HRP20191075T1 - Muteini interleukina-2 za ekspanziju t-regulatornih stanica - Google Patents
Muteini interleukina-2 za ekspanziju t-regulatornih stanica Download PDFInfo
- Publication number
- HRP20191075T1 HRP20191075T1 HRP20191075TT HRP20191075T HRP20191075T1 HR P20191075 T1 HRP20191075 T1 HR P20191075T1 HR P20191075T T HRP20191075T T HR P20191075TT HR P20191075 T HRP20191075 T HR P20191075T HR P20191075 T1 HRP20191075 T1 HR P20191075T1
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- Prior art keywords
- juvenile
- fusion protein
- disease
- arthritis
- mutein
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- 108010002350 Interleukin-2 Proteins 0.000 title claims 7
- 102000000588 Interleukin-2 Human genes 0.000 title claims 7
- 210000003289 regulatory T cell Anatomy 0.000 title claims 2
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 13
- 230000000366 juvenile effect Effects 0.000 claims 6
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010039710 Scleroderma Diseases 0.000 claims 3
- 206010047115 Vasculitis Diseases 0.000 claims 3
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 3
- 208000002574 reactive arthritis Diseases 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 206010003253 Arthritis enteropathic Diseases 0.000 claims 2
- 208000036487 Arthropathies Diseases 0.000 claims 2
- 208000012657 Atopic disease Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000012659 Joint disease Diseases 0.000 claims 2
- 208000033464 Reiter syndrome Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 201000001981 dermatomyositis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 206010014910 enthesopathy Diseases 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000009890 sinusitis Diseases 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 206010003267 Arthritis reactive Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 241000699800 Cricetinae Species 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010065563 Eosinophilic bronchitis Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 206010015278 Erythrodermic psoriasis Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 206010055690 Foetal death Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000012528 Juvenile dermatomyositis Diseases 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 208000037062 Polyps Diseases 0.000 claims 1
- 208000020410 Psoriasis-related juvenile idiopathic arthritis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010037575 Pustular psoriasis Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000006229 amino acid addition Effects 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 201000010415 childhood type dermatomyositis Diseases 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 206010018797 guttate psoriasis Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 102000055277 human IL2 Human genes 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000004990 juvenile ankylosing spondylitis Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 201000006292 polyarteritis nodosa Diseases 0.000 claims 1
- 208000012102 polyarticular juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
Claims (13)
1. Fc-fuzijski protein koji sadrži Fc i mutein humanog interleukina-2 (IL-2) koji sadrži V91K supstituciju i aminokiselinsku sekvencu najmanje 90% identičnu sa aminokiselinskom sekvencom navedenom u SEQ ID NO:1, pri čemu navedeni IL-2 mutein stimulira T regulatorne stanice.
2. Fc-fuzijski protein prema patentnom zahtjevu 1, naznačen time što Fc je Fc humanog IgG1 ili Fc humanog IgG1 koji sadrži jednu ili više mutacija koje mijenjaju efektornu funkciju navedenog Fc kao što je supstitucija na N297 i/ili supstitucija ili delecija C-terminalnog lizina navedenog Fc humanog IgG.
3. Fc-fuzijski protein prema patentnom zahtjevu 1 ili 2, naznačen time što linker povezuje dijelove Fc i mutein humanog IL-2 navedenog proteina kao što je GGGGS (SEQ ID NO: 5), GGNGT (SEQ ID NO:6) ili YGNGT (SEQ ID NO:7).
4. Fc-fuzijski protein prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time što mutein IL-2 dalje sadrži aminokiselinsku adiciju, supstituciju ili deleciju koja mijenja glikozilaciju navedenog Fc-fuzijskog proteina kada je eksprimiran u stanicama sisavaca.
5. Fc-fuzijski protein prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time što navedeni Fc-fuzijski protein sadrži Fc dimer dva muteina IL-2 ili jednog muteina IL-2.
6. Fc fuzijski protein prema patentnom zahtjevu 1, koji ima sekvencu prema SEQ ID NO:18.
7. Izolirana nukleinska kiselina koja kodira Fc-fuzijski protein prema patentnim zahtjevima 1 do 6.
8. Izolirana nukleinska kiselina prema patentnom zahtjevu 7, naznačena time što Fc je Fc humanog IgG1.
9. Ekspresijski vektor koji sadrži izoliranu nukleinsku kiselinu prema patentnom zahtjevu 7 ili patentnom zahtjevu 8, operativno vezan za promotor.
10. Stanica domaćin koja sadrži izoliranu nukleinsku kiselinu prema patentnom zahtjevu 7 ili patentnom zahtjevu 8 naznačena time što je navedena stanica domaćin prokariotska stanica kao što je E. coli ili eukariotska stanica kao što je stanica sisavca uključujući, ali bez ograničenja na staničnu liniju jajnika kineskog hrčka (CHO).
11. Postupak za pripremu Fc-fuzijskog proteina prema bilo kojem od patentnih zahtjeva 1 do 6 koji sadrži kultivaciju stanice domaćina prema patentnom zahtjevu 10 i sakupljanje Fc-fuzijskog proteina iz navedene kulture.
12. Mutein humanog IL-2 koji sadrži V91K supstituciju i aminokiselinsku sekvencu najmanje 90% identičnu s aminokiselinskom sekvencom navedenom u SEQ ID NO:1 ili Fc-fuzijski protein prema bilo kojem od patentnih zahtjeva 1 do 6 za upotrebu u in vivo postupku za liječenje subjekta sa inflamatornom ili autoimunom bolešću.
13. Mutein IL-2 prema patentnom zahtjevu 1 ili Fc-fuzijski protein prema bilo kojem od patentnih zahtjeva 1 do 6 za upotrebu prema patentnom zahtjevu 12, naznačen time što je bolest atopijska bolest, paraneoplastična autoimuna bolest, inflamacija hrskavice, artritis, reumatoidni artritis, juvenilni artritis, juvenilni reumatoidni artritis, pauciartikularni juvenilni reumatoidni artritis, poliartikularni juvenilni reumatoidni artritis, juvenilni reumatoidni artritis sa sistemskim početkom, juvenilni ankilozni spondilitis, juvenilni enteropatski artritis, juvenilni reaktivni artritis, juvenilni Reiterov sindrom, SEA sindrom (sindrom seronegativnosti, entezopatije, artropatije), juvenilni dermatomiozitis, juvenilni psorijatički artritis, juvenilna skleroderma, juvenilni sistemski lupus eritematozus, juvenilni vaskulitis, pauciartikularni reumatoidni artritis, poliartikularni reumatoidni artritis, reumatoidni artritis sa sistemskim početkom, ankilozni spondilitis, enteropatski artritis, reaktivni artritis, Reiterov sindrom, SEA sindrom (sindrom seronegativnosti, entezopatije, artropatije), dermatomiozitis, psorijatički artritis, skleroderma, vaskulitis, miolitis, polimiolitis, dermatomiolitis, poliarteritis nodoza, Wegenerov granulomatozis, arteritis, polimijalgija reumatika, sarkoidoza, skleroderma, primarna bilijarna skleroza, sklerotizujući holangitis, Sjogrenov sindrom, psorijaza, psorijaza sa plakovima, kapljična psorijaza, inverzna psorijaza, pustularna psorijaza, eritrodermna psorijaza, dermatitis, atopijski dermatitis, ateroskleroza, lupus, Stillova bolest, sistemski lupus eritematozus (SLE), mijastenija gravis, vaskulitis induciran hepatitisom C, dijabetes melitus tipa 1, multipla skleroza, spontani gubitak trudnoće, atopijske bolesti, ili inflamatorne bolesti crijeva, Crohnova bolest, ulcerozni kolitis, celijaklija, astma, COPD, rinosinusitis, rinosinusitis sa polipima, eozinofilni ezofagitis, eozinofilni bronhitis, Guillain-Barreova bolest, tiroiditis (npr., Gravesova bolest), Addisonova bolest, Raynaudov fenomen, autoimuni hepatitis, bolest transplanta protiv domaćina, odbacivanje transplanta ili oštećenje bubrega.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361784669P | 2013-03-14 | 2013-03-14 | |
EP14722463.8A EP2970423B1 (en) | 2013-03-14 | 2014-03-14 | Interleukin-2 muteins for the expansion of t-regulatory cells |
PCT/US2014/029111 WO2014153111A2 (en) | 2013-03-14 | 2014-03-14 | Interleukin-2 muteins for the expansion of t-regulatory cells |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20191075T1 true HRP20191075T1 (hr) | 2019-09-20 |
Family
ID=50680166
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190970TT HRP20190970T1 (hr) | 2013-03-14 | 2019-05-28 | Polipeptidi koji sadrže neglikozilirani fc |
HRP20191075TT HRP20191075T1 (hr) | 2013-03-14 | 2019-06-14 | Muteini interleukina-2 za ekspanziju t-regulatornih stanica |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190970TT HRP20190970T1 (hr) | 2013-03-14 | 2019-05-28 | Polipeptidi koji sadrže neglikozilirani fc |
Country Status (40)
Country | Link |
---|---|
US (7) | US9546203B2 (hr) |
EP (2) | EP2970441B1 (hr) |
JP (5) | JP6450365B2 (hr) |
KR (4) | KR102219124B1 (hr) |
CN (2) | CN105143253B (hr) |
AP (1) | AP2015008737A0 (hr) |
AR (1) | AR095541A1 (hr) |
AU (2) | AU2014236316B2 (hr) |
BR (1) | BR112015022440B1 (hr) |
CA (3) | CA3149348C (hr) |
CL (2) | CL2015002686A1 (hr) |
CR (2) | CR20200004A (hr) |
CY (2) | CY1121767T1 (hr) |
DK (2) | DK2970441T3 (hr) |
EA (2) | EA034326B1 (hr) |
ES (2) | ES2737598T3 (hr) |
HK (1) | HK1220695A1 (hr) |
HR (2) | HRP20190970T1 (hr) |
HU (2) | HUE044321T2 (hr) |
IL (2) | IL241349B (hr) |
JO (1) | JO3796B1 (hr) |
LT (2) | LT2970441T (hr) |
MA (2) | MA38477B1 (hr) |
ME (2) | ME03482B (hr) |
MX (2) | MX366854B (hr) |
MY (1) | MY172991A (hr) |
NZ (1) | NZ751148A (hr) |
PE (1) | PE20151763A1 (hr) |
PH (1) | PH12015502051B1 (hr) |
PL (2) | PL2970423T3 (hr) |
PT (2) | PT2970423T (hr) |
RS (2) | RS58854B1 (hr) |
SG (2) | SG11201507574VA (hr) |
SI (2) | SI2970441T1 (hr) |
TN (1) | TN2015000416A1 (hr) |
TR (2) | TR201910802T4 (hr) |
TW (3) | TWI687435B (hr) |
UA (1) | UA119140C2 (hr) |
UY (1) | UY35454A (hr) |
WO (2) | WO2014153111A2 (hr) |
Families Citing this family (91)
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EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
US20190202898A9 (en) * | 2012-04-03 | 2019-07-04 | Novelmed Therapeutics, Inc. | AGLYCOSYLATED ANTI-C3b ANTIBODIES AND USES THEREOF |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
CN104870474B (zh) * | 2012-10-04 | 2019-03-12 | 诺沃姆德治疗公司 | 用于治疗溶血性疾病的旁路途径特异性抗体 |
US9546203B2 (en) * | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
AP2015008732A0 (en) | 2013-03-15 | 2015-09-30 | Amgen Inc | Human pac1 antibodies |
SI2970422T1 (en) | 2013-03-15 | 2018-07-31 | F. Hoffmann-La Roche Ag | IL-22 polypeptides and IL-22-Fc fusion proteins and procedures for use |
AU2015215001B2 (en) | 2014-02-06 | 2019-08-15 | F. Hoffmann-La Roche Ag | Interleukin-2 fusion proteins and uses thereof |
SG11201700514SA (en) * | 2014-07-21 | 2017-02-27 | Delinia Inc | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
PL3482766T3 (pl) | 2014-08-11 | 2020-11-16 | Delinia, Inc. | Modyfikowane warianty il-2, które selektywnie aktywują limfocyty t regulatorowe do leczenia chorób autoimmunologicznych |
TW201620938A (zh) | 2014-09-15 | 2016-06-16 | 安美基公司 | 雙特異性抗cgrp受體/pac1受體抗原結合蛋白質及其用途 |
EP3233192B1 (en) * | 2014-12-15 | 2021-04-14 | Washington University | Compositions and methods for targeted cytokine delivery |
CA2982362A1 (en) * | 2015-04-10 | 2016-10-13 | Amgen Inc. | Interleukin-2 muteins for the expansion of t-regulatory cells |
MX2017012966A (es) | 2015-04-10 | 2018-06-06 | Amgen Inc | Muteinas de interleuquina 2 para la expansion de celulas t regulatorias. |
TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
MA43567A (fr) | 2015-12-15 | 2018-11-14 | Amgen Inc | Anticorps pacap et leurs utilisations |
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