AR020102A1 - Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento - Google Patents
Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimentoInfo
- Publication number
- AR020102A1 AR020102A1 ARP990103185A ARP990103185A AR020102A1 AR 020102 A1 AR020102 A1 AR 020102A1 AR P990103185 A ARP990103185 A AR P990103185A AR P990103185 A ARP990103185 A AR P990103185A AR 020102 A1 AR020102 A1 AR 020102A1
- Authority
- AR
- Argentina
- Prior art keywords
- food
- composition
- compound
- antigenic determinant
- allergen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 206010020751 Hypersensitivity Diseases 0.000 title abstract 3
- 208000026935 allergic disease Diseases 0.000 title abstract 3
- 230000007815 allergy Effects 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 7
- 239000013566 allergen Substances 0.000 abstract 6
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 4
- 230000004913 activation Effects 0.000 abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 2
- 241001225321 Aspergillus fumigatus Species 0.000 abstract 1
- 206010003645 Atopy Diseases 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000238710 Dermatophagoides Species 0.000 abstract 1
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 abstract 1
- 241000712079 Measles morbillivirus Species 0.000 abstract 1
- 206010043376 Tetanus Diseases 0.000 abstract 1
- 229940091771 aspergillus fumigatus Drugs 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 206010013023 diphtheria Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 231100000655 enterotoxin Toxicity 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Insects & Arthropods (AREA)
- Otolaryngology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un compuesto para la prevencion y/o tratamiento de la alergia que comprende al menos un determinante antigénico de un alergeno que es reconocido por unacélula B o un anticuerpo secretado por una célula B de un individuo no-atopico a dicho alergeno yal menos un determinante antigénico de un antígeno diferentede dicho alergeno que dispara la activacion de las células T. Un compuesto para la prevencion y/o tratamiento de la alergia que comprende preferentemente unasecuencia de nucleotidos que codifica ambos determinantes antigénicos del compuesto de acuerdo con lo descripto, la cual puede unirse a una o más secuenciasregulatorias activas en una célula del paciente. Dicho determinante antigénico de un alergeno puede no ser reconocido por una célula T y puede ser seleccionadodel grupo integrado por los siguientes alergenos principales; Der pl y Der pll del ácaro doméstico Dermatofagoideo pteronyssinus, el antígeno principal deAspergillus fumigatus, la enterotoxina B estafilococcica (SEB) yla betalactoglubina bovina. El determinante antigénico del antígeno que dispara la activacionde las células T puede ser un epitope de célula T de antígenos del toxoide del tétano, difteria, micobacteria, influenza, o el virus del sarampion. Eldeterminante antigénico del alergeno y el determinante antigénico del antígeno son secuencias peptídicas, preferentemente unidas, por un enlace peptídico.Composicion farmacéutica, composicion cosmética, composicion en forma de bebida, alimento y/o alimentos para animales domésticos que lo comprende y uso dedicho compuesto o dicha composicion farmacéutica para la fabricacion de medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98870167 | 1998-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020102A1 true AR020102A1 (es) | 2002-04-10 |
Family
ID=8237074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990103185A AR020102A1 (es) | 1998-07-30 | 1999-06-30 | Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6602509B1 (es) |
| EP (1) | EP1105505B1 (es) |
| JP (1) | JP4383667B2 (es) |
| CN (1) | CN1313903A (es) |
| AR (1) | AR020102A1 (es) |
| AT (1) | ATE349537T1 (es) |
| AU (1) | AU767279B2 (es) |
| BR (1) | BR9912702A (es) |
| CA (1) | CA2337969C (es) |
| DE (1) | DE69934590T2 (es) |
| ES (1) | ES2279625T3 (es) |
| MX (1) | MXPA01001093A (es) |
| PE (1) | PE20000760A1 (es) |
| TW (1) | TW589378B (es) |
| WO (1) | WO2000006694A2 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146005A0 (en) | 1999-05-07 | 2002-07-25 | Genentech Inc | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| AUPQ761200A0 (en) * | 2000-05-19 | 2000-06-15 | Hunter Immunology Limited | Compositions and methods for treatment of mucosal infections |
| US20040202673A1 (en) * | 2003-04-08 | 2004-10-14 | Jen-Pin Huang | Constructs of branched synthetic peptide immunogens with artificial T helper cell epitopes coupled to B cell epitopes |
| US8543566B2 (en) | 2003-09-23 | 2013-09-24 | Salesforce.Com, Inc. | System and methods of improving a multi-tenant database query using contextual knowledge about non-homogeneously distributed tenant data |
| US7529728B2 (en) * | 2003-09-23 | 2009-05-05 | Salesforce.Com, Inc. | Query optimization in a multi-tenant database system |
| DE102004035337A1 (de) * | 2004-07-21 | 2006-03-16 | Merck Patent Gmbh | Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität |
| NZ561040A (en) | 2005-03-18 | 2009-04-30 | Cytos Biotechnology Ag | Cat allergen fusion proteins and use thereof |
| AU2007283731B2 (en) * | 2006-08-11 | 2013-10-24 | Katholieke Universiteit Leuven | Immunogenic peptides and their use in immune disorders |
| US10068303B2 (en) * | 2006-09-29 | 2018-09-04 | Gearbox Llc | Computational systems for biomedical data |
| US8122073B2 (en) * | 2006-09-29 | 2012-02-21 | The Invention Science Fund I | Computational systems for biomedical data |
| US20080082307A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc | Computational systems for biomedical data |
| US20080082306A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc | Computational systems for biomedical data |
| US20080082584A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US20080091730A1 (en) * | 2006-09-29 | 2008-04-17 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US10546652B2 (en) * | 2006-09-29 | 2020-01-28 | Gearbox Llc | Computational systems for biomedical data |
| US20080082364A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US20080109484A1 (en) * | 2006-09-29 | 2008-05-08 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US20080082271A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc | Computational systems for biomedical data |
| US10503872B2 (en) * | 2006-09-29 | 2019-12-10 | Gearbox Llc | Computational systems for biomedical data |
| US7853626B2 (en) * | 2006-09-29 | 2010-12-14 | The Invention Science Fund I, Llc | Computational systems for biomedical data |
| US10095836B2 (en) * | 2006-09-29 | 2018-10-09 | Gearbox Llc | Computational systems for biomedical data |
| US20080082367A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| US20080082359A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of State Of Delaware | Computational systems for biomedical data |
| US20080082583A1 (en) * | 2006-09-29 | 2008-04-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems for biomedical data |
| ITRM20060583A1 (it) * | 2006-10-27 | 2008-04-28 | Francesco Bistoni | Uso della timosina alfa 1 per la preparazione di un medicamento per la prevenzione e la cura delle allergie |
| ES2545885T3 (es) | 2008-02-14 | 2015-09-16 | Life Sciences Research Partners Vzw | Eliminación de respuestas inmunitarias contra vectores virales |
| EP2244733B1 (en) * | 2008-02-14 | 2015-06-17 | Life Sciences Research Partners VZW | Immunotherapy targeting intracellular pathogens |
| AU2009214041A1 (en) | 2008-02-14 | 2009-08-20 | Katholieke Universiteit Leuven | CD4+ T-cells with cytolytic properties |
| ES2627882T3 (es) | 2008-02-14 | 2017-07-31 | Life Sciences Research Partners Vzw | Control inmunogénico de tumores y células tumorales |
| DE11787873T1 (de) | 2010-11-25 | 2013-12-12 | Imnate Sarl | Immugene Peptide zur Verwendung bei der Vorbeugung und/oder Behandlung von Infektionskrankheiten, Autoimmunerkrankungen, Immunreaktionen auf Allofaktoren, allergischen Erkrankungen, Tumoren, Transplantatabstossungen und Immunreaktionen auf virale Vektoren |
| GB201201511D0 (en) | 2012-01-30 | 2012-03-14 | Univ Leuven Kath | Modified epitopes for boosting CD4+ T-cell responses |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
| US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
| EP3939606A3 (en) | 2015-09-25 | 2022-04-20 | ImCyse SA | Improved methods and compounds for eliminating immune responses to therapeutic agents |
| CA3019266A1 (en) | 2016-04-19 | 2017-10-26 | Imcyse Sa | Novel immunogenic cd1d binding peptides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5785973A (en) * | 1988-02-01 | 1998-07-28 | Praxis Biologics, Inc. | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines |
| WO1993008279A1 (en) * | 1991-10-16 | 1993-04-29 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
| NZ284637A (en) * | 1994-04-14 | 1998-09-24 | Immulogic Pharma Corp | Pharmaceutical formulations for treating dust mite allergy |
| EP0759941B1 (en) * | 1994-05-18 | 2000-09-13 | S.P.I. Synthetic Peptides Incorporated | Heterodimer polypeptideimmunogen carrier composition and method for their use |
-
1999
- 1999-06-30 AR ARP990103185A patent/AR020102A1/es unknown
- 1999-07-01 PE PE1999000617A patent/PE20000760A1/es not_active Application Discontinuation
- 1999-07-20 BR BR9912702-4A patent/BR9912702A/pt not_active IP Right Cessation
- 1999-07-20 ES ES99936190T patent/ES2279625T3/es not_active Expired - Lifetime
- 1999-07-20 JP JP2000562477A patent/JP4383667B2/ja not_active Expired - Lifetime
- 1999-07-20 WO PCT/BE1999/000092 patent/WO2000006694A2/en not_active Ceased
- 1999-07-20 EP EP99936190A patent/EP1105505B1/en not_active Expired - Lifetime
- 1999-07-20 AT AT99936190T patent/ATE349537T1/de not_active IP Right Cessation
- 1999-07-20 AU AU51421/99A patent/AU767279B2/en not_active Ceased
- 1999-07-20 CN CN99810025A patent/CN1313903A/zh active Pending
- 1999-07-20 MX MXPA01001093A patent/MXPA01001093A/es not_active IP Right Cessation
- 1999-07-20 DE DE69934590T patent/DE69934590T2/de not_active Expired - Lifetime
- 1999-07-20 CA CA2337969A patent/CA2337969C/en not_active Expired - Fee Related
- 1999-07-22 TW TW088112444A patent/TW589378B/zh not_active IP Right Cessation
- 1999-07-29 US US09/362,731 patent/US6602509B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE349537T1 (de) | 2007-01-15 |
| PE20000760A1 (es) | 2000-08-30 |
| DE69934590T2 (de) | 2007-07-26 |
| BR9912702A (pt) | 2001-05-08 |
| ES2279625T3 (es) | 2007-08-16 |
| CA2337969A1 (en) | 2000-02-10 |
| TW589378B (en) | 2004-06-01 |
| DE69934590D1 (de) | 2007-02-08 |
| WO2000006694A3 (en) | 2000-03-16 |
| EP1105505B1 (en) | 2006-12-27 |
| US6602509B1 (en) | 2003-08-05 |
| MXPA01001093A (es) | 2002-04-24 |
| EP1105505A2 (en) | 2001-06-13 |
| CN1313903A (zh) | 2001-09-19 |
| CA2337969C (en) | 2010-06-29 |
| JP4383667B2 (ja) | 2009-12-16 |
| AU5142199A (en) | 2000-02-21 |
| AU767279B2 (en) | 2003-11-06 |
| WO2000006694A2 (en) | 2000-02-10 |
| JP2002524031A (ja) | 2002-08-06 |
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