HRP20201614T1 - Novi imunoadhezini ctla4-ig - Google Patents
Novi imunoadhezini ctla4-ig Download PDFInfo
- Publication number
- HRP20201614T1 HRP20201614T1 HRP20201614TT HRP20201614T HRP20201614T1 HR P20201614 T1 HRP20201614 T1 HR P20201614T1 HR P20201614T T HRP20201614T T HR P20201614TT HR P20201614 T HRP20201614 T HR P20201614T HR P20201614 T1 HRP20201614 T1 HR P20201614T1
- Authority
- HR
- Croatia
- Prior art keywords
- variant
- immunoadhesin
- substitutions
- ctla4
- combination
- Prior art date
Links
- 102220039558 rs193922749 Human genes 0.000 claims 14
- 102220590514 Non-homologous end-joining factor 1_L61E_mutation Human genes 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 8
- 102220627914 Peptidyl-prolyl cis-trans isomerase D_A29H_mutation Human genes 0.000 claims 7
- 102220438001 rs730881122 Human genes 0.000 claims 7
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 6
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
Claims (13)
1. Imunoadhezin, naznačen time što sadrži:
prvu domenu, koja sadrži CTLA4 sa SEQ ID NO:6 ili varijantu CTLA4 u usporedbi s SEQ ID NO: 6, gdje navedena varijanta CTLA4 sadrži najmanje jednu aminokiselinsku modifikaciju u nativnom CTLA4, gdje je navedena modifikacija zamjena na položaju T51 u CTLA4, gdje navedena varijanta osigurava pojačano vezanje na B7-1, B7-2, ili i B7-1 i B7-2; i
drugu domenu, koja sadrži varijantu Fc područja u polipeptidu Fc divljeg tipa, gdje navedena varijanta Fc koja sadrži zamjene aminokiselina u Fc području navedenog polipeptida Fc divljeg tipa od M428L i N434S, gdje se obrojčavanje provodi prema EU indeksu kao kod Kabata.
2. Imunoadhezin u skladu s patentnim zahtjevom 1, naznačen time što navedena varijanta CTLA4 sadrži aminokiselinsku modifikaciju, koju se bira iz skupine koju čine T51N, A29H, M53Y, L61E, te K93Q, gdje navedena varijanta osigurava pojačano vezanje na B7-1, B7-2 ili B7-1 i B7-2, te gdje navedena varijanta sadrži kombinaciju zamjena koje se bira iz skupine koju čine A29H/T51N, T51N/M53Y, A29H/T51N/L61E, T51N/L61E/K93Q, T51N/M53Y/L61E, A29H/T51N/L61E/K93Q, T51N/M53Y/L61E/K93Q, te A29H/T51N/M53Y/L61E/K93Q.
3. Imunoadhezin u skladu s patentnim zahtjevom 1, naznačen time što navedena varijanta osigurava pojačano vezanje na B7-1 i B7-2.
4. Imunoadhezin u skladu s patentnim zahtjevom 1, naznačen time što navedena varijanta sadrži kombinaciju zamjena A29H/T51N.
5. Imunoadhezin u skladu s patentnim zahtjevom 1, naznačen time što navedena varijanta sadrži kombinaciju zamjena T51N/M53Y.
6. Imunoadhezin u skladu s patentnim zahtjevom 1, naznačen time što navedena varijanta sadrži kombinaciju zamjena T51N/M53Y/L61E.
7. Imunoadhezin u skladu s patentnim zahtjevom 1, naznačen time što navedena varijanta sadrži kombinaciju zamjena T51N/L61E/K93Q.
8. Imunoadhezin u skladu s patentnim zahtjevom 1, naznačen time što navedena varijanta sadrži kombinaciju zamjena A29H/T51N/L61E/K93Q.
9. Imunoadhezin u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačen time što je namijenjen upotrebi u liječenju pacijenta s poremećajem povezan s imunošću.
10. Imunoadhezin u skladu s bilo kojim od patentnih zahtjeva 1 do 8, namijenjen upotrebi u skladu s patentnim zahtjevom 9, naznačen time što se navedeni poremećaj povezan s imunošću bira iz skupine koju čine Crohnova bolest, sistemni eritematozni lupus (SLE), lupozni nefritis, psorijatični artritis, psorijaza, reumatoidni artritis, ulcerozni kolitis, te odbacivanje presatka.
11. Nukleinska kiselina, naznačena time što kodira imunoadhezin u skladu s bilo kojim od patentnih zahtjeva 1 do 8.
12. Stanica domaćin, naznačena time što sadrži nukleinsku kiselinu u skladu s patentnim zahtjevom 11.
13. Postupak proizvodnje imunoadhezina, naznačen time što se sastoji u uzgoju stanice domaćina u skladu s patentnim zahtjevom 12 u uvjetima u kojima se proizvodi navedeni imunoadhezin.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30631110P | 2010-02-19 | 2010-02-19 | |
US33480610P | 2010-05-14 | 2010-05-14 | |
US41230910P | 2010-11-10 | 2010-11-10 | |
EP15198516.5A EP3053932B1 (en) | 2010-02-19 | 2011-02-22 | Novel ctla4-ig immunoadhesins |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201614T1 true HRP20201614T1 (hr) | 2020-12-11 |
Family
ID=44483626
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160938TT HRP20160938T1 (hr) | 2010-02-19 | 2016-07-25 | NOVI IMUNOADHEZINI CTLA4-Ig |
HRP20201614TT HRP20201614T1 (hr) | 2010-02-19 | 2020-10-08 | Novi imunoadhezini ctla4-ig |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160938TT HRP20160938T1 (hr) | 2010-02-19 | 2016-07-25 | NOVI IMUNOADHEZINI CTLA4-Ig |
Country Status (19)
Country | Link |
---|---|
US (7) | US8329867B2 (hr) |
EP (2) | EP2536745B1 (hr) |
JP (1) | JP5705242B2 (hr) |
KR (1) | KR101926663B1 (hr) |
CN (3) | CN106432473B (hr) |
AU (2) | AU2011217770B2 (hr) |
CA (1) | CA2790487C (hr) |
CY (2) | CY1118001T1 (hr) |
DK (2) | DK2536745T3 (hr) |
ES (2) | ES2826894T3 (hr) |
HR (2) | HRP20160938T1 (hr) |
HU (2) | HUE030100T2 (hr) |
LT (2) | LT3053932T (hr) |
PL (2) | PL2536745T3 (hr) |
PT (1) | PT3053932T (hr) |
RS (1) | RS61136B1 (hr) |
SI (2) | SI3053932T1 (hr) |
SM (1) | SMT201600289B (hr) |
WO (1) | WO2011103584A2 (hr) |
Families Citing this family (107)
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US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
CN101479381B (zh) | 2006-03-31 | 2015-04-29 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
US9096651B2 (en) | 2007-09-26 | 2015-08-04 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
CN103251948A (zh) | 2008-04-11 | 2013-08-21 | 中外制药株式会社 | 与多个分子的抗原反复结合的抗原结合分子 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
RS55460B1 (sr) | 2009-11-30 | 2017-04-28 | Janssen Biotech Inc | Mutirana fc antitela sa uklonjenom efektorskom funkcijom |
US10053513B2 (en) * | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
CN106432473B (zh) | 2010-02-19 | 2021-04-02 | Xencor公司 | 新颖ctla4-ig免疫粘附素 |
TW201134481A (en) | 2010-03-12 | 2011-10-16 | Abbott Biotherapeutics Corp | CTLA4 proteins and their uses |
TWI667257B (zh) * | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
CN107973851A (zh) | 2010-11-30 | 2018-05-01 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
US20140093496A1 (en) | 2011-02-25 | 2014-04-03 | Chugai Seiyaku Kabushiki Kaisha | Fc-gamma-RIIb-SPECIFIC Fc ANTIBODY |
JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
US20150056182A1 (en) | 2011-11-30 | 2015-02-26 | Chugai Seiyaku Kabushiki Kaisha | Drug containing carrier into cell for forming immune complex |
KR101536151B1 (ko) * | 2012-01-31 | 2015-07-14 | 서울대학교산학협력단 | 새로운 CTLA-4IgG 융합 단백질 |
WO2013148049A1 (en) * | 2012-03-29 | 2013-10-03 | The General Hospital Corporation | Recombinant cytotoxic t-lymphocyte-associated protein 4 (ctla4) |
AU2013260172B2 (en) * | 2012-05-11 | 2017-11-23 | Medimmune Limited | CTLA-4 variants |
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TWI717591B (zh) | 2012-08-24 | 2021-02-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
WO2014149067A1 (en) | 2013-03-15 | 2014-09-25 | Momenta Pharmaceuticals, Inc. | Methods related to ctla4-fc fusion proteins |
CA2908350C (en) | 2013-04-02 | 2023-08-08 | Futa Mimoto | Fc region variant |
US10464996B2 (en) | 2013-05-13 | 2019-11-05 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
US20150004161A1 (en) * | 2013-07-01 | 2015-01-01 | University Of Maryland | Fc Coupled Compositions and Methods of Their Use |
CN112457403B (zh) * | 2013-09-13 | 2022-11-29 | 广州百济神州生物制药有限公司 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
EP3058084A4 (en) | 2013-10-16 | 2017-07-05 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
TWI726608B (zh) | 2014-07-03 | 2021-05-01 | 英屬開曼群島商百濟神州有限公司 | 抗pd-l1抗體及其作為治療及診斷之用途 |
SG11201700496WA (en) | 2014-07-22 | 2017-02-27 | Cb Therapeutics Inc | Anti-pd-1 antibodies |
CN110964108B (zh) | 2014-08-05 | 2023-07-07 | 中美冠科生物技术(太仓)有限公司 | 抗pd-l1抗体 |
MX2017002765A (es) | 2014-09-03 | 2017-10-16 | Boehringer Ingelheim Int | Il-23a y tnf-alfa orientados y compuesto y sus usos. |
SI3221346T1 (sl) | 2014-11-21 | 2020-11-30 | Bristol-Myers Squibb Company | Protitelesa vsebujoča modificirana težko konstantna območja |
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