CR20200004A - Muteínas de interleucina-2 para la expansión de células t reguladoras (divisional 2015-557) - Google Patents

Muteínas de interleucina-2 para la expansión de células t reguladoras (divisional 2015-557)

Info

Publication number
CR20200004A
CR20200004A CR20200004A CR20200004A CR20200004A CR 20200004 A CR20200004 A CR 20200004A CR 20200004 A CR20200004 A CR 20200004A CR 20200004 A CR20200004 A CR 20200004A CR 20200004 A CR20200004 A CR 20200004A
Authority
CR
Costa Rica
Prior art keywords
muteins
regulatory cells
interleukin
expansion
molecules
Prior art date
Application number
CR20200004A
Other languages
English (en)
Inventor
Gunasekaran Kannan
Joshua T Pearson
Margaret Karow
Li Li
Marc A Gavin
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CR20200004A publication Critical patent/CR20200004A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se proporcionan muteínas de la IL-2 y moléculas de fusión Fc de muteína de la IL-2 que preferentemente se expanden y activan las células reguladoras T y son susceptibles a producción a gran escala. También se proporcionan en la presente moléculas de Fc de IgG1 humana que carecen de o con función efectora altamente reducida y alta estabilidad a pesar de la falta de glicosilación en N297. También, se proporcionan en la presente péptidos enlazadores que están glicosilados cuando se expresan en células de mamífero.
CR20200004A 2013-03-14 2014-03-14 Muteínas de interleucina-2 para la expansión de células t reguladoras (divisional 2015-557) CR20200004A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784669P 2013-03-14 2013-03-14
PCT/US2014/029111 WO2014153111A2 (en) 2013-03-14 2014-03-14 Interleukin-2 muteins for the expansion of t-regulatory cells

Publications (1)

Publication Number Publication Date
CR20200004A true CR20200004A (es) 2020-03-11

Family

ID=50680166

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20200004A CR20200004A (es) 2013-03-14 2014-03-14 Muteínas de interleucina-2 para la expansión de células t reguladoras (divisional 2015-557)
CR20150557A CR20150557A (es) 2013-03-14 2015-10-14 Muteínas de interleucina-2 para la expansión de células t reguladoras

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20150557A CR20150557A (es) 2013-03-14 2015-10-14 Muteínas de interleucina-2 para la expansión de células t reguladoras

Country Status (40)

Country Link
US (8) US9580486B2 (es)
EP (2) EP2970423B1 (es)
JP (5) JP6480409B2 (es)
KR (4) KR20220101009A (es)
CN (2) CN105143253B (es)
AP (1) AP2015008737A0 (es)
AR (1) AR095541A1 (es)
AU (2) AU2014236316B2 (es)
BR (1) BR112015022440B1 (es)
CA (3) CA2906708C (es)
CL (2) CL2015002669A1 (es)
CR (2) CR20200004A (es)
CY (2) CY1121767T1 (es)
DK (2) DK2970423T3 (es)
EA (2) EA032863B1 (es)
ES (2) ES2737598T3 (es)
HK (1) HK1220695A1 (es)
HR (2) HRP20190970T1 (es)
HU (2) HUE044321T2 (es)
IL (2) IL241349B (es)
JO (1) JO3796B1 (es)
LT (2) LT2970441T (es)
MA (2) MA38477B1 (es)
ME (2) ME03482B (es)
MX (2) MX366854B (es)
MY (2) MY202248A (es)
NZ (1) NZ751148A (es)
PE (1) PE20151763A1 (es)
PH (1) PH12015502051B1 (es)
PL (2) PL2970441T3 (es)
PT (2) PT2970441T (es)
RS (2) RS58854B1 (es)
SG (2) SG11201507420UA (es)
SI (2) SI2970423T1 (es)
TN (1) TN2015000416A1 (es)
TR (2) TR201908362T4 (es)
TW (3) TWI687435B (es)
UA (1) UA119140C2 (es)
UY (1) UY35454A (es)
WO (2) WO2014153063A1 (es)

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