JP2002523036A5 - - Google Patents
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- Publication number
- JP2002523036A5 JP2002523036A5 JP2000566305A JP2000566305A JP2002523036A5 JP 2002523036 A5 JP2002523036 A5 JP 2002523036A5 JP 2000566305 A JP2000566305 A JP 2000566305A JP 2000566305 A JP2000566305 A JP 2000566305A JP 2002523036 A5 JP2002523036 A5 JP 2002523036A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- target protein
- protein
- region
- homodimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000037865 fusion proteins Human genes 0.000 description 15
- 108020001507 fusion proteins Proteins 0.000 description 15
- 239000012634 fragment Substances 0.000 description 7
- 102000012936 Angiostatins Human genes 0.000 description 5
- 108010079709 Angiostatins Proteins 0.000 description 5
- 102400001047 Endostatin Human genes 0.000 description 5
- 108010079505 Endostatins Proteins 0.000 description 5
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 5
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 108010001463 Collagen Type XVIII Proteins 0.000 description 2
- 102000047200 Collagen Type XVIII Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 102000013566 Plasminogen Human genes 0.000 description 2
- 108010051456 Plasminogen Proteins 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 239000000710 homodimer Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000000964 angiostatic effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9788398P | 1998-08-25 | 1998-08-25 | |
| US60/097,883 | 1998-08-25 | ||
| PCT/US1999/019329 WO2000011033A2 (en) | 1998-08-25 | 1999-08-25 | Expression and export of angiostatin and endostatin as immunofusins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009196091A Division JP2009273478A (ja) | 1998-08-25 | 2009-08-26 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002523036A JP2002523036A (ja) | 2002-07-30 |
| JP2002523036A5 true JP2002523036A5 (enExample) | 2006-10-19 |
Family
ID=22265602
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000566305A Pending JP2002523036A (ja) | 1998-08-25 | 1999-08-25 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
| JP2009196091A Pending JP2009273478A (ja) | 1998-08-25 | 2009-08-26 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
| JP2013041498A Pending JP2013128490A (ja) | 1998-08-25 | 2013-03-04 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009196091A Pending JP2009273478A (ja) | 1998-08-25 | 2009-08-26 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
| JP2013041498A Pending JP2013128490A (ja) | 1998-08-25 | 2013-03-04 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20030139365A1 (enExample) |
| EP (1) | EP1107989B1 (enExample) |
| JP (3) | JP2002523036A (enExample) |
| CN (2) | CN100422332C (enExample) |
| AT (1) | ATE462725T1 (enExample) |
| AU (1) | AU761027B2 (enExample) |
| BR (1) | BR9913331A (enExample) |
| CA (1) | CA2339331C (enExample) |
| CZ (1) | CZ302303B6 (enExample) |
| DE (1) | DE69942207D1 (enExample) |
| DK (1) | DK1107989T3 (enExample) |
| ES (1) | ES2342239T3 (enExample) |
| HK (1) | HK1042503A1 (enExample) |
| HU (1) | HUP0103329A3 (enExample) |
| NO (1) | NO20010918L (enExample) |
| PL (1) | PL202057B1 (enExample) |
| PT (1) | PT1107989E (enExample) |
| RU (1) | RU2240328C2 (enExample) |
| WO (1) | WO2000011033A2 (enExample) |
| ZA (1) | ZA200101290B (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999016889A1 (en) * | 1997-10-01 | 1999-04-08 | G.D. Searle & Co. | Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| HK1038882A1 (zh) * | 1998-04-15 | 2002-04-04 | 利思进药品公司 | 通过共同给予血管生成抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答 |
| PL202057B1 (pl) * | 1998-08-25 | 2009-05-29 | Merck Patent Gmbh | Homodimeryczne białko fuzyjne będące inhibitorem angiogenezy, sposób jego otrzymywania oraz cząsteczka DNA i wektor ekspresyjny zawierający to DNA |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU778611B2 (en) | 1999-08-09 | 2004-12-16 | Merck Patent Gmbh | Multiple cytokine-antibody complexes |
| IL131803A0 (en) * | 1999-09-08 | 2001-03-19 | Genena Ltd | Method for improving the efficiency of cancer gene therapy |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| ATE368475T1 (de) | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| EP1197550A3 (en) * | 2000-08-25 | 2002-11-20 | Pfizer Products Inc. | Methods and compositions for diagnosing and treating disorders involving angiogenesis |
| JP2003000268A (ja) * | 2000-08-25 | 2003-01-07 | Pfizer Prod Inc | 血管新生にかかわる疾患を診断および治療するための方法および組成物 |
| DE60124927T2 (de) * | 2000-09-01 | 2007-09-20 | Philadelphia Health And Education Corp. | Verfahren und zusammensetzungen zur inhibition der angiogenese |
| US7160858B2 (en) | 2000-09-01 | 2007-01-09 | Philadelphia, Health And Education Corporation | Methods and compositions for inhibiting angiogenesis |
| BR0207854A (pt) * | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| DK1383785T3 (da) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| JP2006508635A (ja) | 2002-05-06 | 2006-03-16 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 治療用または診断用試薬を送達するためのターゲティングタンパク質 |
| DK1572748T3 (da) * | 2002-12-17 | 2010-08-23 | Merck Patent Gmbh | Humaniseret antistof (H14.18) af muse-14.18-antistof der binder til GD2 og dets fusionsprotein med IL-2 |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| JP2007529410A (ja) * | 2003-08-29 | 2007-10-25 | チルドレンズ メディカル センター コーポレーション | 子宮内膜症を治療又は防止するためのペプチド |
| US7524811B2 (en) | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| ES2305886T3 (es) | 2003-12-30 | 2008-11-01 | Merck Patent Gmbh | Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo. |
| KR20060124656A (ko) | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 |
| US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| EP1706428B1 (en) * | 2004-01-22 | 2009-09-23 | MERCK PATENT GmbH | Anti-cancer antibodies with reduced complement fixation |
| JP2005301419A (ja) * | 2004-04-07 | 2005-10-27 | Hitachi Ltd | ディスクアレイ装置およびそのデータ処理方法 |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| ES2325344B1 (es) * | 2004-11-02 | 2010-06-09 | Univ Madrid Autonoma | Inhibidores de angiogenesis multifuncionales y multivalentes. |
| JP4937132B2 (ja) | 2004-12-09 | 2012-05-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫原性の低下したｉｌ−７変種 |
| US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| RU2303997C2 (ru) * | 2005-09-27 | 2007-08-10 | Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" | Конъюгат, обладающий избирательным действием по отношению к раковым опухолям |
| JP4860702B2 (ja) | 2005-10-21 | 2012-01-25 | エフ．ホフマン−ラ ロシュ アーゲー | ポリペプチドのリコンビナント発現のための方法 |
| ES2365046T3 (es) | 2005-12-30 | 2011-09-21 | Merck Patent Gmbh | Anticuerpos anti-cd19 con inmunogenicidad reducida. |
| PT1966238E (pt) * | 2005-12-30 | 2012-07-31 | Merck Patent Gmbh | Uso de hsp70 como um regulador de atividade enzimática |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| KR100888022B1 (ko) * | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8Ｆｃ |
| US7981446B2 (en) * | 2007-11-26 | 2011-07-19 | Forhumantech. Co., Ltd. | Pharmaceutical compositions and methods for delivering nucleic acids into cells |
| AT506216B1 (de) | 2008-02-13 | 2009-07-15 | Peter Dr Hernuss | Zusammensetzung zur aufnahme über mukoses gewebe |
| RU2372354C1 (ru) * | 2008-02-28 | 2009-11-10 | Сергей Викторович Луценко | Слитый белок, имеющий активность ингибитора ангиогенеза |
| EP2413969A4 (en) * | 2009-03-30 | 2012-09-05 | Boehringer Ingelheim Int | FUSION PROTEINS WITH DOG FC ELEMENTS |
| MX2011011044A (es) | 2009-04-22 | 2011-11-04 | Merck Patent Gmbh | Proteinas de fusion de anticuerpos con sitios de enlace de receptor fc neonatal (fcrn) modificados. |
| KR101579318B1 (ko) * | 2010-04-29 | 2015-12-21 | 엘지전자 주식회사 | 태양 전지 및 그 제조 방법 |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| RU2465283C1 (ru) * | 2011-06-27 | 2012-10-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвити | Рекомбинантный гибридный полипептид, способный ингибировать пролиферацию эндотелиальных клеток человека in vitro, и способ его получения |
| EP2561888A1 (en) * | 2011-08-23 | 2013-02-27 | Deutsches Krebsforschungszentrum | Protein comprising NC-1 for treating angiogenesis-related diseases |
| JP6162891B2 (ja) * | 2013-06-14 | 2017-07-12 | エルジー・ケム・リミテッド | 有機太陽電池およびその製造方法 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US20160126391A1 (en) * | 2014-10-31 | 2016-05-05 | Byd Company Limited | Solar cell module and manufacturing method thereof |
| CN108368511B (zh) * | 2015-10-23 | 2022-12-06 | 阿珀吉科吉尼科斯股份公司 | 单链cd137受体激动剂蛋白 |
| CN108430492B (zh) * | 2015-10-23 | 2022-05-03 | 阿珀吉科吉尼科斯股份公司 | 单链cd27受体激动剂蛋白 |
| WO2017068185A1 (en) | 2015-10-23 | 2017-04-27 | Apogenix Ag | Single-chain gitr-receptor agonist proteins |
| WO2017093569A1 (en) | 2015-12-03 | 2017-06-08 | Deutsches Krebsforschungszentrum | Means and methods for treating and diagnosing fibrosis or fibrosis-associated diseases |
| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| CN109824779B (zh) * | 2017-11-23 | 2023-05-26 | 中山大学 | 一种包含IgG的Fc结构域和EB病毒包膜糖蛋白胞外域的融合蛋白 |
| EP4316502A3 (en) | 2018-04-17 | 2024-08-07 | Heidelberg Biotech GmbH | Means and methods for the treatment of angiogenesis-, fibrosis- and cancer-related diseases with protein oligomers comprising nc-1-fc |
| US20220047710A1 (en) * | 2018-09-12 | 2022-02-17 | Washington University | Single chain constructs |
| AU2022209867A1 (en) * | 2021-01-20 | 2023-08-17 | Monash University | Fusion proteins |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05271294A (ja) * | 1992-01-24 | 1993-10-19 | Japan Found Cancer Res | ヒトプロヒビチンおよびそれをコードするｄｎａ |
| US5643783A (en) * | 1993-12-01 | 1997-07-01 | President And Fellows Of Harvard College | Collagen and uses therefor |
| US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5922852A (en) * | 1995-06-07 | 1999-07-13 | Oklahoma Medical Research Foundation | 3' untranslated region of the human prohibitin gene |
| US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| EP0857210B1 (en) * | 1995-10-23 | 2003-09-03 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
| US5854205A (en) * | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
| HK1038882A1 (zh) * | 1998-04-15 | 2002-04-04 | 利思进药品公司 | 通过共同给予血管生成抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答 |
| MXPA00010151A (es) * | 1998-04-17 | 2002-08-06 | Lexigen Pharm Corp | Mejoramiento de las respuestas inmunes mediadas por proteina de fusion de anticuerpo-citocina mediante la soadministracion con inhibidores de prostaglandina. |
| WO1999062944A2 (en) * | 1998-06-03 | 1999-12-09 | The Children's Medical Center Corporation | Protein oligomer compositions comprising endostatin protein and methods of using the same |
| PL202057B1 (pl) * | 1998-08-25 | 2009-05-29 | Merck Patent Gmbh | Homodimeryczne białko fuzyjne będące inhibitorem angiogenezy, sposób jego otrzymywania oraz cząsteczka DNA i wektor ekspresyjny zawierający to DNA |
| US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
-
1999
- 1999-08-25 PL PL346703A patent/PL202057B1/pl unknown
- 1999-08-25 EP EP99942468A patent/EP1107989B1/en not_active Expired - Lifetime
- 1999-08-25 WO PCT/US1999/019329 patent/WO2000011033A2/en not_active Ceased
- 1999-08-25 AU AU55836/99A patent/AU761027B2/en not_active Ceased
- 1999-08-25 DE DE69942207T patent/DE69942207D1/de not_active Expired - Lifetime
- 1999-08-25 DK DK99942468.2T patent/DK1107989T3/da active
- 1999-08-25 HU HU0103329A patent/HUP0103329A3/hu unknown
- 1999-08-25 HK HK02104318.5A patent/HK1042503A1/zh unknown
- 1999-08-25 CA CA2339331A patent/CA2339331C/en not_active Expired - Fee Related
- 1999-08-25 AT AT99942468T patent/ATE462725T1/de active
- 1999-08-25 BR BR9913331-8A patent/BR9913331A/pt not_active IP Right Cessation
- 1999-08-25 ES ES99942468T patent/ES2342239T3/es not_active Expired - Lifetime
- 1999-08-25 PT PT99942468T patent/PT1107989E/pt unknown
- 1999-08-25 RU RU2001105917/13A patent/RU2240328C2/ru not_active IP Right Cessation
- 1999-08-25 CN CNB998124567A patent/CN100422332C/zh not_active Expired - Fee Related
- 1999-08-25 JP JP2000566305A patent/JP2002523036A/ja active Pending
- 1999-08-25 CZ CZ20010643A patent/CZ302303B6/cs not_active IP Right Cessation
- 1999-08-25 CN CNA2008102106518A patent/CN101386651A/zh active Pending
-
2001
- 2001-02-15 ZA ZA200101290A patent/ZA200101290B/xx unknown
- 2001-02-23 NO NO20010918A patent/NO20010918L/no not_active Application Discontinuation
-
2002
- 2002-11-12 US US10/292,418 patent/US20030139365A1/en not_active Abandoned
-
2006
- 2006-06-27 US US11/475,627 patent/US8206718B2/en not_active Expired - Fee Related
-
2009
- 2009-08-26 JP JP2009196091A patent/JP2009273478A/ja active Pending
-
2012
- 2012-06-26 US US13/533,250 patent/US8703908B2/en not_active Expired - Fee Related
-
2013
- 2013-03-04 JP JP2013041498A patent/JP2013128490A/ja active Pending
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