HRP20100128T1 - Tumoru pridruženi peptid koji se slobodno veže na molekule humanog leukocitnog antigena (hla) klase ii - Google Patents
Tumoru pridruženi peptid koji se slobodno veže na molekule humanog leukocitnog antigena (hla) klase ii Download PDFInfo
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- HRP20100128T1 HRP20100128T1 HR20100128T HRP20100128T HRP20100128T1 HR P20100128 T1 HRP20100128 T1 HR P20100128T1 HR 20100128 T HR20100128 T HR 20100128T HR P20100128 T HRP20100128 T HR P20100128T HR P20100128 T1 HRP20100128 T1 HR P20100128T1
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 24
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 16
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 9
- 239000000427 antigen Substances 0.000 title claims 6
- 108091007433 antigens Proteins 0.000 title claims 6
- 102000036639 antigens Human genes 0.000 title claims 6
- 210000000265 leukocyte Anatomy 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims abstract 13
- 238000000034 method Methods 0.000 claims abstract 9
- 201000011510 cancer Diseases 0.000 claims abstract 4
- 230000028993 immune response Effects 0.000 claims abstract 4
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 108091008874 T cell receptors Proteins 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 102000043131 MHC class II family Human genes 0.000 claims 3
- 108091054438 MHC class II family Proteins 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000008030 elimination Effects 0.000 claims 2
- 238000003379 elimination reaction Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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Abstract
Tumoru pridruženi peptid koji se sastoji od aminokiselinskog slijeda prema Identifikacijskom broju slijeda 42. Patent sadrži još 18 patentnih zahtjeva.
Claims (19)
1. Tumoru pridruženi peptid koji se sastoji od aminokiselinskog slijeda prema Identifikacijskom broju slijeda 42.
2. Tumoru pridruženi peptid prema koji se sastoji od aminokiselinskog slijeda prema Identifikacijskom broju slijeda 42, gdje su jedan ili dva aminokiselinska ostatka izmijenjeni zamjenom bočnih lanaca s drugim aminokiselinskim ostatkom koji se javlja u prirodi, tako da je peptid još uvijek sposoban za vezivanje na HLA molekulu na jednak način kao i spomenuti peptid na Identifikacijski broj slijeda 42.
3. Tumoru pridružen peptid prema bilo kojem od Zahtjeva 1 ili 2, gdje peptid uključuje veze koje nisu peptidne.
4. Nukleinska kiselina koja se sastoji od niza koji kodira peptid prema jednom od Zahtjeva 1 do 3.
5. Nukleinska kiselina prema Zahtjevu 4 koja je DNK, cDNK, PNK, CNK, RNK ili kombinacija navedenih.
6. Vektor ekspresije sposoban za ekspresiju nukleinske kiseline prema Zahtjevu 4 ili 5.
7. Stanica domaćina koja sadrži nukleinsku kiselinu prema Zahtjevu 4 ili 5 ili vektor ekspresije prema Zahtjevu 6 gdje spomenuta stanica domaćina nije stanica humanog embrija.
8. Metoda proizvodnje tumoru pridruženog peptida prema bilo kojem od Zahtjeva 1 ili 2, pri čemu se metoda sastoji od kultiviranja stanice domaćina prema Zahtjevu 7 te izolacije peptida iz stanice domaćina ili njezinog hranidbenog medija.
9. Farmaceutski sastav koji obuhvaća tumoru pridruženi peptid prema bilo kojem od Zahtjeva 1 do 3, nukleinsku kiselinu prema Zahtjevu 4 ili 5 ili vektor ekspresije prema Zahtjevu 6 te farmaceutski prikladan nosač, poželjno u obliku cjepiva protiv raka, a po izboru može sadržavati barem jedan prikladan adjuvans.
10. Tumoru pridruženi peptid prema bilo kojem od Zahtjeva 1 do 3, nukleinsku kiselinu prema Zahtjevima 4 ili 5 ili vektor ekspresije prema Zahtjevu 6 za upotrebu u medicini.
11. Upotreba tumoru pridruženog peptida prema bilo kojem od Zahtjeva 1 do 3 ili nukleinske kiseline prema Zahtjevima 4 ili 5 ili vektora ekspresije prema Zahtjevu 6 u proizvodnji lijekova za eliminaciju stanica raka kod pacijenta, a koje abnormalno eksprimiraju polipeptid sastavljen od aminokiselinskog slijeda prikazanog u bilo kojem od Zahtjeva 1 ili 2.
12. Upotreba tumoru pridruženih peptida prema bilo kojem od Zahtjeva 1 do 3 ili nukleinske kiseline prema Zahtjevu 4 ili 5 ili vektora ekspresije prema Zahtjevu 6 za proizvodnju lijekova za indukciju imunološkog odgovora, posebice staničnog imunološkog odgovora, specifičnije za imunološki odgovor posredovan T limfocitima protiv stanica solidnih tumora koje eksprimiraju humane MHC molekule razreda II na svojoj površini te prikazuju polipeptid koji se sastoji od slijeda aminokiselina navedenog u bilo kojem od Zahtjeva 1 ili 2.
13. In vitro metoda za proizvodnju aktiviranih citotoksičnih T limfocita (CTL), pri čemu se metoda sastoji od in vitro doticaja CTL-a s uklopljenim antigenima MHC molekula razreda II, prikazanim na površini prikladne stanice koja prikazuje antigen u vremenskom razdoblju dovoljnom za aktivaciju spomenutog CTL-a na antigen-specifičan način, gdje je spomenuti antigen peptid iz bilo kojeg od Zahtjeva 1 ili 2.
14. Metoda prema Zahtjevu 13, gdje je antigen uklopljen u MHC molekule razreda II prikazan na površini prikladne stanice koja prikazuje antigen putem kontakta dovoljne količine antigena sa spomenutom stanicom.
15. Metoda iz Zahtjeva 13, gdje se stanica koja prikazuje antigen sastoji od vektora ekspresije prema Zahtjevu 6.
16. Aktivirani citotoksični T limfociti (CTL), dobiveni metodom prema bilo kojem od Zahtjeva 13 do 15, a koji selektivno prepoznaju stanicu koja abnormalno eksprimira polipeptid sastavljen od aminokiselinskog slijeda spomenutog u bilo kojem od Zahtjeva 1 ili 2.
17. Receptor T stanica (TCR) koji prepoznaje stanicu koja abnormalno eksprimira polipeptid sastavljen od aminokiselinskog slijeda spomenutog u bilo kojem od Zahtjeva 1 ili 2, pri čemu je TCR specifičan za peptide iz bilo kojeg Zahtjeva od 1 ili 2 te se može dobiti od citotoksičnih limfocita (CTL-a) iz Zahtjeva 16.
18. Nukleinska kiselina koja kodira receptor T stanica (TCR) prema Zahtjevu 17 ili vektor ekspresije sposoban za ekspresiju spomenutog receptora T stanice (TCR).
19. Uporaba citotoksičnih T limfocita kao što je definirano u Zahtjevu 16 u proizvodnji lijekova za eliminaciju stanica raka kod pacijenta čije stanice raka abnormalno eksprimiraju polipeptid koji se sastoji od aminokiselinskog slijeda prikazanog u bilo kojem od Zahtjeva 1 ili 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05019254A EP1760088B1 (en) | 2005-09-05 | 2005-09-05 | Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules |
| PCT/EP2006/008642 WO2007028574A2 (en) | 2005-09-05 | 2006-09-05 | Tumor-associated peptides binding promiscuously to human leukocyte antigen (hla) class ii molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100128T1 true HRP20100128T1 (hr) | 2010-04-30 |
Family
ID=35170099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100128T HRP20100128T1 (hr) | 2005-09-05 | 2010-03-09 | Tumoru pridruženi peptid koji se slobodno veže na molekule humanog leukocitnog antigena (hla) klase ii |
| HR20110981T HRP20110981T1 (hr) | 2005-09-05 | 2011-12-30 | Tumoru pridruženi peptidi koji se slobodno vežu na molekule ljudskog leukocitnog antigena (hla) klasa ii |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110981T HRP20110981T1 (hr) | 2005-09-05 | 2011-12-30 | Tumoru pridruženi peptidi koji se slobodno vežu na molekule ljudskog leukocitnog antigena (hla) klasa ii |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US10196432B2 (hr) |
| EP (6) | EP1806358B1 (hr) |
| JP (1) | JP5627180B2 (hr) |
| KR (3) | KR101386790B1 (hr) |
| CN (3) | CN101287754B (hr) |
| AT (5) | ATE388164T1 (hr) |
| AU (2) | AU2006289290B2 (hr) |
| BR (1) | BRPI0615462A2 (hr) |
| CA (2) | CA2929252A1 (hr) |
| CY (5) | CY1107973T1 (hr) |
| DE (4) | DE602005020046D1 (hr) |
| DK (5) | DK1806359T3 (hr) |
| EA (1) | EA013876B1 (hr) |
| ES (5) | ES2341802T3 (hr) |
| HK (2) | HK1183678A1 (hr) |
| HR (2) | HRP20100128T1 (hr) |
| NO (1) | NO340870B1 (hr) |
| NZ (2) | NZ566104A (hr) |
| PL (5) | PL1806359T3 (hr) |
| PT (5) | PT1806358E (hr) |
| SI (5) | SI1806358T1 (hr) |
| UA (1) | UA98295C2 (hr) |
| WO (1) | WO2007028574A2 (hr) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1806359T3 (da) * | 2005-09-05 | 2010-06-14 | Immatics Biotechnologies Gmbh | Tumorassocierede peptider, der bindes promiskuøst til Humant Leukocyt-Antigen (HLA) klasse II molekyler |
| US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| PL2338907T3 (pl) * | 2007-07-27 | 2016-03-31 | Immatics Biotechnologies Gmbh | Nowe immunogenne epitopy do immunoterapii |
| PT2660248E (pt) | 2007-07-27 | 2015-10-12 | Immatics Biotechnologies Gmbh | Nova imunoterapia para tumores neuronais e cerebrais |
| BRPI0814140A2 (pt) | 2007-07-27 | 2017-03-28 | Immatics Biotechnologies Gmbh | composição de peptídeos associados a tumor e vacina anticâncer relacionada |
| EP2192179B9 (en) | 2007-08-20 | 2017-11-15 | Oncotherapy Science, Inc. | Cdh3 peptide and medicinal agent comprising the same |
| EP3085707B1 (en) | 2007-11-01 | 2019-02-27 | Mayo Foundation for Medical Education and Research | Hla-dr binding peptides and their uses |
| ES2554981T3 (es) | 2008-03-27 | 2015-12-28 | Immatics Biotechnologies Gmbh | Nueva inmunoterapia contra tumores neuronales y cerebrales |
| ATE462442T1 (de) * | 2008-04-30 | 2010-04-15 | Immatics Biotechnologies Gmbh | Neuartige formulierungen von tumor-assoziierten peptiden, welche an menschliche leukozytenantigene der klasse i oder ii für impfungen binden |
| NO2119726T3 (hr) | 2008-05-14 | 2015-05-23 | ||
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| EP2172211B1 (en) * | 2008-10-01 | 2014-12-03 | Immatics Biotechnologies GmbH | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
| BRPI1007443B8 (pt) | 2009-01-28 | 2021-07-27 | Bio Preventive Medicine Corp | método para diagnosticar nefropatia diabética em um indivíduo, método para avaliar a eficácia de um tratamento para nefropatia diabética em um indivíduo, método para determinação do estágio da nefropatia diabética em um indivíduo, método para monitoramento do progresso da nefropatia diabética em um indivíduo, e método para avaliar a eficácia de um tratamento para nefropatia diabética em um indivíduo |
| WO2011073215A2 (en) | 2009-12-14 | 2011-06-23 | Immatics Biotechnologies Gmbh | Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof |
| GB201004575D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
| GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| GB201009222D0 (en) | 2010-06-02 | 2010-07-21 | Immatics Biotechnologies Gmbh | Improved cancer therapy based on tumour associated antigens derived from cyclin D1 |
| NZ609916A (en) | 2010-12-14 | 2015-03-27 | Immatics Biotechnologies Gmbh | Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof |
| CN106074601A (zh) * | 2011-03-23 | 2016-11-09 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| CN110041403B (zh) | 2013-08-05 | 2023-03-10 | 伊玛提克斯生物技术有限公司 | 针对多种肿瘤例如包括nsclc在内的肺癌的新型免疫疗法 |
| TWI819228B (zh) * | 2013-08-05 | 2023-10-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（八） |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| GB201408255D0 (en) | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
| IL248203A0 (en) | 2014-05-09 | 2016-11-30 | Immatics Biotechnologies Gmbh | Innovative immunotherapy against blood tumors such as acute leukemia in the spinal cord |
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