MX2016010998A - Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados. - Google Patents

Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados.

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Publication number
MX2016010998A
MX2016010998A MX2016010998A MX2016010998A MX2016010998A MX 2016010998 A MX2016010998 A MX 2016010998A MX 2016010998 A MX2016010998 A MX 2016010998A MX 2016010998 A MX2016010998 A MX 2016010998A MX 2016010998 A MX2016010998 A MX 2016010998A
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MX
Mexico
Prior art keywords
agonist
retinoic acid
therapeutic methods
rory
cellular therapy
Prior art date
Application number
MX2016010998A
Other languages
English (en)
Inventor
Gary D Glick
Clarke B Taylor
L Toogood Peter
Hu Xiao
Daniel Aicher Thomas
Lee Celeste Laura
Liu Xikui
A Van Huis Chad
Original Assignee
Lycera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Lycera Corp filed Critical Lycera Corp
Publication of MX2016010998A publication Critical patent/MX2016010998A/es

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    • C12N5/0636—T lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C12N2501/30—Hormones
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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La invención se refiere a terapia médica que usa un agonista del receptor huérfano gamma relacionado con receptor de ácido retinoico (RORy) y proporciona terapias celulares adoptivas que usan un agonista de RORy, poblaciones de células linfocíticas que se han expuesto a un agonista de RORy, poblaciones de células dendríticas que se han expuesto a un agonista de RORy, composiciones farmacéuticas, y métodos para potenciar los efectos terapéuticos de células linfocíticas y/o células dendríticas en un paciente mediante la administración de un agonista de RORy a un paciente.
MX2016010998A 2014-02-27 2015-02-27 Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados. MX2016010998A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461945431P 2014-02-27 2014-02-27
PCT/US2015/017977 WO2015131035A1 (en) 2014-02-27 2015-02-27 Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma & related therapeutic methods

Publications (1)

Publication Number Publication Date
MX2016010998A true MX2016010998A (es) 2017-03-31

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MX2016010998A MX2016010998A (es) 2014-02-27 2015-02-27 Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados.

Country Status (9)

Country Link
US (1) US10532088B2 (es)
EP (1) EP3110429A4 (es)
JP (1) JP2017507950A (es)
CN (1) CN106132422A (es)
AU (1) AU2015222917A1 (es)
CA (1) CA2939305A1 (es)
IL (1) IL247457B (es)
MX (1) MX2016010998A (es)
WO (1) WO2015131035A1 (es)

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MX2016010998A (es) 2014-02-27 2017-03-31 Lycera Corp Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados.
JP6523337B2 (ja) 2014-05-05 2019-05-29 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物
US9896441B2 (en) 2014-05-05 2018-02-20 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
US20160136205A1 (en) * 2014-11-17 2016-05-19 The Board Of Regents Of The University Of Texas System Targeting type i nkt cells to control inflammation
CA2982847A1 (en) 2015-05-05 2016-11-10 Lycera Corporation Dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of ror.gamma. and the treatment of disease
HK1253734A1 (zh) 2015-06-11 2019-06-28 The Regents Of The University Of Michigan 用作RORγ激动剂和用於治疗疾病的芳基二氢-2H-苯并[B][1，4]恶嗪磺酰胺和相关化合物
CN120617525A (zh) * 2016-03-31 2025-09-12 江苏亚虹医药科技股份有限公司 硝羟喹啉和其类似物与化学疗法和免疫疗法在癌症治疗中的组合用途
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CN113480530A (zh) 2016-12-26 2021-10-08 阿里根公司 芳香烃受体调节剂
JP2021503498A (ja) 2017-11-20 2021-02-12 アリアジェン，インコーポレイテッド アリール炭化水素受容体（ａｈｒ）調節剤としてのインドール化合物
CN113906021A (zh) 2019-04-15 2022-01-07 阿里根公司 手性吲哚化合物及其用途
WO2020220562A1 (zh) * 2019-04-29 2020-11-05 上海和誉生物医药科技有限公司 苯并呋喃-6-甲酰胺衍生物、其制备方法和药学上的应用
WO2021261635A1 (ko) * 2020-06-26 2021-12-30 대한민국(농림축산식품부 농림축산검역본부장) 신규 면역증강제 및 이를 포함하는 백신 조성물
CN114426466B (zh) * 2020-10-29 2023-11-21 江苏和成新材料有限公司 一种醇羟基供体与活性氢供体进行光延反应的方法
WO2023016528A1 (zh) * 2021-08-13 2023-02-16 南京明德新药研发有限公司 一类苯并吗啉类化合物及其制备方法和用途
WO2023016530A1 (zh) * 2021-08-13 2023-02-16 南京明德新药研发有限公司 一类3,4-二氢-2H-苯并[b][1,4]噁嗪类化合物及其制备方法
WO2023016527A1 (zh) * 2021-08-13 2023-02-16 南京明德新药研发有限公司 一类苯并噁嗪螺环类化合物及其制备方法
JP2026507104A (ja) 2023-03-01 2026-02-27 ソルベンタム インテレクチュアル プロパティズ カンパニー セラミックベニア及びセラミックベニアを作製する連続付加製造

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