HRP20211594T1 - Anti-pd1 protutijela i načini uporabe - Google Patents
Anti-pd1 protutijela i načini uporabe Download PDFInfo
- Publication number
- HRP20211594T1 HRP20211594T1 HRP20211594TT HRP20211594T HRP20211594T1 HR P20211594 T1 HRP20211594 T1 HR P20211594T1 HR P20211594T T HRP20211594T T HR P20211594TT HR P20211594 T HRP20211594 T HR P20211594T HR P20211594 T1 HRP20211594 T1 HR P20211594T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- sequence
- antibody
- binds
- human
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 3
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 5
- 102000048362 human PDCD1 Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Claims (13)
1. Izolirano protutijelo koje se veže na humani PD1, naznačeno time, da protutijelo
i) sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 58, ili
ii) sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 59, ili
iii) sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 60, ili
iv) sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 61.
2. Izolirano protutijelo koje se veže na humani PD1, naznačeno time, da protutijelo sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 58.
3. Izolirano protutijelo koje se veže na humani PD1, naznačeno time, da protutijelo sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 59.
4. Izolirano protutijelo koje se veže na humani PD1, naznačeno time, da protutijelo sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 60.
5. Izolirano protutijelo koje se veže na humani PD1, naznačeno time, da protutijelo sadrži VH slijed SEQ ID NO: 57 i VL slijed SEQ ID NO: 61.
6. Protutijelo prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time, da je IgG1 protutijelo cijele dužine s mutacijama L234A, L235A i P329G prema shemi za numeriranje prema EU indeksu.
7. Izolirana nukleinska kiselina, naznačena time, da kodira protutijelo prema bilo kojem od prethodnih patentnih zahtjeva.
8. Stanica domaćina, naznačena time, da sadrži nukleinsku kiselinu prema patentnom zahtjevu 7.
9. Postupak za proizvodnju protutijela, naznačen time, da obuhvaća uzgoj stanice domaćina prema patentnom zahtjevu 8 tako da se proizvede protutijelo.
10. Postupak prema patentnom zahtjevu 9, naznačen time, da se nadalje obuhvaća izdvajanje protutijela iz stanice domaćina.
11. Farmaceutska formulacija, naznačena time, da sadrži protutijelo prema bilo kojem od patentnih zahtjeva 1 do 6 i farmaceutski prihvatljivi nosač.
12. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 6, naznačeno time, da je za uporabu kao lijek.
13. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 6, naznačeno time, da je za uporabu u liječenju raka.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15188061 | 2015-10-02 | ||
| EP16774499.4A EP3356404B1 (en) | 2015-10-02 | 2016-09-29 | Anti-pd1 antibodies and methods of use |
| PCT/EP2016/073248 WO2017055443A1 (en) | 2015-10-02 | 2016-09-29 | Anti-pd1 antibodies and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211594T1 true HRP20211594T1 (hr) | 2022-01-21 |
Family
ID=54252164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211594TT HRP20211594T1 (hr) | 2015-10-02 | 2016-09-29 | Anti-pd1 protutijela i načini uporabe |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US20170247454A1 (hr) |
| EP (1) | EP3356404B1 (hr) |
| JP (1) | JP6654694B2 (hr) |
| KR (1) | KR102072317B1 (hr) |
| CN (1) | CN108368173B (hr) |
| AR (1) | AR106232A1 (hr) |
| AU (1) | AU2016329251B2 (hr) |
| BR (1) | BR112018005164A2 (hr) |
| CA (1) | CA2997799A1 (hr) |
| CL (1) | CL2018000595A1 (hr) |
| CO (1) | CO2018003477A2 (hr) |
| CR (1) | CR20180151A (hr) |
| DK (1) | DK3356404T3 (hr) |
| ES (1) | ES2895034T3 (hr) |
| HK (1) | HK1259019A1 (hr) |
| HR (1) | HRP20211594T1 (hr) |
| HU (1) | HUE056033T2 (hr) |
| IL (1) | IL257858B (hr) |
| LT (1) | LT3356404T (hr) |
| MA (1) | MA43018B1 (hr) |
| MX (1) | MX2018003629A (hr) |
| MY (1) | MY190297A (hr) |
| NZ (1) | NZ741129A (hr) |
| PE (1) | PE20181092A1 (hr) |
| PH (1) | PH12018500711A1 (hr) |
| PL (1) | PL3356404T3 (hr) |
| PT (1) | PT3356404T (hr) |
| RS (1) | RS62450B1 (hr) |
| RU (1) | RU2746409C1 (hr) |
| SI (1) | SI3356404T1 (hr) |
| TW (1) | TWI625336B (hr) |
| UA (1) | UA123826C2 (hr) |
| WO (1) | WO2017055443A1 (hr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102610592B1 (ko) | 2015-03-30 | 2023-12-07 | 주식회사 에스티큐브 | 당화 pd-l1에 특이적인 항체 및 그의 사용 방법 |
| US11933786B2 (en) | 2015-03-30 | 2024-03-19 | Stcube, Inc. | Antibodies specific to glycosylated PD-L1 and methods of use thereof |
| BR112018000768A2 (pt) | 2015-07-13 | 2018-09-25 | Cytomx Therapeutics Inc | anticorpos anti-pd-1, anticorpos anti-pd-1 ativáveis e métodos de uso dos mesmos |
| CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
| AU2016332725A1 (en) | 2015-09-29 | 2018-03-22 | Celgene Corporation | PD-1 binding proteins and methods of use thereof |
| SG10202008325XA (en) | 2015-10-02 | 2020-09-29 | Hoffmann La Roche | Bispecific antibodies specific for pd1 and tim3 |
| MA43186B1 (fr) | 2015-11-03 | 2022-03-31 | Janssen Biotech Inc | Anticorps se liant spécifiquement à pd-1 et leurs utilisations |
| JO3744B1 (ar) | 2015-11-18 | 2021-01-31 | Merck Sharp & Dohme | مواد ربط لـpd1 و/ أو lag3 |
| JP7003036B2 (ja) * | 2015-12-02 | 2022-02-04 | エスティーキューブ，インコーポレイテッド | グリコシル化ｐｄ－１に対して特異的な抗体およびその使用方法 |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| EP3436481B1 (en) | 2016-03-29 | 2021-06-30 | Stcube, Inc. | Dual function antibodies specific to glycosylated pd-l1 and methods of use thereof |
| DK3476865T3 (da) | 2016-06-28 | 2023-12-18 | Biocytogen Pharmaceuticals Beijing Co Ltd | Fremgangsmåde til konstruktion af pd-1-gen-modificeret humaniseret dyremodel og anvendelse deraf |
| US11746152B2 (en) | 2016-07-20 | 2023-09-05 | Stcube, Inc. | Methods of cancer treatment and therapy using a combination of antibodies that bind glycosylated PD-L1 |
| KR102391338B1 (ko) | 2016-09-16 | 2022-04-26 | 상하이 헨리우스 바이오테크, 인크. | 항-pd-1 항체 |
| JP2019534859A (ja) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Ｐｄ−１結合タンパク質を使用して白斑を治療する方法 |
| EP3515944A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING IMMUNE DISORDERS WITH PD-1 BINDING PROTEINS |
| CN117003887A (zh) * | 2017-04-03 | 2023-11-07 | 豪夫迈·罗氏有限公司 | 抗pd-1抗体与突变体il-2或与il-15的免疫缀合物 |
| BR112019019821A2 (pt) * | 2017-04-05 | 2020-04-22 | Hoffmann La Roche | anticorpo biespecífico, polinucleotídeo, célula hospedeira procariótica ou eucariótica, métodos de produção do anticorpo biespecífico, de tratamento de um indivíduo que tem câncer ou uma infecção viral crônica e de inibição do crescimento de células de tumor, composição farmacêutica e uso do anticorpo biespecífico |
| US11492403B2 (en) | 2017-04-20 | 2022-11-08 | Dana-Farber Cancer Institute, Inc. | Anti-phosphotyrosinylated programmed death 1 (PD-1) monoclonal antibodies, methods of making and methods of using thereof |
| SI3661954T1 (sl) | 2017-08-03 | 2022-05-31 | Amgen Inc. | Muteini interlevkina-21 in postopki zdravljenja |
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| WO2019094265A1 (en) * | 2017-11-10 | 2019-05-16 | Armo Biosciences, Inc. | Pd1 polypeptide binding molecules |
| BR112020014121A2 (pt) | 2018-01-12 | 2020-12-01 | Amgen Inc. | anticorpos anti-pd-1 e métodos de tratamento |
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| JP7469305B2 (ja) | 2018-11-19 | 2024-04-16 | バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド | 抗ｐｄ－１抗体およびその使用 |
| KR20220041079A (ko) | 2019-06-18 | 2022-03-31 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(hbv) 백신 및 항-pd-1 항체의 조합 |
| WO2020255011A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody |
| TWI809286B (zh) | 2019-07-05 | 2023-07-21 | 日商小野藥品工業股份有限公司 | 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療 |
| EP4011918A4 (en) | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
| CN115485028A (zh) | 2020-04-15 | 2022-12-16 | 豪夫迈·罗氏有限公司 | 免疫缀合物 |
| EP4147052A1 (en) | 2020-05-05 | 2023-03-15 | F. Hoffmann-La Roche AG | Predicting response to pd-1 axis inhibitors |
| AU2022231874A1 (en) | 2021-03-09 | 2023-07-27 | F. Hoffmann-La Roche Ag | Combination therapy of pd-1-targeted il-2 variant immunoconjugates and fap/4-1bb binding molecules |
| JP2024512382A (ja) | 2021-03-09 | 2024-03-19 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｐｄ－１標的化ｉｌ－２バリアント免疫コンジュゲートと抗ｔｙｒｐ１／抗ｃｄ３二重特異性抗体の併用療法 |
| CN117794953A (zh) | 2021-08-03 | 2024-03-29 | 豪夫迈·罗氏有限公司 | 双特异性抗体及使用方法 |
| CA3234731A1 (en) | 2021-10-14 | 2023-04-20 | F. Hoffmann-La Roche Ag | New interleukin-7 immunoconjugates |
| WO2023062048A1 (en) | 2021-10-14 | 2023-04-20 | F. Hoffmann-La Roche Ag | Alternative pd1-il7v immunoconjugates for the treatment of cancer |
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