JP2016518823A5 - - Google Patents
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- JP2016518823A5 JP2016518823A5 JP2016502985A JP2016502985A JP2016518823A5 JP 2016518823 A5 JP2016518823 A5 JP 2016518823A5 JP 2016502985 A JP2016502985 A JP 2016502985A JP 2016502985 A JP2016502985 A JP 2016502985A JP 2016518823 A5 JP2016518823 A5 JP 2016518823A5
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- Prior art keywords
- fusion protein
- mutein
- cells
- disease
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- Prior art date
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- 108091006020 Fc-tagged proteins Proteins 0.000 claims 30
- 210000004027 cell Anatomy 0.000 claims 21
- 238000000034 method Methods 0.000 claims 15
- 210000005259 peripheral blood Anatomy 0.000 claims 13
- 239000011886 peripheral blood Substances 0.000 claims 13
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 12
- 108010002350 Interleukin-2 Proteins 0.000 claims 12
- 102000000588 Interleukin-2 Human genes 0.000 claims 12
- 210000003289 regulatory T cell Anatomy 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 8
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 6
- 230000000366 juvenile effect Effects 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 5
- 201000004681 Psoriasis Diseases 0.000 claims 5
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 5
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 5
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 5
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 4
- 206010047115 Vasculitis Diseases 0.000 claims 4
- 208000024908 graft versus host disease Diseases 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 4
- 208000002574 reactive arthritis Diseases 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 3
- 201000001981 dermatomyositis Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 206010000234 Abortion spontaneous Diseases 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
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- 208000012657 Atopic disease Diseases 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
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- 210000004962 mammalian cell Anatomy 0.000 claims 2
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- ZDTNHRWWURISAA-UHFFFAOYSA-N 4',5'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C(Br)=C1OC1=C(Br)C(O)=CC=C21 ZDTNHRWWURISAA-UHFFFAOYSA-N 0.000 claims 1
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000036487 Arthropathies Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 claims 1
- 206010065563 Eosinophilic bronchitis Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 208000012528 Juvenile dermatomyositis Diseases 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 206010030216 Oesophagitis Diseases 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 208000020410 Psoriasis-related juvenile idiopathic arthritis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010037575 Pustular psoriasis Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000019802 Sexually transmitted disease Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 201000010415 childhood type dermatomyositis Diseases 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 208000006881 esophagitis Diseases 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 201000004990 juvenile ankylosing spondylitis Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001185 psoriatic effect Effects 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784669P | 2013-03-14 | 2013-03-14 | |
| US61/784,669 | 2013-03-14 | ||
| PCT/US2014/029111 WO2014153111A2 (en) | 2013-03-14 | 2014-03-14 | Interleukin-2 muteins for the expansion of t-regulatory cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018228769A Division JP2019058182A (ja) | 2013-03-14 | 2018-12-06 | 制御性ｔ細胞の増殖のためのインターロイキン−２ムテイン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518823A JP2016518823A (ja) | 2016-06-30 |
| JP2016518823A5 true JP2016518823A5 (enExample) | 2017-04-20 |
| JP6450365B2 JP6450365B2 (ja) | 2019-01-09 |
Family
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Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
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| JP2016502985A Active JP6450365B2 (ja) | 2013-03-14 | 2014-03-14 | 制御性ｔ細胞の増殖のためのインターロイキン−２ムテイン |
| JP2016502936A Active JP6480409B2 (ja) | 2013-03-14 | 2014-03-14 | アグリコシル化Ｆｃ含有ポリペプチド |
| JP2018228769A Pending JP2019058182A (ja) | 2013-03-14 | 2018-12-06 | 制御性ｔ細胞の増殖のためのインターロイキン−２ムテイン |
| JP2020175778A Active JP7227951B2 (ja) | 2013-03-14 | 2020-10-20 | 制御性ｔ細胞の増殖のためのインターロイキン－２ムテイン |
| JP2023019024A Pending JP2023053148A (ja) | 2013-03-14 | 2023-02-10 | 制御性ｔ細胞の増殖のためのインターロイキン－２ムテイン |
| JP2025013617A Pending JP2025066162A (ja) | 2013-03-14 | 2025-01-30 | 制御性ｔ細胞の増殖のためのインターロイキン－２ムテイン |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502936A Active JP6480409B2 (ja) | 2013-03-14 | 2014-03-14 | アグリコシル化Ｆｃ含有ポリペプチド |
| JP2018228769A Pending JP2019058182A (ja) | 2013-03-14 | 2018-12-06 | 制御性ｔ細胞の増殖のためのインターロイキン−２ムテイン |
| JP2020175778A Active JP7227951B2 (ja) | 2013-03-14 | 2020-10-20 | 制御性ｔ細胞の増殖のためのインターロイキン－２ムテイン |
| JP2023019024A Pending JP2023053148A (ja) | 2013-03-14 | 2023-02-10 | 制御性ｔ細胞の増殖のためのインターロイキン－２ムテイン |
| JP2025013617A Pending JP2025066162A (ja) | 2013-03-14 | 2025-01-30 | 制御性ｔ細胞の増殖のためのインターロイキン－２ムテイン |
Country Status (40)
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