AR020102A1 - Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento - Google Patents
Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimentoInfo
- Publication number
- AR020102A1 AR020102A1 ARP990103185A ARP990103185A AR020102A1 AR 020102 A1 AR020102 A1 AR 020102A1 AR P990103185 A ARP990103185 A AR P990103185A AR P990103185 A ARP990103185 A AR P990103185A AR 020102 A1 AR020102 A1 AR 020102A1
- Authority
- AR
- Argentina
- Prior art keywords
- food
- composition
- compound
- antigenic determinant
- allergen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 206010020751 Hypersensitivity Diseases 0.000 title abstract 3
- 208000026935 allergic disease Diseases 0.000 title abstract 3
- 230000007815 allergy Effects 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 7
- 239000013566 allergen Substances 0.000 abstract 6
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 4
- 230000004913 activation Effects 0.000 abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 2
- 241001225321 Aspergillus fumigatus Species 0.000 abstract 1
- 206010003645 Atopy Diseases 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000238710 Dermatophagoides Species 0.000 abstract 1
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 abstract 1
- 241000712079 Measles morbillivirus Species 0.000 abstract 1
- 206010043376 Tetanus Diseases 0.000 abstract 1
- 229940091771 aspergillus fumigatus Drugs 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 206010013023 diphtheria Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 231100000655 enterotoxin Toxicity 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Insects & Arthropods (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Otolaryngology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Dairy Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un compuesto para la prevencion y/o tratamiento de la alergia que comprende al menos un determinante antigénico de un alergeno que es reconocido por unacélula B o un anticuerpo secretado por una célula B de un individuo no-atopico a dicho alergeno yal menos un determinante antigénico de un antígeno diferentede dicho alergeno que dispara la activacion de las células T. Un compuesto para la prevencion y/o tratamiento de la alergia que comprende preferentemente unasecuencia de nucleotidos que codifica ambos determinantes antigénicos del compuesto de acuerdo con lo descripto, la cual puede unirse a una o más secuenciasregulatorias activas en una célula del paciente. Dicho determinante antigénico de un alergeno puede no ser reconocido por una célula T y puede ser seleccionadodel grupo integrado por los siguientes alergenos principales; Der pl y Der pll del ácaro doméstico Dermatofagoideo pteronyssinus, el antígeno principal deAspergillus fumigatus, la enterotoxina B estafilococcica (SEB) yla betalactoglubina bovina. El determinante antigénico del antígeno que dispara la activacionde las células T puede ser un epitope de célula T de antígenos del toxoide del tétano, difteria, micobacteria, influenza, o el virus del sarampion. Eldeterminante antigénico del alergeno y el determinante antigénico del antígeno son secuencias peptídicas, preferentemente unidas, por un enlace peptídico.Composicion farmacéutica, composicion cosmética, composicion en forma de bebida, alimento y/o alimentos para animales domésticos que lo comprende y uso dedicho compuesto o dicha composicion farmacéutica para la fabricacion de medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98870167 | 1998-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020102A1 true AR020102A1 (es) | 2002-04-10 |
Family
ID=8237074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990103185A AR020102A1 (es) | 1998-07-30 | 1999-06-30 | Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6602509B1 (es) |
| EP (1) | EP1105505B1 (es) |
| JP (1) | JP4383667B2 (es) |
| CN (1) | CN1313903A (es) |
| AR (1) | AR020102A1 (es) |
| AT (1) | ATE349537T1 (es) |
| AU (1) | AU767279B2 (es) |
| BR (1) | BR9912702A (es) |
| CA (1) | CA2337969C (es) |
| DE (1) | DE69934590T2 (es) |
| ES (1) | ES2279625T3 (es) |
| MX (1) | MXPA01001093A (es) |
| PE (1) | PE20000760A1 (es) |
| TW (1) | TW589378B (es) |
| WO (1) | WO2000006694A2 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01011279A (es) | 1999-05-07 | 2002-07-02 | Genentech Inc | Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b. |
| AUPQ761200A0 (en) | 2000-05-19 | 2000-06-15 | Hunter Immunology Limited | Compositions and methods for treatment of mucosal infections |
| US20040202673A1 (en) * | 2003-04-08 | 2004-10-14 | Jen-Pin Huang | Constructs of branched synthetic peptide immunogens with artificial T helper cell epitopes coupled to B cell epitopes |
| US8543566B2 (en) | 2003-09-23 | 2013-09-24 | Salesforce.Com, Inc. | System and methods of improving a multi-tenant database query using contextual knowledge about non-homogeneously distributed tenant data |
| US7529728B2 (en) * | 2003-09-23 | 2009-05-05 | Salesforce.Com, Inc. | Query optimization in a multi-tenant database system |
| DE102004035337A1 (de) * | 2004-07-21 | 2006-03-16 | Merck Patent Gmbh | Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität |
| EP1868642B1 (en) | 2005-03-18 | 2013-05-08 | Cytos Biotechnology AG | Cat allergen fusion proteins and uses thereof |
| ES2709176T3 (es) * | 2006-08-11 | 2019-04-15 | Life Sciences Res Partners Vzw | Péptidos inmunogénicos y su uso en trastornos inmunitarios |
| US20080082359A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of State Of Delaware | Computational systems for biomedical data |
| US20080082364A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US20080082307A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc | Computational systems for biomedical data |
| US20080082367A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US10068303B2 (en) * | 2006-09-29 | 2018-09-04 | Gearbox Llc | Computational systems for biomedical data |
| US8122073B2 (en) * | 2006-09-29 | 2012-02-21 | The Invention Science Fund I | Computational systems for biomedical data |
| US10503872B2 (en) * | 2006-09-29 | 2019-12-10 | Gearbox Llc | Computational systems for biomedical data |
| US10095836B2 (en) * | 2006-09-29 | 2018-10-09 | Gearbox Llc | Computational systems for biomedical data |
| US20080082271A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc | Computational systems for biomedical data |
| US20080082306A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc | Computational systems for biomedical data |
| US20080091730A1 (en) * | 2006-09-29 | 2008-04-17 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US7853626B2 (en) * | 2006-09-29 | 2010-12-14 | The Invention Science Fund I, Llc | Computational systems for biomedical data |
| US20080109484A1 (en) * | 2006-09-29 | 2008-05-08 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US10546652B2 (en) * | 2006-09-29 | 2020-01-28 | Gearbox Llc | Computational systems for biomedical data |
| US20080082584A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US20080082583A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| ITRM20060583A1 (it) * | 2006-10-27 | 2008-04-28 | Francesco Bistoni | Uso della timosina alfa 1 per la preparazione di un medicamento per la prevenzione e la cura delle allergie |
| CA2715536C (en) | 2008-02-14 | 2018-01-16 | Life Sciences Research Partners Vzw | Cd4+ t-cells with cytolytic properties |
| EP2247306B1 (en) | 2008-02-14 | 2018-04-18 | Life Sciences Research Partners VZW | Immunogenic control of tumours and tumour cells |
| EP2252329B1 (en) | 2008-02-14 | 2015-06-17 | Life Sciences Research Partners VZW | Elimination of immune responses to viral vectors |
| ES2545886T3 (es) | 2008-02-14 | 2015-09-16 | Life Sciences Research Partners Vzw | Inmunoterapia dirigida a patógenos intracelulares |
| ES2924027T3 (es) | 2010-11-25 | 2022-10-04 | Imcyse Sa | Péptidos inmunogénicos para su uso en la prevención y/o tratamiento de enfermedades infecciosas, enfermedades autoinmunitarias, respuestas inmunitarias a alofactores, enfermedades alérgicas, tumores, rechazo de injerto y respuestas inmunitarias contra vectores virales usados para terapia génica o vacunación génica |
| GB201201511D0 (en) | 2012-01-30 | 2012-03-14 | Univ Leuven Kath | Modified epitopes for boosting CD4+ T-cell responses |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
| US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
| JP7090335B2 (ja) | 2015-09-25 | 2022-06-24 | イムサイス エスエー | 治療剤に対する免疫応答を除去するための改善された方法及び化合物 |
| AU2017252192C1 (en) | 2016-04-19 | 2023-06-08 | Imcyse Sa | Novel immunogenic CD1d binding peptides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5785973A (en) * | 1988-02-01 | 1998-07-28 | Praxis Biologics, Inc. | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines |
| ATE444360T1 (de) * | 1991-10-16 | 2009-10-15 | Merck Patent Gmbh | T-zell epitopen von den wichtigsten allergene von dermatophagoides (hausmilbe) |
| ES2285703T3 (es) * | 1994-04-14 | 2007-11-16 | Merck Patent Gmbh | Formulaciones farmaceuticas de peptidos para el tratamiento de alergia a los acaros del polvo. |
| ATE196297T1 (de) * | 1994-05-18 | 2000-09-15 | Synthetic Peptides Inc | Heterodimere trägerzusammensetzung von immunogenen polypeptiden und verfahren zu deren verwendung |
-
1999
- 1999-06-30 AR ARP990103185A patent/AR020102A1/es unknown
- 1999-07-01 PE PE1999000617A patent/PE20000760A1/es not_active Application Discontinuation
- 1999-07-20 DE DE69934590T patent/DE69934590T2/de not_active Expired - Lifetime
- 1999-07-20 EP EP99936190A patent/EP1105505B1/en not_active Expired - Lifetime
- 1999-07-20 CA CA2337969A patent/CA2337969C/en not_active Expired - Fee Related
- 1999-07-20 JP JP2000562477A patent/JP4383667B2/ja not_active Expired - Lifetime
- 1999-07-20 ES ES99936190T patent/ES2279625T3/es not_active Expired - Lifetime
- 1999-07-20 MX MXPA01001093A patent/MXPA01001093A/es not_active IP Right Cessation
- 1999-07-20 WO PCT/BE1999/000092 patent/WO2000006694A2/en not_active Ceased
- 1999-07-20 BR BR9912702-4A patent/BR9912702A/pt not_active IP Right Cessation
- 1999-07-20 CN CN99810025A patent/CN1313903A/zh active Pending
- 1999-07-20 AT AT99936190T patent/ATE349537T1/de not_active IP Right Cessation
- 1999-07-20 AU AU51421/99A patent/AU767279B2/en not_active Ceased
- 1999-07-22 TW TW088112444A patent/TW589378B/zh not_active IP Right Cessation
- 1999-07-29 US US09/362,731 patent/US6602509B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PE20000760A1 (es) | 2000-08-30 |
| WO2000006694A2 (en) | 2000-02-10 |
| TW589378B (en) | 2004-06-01 |
| CA2337969A1 (en) | 2000-02-10 |
| DE69934590D1 (de) | 2007-02-08 |
| WO2000006694A3 (en) | 2000-03-16 |
| US6602509B1 (en) | 2003-08-05 |
| JP4383667B2 (ja) | 2009-12-16 |
| BR9912702A (pt) | 2001-05-08 |
| EP1105505B1 (en) | 2006-12-27 |
| JP2002524031A (ja) | 2002-08-06 |
| CA2337969C (en) | 2010-06-29 |
| AU5142199A (en) | 2000-02-21 |
| MXPA01001093A (es) | 2002-04-24 |
| EP1105505A2 (en) | 2001-06-13 |
| ATE349537T1 (de) | 2007-01-15 |
| AU767279B2 (en) | 2003-11-06 |
| ES2279625T3 (es) | 2007-08-16 |
| CN1313903A (zh) | 2001-09-19 |
| DE69934590T2 (de) | 2007-07-26 |
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