HRP20191859T1 - Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni i gastrični karcinom - Google Patents
Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni i gastrični karcinom Download PDFInfo
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- HRP20191859T1 HRP20191859T1 HRP20191859TT HRP20191859T HRP20191859T1 HR P20191859 T1 HRP20191859 T1 HR P20191859T1 HR P20191859T T HRP20191859T T HR P20191859TT HR P20191859 T HRP20191859 T HR P20191859T HR P20191859 T1 HRP20191859 T1 HR P20191859T1
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- 230000002496 gastric effect Effects 0.000 title claims 3
- 206010028980 Neoplasm Diseases 0.000 title claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 title 1
- 208000005718 Stomach Neoplasms Diseases 0.000 title 1
- 206010017758 gastric cancer Diseases 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 201000011549 stomach cancer Diseases 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 6
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 108700005089 MHC Class I Genes Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12P21/00—Preparation of peptides or proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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Claims (15)
1. Peptid koji se sastoji od sekvence aminokiselina u skladu s ID BR SEKV 58.
2. Peptid u skladu s patentnim zahtjevom 1, koji ima sposobnost vezivanja s molekulom glavnog kompleksa gena tkivne podudarnosti (MHC) klase I.
3. Peptid u skladu s patentnim zahtjevom 1 ili 2, pri čemu peptid uključuje nepeptidne veze.
4. Peptid u skladu s bilo kojim patentnim zahtjevom od 1 ili 3, pri čemu je navedeni peptid dio fuzijske bjelančevine koja se sastoji od N-terminalne aminokiseline HLA-DR invarijantnog lanca vezanog za antigene (Ii).
5. Nukleinska kiselina, koja kodira peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 4, uz uvjet da peptid nije potpuno humani protein, pri čemu je navedena nukleinska kiselina po mogućnosti DNK, cDNK, PNK, RNK ili kombinacija navedenih, ili ekspresijski vektor koji eksprimira navedenu nukleinsku kiselinu.
6. Peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 4, nukleinska kiselina ili ekspresijski vektor u skladu s patentnim zahtjevom 5 za upotrebu u medicini.
7. Stanica domaćin, sastoji se od nukleinske kiseline ili ekspresijskog vektora u skladu s patentnim zahtjevom 5, koja je po mogućnosti stanica koja prezentira antigen, kao što je primjerice dendritična stanica.
8. Metoda za proizvodnju peptida u skladu s bilo kojim od patentnih zahtjeva od 1 do 4 metoda je koja se sastoji od kultiviranja stanice domaćina u skladu s patentnim zahtjevom 7 i izoliranjem navedenog peptida iz stanice domaćina ili medija za kultiviranje.
9. In vitro metoda za proizvodnju aktiviranih citotoksičnih T-limoficta (CTL) metoda je koja obuhvaća kontaktiranje in vitro CTL-a humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen u vremenskom razdoblju dovoljnom da se aktivira navedeni CTL na način svojstven antigenu, pri čemu je navedeni antigen peptid u skladu s patentnim zahtjevom 1 ili 2,pri čemu opcionalno stanica koja prezentira antigen sadrži vektor ekspresije koji eksprimira navedeni peptid u skladu sa zahtjevom 1 ili 2.
10. Aktivirani citotoksični T-limfocit (CTL), proizveden metodom u skladu s patentnim zahtjevom 9, koji selektivno prepoznaje stanicu koja greškom ekspresira polipeptid koji sadrži sekvencu aminokiselina navedenu u zahtjevu 1 ili 2.
11. Citotoksični T-limfocit (CTL) u skladu s patentnim zahtjevom 10 za upotrebu u liječenju karcinogenih stanica u pacijentu, pri čemu navedene kancerogene stanice predstavljaju peptid koji se sastoji od sekvence aminokiselina navedene u zahtjevu 1 ili 2.
12. Peptid u skladu s patentnim zahtjevom 1 ili 2, nukleinska kiselina ili ekspresijski vektor u skladu s patentnim zahtjevom 5, stanica u skladu sa zahtjevom 7 ili aktivirani citotoksični T-limfocit u skladu s patentnim zahtjevom 11 za upotrebu u liječenju karcinoma, kao što su gastrični, gastrointestinalni, kolorektalni karcinomi te karcinomi gušterače, pluća ili bubrega.
13. Peptid, nukleinska kiselina ili ekspresijski vektor, stanica, aktivirani citotoksični T-limfocit za upotrebu u skladu s patentnim zahtjevom 12, pri čemu se navedeni peptidi koriste kao cjepivo.
14. Neterapijska upotreba peptida u skladu sa zahtjevom 1 ili 2 za generiranje i razvoj protutijela koja su specifična u odnosu na kompleks MHC/peptid koji sadrži navedeni peptid.
15. Antitijelo, kao što je monoklonalno antitijelo koje se specifično veže za kompleks MHC/peptida koji sadrži peptid u skladu sa zahtjevom 1 ili 2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31570410P | 2010-03-19 | 2010-03-19 | |
GBGB1004551.6A GB201004551D0 (en) | 2010-03-19 | 2010-03-19 | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
EP17157398.3A EP3195873B1 (en) | 2010-03-19 | 2011-03-15 | Novel immunotherapy against several tumors including gastrointestinal and gastric cancer |
Publications (1)
Publication Number | Publication Date |
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HRP20191859T1 true HRP20191859T1 (hr) | 2019-12-27 |
Family
ID=42227949
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20150867TT HRP20150867T1 (hr) | 2010-03-19 | 2015-08-13 | Nova inumoterapija protiv nekoliko tumora ukljuäśujuä†i gastrointestinalni i gastriäśni karcinom |
HRP20170718TT HRP20170718T1 (hr) | 2010-03-19 | 2017-05-12 | Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni i gastrični karcinom |
HRP20171504TT HRP20171504T1 (hr) | 2010-03-19 | 2017-10-06 | Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni i gastrični karcinom |
HRP20191859TT HRP20191859T1 (hr) | 2010-03-19 | 2019-10-14 | Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni i gastrični karcinom |
HRP20201467TT HRP20201467T1 (hr) | 2010-03-19 | 2020-09-14 | Nova imunoterapija protiv raznih vrsta karcinoma, uključujući gastrointestinalni karcinom i gastrični karcinom |
HRP20201770TT HRP20201770T1 (hr) | 2010-03-19 | 2020-11-02 | Nova imunoterapija protiv raznih vrsta karcinoma, uključujući gastrointestinalni karcinom i gastrični karcinom |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20150867TT HRP20150867T1 (hr) | 2010-03-19 | 2015-08-13 | Nova inumoterapija protiv nekoliko tumora ukljuäśujuä†i gastrointestinalni i gastriäśni karcinom |
HRP20170718TT HRP20170718T1 (hr) | 2010-03-19 | 2017-05-12 | Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni i gastrični karcinom |
HRP20171504TT HRP20171504T1 (hr) | 2010-03-19 | 2017-10-06 | Nova imunoterapija protiv nekoliko tumora uključujući gastrointestinalni i gastrični karcinom |
Family Applications After (2)
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HRP20201467TT HRP20201467T1 (hr) | 2010-03-19 | 2020-09-14 | Nova imunoterapija protiv raznih vrsta karcinoma, uključujući gastrointestinalni karcinom i gastrični karcinom |
HRP20201770TT HRP20201770T1 (hr) | 2010-03-19 | 2020-11-02 | Nova imunoterapija protiv raznih vrsta karcinoma, uključujući gastrointestinalni karcinom i gastrični karcinom |
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US (24) | US10064913B2 (hr) |
EP (9) | EP2923708B1 (hr) |
JP (9) | JP5891181B2 (hr) |
KR (13) | KR20190033577A (hr) |
CN (8) | CN105001339B (hr) |
AU (1) | AU2011229199B2 (hr) |
BR (1) | BR112012023692B1 (hr) |
CA (5) | CA2789857C (hr) |
CY (5) | CY1119366T1 (hr) |
DK (6) | DK2547354T3 (hr) |
EA (8) | EA202091233A3 (hr) |
ES (6) | ES2753206T3 (hr) |
GB (1) | GB201004551D0 (hr) |
HK (5) | HK1226297A1 (hr) |
HR (6) | HRP20150867T1 (hr) |
HU (6) | HUE027036T2 (hr) |
LT (5) | LT3329933T (hr) |
ME (3) | ME03569B (hr) |
MX (6) | MX2012010813A (hr) |
MY (2) | MY178651A (hr) |
NZ (7) | NZ769427A (hr) |
PH (2) | PH12016500949B1 (hr) |
PL (6) | PL2923708T3 (hr) |
PT (6) | PT3363456T (hr) |
RS (6) | RS60765B1 (hr) |
SG (4) | SG10201710446PA (hr) |
SI (6) | SI3363456T1 (hr) |
TW (9) | TWI681967B (hr) |
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