JP2015511599A5 - - Google Patents

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Publication number
JP2015511599A5
JP2015511599A5 JP2014561543A JP2014561543A JP2015511599A5 JP 2015511599 A5 JP2015511599 A5 JP 2015511599A5 JP 2014561543 A JP2014561543 A JP 2014561543A JP 2014561543 A JP2014561543 A JP 2014561543A JP 2015511599 A5 JP2015511599 A5 JP 2015511599A5
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JP
Japan
Prior art keywords
pharmaceutical composition
seq
polypeptide
soluble
composition according
Prior art date
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Application number
JP2014561543A
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English (en)
Japanese (ja)
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JP2015511599A (ja
JP6200437B2 (ja
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Priority claimed from PCT/IB2013/001179 external-priority patent/WO2013136193A2/en
Publication of JP2015511599A publication Critical patent/JP2015511599A/ja
Publication of JP2015511599A5 publication Critical patent/JP2015511599A5/ja
Application granted granted Critical
Publication of JP6200437B2 publication Critical patent/JP6200437B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2014561543A 2012-03-16 2013-03-14 Toso活性を調節するための方法および組成物 Expired - Fee Related JP6200437B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261612183P 2012-03-16 2012-03-16
US61/612,183 2012-03-16
US201261646143P 2012-05-11 2012-05-11
US61/646,143 2012-05-11
US201261731428P 2012-11-29 2012-11-29
US61/731,428 2012-11-29
PCT/IB2013/001179 WO2013136193A2 (en) 2012-03-16 2013-03-14 Methods and compositions for modulating toso activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017162409A Division JP6462800B2 (ja) 2012-03-16 2017-08-25 Toso活性を調節するための方法および組成物

Publications (3)

Publication Number Publication Date
JP2015511599A JP2015511599A (ja) 2015-04-20
JP2015511599A5 true JP2015511599A5 (enExample) 2016-04-21
JP6200437B2 JP6200437B2 (ja) 2017-09-20

Family

ID=48747619

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014561543A Expired - Fee Related JP6200437B2 (ja) 2012-03-16 2013-03-14 Toso活性を調節するための方法および組成物
JP2017162409A Expired - Fee Related JP6462800B2 (ja) 2012-03-16 2017-08-25 Toso活性を調節するための方法および組成物
JP2018244907A Expired - Fee Related JP6744391B2 (ja) 2012-03-16 2018-12-27 Toso活性を調節するための方法および組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017162409A Expired - Fee Related JP6462800B2 (ja) 2012-03-16 2017-08-25 Toso活性を調節するための方法および組成物
JP2018244907A Expired - Fee Related JP6744391B2 (ja) 2012-03-16 2018-12-27 Toso活性を調節するための方法および組成物

Country Status (9)

Country Link
US (5) US9228006B2 (enExample)
EP (2) EP2825191B1 (enExample)
JP (3) JP6200437B2 (enExample)
KR (1) KR102143887B1 (enExample)
CN (1) CN104394880B (enExample)
AU (3) AU2013234046B2 (enExample)
CA (1) CA2867444C (enExample)
IL (1) IL234683B (enExample)
WO (1) WO2013136193A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2825191B1 (en) 2012-03-16 2019-08-28 University Health Network Soluble toso protein and its use in treating autoimmune disorders
CA2917077A1 (en) 2013-07-03 2015-01-08 University Health Network Antibodies to toso
SI3094353T1 (sl) 2014-01-15 2020-07-31 Medimmune, Llc RSY-specifična protitelesa in njihovi funkcionalni deli
US20150252434A1 (en) * 2014-03-07 2015-09-10 University Health Network Methods and compositions for detection of targets involved in cancer metastasis
EP3009841A1 (en) * 2014-10-14 2016-04-20 Bernhard-Nocht-Institut für Tropenmedizin Detection of IgM Antibodies using an immune complex (IC) ELISA
JP6738831B2 (ja) * 2015-05-04 2020-08-12 アポジェニックス アーゲー 単鎖cd40受容体アゴニストタンパク質
EP3098237B1 (en) 2015-05-28 2018-08-01 Universität Zu Köln Anti-toso chimeric antigen receptor and its use
JP7631203B2 (ja) 2019-01-18 2025-02-18 ユニバーシティ ヘルス ネットワーク Lilrb3結合分子とその使用
US12286476B2 (en) * 2019-02-15 2025-04-29 University Health Network FCMR-binding molecules and uses thereof

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
WO1986005803A1 (fr) 1985-03-30 1986-10-09 Marc Ballivet Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
EP0272253A4 (en) 1986-03-07 1990-02-05 Massachusetts Inst Technology METHOD FOR IMPROVING GLYCOPROTE INSTABILITY.
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
EP0832981A1 (en) 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ATE148348T1 (de) 1989-09-15 1997-02-15 Tanox Biosystems Inc Behandlung von einer autoimmun-krankheit
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5686073A (en) 1990-05-23 1997-11-11 The University Of Iowa Research Foundation Polyclonal and monoclonal antibodies against a 43 KDA dystrophin associated protein
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
US6797492B2 (en) 1991-05-17 2004-09-28 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
WO1993006126A1 (en) 1991-09-13 1993-04-01 Chiron Corporation Immunoreactive hepatitis c virus polypeptide compositions
EP0641353A4 (en) * 1991-11-18 1997-07-02 Tanox Biosystems Inc ANTISENSE OLIGONUCLEOTIDES FOR ISOTYPE-SPECIFIC SUPPRESSION OF IMMUNOGLOBULIN PRODUCTION.
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
DE69233204T2 (de) 1991-12-13 2004-07-15 Xoma Corp., Berkeley Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
US5455338A (en) 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US6709659B1 (en) 1996-08-02 2004-03-23 Zymogenetics, Inc. Antibodies that bind testis-specific insulin homolog polypeptides
US6727350B2 (en) * 1997-11-17 2004-04-27 The Board Of Trustees Of The Leland Stanford Junior University Toso
US6555314B1 (en) * 1998-03-30 2003-04-29 Rigel Pharmaceuticals, Inc. Toso as a target for drug screening
JP4334141B2 (ja) 1998-04-20 2009-09-30 グリカート バイオテクノロジー アクチェンゲゼルシャフト 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
US6683168B1 (en) 1998-04-21 2004-01-27 Boston Medical Center Corporation Genes and methods that modulate apoptosis
US6322788B1 (en) 1998-08-20 2001-11-27 Stanley Arthur Kim Anti-bacterial antibodies and methods of use
JP2002530081A (ja) 1998-11-18 2002-09-17 ジェネンテック・インコーポレーテッド 親抗体より高度な結合親和性を持つ抗体変異体
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
CA2369292C (en) 1999-04-09 2010-09-21 Kyowa Hakko Kogyo Co. Ltd. Method of modulating the activity of functional immune molecules
JP2002541195A (ja) * 1999-04-14 2002-12-03 アメリカ合衆国 移植片に対する免疫寛容を誘導するための、免疫毒素および樹状細胞の成熟を阻害する作用剤を含有する組成物
US6939545B2 (en) 1999-04-28 2005-09-06 Genetics Institute, Llc Composition and method for treating inflammatory disorders
WO2001029246A1 (fr) 1999-10-19 2001-04-26 Kyowa Hakko Kogyo Co., Ltd. Procede de production d'un polypeptide
US7074408B2 (en) 2000-02-25 2006-07-11 Immunex Corporation Use of integrin antagonists to inhibit angiogenesis
EP2298789B1 (en) 2000-09-08 2012-03-14 Schering Corporation Mammalian genes; related reagents and methods
AU2001294175A1 (en) 2000-10-06 2002-04-22 Kyowa Hakko Kogyo Co. Ltd. Method of purifying antibody
EA013563B1 (ru) 2000-10-06 2010-06-30 Киова Хакко Кирин Ко., Лтд. Трансгенное животное, продуцирующее антитела с измененными углеводными цепями, способ получения антител и содержащее антитела лекарственное средство
EP1391213A1 (en) 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP2322203A3 (en) * 2002-10-29 2011-07-27 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP1444989A1 (en) 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensitizing cells for apoptosis by selectively blocking cytokines
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
EP2298888A1 (en) 2004-12-30 2011-03-23 Agency for Science, Technology and Research Chinese hamster apoptosis-related genes
US7119179B1 (en) 2005-03-21 2006-10-10 Los Alamos National Security, Llc Preparation of high nitrogen compound and materials therefrom
CA2662752C (en) * 2006-09-08 2016-04-12 Ambrx, Inc. Site specific incorporation of non-natural amino acids by vertebrate cells
EP2170938B1 (en) * 2007-06-06 2012-04-18 Research Development Foundation Rtef-1 variants and the use thereof for inhibition of angiogenesis
SI2291657T1 (sl) 2008-05-01 2016-09-30 Zymogenetics, Inc. Nivoji blys/april heterotrimerjev v serumu in uporaba pri diagnostičnih postopkih
WO2011022334A1 (en) 2009-08-17 2011-02-24 The Penn State Research Foundation Use of nkg2d inhibitors for treating cardiovascular and metabolic diseases, such as type 2 diabetes
EP2825191B1 (en) * 2012-03-16 2019-08-28 University Health Network Soluble toso protein and its use in treating autoimmune disorders
US11392902B2 (en) 2017-06-06 2022-07-19 United Parcel Service Of America, Inc. Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery

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