CO2018003477A2 - Anticuerpos anti-pd1 y métodos de uso - Google Patents

Anticuerpos anti-pd1 y métodos de uso

Info

Publication number
CO2018003477A2
CO2018003477A2 CONC2018/0003477A CO2018003477A CO2018003477A2 CO 2018003477 A2 CO2018003477 A2 CO 2018003477A2 CO 2018003477 A CO2018003477 A CO 2018003477A CO 2018003477 A2 CO2018003477 A2 CO 2018003477A2
Authority
CO
Colombia
Prior art keywords
antibodies
methods
cells
human
preparation
Prior art date
Application number
CONC2018/0003477A
Other languages
English (en)
Inventor
Guy Georges
Stefan Seeber
Christian Klein
Joerg Benz
Stefan Dengl
Jens Fischer
Barbara Weiser
Ildiko Wuensche
Valeria Lifke
Oliver Ploettner
Viktor Levitski
Adrian Zwick
Deak Laura Codarri
Sebastian Fenn
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO2018003477A2 publication Critical patent/CO2018003477A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La presente invención se refiere a anticuerpos anti-PD1, a su preparación y a formulaciones farmacéuticas. Los anticuerpos se unen a PD1 humano y potencian la secreción de citocinas por células T alogénicas estimuladas.”
CONC2018/0003477A 2015-10-02 2018-03-28 Anticuerpos anti-pd1 y métodos de uso CO2018003477A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15188061 2015-10-02
PCT/EP2016/073248 WO2017055443A1 (en) 2015-10-02 2016-09-29 Anti-pd1 antibodies and methods of use

Publications (1)

Publication Number Publication Date
CO2018003477A2 true CO2018003477A2 (es) 2018-06-20

Family

ID=54252164

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0003477A CO2018003477A2 (es) 2015-10-02 2018-03-28 Anticuerpos anti-pd1 y métodos de uso

Country Status (33)

Country Link
US (4) US20170247454A1 (es)
EP (1) EP3356404B1 (es)
JP (1) JP6654694B2 (es)
KR (1) KR102072317B1 (es)
CN (1) CN108368173B (es)
AR (1) AR106232A1 (es)
AU (1) AU2016329251B2 (es)
BR (1) BR112018005164A2 (es)
CA (1) CA2997799A1 (es)
CL (1) CL2018000595A1 (es)
CO (1) CO2018003477A2 (es)
CR (1) CR20180151A (es)
DK (1) DK3356404T3 (es)
ES (1) ES2895034T3 (es)
HK (1) HK1259019A1 (es)
HR (1) HRP20211594T1 (es)
HU (1) HUE056033T2 (es)
IL (1) IL257858B (es)
LT (1) LT3356404T (es)
MA (1) MA43018B1 (es)
MX (1) MX2018003629A (es)
MY (1) MY190297A (es)
NZ (1) NZ741129A (es)
PE (1) PE20181092A1 (es)
PH (1) PH12018500711A1 (es)
PL (1) PL3356404T3 (es)
PT (1) PT3356404T (es)
RS (1) RS62450B1 (es)
RU (1) RU2746409C1 (es)
SI (1) SI3356404T1 (es)
TW (1) TWI625336B (es)
UA (1) UA123826C2 (es)
WO (1) WO2017055443A1 (es)

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