JP2025028857A5 - - Google Patents
Info
- Publication number
- JP2025028857A5 JP2025028857A5 JP2024192680A JP2024192680A JP2025028857A5 JP 2025028857 A5 JP2025028857 A5 JP 2025028857A5 JP 2024192680 A JP2024192680 A JP 2024192680A JP 2024192680 A JP2024192680 A JP 2024192680A JP 2025028857 A5 JP2025028857 A5 JP 2025028857A5
- Authority
- JP
- Japan
- Prior art keywords
- cas9
- terminal fragment
- composition
- terminal
- deaminase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862728703P | 2018-09-07 | 2018-09-07 | |
| US62/728,703 | 2018-09-07 | ||
| US201862779404P | 2018-12-13 | 2018-12-13 | |
| US62/779,404 | 2018-12-13 | ||
| PCT/US2019/050111 WO2020051561A1 (en) | 2018-09-07 | 2019-09-07 | Compositions and methods for delivering a nucleobase editing system |
| JP2021512514A JP7657711B2 (ja) | 2018-09-07 | 2019-09-07 | 核酸塩基編集システムを送達するための組成物および方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021512514A Division JP7657711B2 (ja) | 2018-09-07 | 2019-09-07 | 核酸塩基編集システムを送達するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025028857A JP2025028857A (ja) | 2025-03-05 |
| JP2025028857A5 true JP2025028857A5 (enExample) | 2025-10-09 |
Family
ID=69722796
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021512514A Active JP7657711B2 (ja) | 2018-09-07 | 2019-09-07 | 核酸塩基編集システムを送達するための組成物および方法 |
| JP2024192680A Pending JP2025028857A (ja) | 2018-09-07 | 2024-11-01 | 核酸塩基編集システムを送達するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021512514A Active JP7657711B2 (ja) | 2018-09-07 | 2019-09-07 | 核酸塩基編集システムを送達するための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210301274A1 (enExample) |
| EP (1) | EP3847254A4 (enExample) |
| JP (2) | JP7657711B2 (enExample) |
| KR (1) | KR20210055733A (enExample) |
| CN (1) | CN112969790B (enExample) |
| AU (1) | AU2019336245A1 (enExample) |
| CA (1) | CA3112011A1 (enExample) |
| WO (1) | WO2020051561A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| EP3799603A4 (en) | 2018-05-11 | 2022-03-02 | Beam Therapeutics, Inc. | METHODS OF PATHOGENIC AMINO ACID SUBSTITUTION USING PROGRAMMABLE BASE EDITOR SYSTEMS |
| US20210301274A1 (en) * | 2018-09-07 | 2021-09-30 | Beam Therapeutics Inc. | Compositions and Methods for Delivering a Nucleobase Editing System |
| US12454694B2 (en) | 2018-09-07 | 2025-10-28 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| JP2022536364A (ja) | 2019-06-13 | 2022-08-15 | ザ ジェネラル ホスピタル コーポレイション | 操作されたヒト内在性ウイルス様粒子および細胞への送達のためのその使用方法 |
| CA3147875A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| WO2021188840A1 (en) * | 2020-03-19 | 2021-09-23 | Rewrite Therapeutics, Inc. | Methods and compositions for directed genome editing |
| GB2632564B (en) | 2020-04-09 | 2025-06-18 | Verve Therapeutics Inc | Base editing of angptl3 and methods of using same for treatment of disease |
| WO2022020800A2 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| WO2022081890A1 (en) * | 2020-10-14 | 2022-04-21 | Beam Therapeutics Inc. | Compositions and methods for treating glycogen storage disease type 1a |
| EP4377460A1 (en) | 2021-07-30 | 2024-06-05 | Tune Therapeutics, Inc. | Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) |
| EP4377459A2 (en) | 2021-07-30 | 2024-06-05 | Tune Therapeutics, Inc. | Compositions and methods for modulating expression of frataxin (fxn) |
| MX2024002927A (es) | 2021-09-08 | 2024-05-29 | Flagship Pioneering Innovations Vi Llc | Metodos y composiciones para modular un genoma. |
| EP4441074A2 (en) | 2021-12-03 | 2024-10-09 | The Broad Institute, Inc. | Compositions and methods for efficient in vivo delivery |
| WO2023169454A1 (zh) * | 2022-03-08 | 2023-09-14 | 中国科学院遗传与发育生物学研究所 | 腺嘌呤脱氨酶及其在碱基编辑中的用途 |
| WO2023225572A2 (en) | 2022-05-17 | 2023-11-23 | Nvelop Therapeutics, Inc. | Compositions and methods for efficient in vivo delivery |
| CA3261865A1 (en) | 2022-07-12 | 2024-01-18 | Tune Therapeutics, Inc. | TARGETED TRANSCRIPTIONAL ACTIVATION COMPOSITIONS, SYSTEMS AND METHODS |
| CN120641436A (zh) * | 2022-11-01 | 2025-09-12 | 纪念斯隆-凯特琳癌症中心 | 基于内含肽的分选系统和模块化嵌合多肽 |
| WO2024163678A2 (en) | 2023-02-01 | 2024-08-08 | Tune Therapeutics, Inc. | Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods |
| WO2024163683A2 (en) | 2023-02-01 | 2024-08-08 | Tune Therapeutics, Inc. | Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist) |
| WO2024233941A1 (en) * | 2023-05-11 | 2024-11-14 | Massachusetts Eye And Ear Infirmary | Base editing approaches to treat abca4-associated stargardt disease |
| WO2024249954A1 (en) | 2023-05-31 | 2024-12-05 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025038955A1 (en) * | 2023-08-16 | 2025-02-20 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Systems and methods for improving safety of split intein aav mediated gene therapy |
| CN117568313B (zh) * | 2024-01-15 | 2024-04-26 | 上海贝斯昂科生物科技有限公司 | 基因编辑组合物及其用途 |
| WO2025194138A1 (en) | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | St1cas9 compositions and methods for modulating a genome |
| WO2025194124A1 (en) | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | Modified st1cas9 guide nucleic acids |
| WO2025243196A1 (en) * | 2024-05-21 | 2025-11-27 | Fondazione Istituto Italiano Di Tecnologia | Gene regulation system (tuser) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613854A1 (en) * | 2014-03-05 | 2020-02-26 | National University Corporation Kobe University | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
| AU2015298571B2 (en) * | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2016112242A1 (en) * | 2015-01-08 | 2016-07-14 | President And Fellows Of Harvard College | Split cas9 proteins |
| CN106011104B (zh) * | 2015-05-21 | 2019-09-27 | 清华大学 | 利用拆分Cas系统进行基因编辑和表达调控方法 |
| WO2016205759A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
| JP2019524162A (ja) * | 2016-08-18 | 2019-09-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ−Ｃａｓゲノム編集 |
| GB2573062A (en) * | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
| US20210301274A1 (en) * | 2018-09-07 | 2021-09-30 | Beam Therapeutics Inc. | Compositions and Methods for Delivering a Nucleobase Editing System |
-
2019
- 2019-09-07 US US17/273,209 patent/US20210301274A1/en active Pending
- 2019-09-07 KR KR1020217009863A patent/KR20210055733A/ko active Pending
- 2019-09-07 CN CN201980073055.6A patent/CN112969790B/zh active Active
- 2019-09-07 EP EP19857653.0A patent/EP3847254A4/en active Pending
- 2019-09-07 AU AU2019336245A patent/AU2019336245A1/en active Pending
- 2019-09-07 JP JP2021512514A patent/JP7657711B2/ja active Active
- 2019-09-07 WO PCT/US2019/050111 patent/WO2020051561A1/en not_active Ceased
- 2019-09-07 CA CA3112011A patent/CA3112011A1/en active Pending
-
2024
- 2024-11-01 JP JP2024192680A patent/JP2025028857A/ja active Pending
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