JP2017521074A5 - - Google Patents
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- Publication number
- JP2017521074A5 JP2017521074A5 JP2017500932A JP2017500932A JP2017521074A5 JP 2017521074 A5 JP2017521074 A5 JP 2017521074A5 JP 2017500932 A JP2017500932 A JP 2017500932A JP 2017500932 A JP2017500932 A JP 2017500932A JP 2017521074 A5 JP2017521074 A5 JP 2017521074A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- bmp9
- pharmaceutical composition
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1412290.7 | 2014-07-10 | ||
| GBGB1412290.7A GB201412290D0 (en) | 2014-07-10 | 2014-07-10 | Novel use |
| PCT/GB2015/051989 WO2016005756A1 (en) | 2014-07-10 | 2015-07-09 | Therapeutic use of bone morphogenetic proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521074A JP2017521074A (ja) | 2017-08-03 |
| JP2017521074A5 true JP2017521074A5 (enExample) | 2018-08-23 |
| JP6737770B2 JP6737770B2 (ja) | 2020-08-12 |
Family
ID=51453948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500932A Expired - Fee Related JP6737770B2 (ja) | 2014-07-10 | 2015-07-09 | 骨形成タンパク質の治療上の使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10336800B2 (enExample) |
| EP (3) | EP3669886B1 (enExample) |
| JP (1) | JP6737770B2 (enExample) |
| KR (2) | KR102519869B1 (enExample) |
| CN (1) | CN106661094B (enExample) |
| AU (1) | AU2015287397B2 (enExample) |
| CA (1) | CA2954221C (enExample) |
| CY (2) | CY1123011T1 (enExample) |
| DK (2) | DK3166628T3 (enExample) |
| ES (2) | ES2770073T5 (enExample) |
| GB (1) | GB201412290D0 (enExample) |
| HR (2) | HRP20200418T1 (enExample) |
| HU (2) | HUE048924T2 (enExample) |
| LT (2) | LT3166628T (enExample) |
| MX (2) | MX378431B (enExample) |
| PL (2) | PL3669886T3 (enExample) |
| PT (2) | PT3669886T (enExample) |
| RS (2) | RS60181B1 (enExample) |
| RU (1) | RU2733318C2 (enExample) |
| SI (2) | SI3166628T1 (enExample) |
| SM (2) | SMT202100323T1 (enExample) |
| WO (1) | WO2016005756A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| GB201603653D0 (en) * | 2016-03-02 | 2016-04-13 | Cambridge Entpr Ltd | Combination Therapy |
| US20200087367A1 (en) * | 2017-02-06 | 2020-03-19 | Acceleron Pharma Inc. | Compositions and methods for treating heart failure |
| JP7433224B2 (ja) | 2017-11-02 | 2024-02-19 | バイエル・アクチエンゲゼルシヤフト | Ａｌｋ－１およびｂｍｐｒ－２に結合する二重特異性抗体 |
| CN107760779B (zh) * | 2017-11-03 | 2020-10-16 | 中国医学科学院阜外医院 | 肺动脉高压相关的突变型bmp9基因及其应用 |
| KR102790528B1 (ko) * | 2017-12-12 | 2025-04-07 | 쿄와 기린 가부시키가이샤 | 항bmp10 항체 및 해당 항체를 유효 성분으로 하는, 고혈압 및 고혈압성 질환에 대한 치료제 |
| CN111939245B (zh) * | 2019-05-16 | 2024-03-01 | 龚笑海 | 一种心脏治疗和保护的药物组合物 |
| WO2021113544A1 (en) * | 2019-12-03 | 2021-06-10 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| KR20220021207A (ko) * | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
| WO2023012318A1 (en) * | 2021-08-05 | 2023-02-09 | Actelion Pharmaceuticals Ltd | Bmp9 variant polypeptides and uses thereof |
| CN114317604B (zh) * | 2022-03-04 | 2022-06-17 | 中国医学科学院阜外医院 | 一种自发性肺动脉高压模型及构建方法 |
| CN120586063A (zh) * | 2025-06-18 | 2025-09-05 | 中国人民解放军总医院第六医学中心 | Bmp9抑制剂在制备用于治疗高血压的药物中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US171355A (en) * | 1875-12-21 | Improvement in driers | ||
| KR100255415B1 (ko) | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| DE69433742T2 (de) | 1993-05-12 | 2005-07-07 | Genetics Institute, LLC, Cambridge | Bmp-10 zusammensetzungen |
| AU6787594A (en) | 1994-03-10 | 1995-09-25 | Human Genome Sciences, Inc. | Bone morphogenic protein-10 |
| AU2947395A (en) | 1995-06-06 | 1996-12-24 | Human Genome Sciences, Inc. | Bone morphogenic protein-10 |
| GB9912350D0 (en) * | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| FI117667B (fi) * | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| EP1571159A1 (en) | 2004-03-04 | 2005-09-07 | Bayerische Julius-Maximilians-Universität Würzburg | Mutein of a bone morphogenetic protein and use thereof |
| WO2005113590A2 (en) | 2004-05-12 | 2005-12-01 | Acceleron Pharma Inc. | Bmp10 propeptides and related methods |
| WO2006130022A1 (en) | 2005-05-30 | 2006-12-07 | Agresearch Limited | Modulation of ovulation by agonists and antagonists of bmprii |
| WO2008014054A2 (en) | 2006-07-27 | 2008-01-31 | Centocor, Inc. | Bmp-7 variant compositions, methods and uses |
| CN111518218A (zh) * | 2006-11-02 | 2020-08-11 | 阿塞勒隆制药公司 | Alk1受体和配体拮抗剂及其用途 |
| US20090017019A1 (en) * | 2007-06-01 | 2009-01-15 | Wyeth | Methods and compositions for modulating bmp-10 activity |
| EP2265603B1 (en) | 2008-03-13 | 2014-05-07 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
| US8999928B2 (en) | 2009-04-01 | 2015-04-07 | Indiana University Research And Technology Corporation | Methods for treating diseases using a bone morphogenetic protein |
| WO2010115874A1 (en) | 2009-04-07 | 2010-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment and the diagnosis ofpulmonary arterial hypertension |
| JP6161541B2 (ja) * | 2011-02-03 | 2017-07-12 | ゾーマ テクノロジー リミテッド | 細菌中の機能的タンパク質発現を向上させるための方法および物質 |
| CN108178789B (zh) | 2011-04-20 | 2021-11-02 | 阿塞勒隆制药公司 | 内皮糖蛋白多肽及其用途 |
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| US9682983B2 (en) | 2013-03-14 | 2017-06-20 | The Brigham And Women's Hospital, Inc. | BMP inhibitors and methods of use thereof |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| CN116531490A (zh) * | 2016-07-15 | 2023-08-04 | 阿塞勒隆制药公司 | 用于治疗肺高血压的组合物和方法 |
| CN107760779B (zh) | 2017-11-03 | 2020-10-16 | 中国医学科学院阜外医院 | 肺动脉高压相关的突变型bmp9基因及其应用 |
| KR20220021207A (ko) | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
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2014
- 2014-07-10 GB GBGB1412290.7A patent/GB201412290D0/en not_active Ceased
-
2015
- 2015-07-09 EP EP19220066.5A patent/EP3669886B1/en active Active
- 2015-07-09 RS RS20200199A patent/RS60181B1/sr unknown
- 2015-07-09 EP EP15739658.1A patent/EP3166628B2/en active Active
- 2015-07-09 PT PT192200665T patent/PT3669886T/pt unknown
- 2015-07-09 SI SI201531119T patent/SI3166628T1/sl unknown
- 2015-07-09 LT LTEP15739658.1T patent/LT3166628T/lt unknown
- 2015-07-09 DK DK15739658.1T patent/DK3166628T3/da active
- 2015-07-09 US US15/324,864 patent/US10336800B2/en active Active
- 2015-07-09 PL PL19220066T patent/PL3669886T3/pl unknown
- 2015-07-09 SI SI201531606T patent/SI3669886T1/sl unknown
- 2015-07-09 PT PT157396581T patent/PT3166628T/pt unknown
- 2015-07-09 EP EP21158441.2A patent/EP3906936A1/en not_active Withdrawn
- 2015-07-09 DK DK19220066.5T patent/DK3669886T3/da active
- 2015-07-09 RS RS20210631A patent/RS61961B1/sr unknown
- 2015-07-09 JP JP2017500932A patent/JP6737770B2/ja not_active Expired - Fee Related
- 2015-07-09 WO PCT/GB2015/051989 patent/WO2016005756A1/en not_active Ceased
- 2015-07-09 SM SM20210323T patent/SMT202100323T1/it unknown
- 2015-07-09 ES ES15739658T patent/ES2770073T5/es active Active
- 2015-07-09 KR KR1020177003531A patent/KR102519869B1/ko active Active
- 2015-07-09 HU HUE15739658A patent/HUE048924T2/hu unknown
- 2015-07-09 MX MX2017000448A patent/MX378431B/es unknown
- 2015-07-09 SM SM20200171T patent/SMT202000171T1/it unknown
- 2015-07-09 HU HUE19220066A patent/HUE054512T2/hu unknown
- 2015-07-09 CA CA2954221A patent/CA2954221C/en active Active
- 2015-07-09 CN CN201580036984.1A patent/CN106661094B/zh active Active
- 2015-07-09 RU RU2017102381A patent/RU2733318C2/ru active
- 2015-07-09 KR KR1020237010855A patent/KR20230049757A/ko not_active Ceased
- 2015-07-09 ES ES19220066T patent/ES2876124T3/es active Active
- 2015-07-09 HR HRP20200418TT patent/HRP20200418T1/hr unknown
- 2015-07-09 LT LTEP19220066.5T patent/LT3669886T/lt unknown
- 2015-07-09 AU AU2015287397A patent/AU2015287397B2/en not_active Ceased
- 2015-07-09 PL PL15739658.1T patent/PL3166628T5/pl unknown
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2017
- 2017-01-10 MX MX2020011333A patent/MX2020011333A/es unknown
- 2017-01-12 US US15/404,265 patent/US20170121383A1/en not_active Abandoned
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2019
- 2019-05-17 US US16/415,006 patent/US11572396B2/en active Active
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2020
- 2020-03-19 CY CY20201100261T patent/CY1123011T1/el unknown
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2021
- 2021-05-11 HR HRP20210734TT patent/HRP20210734T1/hr unknown
- 2021-05-14 CY CY20211100420T patent/CY1124143T1/el unknown
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2023
- 2023-01-03 US US18/149,403 patent/US20240043485A1/en not_active Abandoned