AU2015274242A1 - Method of producing leukocytes using PTPN2 inhibition for adoptive cell transfer - Google Patents
Method of producing leukocytes using PTPN2 inhibition for adoptive cell transfer Download PDFInfo
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- AU2015274242A1 AU2015274242A1 AU2015274242A AU2015274242A AU2015274242A1 AU 2015274242 A1 AU2015274242 A1 AU 2015274242A1 AU 2015274242 A AU2015274242 A AU 2015274242A AU 2015274242 A AU2015274242 A AU 2015274242A AU 2015274242 A1 AU2015274242 A1 AU 2015274242A1
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| AU2014902203A AU2014902203A0 (en) | 2014-06-10 | Method of producing cells for adoptive cell transfer | |
| AU2015901171 | 2015-03-31 | ||
| AU2015901171A AU2015901171A0 (en) | 2015-03-31 | Method of producing cells for adoptive cell transfer (2) | |
| PCT/AU2015/050318 WO2015188228A1 (en) | 2014-06-10 | 2015-06-10 | Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer |
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| IL295616A (en) | 2015-07-31 | 2022-10-01 | Us Health | Adapted cells and treatment methods |
| EP4338799A3 (en) | 2016-10-18 | 2024-06-05 | Regents of the University of Minnesota | Tumor infiltrating lymphocytes and methods of therapy |
| WO2018148378A1 (en) * | 2017-02-08 | 2018-08-16 | Dana-Farber Cancer Institute, Inc. | Modulating biomarkers to increase tumor immunity and improve the efficiacy of cancer immunotherapy |
| EP3645021A4 (en) | 2017-06-30 | 2021-04-21 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| WO2019036815A1 (en) * | 2017-08-24 | 2019-02-28 | The Royal Institution For The Advancement Of Learning/Mcgill University | ENHANCEMENT OF CD8 + T LYMPHOCYTES FOR ADOPTIVE CELL THERAPY BY INHIBITING PTPN1 (PTP1B) AND PTPN2 (TC-PTP)) |
| JP2021518160A (ja) | 2018-03-15 | 2021-08-02 | ケーエスキュー セラピューティクス， インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| AU2019236204B2 (en) | 2018-03-15 | 2026-02-26 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| EP3765608A4 (en) * | 2018-03-15 | 2022-01-12 | KSQ Therapeutics, Inc. | GENE REGULATORY COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPY |
| US20210207095A1 (en) * | 2018-06-01 | 2021-07-08 | Monash University | Methods of activating cells via ptp 1b inhibition |
| CA3104507A1 (en) | 2018-06-21 | 2019-12-26 | Calico Life Sciences Llc | Protein tyrosine phosphatase inhibitors and methods of use thereof |
| WO2020072126A2 (en) * | 2018-08-07 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages |
| WO2020163365A2 (en) * | 2019-02-04 | 2020-08-13 | KSQ Therapeutics, Inc. | Combination gene targets for improved immunotherapy |
| MX2021010544A (es) | 2019-03-14 | 2021-10-01 | Calico Life Sciences Llc | Inhibidores de la proteina tirosina fosfatasa y metodos para usarlos. |
| US12188045B2 (en) | 2019-06-07 | 2025-01-07 | KSQ Therapeutics, Inc. | Guide RNA combinations and methods of use |
| KR20220119038A (ko) * | 2019-11-25 | 2022-08-26 | 케이에스큐 세러퓨틱스 인코포레이티드 | 종양 침윤 림프구의 활성화 및 확장을 위한 방법 |
| AU2020395612A1 (en) * | 2019-12-04 | 2022-06-09 | Monash University | Methods of activating cytotoxic leukocytes using PTP1B and PTPN2 inhibitors |
| CA3163012A1 (en) * | 2019-12-12 | 2021-06-17 | Yi Liu | Compositions and methods for potentiating immune activity |
| CN113827727B (zh) * | 2020-06-24 | 2025-04-29 | 上海交通大学医学院附属瑞金医院 | Ptpn2抑制剂在kras突变肿瘤中的应用 |
| KR20240099259A (ko) | 2021-10-14 | 2024-06-28 | 아스널 바이오사이언시스, 인크. | 공동 발현된 shrna 및 논리 게이트 시스템을 갖는 면역 세포 |
| JP2026507228A (ja) | 2023-03-03 | 2026-02-27 | アーセナル バイオサイエンシズ インコーポレイテッド | Ｐｓｍａ及びｃａ９を標的とするシステム |
| TW202500126A (zh) | 2023-05-24 | 2025-01-01 | 美商金橘生物科技公司 | 雜環化合物及其用途 |
| WO2025075947A1 (en) * | 2023-10-06 | 2025-04-10 | Purdue Research Foundation | Selective tc-ptp degraders for cancer immunotherapy |
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| WO2008043181A1 (en) * | 2006-10-12 | 2008-04-17 | Mcgill University | Augmenting stem cell populations by modulating t-cell protein tyrosine phosphatase (tc-ptp) |
| WO2010118241A2 (en) * | 2009-04-08 | 2010-10-14 | Indiana University Research & Technology Corporation | Inhibitors of protein tyrosine phosphatases |
| US9937205B2 (en) * | 2012-09-04 | 2018-04-10 | The Trustees Of The University Of Pennsylvania | Inhibition of diacylglycerol kinase to augment adoptive T cell transfer |
| AR092745A1 (es) * | 2012-10-01 | 2015-04-29 | Univ Pennsylvania | Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer |
| WO2014066137A1 (en) * | 2012-10-22 | 2014-05-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for enhancing cancer immunotherapy |
| RU2725542C2 (ru) * | 2013-05-13 | 2020-07-02 | Селлектис | Способы конструирования высокоактивных т-клеток для иммунотерапии |
| CN105431524B (zh) * | 2013-06-10 | 2020-04-21 | 达娜-法勃肿瘤研究所公司 | 用于降低肿瘤细胞的免疫抑制的方法和组合物 |
| WO2015127548A1 (en) * | 2014-02-28 | 2015-09-03 | The Royal Institution For The Advancement Of Learning / Mcgill University | Tc-ptp inhibitors as apc activators for immunotherapy |
| WO2015136001A1 (en) * | 2014-03-11 | 2015-09-17 | Cellectis | Method for generating t-cells compatible for allogenic transplantation |
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| EP3154555A1 (en) | 2017-04-19 |
| EP3154555A4 (en) | 2018-02-28 |
| WO2015188228A1 (en) | 2015-12-17 |
| JP2017524348A (ja) | 2017-08-31 |
| US20210052648A1 (en) | 2021-02-25 |
| US20170224731A1 (en) | 2017-08-10 |
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