JP2017521074A5 - - Google Patents

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Publication number
JP2017521074A5
JP2017521074A5 JP2017500932A JP2017500932A JP2017521074A5 JP 2017521074 A5 JP2017521074 A5 JP 2017521074A5 JP 2017500932 A JP2017500932 A JP 2017500932A JP 2017500932 A JP2017500932 A JP 2017500932A JP 2017521074 A5 JP2017521074 A5 JP 2017521074A5
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JP
Japan
Prior art keywords
variant
bmp9
pharmaceutical composition
seq
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017500932A
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English (en)
Japanese (ja)
Other versions
JP2017521074A (ja
JP6737770B2 (ja
Filing date
Publication date
Priority claimed from GBGB1412290.7A external-priority patent/GB201412290D0/en
Application filed filed Critical
Publication of JP2017521074A publication Critical patent/JP2017521074A/ja
Publication of JP2017521074A5 publication Critical patent/JP2017521074A5/ja
Application granted granted Critical
Publication of JP6737770B2 publication Critical patent/JP6737770B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2017500932A 2014-07-10 2015-07-09 骨形成タンパク質の治療上の使用 Active JP6737770B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1412290.7A GB201412290D0 (en) 2014-07-10 2014-07-10 Novel use
GB1412290.7 2014-07-10
PCT/GB2015/051989 WO2016005756A1 (en) 2014-07-10 2015-07-09 Therapeutic use of bone morphogenetic proteins

Publications (3)

Publication Number Publication Date
JP2017521074A JP2017521074A (ja) 2017-08-03
JP2017521074A5 true JP2017521074A5 (enExample) 2018-08-23
JP6737770B2 JP6737770B2 (ja) 2020-08-12

Family

ID=51453948

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017500932A Active JP6737770B2 (ja) 2014-07-10 2015-07-09 骨形成タンパク質の治療上の使用

Country Status (22)

Country Link
US (4) US10336800B2 (enExample)
EP (3) EP3166628B2 (enExample)
JP (1) JP6737770B2 (enExample)
KR (2) KR102519869B1 (enExample)
CN (1) CN106661094B (enExample)
AU (1) AU2015287397B2 (enExample)
CA (1) CA2954221C (enExample)
CY (2) CY1123011T1 (enExample)
DK (2) DK3166628T3 (enExample)
ES (2) ES2770073T5 (enExample)
GB (1) GB201412290D0 (enExample)
HR (2) HRP20200418T1 (enExample)
HU (2) HUE054512T2 (enExample)
LT (2) LT3669886T (enExample)
MX (2) MX378431B (enExample)
PL (2) PL3669886T3 (enExample)
PT (2) PT3669886T (enExample)
RS (2) RS61961B1 (enExample)
RU (1) RU2733318C2 (enExample)
SI (2) SI3166628T1 (enExample)
SM (2) SMT202000171T1 (enExample)
WO (1) WO2016005756A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201412290D0 (en) 2014-07-10 2014-08-27 Cambridge Entpr Ltd Novel use
GB201603653D0 (en) * 2016-03-02 2016-04-13 Cambridge Entpr Ltd Combination Therapy
EP3576776A4 (en) * 2017-02-06 2020-10-14 Acceleron Pharma Inc. COMPOSITIONS AND METHODS OF TREATMENT OF HEART FAILURE
MX2020004561A (es) * 2017-11-02 2020-08-13 Bayer Ag Anticuerpos biespecificos que se unen a alk-1 y bmpr-2.
CN107760779B (zh) * 2017-11-03 2020-10-16 中国医学科学院阜外医院 肺动脉高压相关的突变型bmp9基因及其应用
EP3725804A4 (en) * 2017-12-12 2021-10-06 Kyowa Kirin Co., Ltd. ANTIBODY ANTI- &XFF22; &XFF2D; &XFF30; &XFF11; &XFF10;, AND TH &XC9; RAPEUTIC AGENT AGAINST HYPERTENSION AND HYPERTENSION DISEASES WITH THIS ANTIBODY AS ACTIVE PRINCIPLE
CN111939245B (zh) * 2019-05-16 2024-03-01 龚笑海 一种心脏治疗和保护的药物组合物
US20230285506A1 (en) * 2019-12-03 2023-09-14 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
KR20220021207A (ko) * 2020-08-13 2022-02-22 주식회사 나이벡 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물
WO2023012318A1 (en) * 2021-08-05 2023-02-09 Actelion Pharmaceuticals Ltd Bmp9 variant polypeptides and uses thereof
CN114317604B (zh) * 2022-03-04 2022-06-17 中国医学科学院阜外医院 一种自发性肺动脉高压模型及构建方法
CN120586063A (zh) * 2025-06-18 2025-09-05 中国人民解放军总医院第六医学中心 Bmp9抑制剂在制备用于治疗高血压的药物中的应用

Family Cites Families (26)

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Publication number Priority date Publication date Assignee Title
US171355A (en) * 1875-12-21 Improvement in driers
US5661007A (en) 1991-06-25 1997-08-26 Genetics Institute, Inc. Bone morphogenetic protein-9 compositions
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
BR9406716A (pt) 1993-05-12 1996-02-06 Genetics Inst Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-10) polipeptideo de proteina-10 morfogenética de osso purificada (BMP-10) e molécula de DNA quimérica
WO1995024474A1 (en) 1994-03-10 1995-09-14 Human Genome Sciences, Inc. Bone morphogenic protein-10
AU2947395A (en) 1995-06-06 1996-12-24 Human Genome Sciences, Inc. Bone morphogenic protein-10
GB9912350D0 (en) * 1999-05-26 1999-07-28 European Molecular Biology Lab Embl Modified cytokine
FI117667B (fi) * 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
EP1571159A1 (en) † 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
WO2005113590A2 (en) 2004-05-12 2005-12-01 Acceleron Pharma Inc. Bmp10 propeptides and related methods
WO2006130022A1 (en) 2005-05-30 2006-12-07 Agresearch Limited Modulation of ovulation by agonists and antagonists of bmprii
WO2008014054A2 (en) 2006-07-27 2008-01-31 Centocor, Inc. Bmp-7 variant compositions, methods and uses
MX2009004718A (es) 2006-11-02 2009-06-19 Acceleron Pharma Inc Antagonistas de receptor de alk1 y ligando y sus usos.
JP2010529041A (ja) 2007-06-01 2010-08-26 ワイス・エルエルシー Ｂｍｐ−１０活性を調整する方法および組成物
US8507501B2 (en) 2008-03-13 2013-08-13 The Brigham And Women's Hospital, Inc. Inhibitors of the BMP signaling pathway
US8999928B2 (en) 2009-04-01 2015-04-07 Indiana University Research And Technology Corporation Methods for treating diseases using a bone morphogenetic protein
WO2010115874A1 (en) 2009-04-07 2010-10-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment and the diagnosis ofpulmonary arterial hypertension
US9732143B2 (en) * 2011-02-03 2017-08-15 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
AU2012245439B2 (en) 2011-04-20 2017-04-06 Acceleron Pharma, Inc. Endoglin polypeptides and uses thereof
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
EP2970311A4 (en) 2013-03-14 2016-11-23 Brigham & Womens Hospital BMP HEMMER AND METHOD OF USE THEREOF
GB201412290D0 (en) 2014-07-10 2014-08-27 Cambridge Entpr Ltd Novel use
AU2017296040C1 (en) * 2016-07-15 2023-06-22 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
CN107760779B (zh) 2017-11-03 2020-10-16 中国医学科学院阜外医院 肺动脉高压相关的突变型bmp9基因及其应用
KR20220021207A (ko) 2020-08-13 2022-02-22 주식회사 나이벡 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물

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