MX2019005821A - Proteínas de unión a antígenos anti-gitr y métodos de uso de las mismas. - Google Patents

Proteínas de unión a antígenos anti-gitr y métodos de uso de las mismas.

Info

Publication number
MX2019005821A
MX2019005821A MX2019005821A MX2019005821A MX2019005821A MX 2019005821 A MX2019005821 A MX 2019005821A MX 2019005821 A MX2019005821 A MX 2019005821A MX 2019005821 A MX2019005821 A MX 2019005821A MX 2019005821 A MX2019005821 A MX 2019005821A
Authority
MX
Mexico
Prior art keywords
methods
binding proteins
gitr antigen
abps
gitr
Prior art date
Application number
MX2019005821A
Other languages
English (en)
Inventor
Winston William
Seidel-Dugan Cynthia
Hicklin Daniel
Andres Salmeron-Garcia Jose-
Brodkin Heather
Kleffel Sonja
P Nielson Nels
Original Assignee
Potenza Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Potenza Therapeutics Inc filed Critical Potenza Therapeutics Inc
Publication of MX2019005821A publication Critical patent/MX2019005821A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Se proporcionan en la presente memoria proteinas de union a antigenos (ABPs) que se unen selectivamente a GITR y sus isoformas y homologos, y composiciones que comprenden las ABP. Tambien se proporcionan metodos para utilizar las ABP, tal como metodos terapeuticos y de diagnostico.
MX2019005821A 2016-11-19 2017-11-19 Proteínas de unión a antígenos anti-gitr y métodos de uso de las mismas. MX2019005821A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662497428P 2016-11-19 2016-11-19
US201762448644P 2017-01-20 2017-01-20
PCT/US2017/062443 WO2018094300A1 (en) 2016-11-19 2017-11-19 Anti-gitr antigen-binding proteins and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2019005821A true MX2019005821A (es) 2019-10-07

Family

ID=62146165

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019005821A MX2019005821A (es) 2016-11-19 2017-11-19 Proteínas de unión a antígenos anti-gitr y métodos de uso de las mismas.

Country Status (17)

Country Link
US (2) US10988545B2 (es)
EP (1) EP3541845A1 (es)
JP (1) JP2019537449A (es)
KR (1) KR102574071B1 (es)
CN (1) CN110248960A (es)
AU (1) AU2017362721A1 (es)
BR (1) BR112019010128A2 (es)
CO (1) CO2019006424A2 (es)
IL (1) IL266720A (es)
JO (1) JOP20190100A1 (es)
MA (1) MA46844A (es)
MX (1) MX2019005821A (es)
PH (1) PH12019501108A1 (es)
TW (1) TWI783953B (es)
UA (1) UA126389C2 (es)
WO (1) WO2018094300A1 (es)
ZA (1) ZA201902939B (es)

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KR102239781B1 (ko) * 2019-04-08 2021-04-13 주식회사 녹십자 Gpnmb 및 cd3에 특이적으로 결합하는 이중특이적 항체 및 이의 용도
US10994021B1 (en) * 2020-04-11 2021-05-04 Bliss Biopharmaceutical (Hangzhou) Co., Ltd. Tetravalent antibody-drug conjugates and use thereof
CA3180541A1 (en) 2020-06-08 2021-12-16 George Ueda Antibody-bound nanoparticles
WO2022240161A1 (ko) * 2021-05-10 2022-11-17 메디맵바이오 주식회사 항-gitr 항체 및 이의 용도
WO2023094507A1 (en) * 2021-11-24 2023-06-01 Formycon Ag Improved ace2 fusion proteins
WO2023175614A1 (en) 2022-03-15 2023-09-21 Yeda Research And Development Co. Ltd. Anti glucocorticoid-induced tnfr-related (gitr) protein antibodies and uses thereof

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Also Published As

Publication number Publication date
ZA201902939B (en) 2022-08-31
TWI783953B (zh) 2022-11-21
CN110248960A (zh) 2019-09-17
WO2018094300A8 (en) 2019-05-02
US10988545B2 (en) 2021-04-27
WO2018094300A1 (en) 2018-05-24
JP2019537449A (ja) 2019-12-26
TW201819416A (zh) 2018-06-01
RU2019118800A (ru) 2020-12-21
EP3541845A1 (en) 2019-09-25
KR20190095298A (ko) 2019-08-14
KR102574071B1 (ko) 2023-09-06
PH12019501108A1 (en) 2019-07-29
UA126389C2 (uk) 2022-09-28
AU2017362721A1 (en) 2019-05-23
JOP20190100A1 (ar) 2019-05-01
CO2019006424A2 (es) 2019-08-20
IL266720A (en) 2019-07-31
MA46844A (fr) 2019-09-25
US20180208665A1 (en) 2018-07-26
BR112019010128A2 (pt) 2019-10-08
US20210269542A1 (en) 2021-09-02
RU2019118800A3 (es) 2021-03-23

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