US5324A
(en)
|
|
1847-10-09 |
|
Cooking-stove |
US5990A
(en)
|
|
1848-12-26 |
|
of baltimore |
US569A
(en)
|
|
1838-01-09 |
|
Caruiag-e-spiiln g |
US5795A
(en)
|
|
1848-09-19 |
|
Saddletree for carts |
US237A
(en)
|
|
1837-06-15 |
|
Egbert beale |
US844A
(en)
|
|
1838-07-17 |
|
Boiler for |
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
US4952496A
(en)
|
1984-03-30 |
1990-08-28 |
Associated Universities, Inc. |
Cloning and expression of the gene for bacteriophage T7 RNA polymerase
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
US5283187A
(en)
|
1987-11-17 |
1994-02-01 |
Brown University Research Foundation |
Cell culture-containing tubular capsule produced by co-extrusion
|
US4892538A
(en)
|
1987-11-17 |
1990-01-09 |
Brown University Research Foundation |
In vivo delivery of neurotransmitters by implanted, encapsulated cells
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
DE3921528A1
(en)
|
1989-06-30 |
1991-01-10 |
Draegerwerk Ag |
MEASURING CELL FOR ELECTROCHEMICAL GAS DETECTION
|
US5256643A
(en)
|
1990-05-29 |
1993-10-26 |
The Government Of The United States |
Human cripto protein
|
US5262522A
(en)
|
1991-11-22 |
1993-11-16 |
Immunex Corporation |
Receptor for oncostatin M and leukemia inhibitory factor
|
AU7097094A
(en)
|
1993-06-01 |
1994-12-20 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
US5457035A
(en)
|
1993-07-23 |
1995-10-10 |
Immunex Corporation |
Cytokine which is a ligand for OX40
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
US5795569A
(en)
|
1994-03-31 |
1998-08-18 |
Amgen Inc. |
Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
|
WO1995026746A1
(en)
|
1994-03-31 |
1995-10-12 |
Amgen Inc. |
Compositions and methods for stimulating megakaryocyte growth and differentiation
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
US6258351B1
(en)
|
1996-11-06 |
2001-07-10 |
Shearwater Corporation |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
EP1061954B1
(en)
|
1998-03-12 |
2004-06-09 |
Nektar Therapeutics Al, Corporation |
Poly(ethylene glycol) derivatives with proximal reactive groups
|
EP1095243A2
(en)
|
1998-07-03 |
2001-05-02 |
Neles Field Controls Oy |
Method and arrangement for measuring fluid
|
US6153394A
(en)
|
1998-09-18 |
2000-11-28 |
Board Of Trustees Operating Michigan State University |
Immunoassay for equine protozoal myeloencephalitis in horses
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
JP2003514765A
(en)
|
1999-02-28 |
2003-04-22 |
ワシントン ユニバーシティー |
Novel transducing molecules and methods of use
|
CA2362670A1
(en)
|
1999-03-12 |
2000-09-14 |
Georgetown University |
Matriptase, a serine protease and its applications
|
CZ299516B6
(en)
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof
|
JO2291B1
(en)
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythopintin derivatives
|
US6461802B1
(en)
|
1999-08-02 |
2002-10-08 |
Agfa-Gevaert |
Adhesive layer for polyester film
|
US7030231B1
(en)
|
1999-09-30 |
2006-04-18 |
Catalyst Biosciences, Inc. |
Membrane type serine protease 1 (MT-SP1) and uses thereof
|
AU1436401A
(en)
|
1999-10-21 |
2001-05-14 |
Board Of Trustees Of The University Of Arkansas, The |
RepO-associated virus AAV REP78 major regulatory protein, mutants thereof and uses thereof
|
DK1259562T3
(en)
|
1999-12-22 |
2006-04-18 |
Nektar Therapeutics Al Corp |
Sterically hindered derivatives of water-soluble polymers
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
US7700341B2
(en)
|
2000-02-03 |
2010-04-20 |
Dendreon Corporation |
Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
|
WO2001062827A2
(en)
|
2000-02-22 |
2001-08-30 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
ATE367398T1
(en)
|
2000-05-16 |
2007-08-15 |
Bolder Biotechnology Inc |
METHOD FOR REFOLDING PROTEINS WITH FREE CYSTEINE RESIDUE
|
GB0103110D0
(en)
|
2000-08-25 |
2001-03-28 |
Aventis Pharma Inc |
A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1
|
US7157596B2
(en)
|
2000-09-08 |
2007-01-02 |
Dendreon Corporation |
Inhibitors of serine protease activity of matriptase or MTSP1
|
EP1345628B1
(en)
|
2000-12-20 |
2011-04-13 |
F. Hoffmann-La Roche AG |
Conjugates of erythropoietin (epo) with polyethylene glycol (peg)
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
AU2002305052A1
(en)
|
2001-03-13 |
2002-09-24 |
Corvas International, Inc. |
Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
|
EP1379637A4
(en)
|
2001-03-27 |
2005-04-06 |
Dendreon Corp |
Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon
|
JP2005506832A
(en)
|
2001-05-14 |
2005-03-10 |
デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー |
Nucleic acid molecule encoding transmembrane serine protease 10, encoded polypeptide and method based thereon
|
JP2005518332A
(en)
|
2001-05-23 |
2005-06-23 |
デンドレオン コーポレイション |
Conjugates activated by cell surface proteases and their therapeutic use
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
AU2002356824A1
(en)
|
2001-10-19 |
2003-05-06 |
The Scripps Research Institute |
Novel methods for introducing molecules into cells and vectors and compositions for use in such methods
|
JP4758608B2
(en)
|
2001-11-07 |
2011-08-31 |
ネクター セラピューティックス |
Branched polymers and their conjugates
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US7192468B2
(en)
|
2002-04-15 |
2007-03-20 |
Fluor Technologies Corporation |
Configurations and method for improved gas removal
|
WO2003104394A2
(en)
|
2002-05-21 |
2003-12-18 |
Dendreon San Diego Llc |
Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon
|
KR20100109969A
(en)
|
2002-10-02 |
2010-10-11 |
카탈리스트 바이오사이언시즈, 인코포레이티드 |
Methods of generating and screening for proteases with altered specificity
|
US20060024289A1
(en)
|
2002-10-02 |
2006-02-02 |
Ruggles Sandra W |
Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases
|
US7939304B2
(en)
*
|
2002-10-02 |
2011-05-10 |
Catalyst Biosciences, Inc. |
Mutant MT-SP1 proteases with altered substrate specificity or activity
|
KR20040040782A
(en)
|
2002-11-08 |
2004-05-13 |
선바이오(주) |
Novel hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof
|
AU2003299818A1
(en)
|
2002-12-20 |
2004-07-22 |
Applera Corporation |
Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
|
US7019019B2
(en)
|
2002-12-23 |
2006-03-28 |
Dendreon Corporation |
Matriptase inhibitors and methods of use
|
US20040147027A1
(en)
|
2003-01-28 |
2004-07-29 |
Troy Carol M. |
Complex for facilitating delivery of dsRNA into a cell and uses thereof
|
US20060178297A1
(en)
|
2003-01-28 |
2006-08-10 |
Troy Carol M |
Systems and methods for silencing expression of a gene in a cell and uses thereof
|
EP2572732A1
(en)
|
2003-02-26 |
2013-03-27 |
Nektar Therapeutics |
Polymer-factor VIII moiety conjugates
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
KR100512483B1
(en)
|
2003-05-07 |
2005-09-05 |
선바이오(주) |
Novel Preparation method of PEG-maleimide PEG derivatives
|
NZ541374A
(en)
|
2003-05-23 |
2008-09-26 |
Nektar Therapeutics Al Corp |
PEG derivatives having an amidocarbonate linkage
|
US7595306B2
(en)
|
2003-06-09 |
2009-09-29 |
Alnylam Pharmaceuticals Inc |
Method of treating neurodegenerative disease
|
AU2004316996A1
(en)
|
2003-06-20 |
2005-09-15 |
The Regents Of The University Of California |
Polypeptide transduction and fusogenic peptides
|
US7439226B2
(en)
|
2003-09-30 |
2008-10-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Serine protease inhibitors
|
EP2275448A3
(en)
|
2003-12-19 |
2013-02-06 |
Genentech, Inc. |
Monovalent antibody fragments useful as therapeutics
|
CA2562729C
(en)
|
2004-04-12 |
2013-11-12 |
Sandra Waugh Ruggles |
Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1
|
US8173144B2
(en)
|
2004-11-04 |
2012-05-08 |
L'oreal |
Administration of urea compounds for combating signs of cutaneous aging
|
EP1851543A2
(en)
|
2005-02-24 |
2007-11-07 |
Compugen Ltd. |
Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
|
CA2626356C
(en)
|
2005-10-21 |
2017-08-22 |
Catalyst Biosciences, Inc. |
Modified proteases that inhibit complement activation
|
AU2011218753B2
(en)
*
|
2005-10-21 |
2013-10-24 |
Vertex Pharmaceuticals Incorporated |
Modified proteases that inhibit complement activation
|
JP2009513158A
(en)
|
2005-11-01 |
2009-04-02 |
アリゾナ ボード オブ リージェンツ ア ボディー コーポレート アクティング オン ビハーフ オブ アリゾナ ステイト ユニバーシティ |
Novel protein transduction domains and uses thereof
|
US7579318B2
(en)
|
2005-12-06 |
2009-08-25 |
Centre De La Recherche De La Scientifique |
Cell penetrating peptides for intracellular delivery of molecules
|
WO2007097561A1
(en)
|
2006-02-20 |
2007-08-30 |
Ewha University - Industry Collaboration Foundation |
Peptide having cell membrane penetrating activity
|
EP1867661A1
(en)
|
2006-06-12 |
2007-12-19 |
Diatos |
Compositions and methods for delivering anti-activated ras antibodies into cells
|
CN107630011A
(en)
*
|
2006-07-05 |
2018-01-26 |
催化剂生物科学公司 |
Protease screening procedure and the protease thus differentiated
|
JP4546578B2
(en)
|
2006-07-05 |
2010-09-15 |
カタリスト・バイオサイエンシーズ・インコーポレイテッド |
Protease screening method and protease identified thereby
|
CA2761310C
(en)
|
2009-05-07 |
2017-02-28 |
Charles S. Craik |
Antibodies and methods of use thereof
|
WO2012021891A2
(en)
|
2010-08-13 |
2012-02-16 |
Tufts University |
Compositions, kits and methods for treatment of complement-related disorders
|
CA2843631A1
(en)
|
2011-10-14 |
2013-04-18 |
Alain Moreau |
Methods and kits for diagnosing and/or prognosing osteoarthritis
|
AU2013207900B2
(en)
|
2012-01-12 |
2017-12-07 |
Cambridge Enterprise Limited |
Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase
|
EP2833923A4
(en)
|
2012-04-02 |
2016-02-24 |
Moderna Therapeutics Inc |
Modified polynucleotides for the production of proteins
|
US10029415B2
(en)
|
2012-08-16 |
2018-07-24 |
Stratasys, Inc. |
Print head nozzle for use with additive manufacturing system
|
CA2836167A1
(en)
|
2013-12-10 |
2015-06-10 |
Christina Xiaolin Dai |
Thickness increase spring
|
DK3137595T3
(en)
*
|
2014-04-29 |
2019-06-17 |
Novartis Ag |
New vertebrate cells and methods for recombinant expression of a polypeptide of interest
|
TWI702228B
(en)
|
2014-08-08 |
2020-08-21 |
美商Alx腫瘤技術股份有限公司 |
Sirp-alpha variant constructs and uses thereof
|
EP3733696A1
(en)
|
2015-01-13 |
2020-11-04 |
City of Hope |
Ctla4-binding protein peptide-linker masks
|
KR20220029783A
(en)
|
2015-01-20 |
2022-03-08 |
아비나스 오퍼레이션스, 인코포레이티드 |
Compounds and Methods for the Targeted Degradation of the Androgen Receptor
|
AU2016289480C1
(en)
|
2015-07-06 |
2021-10-21 |
Regeneron Pharmaceuticals, Inc. |
Multispecific antigen-binding molecules and uses thereof
|
US11903996B2
(en)
|
2015-10-07 |
2024-02-20 |
David C. Fritzinger |
Modulators of complement function
|
US9938264B2
(en)
|
2015-11-02 |
2018-04-10 |
Yale University |
Proteolysis targeting chimera compounds and methods of preparing and using same
|
CA3176021A1
(en)
|
2018-12-28 |
2020-07-02 |
Catalyst Biosciences, Inc. |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|