-09-08 2019-03-14 Life Technologies Corporation Methods for improved homologous recombination and compositions thereof
CA3072009A1 (en) 2017-09-08 2019-03-14 Neopep Pharma Gmbh & Co. Kg Crcx4 inhibitor peptides for the treatment of diseases
US20190078133A1 (en) 2017-09-08 2019-03-14 The Charles Stark Draper Laboratory, Inc. Detection and identification of bacteria and determination of antibiotic susceptibility using bacteriophage and reporter molecules
WO2019055817A1 (en) 2017-09-14 2019-03-21 The Regents Of The University Of California Ex vivo maintenance and expansion of stem cells
US20190076473A1 (en) 2017-09-14 2019-03-14 Cellular Approaches, Inc. Autologous and allogenic macrophages and monocytes for use in therapeutic methods
EP4035674A1 (en) 2017-09-15 2022-08-03 Kite Pharma, Inc. Methods and systems for performing a patient-specific immunotherapy procedure with chain-of-custody and chain-of-identity biological sample tracking
WO2019056015A2 (en) 2017-09-18 2019-03-21 Children's Hospital Medical Center A strong insulator and uses thereof in gene delivery
WO2019057774A1 (en) 2017-09-19 2019-03-28 Deutsches Krebsforschungszentrum Non-integrating dna vectors for the genetic modification of cells
EP3684408A1 (en) 2017-09-19 2020-07-29 Massachusetts Institute of Technology Compositions for chimeric antigen receptor t cell therapy and uses thereof
DK3456821T3 (en) 2017-09-19 2020-11-16 Deutsches Krebsforsch NON-INTEGRATING DNA VECTORS FOR GENETIC MODIFICATION OF CELLS
IT201700105911A1 (en) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa METHOD AND APPARATUS FOR THE VOLUME REDUCTION OF A SAMPLE
IT201700105948A1 (en) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa METHOD AND MICROFLUID SYSTEM FOR RECOVERY OF PARTICLES
US11104902B2 (en) 2017-09-22 2021-08-31 City Of Hope Splice inhibiting oligonucleotides
US20200354452A1 (en) 2017-09-29 2020-11-12 City Of Hope Cars and bispecific antibodies for treatment of mantle cell lymphoma
KR20200104284A (en) 2017-10-03 2020-09-03 주노 쎄러퓨티크스 인코퍼레이티드 HPV-specific binding molecule
WO2019070974A1 (en) 2017-10-04 2019-04-11 Bluebird Bio, Inc. Pcsk9 endonuclease variants, compositions, and methods of use
GB2567188A (en) 2017-10-05 2019-04-10 Ft Tech Uk Ltd Fluid flow measuring device and associated method
EP3468225B1 (en) 2017-10-06 2021-05-26 Harman International Industries, Incorporated Vehicle headrest with speakers and contol for adaptive spatial performance
WO2019075409A1 (en) 2017-10-12 2019-04-18 The Regents Of The University Of California Microfluidic label-free isolation and identification of cells using fluorescence lifetime imaging (flim)
JP7117374B2 (en) 2017-10-13 2022-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング perfusion medium
US11702367B2 (en) 2017-10-17 2023-07-18 Desktop Metal, Inc. Binder jetting in additive manufacturing of inhomogeneous three-dimensional parts
US11618780B2 (en) 2017-10-20 2023-04-04 City Of Hope Composition and method for activating latent human immunodeficiency virus (HIV)
CN111511471A (en) 2017-10-25 2020-08-07 里尔大学 Acoustic forceps
WO2019087009A1 (en) 2017-11-01 2019-05-09 Mahmoud Amouzadeh Tabrizi Nanomotors for reduction of nitroarenes
US11788057B2 (en) 2017-11-01 2023-10-17 Mcmaster University 3D label-free contactless formation of cellular structures and co-cultures through diamagnetophoresis
US10304490B2 (en) 2017-11-02 2019-05-28 AcoustiX VR Inc. Acoustic holographic recording and reproduction system using meta material layers
MX2020004907A (en) 2017-11-09 2020-09-09 Sangamo Therapeutics Inc Genetic modification of cytokine inducible sh2-containing protein (cish) gene.

Also Published As

Publication number Publication date
US20200359136A1 (en) 2020-11-12
CN111480345A (en) 2020-07-31
KR102439221B1 (en) 2022-09-01
US10785574B2 (en) 2020-09-22
US11381922B2 (en) 2022-07-05
BR112020009889A2 (en) 2020-11-03
CA3085784A1 (en) 2019-06-20
CN111480345B (en) 2022-04-29
CN114900773A (en) 2022-08-12
JP2021507561A (en) 2021-02-22
US20190191252A1 (en) 2019-06-20
AU2018385759A1 (en) 2020-05-07
AU2018385759B2 (en) 2021-10-21
WO2019118921A1 (en) 2019-06-20
KR20220066413A (en) 2022-05-24
IL274333A (en) 2020-06-30
KR20200089334A (en) 2020-07-24
EP3725092A4 (en) 2021-09-22
EP3725092A1 (en) 2020-10-21

Similar Documents

Publication Publication Date Title
EP3838191C0 (en) Ultrasonic transducer
IL263560A (en) Ultrasound transducer and system
EP3378161A4 (en) Surface acoustic transducer
SG11202003907WA (en) Acoustic transducer drive and controller
HK1248801A1 (en) Ultrasonic microphone and ultrasonic acoustic radio
EP3427092A4 (en) Disdrometer having acoustic transducer and methods thereof
IL272248A (en) Acoustic transducer automated start and run
GB201704979D0 (en) Methods and apparatuses for driving audio and ultrasonics from the same transducer
SG11202003643VA (en) Sound transducer arrangement
EP3291578A4 (en) Ultrasonic transducer and ultrasonic probe
EP3170319A4 (en) Sound transducer
GB201713895D0 (en) Transducer drive and damping technique
GB2539614B (en) Variable thickness acoustic transducers
EP3298633A4 (en) Ultrasonic transducer
EP3291579A4 (en) Ultrasonic transducer production method and ultrasonic transducer
EP3195903A4 (en) Ultrasound focusing transducer and ultrasound focusing treatment head
EP3354042A4 (en) Ultrasonic transducers
GB2555835B (en) Ultrasound transducer
SG11201602832PA (en) Ultra broadband sound and ultrasonic transducer
EP3814024A4 (en) Ultrasonic transducer
PT3324181T (en) Device for emitting torsional ultrasonic waves and transducer comprising said device
EP3214849A4 (en) Acoustic transducer device
EP3373450A4 (en) Piezoelectric transducer and sensor
SG11201802852RA (en) Ultrasound transducer and method of forming the same
EP3165169A4 (en) Ultrasonic vibrator and ultrasonic endoscope