JP2002523036A5 - - Google Patents
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- Publication number
- JP2002523036A5 JP2002523036A5 JP2000566305A JP2000566305A JP2002523036A5 JP 2002523036 A5 JP2002523036 A5 JP 2002523036A5 JP 2000566305 A JP2000566305 A JP 2000566305A JP 2000566305 A JP2000566305 A JP 2000566305A JP 2002523036 A5 JP2002523036 A5 JP 2002523036A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- target protein
- protein
- region
- homodimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000037865 fusion proteins Human genes 0.000 description 15
- 108020001507 fusion proteins Proteins 0.000 description 15
- 239000012634 fragment Substances 0.000 description 7
- 102000012936 Angiostatins Human genes 0.000 description 5
- 108010079709 Angiostatins Proteins 0.000 description 5
- 102400001047 Endostatin Human genes 0.000 description 5
- 108010079505 Endostatins Proteins 0.000 description 5
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 5
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 108010001463 Collagen Type XVIII Proteins 0.000 description 2
- 102000047200 Collagen Type XVIII Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 102000013566 Plasminogen Human genes 0.000 description 2
- 108010051456 Plasminogen Proteins 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 239000000710 homodimer Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000000964 angiostatic effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9788398P | 1998-08-25 | 1998-08-25 | |
| US60/097,883 | 1998-08-25 | ||
| PCT/US1999/019329 WO2000011033A2 (en) | 1998-08-25 | 1999-08-25 | Expression and export of angiostatin and endostatin as immunofusins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009196091A Division JP2009273478A (ja) | 1998-08-25 | 2009-08-26 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002523036A JP2002523036A (ja) | 2002-07-30 |
| JP2002523036A5 true JP2002523036A5 (enExample) | 2006-10-19 |
Family
ID=22265602
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000566305A Pending JP2002523036A (ja) | 1998-08-25 | 1999-08-25 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
| JP2009196091A Pending JP2009273478A (ja) | 1998-08-25 | 2009-08-26 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
| JP2013041498A Pending JP2013128490A (ja) | 1998-08-25 | 2013-03-04 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009196091A Pending JP2009273478A (ja) | 1998-08-25 | 2009-08-26 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
| JP2013041498A Pending JP2013128490A (ja) | 1998-08-25 | 2013-03-04 | イムノフュージンとしての新脈管形成インヒビターの発現および輸送 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20030139365A1 (enExample) |
| EP (1) | EP1107989B1 (enExample) |
| JP (3) | JP2002523036A (enExample) |
| CN (2) | CN100422332C (enExample) |
| AT (1) | ATE462725T1 (enExample) |
| AU (1) | AU761027B2 (enExample) |
| BR (1) | BR9913331A (enExample) |
| CA (1) | CA2339331C (enExample) |
| CZ (1) | CZ302303B6 (enExample) |
| DE (1) | DE69942207D1 (enExample) |
| DK (1) | DK1107989T3 (enExample) |
| ES (1) | ES2342239T3 (enExample) |
| HK (1) | HK1042503A1 (enExample) |
| HU (1) | HUP0103329A3 (enExample) |
| NO (1) | NO20010918L (enExample) |
| PL (1) | PL202057B1 (enExample) |
| PT (1) | PT1107989E (enExample) |
| RU (1) | RU2240328C2 (enExample) |
| WO (1) | WO2000011033A2 (enExample) |
| ZA (1) | ZA200101290B (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1705248A1 (en) * | 1997-10-01 | 2006-09-27 | G.D. Searle LLC. | Fusion proteins comprising an angiostatin moiety and their use in anti-tumour treatment |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| EP1071468B1 (en) * | 1998-04-15 | 2006-06-14 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
| ES2342239T3 (es) * | 1998-08-25 | 2010-07-02 | Merck Patent Gmbh | Expresion y exportacion de angiostatina y de endostatina como inmunofusinas. |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| DE60025832T2 (de) | 1999-08-09 | 2006-08-31 | Emd Lexigen Research Center Corp., Billerica | Mehrere zytokin-antikörper komplexen |
| IL131803A0 (en) * | 1999-09-08 | 2001-03-19 | Genena Ltd | Method for improving the efficiency of cancer gene therapy |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| CN1406249B (zh) | 2000-02-11 | 2010-06-16 | 默克专利股份有限公司 | 增加基于抗体的融合蛋白的循环半衰期 |
| PT1294401E (pt) | 2000-06-29 | 2007-11-09 | Merck Patent Gmbh | Aumento das respostas imunológicas mediadas por proteínas de fusão anticorpo-citoquina por tratamento combinado com agentes que aumentam a captação de imunocitoquinas |
| JP2003000268A (ja) * | 2000-08-25 | 2003-01-07 | Pfizer Prod Inc | 血管新生にかかわる疾患を診断および治療するための方法および組成物 |
| EP1197550A3 (en) * | 2000-08-25 | 2002-11-20 | Pfizer Products Inc. | Methods and compositions for diagnosing and treating disorders involving angiogenesis |
| US7160858B2 (en) | 2000-09-01 | 2007-01-09 | Philadelphia, Health And Education Corporation | Methods and compositions for inhibiting angiogenesis |
| AU2001288648A1 (en) * | 2000-09-01 | 2002-03-13 | Philadelphia, Health And Education Corporation | Methods and compositions for inhibiting angiogenesis |
| RU2003129528A (ru) * | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| CN100503639C (zh) | 2001-05-03 | 2009-06-24 | 默克专利有限公司 | 重组肿瘤特异性抗体及其应用 |
| EP2354791A1 (en) | 2001-12-04 | 2011-08-10 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
| US7893033B2 (en) | 2002-05-06 | 2011-02-22 | Board Of Regents, The University Of Texas System | Targeting proteins to deliver therapeutic or diagnostic reagents |
| PT1572748E (pt) * | 2002-12-17 | 2010-09-28 | Merck Patent Gmbh | Anticorpo humanizado (h14.18) do anticorpo 14.18 de rato que se liga ao gd2 e a sua fusão com a il-2 |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| US7524811B2 (en) | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| JP2007529410A (ja) * | 2003-08-29 | 2007-10-25 | チルドレンズ メディカル センター コーポレーション | 子宮内膜症を治療又は防止するためのペプチド |
| BRPI0418286A (pt) | 2003-12-30 | 2007-05-02 | Merck Patent Gmbh | proteìnas de fusão de il-7 |
| KR20060124656A (ko) | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 |
| JP2007517506A (ja) | 2004-01-05 | 2007-07-05 | イーエムディー・レキシゲン・リサーチ・センター・コーポレーション | 標的化用化合物 |
| WO2005070967A2 (en) * | 2004-01-22 | 2005-08-04 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
| JP2005301419A (ja) * | 2004-04-07 | 2005-10-27 | Hitachi Ltd | ディスクアレイ装置およびそのデータ処理方法 |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| ES2325344B1 (es) * | 2004-11-02 | 2010-06-09 | Univ Madrid Autonoma | Inhibidores de angiogenesis multifuncionales y multivalentes. |
| CN101072793B (zh) | 2004-12-09 | 2012-06-20 | 默克专利有限公司 | 具有降低的免疫原性的il-7变体 |
| RU2303997C2 (ru) * | 2005-09-27 | 2007-08-10 | Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" | Конъюгат, обладающий избирательным действием по отношению к раковым опухолям |
| US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| CN101292036B (zh) * | 2005-10-21 | 2016-04-13 | 弗·哈夫曼-拉罗切有限公司 | 用于重组表达多肽的方法 |
| CN101351475B (zh) * | 2005-12-30 | 2013-05-15 | 默克专利有限公司 | 具有提高的稳定性的白细胞介素12p40变体 |
| DK2270050T3 (da) | 2005-12-30 | 2013-08-12 | Merck Patent Gmbh | Anti-CD19-antistoffer med nedsat immunogenicitet |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| KR100888022B1 (ko) * | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8Ｆｃ |
| US7981446B2 (en) * | 2007-11-26 | 2011-07-19 | Forhumantech. Co., Ltd. | Pharmaceutical compositions and methods for delivering nucleic acids into cells |
| AT506216B1 (de) | 2008-02-13 | 2009-07-15 | Peter Dr Hernuss | Zusammensetzung zur aufnahme über mukoses gewebe |
| RU2372354C1 (ru) * | 2008-02-28 | 2009-11-10 | Сергей Викторович Луценко | Слитый белок, имеющий активность ингибитора ангиогенеза |
| JP2012521784A (ja) * | 2009-03-30 | 2012-09-20 | ベーリンガー・インゲルハイム・インテルナツィオナール・ゲーエムバーハー | イヌＦｃ部分を含む融合タンパク質 |
| AU2010238858A1 (en) | 2009-04-22 | 2011-12-08 | Merck Patent Gmbh | Antibody fusion proteins with modified FcRn binding sites |
| KR101579318B1 (ko) * | 2010-04-29 | 2015-12-21 | 엘지전자 주식회사 | 태양 전지 및 그 제조 방법 |
| EP3626739A1 (en) | 2011-06-24 | 2020-03-25 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| RU2465283C1 (ru) * | 2011-06-27 | 2012-10-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвити | Рекомбинантный гибридный полипептид, способный ингибировать пролиферацию эндотелиальных клеток человека in vitro, и способ его получения |
| EP2561888A1 (en) * | 2011-08-23 | 2013-02-27 | Deutsches Krebsforschungszentrum | Protein comprising NC-1 for treating angiogenesis-related diseases |
| WO2014200312A1 (ko) * | 2013-06-14 | 2014-12-18 | 주식회사 엘지화학 | 유기태양전지 및 이의 제조방법 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US20160126391A1 (en) * | 2014-10-31 | 2016-05-05 | Byd Company Limited | Solar cell module and manufacturing method thereof |
| AU2016341402B2 (en) * | 2015-10-23 | 2020-08-27 | Apogenix Ag | Single-chain GITR-receptor agonist proteins |
| EP3364995B1 (en) * | 2015-10-23 | 2021-08-04 | Apogenix AG | Single-chain cd27-receptor agonist proteins |
| CN108368511B (zh) * | 2015-10-23 | 2022-12-06 | 阿珀吉科吉尼科斯股份公司 | 单链cd137受体激动剂蛋白 |
| EP3383424A1 (en) | 2015-12-03 | 2018-10-10 | Deutsches Krebsforschungszentrum | Means and methods for treating and diagnosing fibrosis or fibrosis-associated diseases |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN109824779B (zh) * | 2017-11-23 | 2023-05-26 | 中山大学 | 一种包含IgG的Fc结构域和EB病毒包膜糖蛋白胞外域的融合蛋白 |
| US11845784B2 (en) | 2018-04-17 | 2023-12-19 | Heidelberg Biotech Gmbh | Means and methods for the treatment of angiogenesis-, fibrosis- and cancer-related diseases with protein oligomers comprising NC-1-Fc |
| WO2020056152A1 (en) * | 2018-09-12 | 2020-03-19 | Chang Liu | Single chain constructs |
| US20240100134A1 (en) * | 2021-01-20 | 2024-03-28 | Monash University | Fusion proteins |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05271294A (ja) * | 1992-01-24 | 1993-10-19 | Japan Found Cancer Res | ヒトプロヒビチンおよびそれをコードするｄｎａ |
| US5643783A (en) * | 1993-12-01 | 1997-07-01 | President And Fellows Of Harvard College | Collagen and uses therefor |
| US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5922852A (en) * | 1995-06-07 | 1999-07-13 | Oklahoma Medical Research Foundation | 3' untranslated region of the human prohibitin gene |
| US5854205A (en) * | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
| ES2206602T3 (es) * | 1995-10-23 | 2004-05-16 | The Children's Medical Center Corporation | Compuestos y metodos terapeuticos inhibidores de angiogenesis. |
| US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| EP1071468B1 (en) * | 1998-04-15 | 2006-06-14 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
| MXPA00010151A (es) * | 1998-04-17 | 2002-08-06 | Lexigen Pharm Corp | Mejoramiento de las respuestas inmunes mediadas por proteina de fusion de anticuerpo-citocina mediante la soadministracion con inhibidores de prostaglandina. |
| KR20010052566A (ko) * | 1998-06-03 | 2001-06-25 | 윌리엄 뉴 | 엔도스타틴 단백질을 포함하는 단백질 올리고머 조성물 및이의 사용방법 |
| ES2342239T3 (es) * | 1998-08-25 | 2010-07-02 | Merck Patent Gmbh | Expresion y exportacion de angiostatina y de endostatina como inmunofusinas. |
| US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
-
1999
- 1999-08-25 ES ES99942468T patent/ES2342239T3/es not_active Expired - Lifetime
- 1999-08-25 EP EP99942468A patent/EP1107989B1/en not_active Expired - Lifetime
- 1999-08-25 HU HU0103329A patent/HUP0103329A3/hu unknown
- 1999-08-25 JP JP2000566305A patent/JP2002523036A/ja active Pending
- 1999-08-25 PL PL346703A patent/PL202057B1/pl unknown
- 1999-08-25 CZ CZ20010643A patent/CZ302303B6/cs not_active IP Right Cessation
- 1999-08-25 DE DE69942207T patent/DE69942207D1/de not_active Expired - Lifetime
- 1999-08-25 AU AU55836/99A patent/AU761027B2/en not_active Ceased
- 1999-08-25 WO PCT/US1999/019329 patent/WO2000011033A2/en not_active Ceased
- 1999-08-25 PT PT99942468T patent/PT1107989E/pt unknown
- 1999-08-25 CN CNB998124567A patent/CN100422332C/zh not_active Expired - Fee Related
- 1999-08-25 AT AT99942468T patent/ATE462725T1/de active
- 1999-08-25 CN CNA2008102106518A patent/CN101386651A/zh active Pending
- 1999-08-25 BR BR9913331-8A patent/BR9913331A/pt not_active IP Right Cessation
- 1999-08-25 HK HK02104318.5A patent/HK1042503A1/zh unknown
- 1999-08-25 RU RU2001105917/13A patent/RU2240328C2/ru not_active IP Right Cessation
- 1999-08-25 CA CA2339331A patent/CA2339331C/en not_active Expired - Fee Related
- 1999-08-25 DK DK99942468.2T patent/DK1107989T3/da active
-
2001
- 2001-02-15 ZA ZA200101290A patent/ZA200101290B/xx unknown
- 2001-02-23 NO NO20010918A patent/NO20010918L/no not_active Application Discontinuation
-
2002
- 2002-11-12 US US10/292,418 patent/US20030139365A1/en not_active Abandoned
-
2006
- 2006-06-27 US US11/475,627 patent/US8206718B2/en not_active Expired - Fee Related
-
2009
- 2009-08-26 JP JP2009196091A patent/JP2009273478A/ja active Pending
-
2012
- 2012-06-26 US US13/533,250 patent/US8703908B2/en not_active Expired - Fee Related
-
2013
- 2013-03-04 JP JP2013041498A patent/JP2013128490A/ja active Pending
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