MX2021007692A - Proteinas de union anti-pd-1 y metodos de uso de las mismas. - Google Patents

Proteinas de union anti-pd-1 y metodos de uso de las mismas.

Info

Publication number
MX2021007692A
MX2021007692A MX2021007692A MX2021007692A MX2021007692A MX 2021007692 A MX2021007692 A MX 2021007692A MX 2021007692 A MX2021007692 A MX 2021007692A MX 2021007692 A MX2021007692 A MX 2021007692A MX 2021007692 A MX2021007692 A MX 2021007692A
Authority
MX
Mexico
Prior art keywords
methods
binding proteins
abps
homologs
isoforms
Prior art date
Application number
MX2021007692A
Other languages
English (en)
Inventor
David Scott Johnson
Adam Shultz Adler
Rena Aviva Mizrahi
Yoong Wearn Lim
Michael Asensio
Original Assignee
Gigagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gigagen Inc filed Critical Gigagen Inc
Publication of MX2021007692A publication Critical patent/MX2021007692A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Se proporcionan en la presente proteínas de unión a antígeno (ABP) que se unen específicamente a PD-1 y sus isoformas y homólogos, y composiciones que comprenden las ABP. También se proporcionan métodos para utilizar las ABP, tal como métodos terapéuticos y de diagnóstico.
MX2021007692A 2018-12-27 2019-12-27 Proteinas de union anti-pd-1 y metodos de uso de las mismas. MX2021007692A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862785660P 2018-12-27 2018-12-27
PCT/US2019/068824 WO2020140088A1 (en) 2018-12-27 2019-12-27 Anti-pd-1 binding proteins and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2021007692A true MX2021007692A (es) 2021-09-30

Family

ID=71127358

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021007692A MX2021007692A (es) 2018-12-27 2019-12-27 Proteinas de union anti-pd-1 y metodos de uso de las mismas.

Country Status (12)

Country Link
US (1) US20220064302A1 (es)
EP (1) EP3902822A4 (es)
JP (1) JP2022516073A (es)
KR (1) KR20210121046A (es)
CN (1) CN113544146A (es)
AU (1) AU2019414968A1 (es)
BR (1) BR112021012667A2 (es)
CA (1) CA3124971A1 (es)
IL (1) IL284157A (es)
MX (1) MX2021007692A (es)
SG (1) SG11202106765XA (es)
WO (1) WO2020140088A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202106768RA (en) * 2018-12-27 2021-07-29 Gigagen Inc Anti-pd-l1 binding proteins and methods of use thereof
WO2022115343A1 (en) * 2020-11-30 2022-06-02 Merck Sharp & Dohme Corp. Arginase 1 binders for inhibiting arginase 1 activity
KR20240004286A (ko) * 2021-04-26 2024-01-11 밀레니엄 파머슈티컬스 인코퍼레이티드 항 Clec12A 항체 및 이의 용도
CA3221903A1 (en) * 2021-06-11 2022-12-15 Scott W. Lowe Anti-upar antibodies and uses thereof
CA3230628A1 (en) * 2021-09-02 2023-03-09 John T. POIRIER Anti-dll3 antibodies and uses thereof
WO2024050371A1 (en) * 2022-08-29 2024-03-07 Fred Hutchinson Cancer Center Antibodies with novel fc modification combinations that increase antibody function

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2439273T (lt) * 2005-05-09 2019-05-10 Ono Pharmaceutical Co., Ltd. Žmogaus monokloniniai antikūnai prieš programuotos mirties 1(pd-1) baltymą, ir vėžio gydymo būdai, naudojant vien tik anti-pd-1 antikūnus arba derinyje su kitais imunoterapiniais vaistais
TWI681969B (zh) * 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
WO2017024515A1 (en) * 2015-08-11 2017-02-16 Wuxi Biologics (Cayman) Inc. Novel anti-pd-1 antibodies
CN106939047B (zh) * 2016-01-04 2021-08-31 江苏怀瑜药业有限公司 一种pd-l1抗体及其制备方法
WO2017124050A1 (en) * 2016-01-14 2017-07-20 Bps Bioscience, Inc. Anti-pd-1 antibodies and uses thereof
CN105754990A (zh) * 2016-01-29 2016-07-13 深圳精准医疗科技有限公司 一种pd-1/ctla-4双特异性抗体的制备方法及其应用

Also Published As

Publication number Publication date
JP2022516073A (ja) 2022-02-24
CA3124971A1 (en) 2020-07-02
SG11202106765XA (en) 2021-07-29
KR20210121046A (ko) 2021-10-07
CN113544146A (zh) 2021-10-22
US20220064302A1 (en) 2022-03-03
IL284157A (en) 2021-08-31
BR112021012667A2 (pt) 2022-01-11
WO2020140088A1 (en) 2020-07-02
EP3902822A1 (en) 2021-11-03
AU2019414968A1 (en) 2021-08-12
EP3902822A4 (en) 2022-12-28

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