MX359903B - Proteínas estructurales de una mutación del parvovirus como vacunas. - Google Patents
Proteínas estructurales de una mutación del parvovirus como vacunas.Info
- Publication number
- MX359903B MX359903B MX2014004345A MX2014004345A MX359903B MX 359903 B MX359903 B MX 359903B MX 2014004345 A MX2014004345 A MX 2014004345A MX 2014004345 A MX2014004345 A MX 2014004345A MX 359903 B MX359903 B MX 359903B
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- vaccines
- structural proteins
- parvovirus structural
- mutated parvovirus
- Prior art date
Links
- 241000125945 Protoparvovirus Species 0.000 title abstract 4
- 101710172711 Structural protein Proteins 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/015—Parvoviridae, e.g. feline panleukopenia virus, human Parvovirus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
La presente invención se refiere a un método para identificar una proteína estructural de una mutación del parvovirus capaz de unirse específicamente con un enlace a un antígeno, una proteína estructural de una mutación del parvovirus que comprende por lo menos un epítopo de linfocitos B heterógeno al parvovirus, una estructura multimérica que comprende la proteína, un ácido nucleico que codifica a la proteína, un virus o célula que comprende la proteína, un método para preparar la proteína, un medicamento que comprende la proteína, ácido nucleico o estructura multimérica y su uso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93244607P | 2007-05-31 | 2007-05-31 | |
EP07013264A EP2012122A1 (en) | 2007-07-06 | 2007-07-06 | Mutated parvovirus structural proteins as vaccines |
PCT/EP2008/004366 WO2008145401A2 (en) | 2007-05-31 | 2008-06-02 | Mutated parvovirus structural proteins as vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
MX359903B true MX359903B (es) | 2018-10-16 |
Family
ID=38860997
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014004345A MX359903B (es) | 2007-05-31 | 2008-06-02 | Proteínas estructurales de una mutación del parvovirus como vacunas. |
MX2009012812A MX2009012812A (es) | 2007-05-31 | 2008-06-02 | Proteinas estructurales de una mutacion del parvovirus como vacunas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009012812A MX2009012812A (es) | 2007-05-31 | 2008-06-02 | Proteinas estructurales de una mutacion del parvovirus como vacunas. |
Country Status (7)
Country | Link |
---|---|
US (4) | US20100297177A1 (es) |
EP (2) | EP2012122A1 (es) |
JP (3) | JP2010530737A (es) |
AU (1) | AU2008258090B9 (es) |
CA (1) | CA2687728C (es) |
MX (2) | MX359903B (es) |
WO (1) | WO2008145401A2 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010093784A2 (en) * | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
PL2403867T3 (pl) | 2009-03-04 | 2019-12-31 | Deutsches Krebsforschungszentrum | Białko aktywujące składanie (aap) i jego zastosowanie do wytwarzania cząstek parwowirusa zasadniczo składających się z vp3 |
WO2010138263A2 (en) | 2009-05-28 | 2010-12-02 | University Of Massachusetts | Novel aav 's and uses thereof |
EP2435575A2 (en) * | 2009-05-28 | 2012-04-04 | Deutsches Krebsforschungszentrum | Modified aav capsid polypeptides |
CN107254451B (zh) * | 2010-07-16 | 2021-12-10 | 英特维特国际股份有限公司 | 活的减毒的细小病毒 |
AR082925A1 (es) | 2010-09-08 | 2013-01-16 | Medigene Ag | Proteinas estructurales mutadas por parvovirus con epitopo de celulas b de proteccion cruzada, producto y metodos relacionados |
US9821043B2 (en) | 2011-09-15 | 2017-11-21 | Medigene Ag | Anti-HER2 vaccine based upon AAV derived multimeric structures |
EP2814846B1 (en) * | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
CA2904366C (en) * | 2013-03-15 | 2023-07-04 | The Children's Hospital Of Philadelphia | Scalable manufacturing process to produce recombinant lentiviral vectors in serum-free suspension cell culture system |
GB201403684D0 (en) | 2014-03-03 | 2014-04-16 | King S College London | Vector |
HUE054471T2 (hu) | 2014-04-01 | 2021-09-28 | Rubius Therapeutics Inc | Immunmodulációs módszerek és készítmények |
WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
AU2015335923B2 (en) | 2014-10-21 | 2021-04-29 | University Of Massachusetts | Recombinant AAV variants and uses thereof |
RU2716991C2 (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
JP6863891B2 (ja) | 2014-11-14 | 2021-04-21 | ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. | 調節性ポリヌクレオチド |
IL292999A (en) | 2014-11-14 | 2022-07-01 | Voyager Therapeutics Inc | Preparations and methods for the treatment of amyotrophic lateral sclerosis |
WO2016094783A1 (en) | 2014-12-12 | 2016-06-16 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
PT3445773T (pt) | 2016-05-13 | 2023-03-13 | 4D Molecular Therapeutics Inc | Cápsides variantes de vírus adeno-associado e métodos de utilização das mesmas |
BR112018073472A2 (pt) | 2016-05-18 | 2019-08-27 | Voyager Therapeutics Inc | composições e métodos de tratamento da doença de huntington |
IL302748A (en) | 2016-05-18 | 2023-07-01 | Voyager Therapeutics Inc | modulatory polynucleotides |
CA3035522A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
CA3040483A1 (en) * | 2016-10-13 | 2018-04-19 | University Of Massachusetts | Aav capsid designs |
AU2018261790A1 (en) | 2017-05-05 | 2019-11-28 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
CN111108198A (zh) | 2017-05-05 | 2020-05-05 | 沃雅戈治疗公司 | 治疗亨廷顿病的组合物和方法 |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
WO2019006043A1 (en) * | 2017-06-27 | 2019-01-03 | Regeneron Pharmaceuticals, Inc. | RECOMBINANT VIRAL VECTORS WITH MODIFIED TROPISM AND USES THEREOF FOR TARGETED INTRODUCTION OF GENETIC MATERIAL INTO HUMAN CELLS |
US11497576B2 (en) | 2017-07-17 | 2022-11-15 | Voyager Therapeutics, Inc. | Trajectory array guide system |
CA3070040A1 (en) * | 2017-08-29 | 2019-03-07 | Ruprecht-Karls-Universitat Heidelberg | Rationally designed virus-like particles for modulation of chimeric antigen receptor (car)-t-cell therapy |
WO2019060454A2 (en) | 2017-09-20 | 2019-03-28 | 4D Molecular Therapeutics Inc. | CAPSID VARIANT ADENO-ASSOCIATED VIRUSES AND METHODS OF USE |
WO2019079240A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
SG11202004545XA (en) | 2017-11-27 | 2020-06-29 | 4D Molecular Therapeutics Inc | Adeno-associated virus variant capsids and use for inhibiting angiogenesis |
EP3527223A1 (en) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutated parvovirus structural protein |
WO2019158636A1 (en) | 2018-02-16 | 2019-08-22 | 2A Pharma Ab | Parvovirus structural protein for the treatment of autoimmune diseases |
EP3902554A4 (en) * | 2018-12-28 | 2022-12-14 | United Biomedical Inc. | INTERLEUKIN 6 (IL-6) TARGETING PEPTIDE IMMUNOGENS AND RELATED FORMULATIONS FOR THE IMMUNOTHERAPY OF DISEASES IMPACTED BY IL-6 DYSREGULATION |
CN113677801A (zh) | 2019-02-25 | 2021-11-19 | 诺华股份有限公司 | 治疗bietti晶体营养不良的组合物和方法 |
WO2020174369A2 (en) | 2019-02-25 | 2020-09-03 | Novartis Ag | Compositions and methods to treat bietti crystalline dystrophy |
TW202102526A (zh) * | 2019-04-04 | 2021-01-16 | 美商銳進科斯生物股份有限公司 | 重組腺相關病毒及其用途 |
EP3999119A1 (en) * | 2019-07-15 | 2022-05-25 | Meiragtx UK II Limited | Modified aav capsid proteins for treatment of arthritic disease |
CN111073859B (zh) * | 2019-12-09 | 2021-09-28 | 东北农业大学 | 一种检测牛细小病毒的双抗体夹心elisa试剂盒及其应用 |
CN116323641A (zh) * | 2020-09-10 | 2023-06-23 | 路德维希-马克西米利安慕尼黑大学 | 工程化的aav载体 |
WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
CN114149497A (zh) * | 2021-12-03 | 2022-03-08 | 河南省农业科学院动物免疫学重点实验室 | 猪细小病毒中和性单克隆抗体及制备方法和应用 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2084180A1 (en) * | 1991-12-11 | 1993-06-12 | Paul P. Hung | Expression of specific immunogens using viral antigens |
US6204059B1 (en) * | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
US6194388B1 (en) | 1994-07-15 | 2001-02-27 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
KR100498198B1 (ko) * | 1996-03-01 | 2005-09-09 | 노파르티스 아게 | 알레르기에 대한 백신접종 및 치료를 위한 펩티드 임뮤노겐 |
US20030021804A1 (en) * | 1997-01-21 | 2003-01-30 | Philip Needleman | Immunological process for increasing the hdl cholestrol concentration |
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
DE19827457C1 (de) | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
TWI229679B (en) * | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
DE69929232T2 (de) * | 1998-10-21 | 2006-08-31 | The United States Government As Represented By The Department Of Health And Human Services | Virusähnliche partikel zur induktion von autoantikörpern |
JP2002538770A (ja) * | 1998-11-10 | 2002-11-19 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | ウイルスベクターとその製造及び投与の方法 |
DE19925199A1 (de) * | 1999-06-01 | 2000-12-07 | Medigene Ag | Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie |
DE19933288A1 (de) | 1999-07-15 | 2001-01-18 | Medigene Ag | Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung |
DE19933719A1 (de) | 1999-07-19 | 2001-01-25 | Medigene Ag | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
DE10024334B4 (de) * | 2000-05-17 | 2006-06-01 | Medigene Ag | Verfahren zum Einbringen von Nukleinsäure in eine Zelle (Transfektion) mittels Calciumphosphat |
AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
DE60100814T2 (de) | 2000-06-08 | 2004-07-01 | Intercell Biomedizinische Forschungs- Und Entwicklungs Gmbh | Immunstimulierende oligodeoxynukleotide |
JP2004506019A (ja) | 2000-08-17 | 2004-02-26 | インターツェル・アクチェンゲゼルシャフト | 少なくとも1つの抗原およびカテリシジン由来の抗菌ペプチドまたはその誘導体を含むワクチン |
DE10066104A1 (de) * | 2000-09-08 | 2003-01-09 | Medigene Ag | Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung |
AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
AU2002248297A1 (en) * | 2001-01-05 | 2002-07-16 | Children's Hospital, Inc. | Aav2 vectors and methods |
US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
AU2002320762B2 (en) | 2001-05-21 | 2006-09-21 | Intercell Ag | Immunostimulatory oligodeoxynucleic molecules |
AU2002325827A1 (en) * | 2001-06-07 | 2002-12-16 | Genfit | Compositions and methods for detecting or regulating cholesteryl ester transfer protein |
WO2003054197A2 (en) * | 2001-12-21 | 2003-07-03 | Medigene Ag | A library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism |
US8927269B2 (en) | 2003-05-19 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Avian adenoassociated virus and uses thereof |
CA2552999A1 (en) * | 2004-02-02 | 2005-08-18 | Tanox, Inc. | Identification of novel ige epitopes |
AT500835B1 (de) * | 2004-09-13 | 2007-12-15 | Affiris Forschungs & Entwicklungs Gmbh | Cholinestertransport-protein-mimotop als atherosklerose-medikament |
AU2005291231B2 (en) * | 2004-10-05 | 2010-12-23 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
AT501621A1 (de) * | 2005-03-15 | 2006-10-15 | Mattner Frank Dr | Zusammensetzungen zur verwendung bei der vorbeugung und behandlung der alzheimer- erkrankung |
US8283151B2 (en) * | 2005-04-29 | 2012-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes |
US20060276400A1 (en) * | 2005-06-06 | 2006-12-07 | Hedy Adari | Modulation of cholesteryl ester transfer protein (CETP) activity |
-
2007
- 2007-07-06 EP EP07013264A patent/EP2012122A1/en not_active Ceased
-
2008
- 2008-06-02 MX MX2014004345A patent/MX359903B/es unknown
- 2008-06-02 MX MX2009012812A patent/MX2009012812A/es active IP Right Grant
- 2008-06-02 AU AU2008258090A patent/AU2008258090B9/en active Active
- 2008-06-02 EP EP08758935.4A patent/EP2158488B1/en active Active
- 2008-06-02 WO PCT/EP2008/004366 patent/WO2008145401A2/en active Application Filing
- 2008-06-02 JP JP2010509748A patent/JP2010530737A/ja active Pending
- 2008-06-02 CA CA2687728A patent/CA2687728C/en active Active
- 2008-06-02 US US12/601,639 patent/US20100297177A1/en not_active Abandoned
-
2013
- 2013-07-09 US US13/937,997 patent/US20130288921A1/en not_active Abandoned
-
2014
- 2014-12-16 JP JP2014253911A patent/JP6345586B2/ja active Active
-
2015
- 2015-11-02 US US14/930,288 patent/US10408834B2/en active Active
-
2018
- 2018-02-13 JP JP2018022685A patent/JP2018109636A/ja active Pending
-
2019
- 2019-07-26 US US16/523,802 patent/US20200191788A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20100297177A1 (en) | 2010-11-25 |
US20160153992A1 (en) | 2016-06-02 |
US20200191788A1 (en) | 2020-06-18 |
AU2008258090B2 (en) | 2013-05-16 |
CA2687728A1 (en) | 2008-12-04 |
JP2010530737A (ja) | 2010-09-16 |
JP6345586B2 (ja) | 2018-06-20 |
US20130288921A1 (en) | 2013-10-31 |
WO2008145401A2 (en) | 2008-12-04 |
WO2008145401A3 (en) | 2009-02-19 |
MX2009012812A (es) | 2010-02-24 |
AU2008258090A1 (en) | 2008-12-04 |
AU2008258090B9 (en) | 2013-12-05 |
EP2158488A2 (en) | 2010-03-03 |
EP2158488B1 (en) | 2017-05-03 |
CA2687728C (en) | 2017-01-17 |
US10408834B2 (en) | 2019-09-10 |
JP2018109636A (ja) | 2018-07-12 |
EP2012122A1 (en) | 2009-01-07 |
JP2015121536A (ja) | 2015-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009012812A (es) | Proteinas estructurales de una mutacion del parvovirus como vacunas. | |
CY1121934T1 (el) | Αντισωματα anti-fcrn | |
MX2020010035A (es) | Receptores de celulas t anti-papilomavirus 16 e7 humano. | |
UA100682C2 (ru) | АНТИТЕЛО, КОТОРОЕ НЕЙТРАЛИЗУЕТ ЧЕЛОВЕЧЕСКИЙ ЦИТОМЕГАЛОВИРУС (hCMV), И ЕГО ПРИМЕНЕНИЕ | |
MY156286A (en) | Human il-23 antigen binding proteins | |
MX2021000211A (es) | Metodos y productos para transfeccion de celulas. | |
GB201003701D0 (en) | System for the expression of a protein | |
TN2011000433A1 (en) | Alpha -4-beta-7heterodimer specific antagonist antibody | |
MX2015008446A (es) | Composiciones de proteinas de union multivalentes. | |
WO2012106377A3 (en) | Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof | |
BR112014012624A2 (pt) | anticorpos, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira, método para a produção de um anticorpo recombinante e uso do anticorpo | |
HK1215954A1 (zh) | 蛋白、核酸、和抗體及其用途 | |
IN2009CN03372A (es) | ||
WO2011156467A3 (en) | Methods of detecting residual amounts of polymers used in the purification of biomolecules | |
PH12016500275A1 (en) | Antibodies | |
WO2012018907A3 (en) | Polypeptides for treating and/or limiting influenza infection | |
MX344103B (es) | Vacunas de virus herpes vectorizado con virus de enfermedad de newcastle. | |
MX2017005661A (es) | Celulas de mamifero que expresan antigenos de citomegalovirus. | |
MX2015000754A (es) | Proteinas de btnl3, acidos nucleicos, y anticuerpos y los usos de los mismos. | |
EA201100674A1 (ru) | Вакцина против вируса африканской чумы лошадей | |
EP2496608A4 (en) | FUSION PROTEIN SPECIFICALLY BINDING TO A CONSTANT REGION OF ANTIBODY, PREPARATION THEREFOR, AND METHOD OF ISOLATING ANTIBODY USING THE SAME | |
WO2013138259A3 (en) | Polypeptides for treating and/or limiting influenza infection | |
MX2009011851A (es) | Plasmidos de dna que tienen expresion y estabilidad mejoradas. | |
WO2011133870A3 (en) | Vaccines comprising adenovirus vectors and signaling lymphocyte activating molecule-associated protein (sap) | |
ATE450546T1 (de) | Impfstoffe mit ornithobakterium rhinotracheale- untereinheit |