JP2017524348A5 - - Google Patents
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- Publication number
- JP2017524348A5 JP2017524348A5 JP2016572566A JP2016572566A JP2017524348A5 JP 2017524348 A5 JP2017524348 A5 JP 2017524348A5 JP 2016572566 A JP2016572566 A JP 2016572566A JP 2016572566 A JP2016572566 A JP 2016572566A JP 2017524348 A5 JP2017524348 A5 JP 2017524348A5
- Authority
- JP
- Japan
- Prior art keywords
- ptpn2
- leukocytes
- cell
- inhibitor
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 16
- 101001135572 Homo sapiens Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 claims 14
- 102100033141 Tyrosine-protein phosphatase non-receptor type 2 Human genes 0.000 claims 13
- 210000000265 leukocyte Anatomy 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 230000002452 interceptive effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108091033409 CRISPR Proteins 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 108700010039 chimeric receptor Proteins 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014902203A AU2014902203A0 (en) | 2014-06-10 | Method of producing cells for adoptive cell transfer | |
| AU2014902203 | 2014-06-10 | ||
| AU2015901171 | 2015-03-31 | ||
| AU2015901171A AU2015901171A0 (en) | 2015-03-31 | Method of producing cells for adoptive cell transfer (2) | |
| PCT/AU2015/050318 WO2015188228A1 (en) | 2014-06-10 | 2015-06-10 | Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017524348A JP2017524348A (ja) | 2017-08-31 |
| JP2017524348A5 true JP2017524348A5 (enExample) | 2018-06-07 |
Family
ID=54832624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572566A Pending JP2017524348A (ja) | 2014-06-10 | 2015-06-10 | 養子細胞移入のためのｐｔｐｎ２阻害を用いた白血球の産生方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20170224731A1 (enExample) |
| EP (1) | EP3154555A4 (enExample) |
| JP (1) | JP2017524348A (enExample) |
| AU (1) | AU2015274242A1 (enExample) |
| WO (1) | WO2015188228A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL257105B (en) | 2015-07-31 | 2022-09-01 | Univ Minnesota | Modified cells and methods of therapy |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| WO2018148378A1 (en) * | 2017-02-08 | 2018-08-16 | Dana-Farber Cancer Institute, Inc. | Modulating biomarkers to increase tumor immunity and improve the efficiacy of cancer immunotherapy |
| JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス，インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
| WO2019036815A1 (en) * | 2017-08-24 | 2019-02-28 | The Royal Institution For The Advancement Of Learning/Mcgill University | ENHANCEMENT OF CD8 + T LYMPHOCYTES FOR ADOPTIVE CELL THERAPY BY INHIBITING PTPN1 (PTP1B) AND PTPN2 (TC-PTP)) |
| JP2021518160A (ja) | 2018-03-15 | 2021-08-02 | ケーエスキュー セラピューティクス， インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| EP3765094A4 (en) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | GENE REGULATORY COMPOSITIONS AND PROCEDURES FOR IMPROVED IMMUNOTHERAPY |
| WO2019178422A1 (en) * | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| WO2019227176A1 (en) * | 2018-06-01 | 2019-12-05 | Monash University | Methods of activating cells via ptp 1b inhibition |
| UY38272A (es) | 2018-06-21 | 2019-12-31 | Abbvie Inc | Inhibidores de proteína tirosina fosfatasa y sus métodos de uso |
| WO2020072126A2 (en) * | 2018-08-07 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages |
| SG11202108452WA (en) * | 2019-02-04 | 2021-09-29 | Ksq Therapeutics Inc | Combination gene targets for improved immunotherapy |
| MA55301A (fr) | 2019-03-14 | 2022-01-19 | Abbvie Inc | Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation |
| US12188045B2 (en) | 2019-06-07 | 2025-01-07 | KSQ Therapeutics, Inc. | Guide RNA combinations and methods of use |
| CA3162272A1 (en) * | 2019-11-25 | 2021-06-03 | KSQ Therapeutics, Inc. | Methods for activation and expansion of tumor infiltrating lymphocytes |
| US20230355670A1 (en) * | 2019-12-04 | 2023-11-09 | Monash University | Methods of activating cytotoxic leukocytes using PTP1B and PTPN2 inhibitors |
| EP4073242A4 (en) * | 2019-12-12 | 2024-01-03 | Kumquat Biosciences Inc. | COMPOSITIONS AND METHODS FOR POTENTIALIZING IMMUNE ACTIVITY |
| CN113827727B (zh) * | 2020-06-24 | 2025-04-29 | 上海交通大学医学院附属瑞金医院 | Ptpn2抑制剂在kras突变肿瘤中的应用 |
| EP4416292A2 (en) | 2021-10-14 | 2024-08-21 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| AU2024233625A1 (en) | 2023-03-03 | 2025-09-18 | Arsenal Biosciences, Inc. | Systems targeting psma and ca9 |
| AU2024276994A1 (en) | 2023-05-24 | 2025-10-23 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| WO2025075947A1 (en) * | 2023-10-06 | 2025-04-10 | Purdue Research Foundation | Selective tc-ptp degraders for cancer immunotherapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008043181A1 (en) * | 2006-10-12 | 2008-04-17 | Mcgill University | Augmenting stem cell populations by modulating t-cell protein tyrosine phosphatase (tc-ptp) |
| US9217012B2 (en) * | 2009-04-08 | 2015-12-22 | Indiana University Research And Technology Corporation | Inhibitors of protein tyrosine phosphatases |
| WO2014039513A2 (en) * | 2012-09-04 | 2014-03-13 | The Trustees Of The University Of Pennsylvania | Inhibition of diacylglycerol kinase to augment adoptive t cell transfer |
| TW201414837A (zh) * | 2012-10-01 | 2014-04-16 | Univ Pennsylvania | 標定基質細胞以治療癌症之組合物和方法 |
| US20150275209A1 (en) * | 2012-10-22 | 2015-10-01 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Service | Compositions and methods for enhancing cancer immunotherapy |
| AU2014266833B2 (en) * | 2013-05-13 | 2020-07-02 | Cellectis | Methods for engineering highly active T cell for immunotherapy |
| CA2912389C (en) * | 2013-06-10 | 2020-01-28 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for reducing immunosupression by tumor cells |
| US9828399B2 (en) * | 2014-02-28 | 2017-11-28 | The Royal Institution For The Advancement Of Learning/Mcgill University | TC-PTP inhibitors as APC activators for immunotherapy |
| ES2782125T3 (es) * | 2014-03-11 | 2020-09-10 | Cellectis | Método para generar linfocitos T compatibles para trasplante alogénico |
-
2015
- 2015-06-10 WO PCT/AU2015/050318 patent/WO2015188228A1/en not_active Ceased
- 2015-06-10 EP EP15807341.1A patent/EP3154555A4/en not_active Withdrawn
- 2015-06-10 AU AU2015274242A patent/AU2015274242A1/en not_active Abandoned
- 2015-06-10 US US15/317,197 patent/US20170224731A1/en not_active Abandoned
- 2015-06-10 JP JP2016572566A patent/JP2017524348A/ja active Pending
-
2020
- 2020-09-08 US US17/014,737 patent/US20210052648A1/en active Pending
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