JP2020506701A5 - - Google Patents
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- JP2020506701A5 JP2020506701A5 JP2019541341A JP2019541341A JP2020506701A5 JP 2020506701 A5 JP2020506701 A5 JP 2020506701A5 JP 2019541341 A JP2019541341 A JP 2019541341A JP 2019541341 A JP2019541341 A JP 2019541341A JP 2020506701 A5 JP2020506701 A5 JP 2020506701A5
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- JP
- Japan
- Prior art keywords
- polypeptide
- tissue
- molecule
- wnt
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000013814 Wnt Human genes 0.000 claims 72
- 108050003627 Wnt Proteins 0.000 claims 72
- 108090000765 processed proteins & peptides Proteins 0.000 claims 60
- 229920001184 polypeptide Polymers 0.000 claims 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims 57
- 210000001519 tissue Anatomy 0.000 claims 44
- 230000011664 signaling Effects 0.000 claims 38
- 150000007523 nucleic acids Chemical group 0.000 claims 37
- 239000000556 agonist Substances 0.000 claims 33
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 239000013598 vector Substances 0.000 claims 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 108020004999 messenger RNA Proteins 0.000 claims 12
- 239000013604 expression vector Substances 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 102100026292 Asialoglycoprotein receptor 1 Human genes 0.000 claims 9
- 101710200897 Asialoglycoprotein receptor 1 Proteins 0.000 claims 9
- 102100026293 Asialoglycoprotein receptor 2 Human genes 0.000 claims 9
- 101710200901 Asialoglycoprotein receptor 2 Proteins 0.000 claims 9
- 101001038507 Homo sapiens Ly6/PLAUR domain-containing protein 3 Proteins 0.000 claims 9
- 101000835086 Homo sapiens Transferrin receptor protein 2 Proteins 0.000 claims 9
- 102100040281 Ly6/PLAUR domain-containing protein 3 Human genes 0.000 claims 9
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims 9
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims 9
- 102100026143 Transferrin receptor protein 2 Human genes 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 9
- 102000011799 Desmoglein Human genes 0.000 claims 8
- 108050002238 Desmoglein Proteins 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 108020004414 DNA Proteins 0.000 claims 7
- 108091006611 SLC10A1 Proteins 0.000 claims 7
- 102000054329 Solute carrier family 10 member 1 Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 230000010354 integration Effects 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 210000005228 liver tissue Anatomy 0.000 claims 5
- 102100026245 E3 ubiquitin-protein ligase RNF43 Human genes 0.000 claims 4
- 101710109241 E3 ubiquitin-protein ligase RNF43 Proteins 0.000 claims 4
- 101000767160 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Intracellular protein transport protein USO1 Proteins 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
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- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 3
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 3
- 108091006207 SLC-Transporter Proteins 0.000 claims 3
- 102000037054 SLC-Transporter Human genes 0.000 claims 3
- 230000000968 intestinal effect Effects 0.000 claims 3
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- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 3
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 239000011574 phosphorus Substances 0.000 claims 3
- 230000001720 vestibular Effects 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 102000004961 Furin Human genes 0.000 claims 2
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 101000802406 Homo sapiens E3 ubiquitin-protein ligase ZNRF3 Proteins 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000026062 Tissue disease Diseases 0.000 claims 2
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 2
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 2
- 101150010310 WNT-4 gene Proteins 0.000 claims 2
- 101150019524 WNT2 gene Proteins 0.000 claims 2
- 102000052547 Wnt-1 Human genes 0.000 claims 2
- 108700020987 Wnt-1 Proteins 0.000 claims 2
- 102000052556 Wnt-2 Human genes 0.000 claims 2
- 108700020986 Wnt-2 Proteins 0.000 claims 2
- 102000052549 Wnt-3 Human genes 0.000 claims 2
- 108700020985 Wnt-3 Proteins 0.000 claims 2
- 102000052548 Wnt-4 Human genes 0.000 claims 2
- 108700020984 Wnt-4 Proteins 0.000 claims 2
- -1 Wnt2B Proteins 0.000 claims 2
- 102000044880 Wnt3A Human genes 0.000 claims 2
- 108700013515 Wnt3A Proteins 0.000 claims 2
- 101100485097 Xenopus laevis wnt11b gene Proteins 0.000 claims 2
- 102000006083 ZNRF3 Human genes 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
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- 108020001507 fusion proteins Proteins 0.000 claims 2
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- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 210000005084 renal tissue Anatomy 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
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- 210000001779 taste bud Anatomy 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 208000010334 End Stage Liver Disease Diseases 0.000 claims 1
- 206010017076 Fracture Diseases 0.000 claims 1
- 201000001925 Fuchs' endothelial dystrophy Diseases 0.000 claims 1
- 101710094892 Furin-1 Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- 102000037126 Leucine-rich repeat-containing G-protein-coupled receptors Human genes 0.000 claims 1
- 108091006332 Leucine-rich repeat-containing G-protein-coupled receptors Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028851 Necrosis Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000001164 Osteoporotic Fractures Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 102100022762 R-spondin-1 Human genes 0.000 claims 1
- 101710110302 R-spondin-1 Proteins 0.000 claims 1
- 102100022763 R-spondin-2 Human genes 0.000 claims 1
- 101710110295 R-spondin-2 Proteins 0.000 claims 1
- 102100022766 R-spondin-3 Human genes 0.000 claims 1
- 101710110310 R-spondin-3 Proteins 0.000 claims 1
- 102100022759 R-spondin-4 Human genes 0.000 claims 1
- 101710110307 R-spondin-4 Proteins 0.000 claims 1
- 201000007737 Retinal degeneration Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical group [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 208000002353 alcoholic hepatitis Diseases 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000002155 anti-virotic effect Effects 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 208000011444 chronic liver failure Diseases 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
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- 235000008521 threonine Nutrition 0.000 claims 1
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- 230000029663 wound healing Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023057334A JP7635291B2 (ja) | 2017-01-26 | 2023-03-31 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP2024195763A JP2025020347A (ja) | 2017-01-26 | 2024-11-08 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450804P | 2017-01-26 | 2017-01-26 | |
| US62/450,804 | 2017-01-26 | ||
| US201762487135P | 2017-04-19 | 2017-04-19 | |
| US62/487,135 | 2017-04-19 | ||
| PCT/US2018/015595 WO2018140821A1 (en) | 2017-01-26 | 2018-01-26 | Tissue-specific wnt signal enhancing molecules and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023057334A Division JP7635291B2 (ja) | 2017-01-26 | 2023-03-31 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506701A JP2020506701A (ja) | 2020-03-05 |
| JP2020506701A5 true JP2020506701A5 (enExample) | 2021-02-25 |
| JP7305543B2 JP7305543B2 (ja) | 2023-07-10 |
Family
ID=62978866
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019541341A Active JP7305543B2 (ja) | 2017-01-26 | 2018-01-26 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP2023057334A Active JP7635291B2 (ja) | 2017-01-26 | 2023-03-31 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP2024195763A Pending JP2025020347A (ja) | 2017-01-26 | 2024-11-08 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023057334A Active JP7635291B2 (ja) | 2017-01-26 | 2023-03-31 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP2024195763A Pending JP2025020347A (ja) | 2017-01-26 | 2024-11-08 | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11958891B2 (enExample) |
| EP (1) | EP3574019A4 (enExample) |
| JP (3) | JP7305543B2 (enExample) |
| CN (1) | CN110234662A (enExample) |
| AU (1) | AU2018211985B2 (enExample) |
| CA (1) | CA3050133A1 (enExample) |
| WO (1) | WO2018140821A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018132572A1 (en) | 2017-01-11 | 2018-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | R-spondin (rspo) surrogate molecules |
| EP3574019A4 (en) | 2017-01-26 | 2021-03-03 | Surrozen, Inc. | TISSUE-SPECIFIC WNT SIGNAL ENHANCEMENT MOLECULES AND THEIR USES |
| CN111727203B (zh) | 2017-12-19 | 2024-04-26 | 瑟罗泽恩奥普瑞汀公司 | Wnt替代分子和其用途 |
| JP7418332B2 (ja) | 2017-12-19 | 2024-01-19 | スロゼン オペレーティング， インコーポレイテッド | 抗フリズルド抗体及び使用方法 |
| CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| JP2021530223A (ja) | 2018-07-09 | 2021-11-11 | スロゼン， インコーポレイテッド | 組織特異性Ｗｎｔシグナル増強分子及びその使用 |
| US20220041753A1 (en) * | 2018-12-27 | 2022-02-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Bispecific antibody for membrane clearance of target receptors |
| EP3924381A4 (en) * | 2019-02-11 | 2023-07-26 | Surrozen Operating, Inc. | MODULATION OF WNT SIGNALING IN EYE DISEASES |
| WO2020206005A1 (en) * | 2019-04-02 | 2020-10-08 | Surrozen, Inc. | Modulation of wnt signaling in auditory disorders |
| JP7377288B2 (ja) * | 2019-06-11 | 2023-11-09 | アントレラ セラピューティクス インコーポレイテッド | 多価ｆｚｄおよびｗｎｔ結合分子とその使用 |
| US11713461B2 (en) | 2019-06-21 | 2023-08-01 | Regeneran Pharmaceuticals, Inc. | Treatment of decreased bone mineral density with zinc and ring finger 3 (ZNRF3) inhibitors |
| KR102192471B1 (ko) * | 2019-10-18 | 2020-12-17 | 주식회사 인코스팜 | 탈모 완화 및 모발 성장을 촉진시키는 펩타이드 및 이를 포함하는 화장료 조성물 |
| EP4087597A4 (en) * | 2020-01-09 | 2023-07-05 | Retinal Solutions, LLC | NEURONAL REGENERATION WITH SYNTHETIC PROTEIN DELIVERY |
| JP2023515505A (ja) * | 2020-02-24 | 2023-04-13 | スロゼン オペレーティング， インコーポレイテッド | Ｗｎｔスーパーアゴニスト |
| JP2023548603A (ja) * | 2020-11-10 | 2023-11-17 | ザ スクリプス リサーチ インスティテュート | オピオイド治療用抗体 |
| KR20230109668A (ko) * | 2020-11-16 | 2023-07-20 | 서로젠 오퍼레이팅, 인크. | 간-특이적 Wnt 신호 증강 분자 및 그의 용도 |
| CN112386687B (zh) * | 2020-12-09 | 2021-05-04 | 爱龄医美国际健康咨询服务(北京)有限公司 | 一种干细胞外泌体及其在药品和化妆品中的应用 |
| CN113307882B (zh) * | 2021-05-12 | 2022-12-20 | 东北大学 | 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物 |
| CN113293214A (zh) * | 2021-06-17 | 2021-08-24 | 深圳华因康基因科技有限公司 | 一种检测神经母细胞瘤复发转移基因wnt2扩增的引物探针及其应用 |
| KR20240040088A (ko) * | 2021-07-15 | 2024-03-27 | 디오젠엑스 | R-스폰딘 단백질의 재조합 변이체 및 그의 용도 |
| JPWO2023080159A1 (enExample) * | 2021-11-02 | 2023-05-11 | ||
| CN116789843B (zh) * | 2022-03-16 | 2024-09-17 | 伯桢生物科技(杭州)有限公司 | Wnt重组蛋白及其应用 |
| CN116836274B (zh) * | 2022-03-23 | 2024-11-22 | 东莞市朋志生物科技有限公司 | 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒 |
| WO2023250291A2 (en) * | 2022-06-21 | 2023-12-28 | Surrozen Operating, Inc. | Modulation of wnt signalling in corneal disorders |
| WO2025146152A1 (zh) * | 2024-01-04 | 2025-07-10 | 上海宝济药业股份有限公司 | 一种药物组合物及其应用 |
| CN120647751B (zh) * | 2025-08-18 | 2025-12-02 | 成都迈科康生物科技有限公司 | 抗人乳头瘤病毒e1蛋白的抗体或其试剂盒和相关应用 |
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| EP2093298A3 (en) * | 2003-10-10 | 2009-09-23 | Deutsches Krebsforschungszentrum | Compositions for diagnosis and therapy of diseases associated with aberrant expression of Futrins (R-Spondins) |
| DE102004050620A1 (de) | 2004-10-13 | 2006-04-20 | Eberhard-Karls-Universität Tübingen | Monoklonaler Antikörper gegen Frizzled-Rezeptoren |
| DE102005035568A1 (de) | 2005-07-25 | 2007-02-01 | M-Phasys Gmbh | Frizzled 9 als Biomarker für Substrukturen des humanen Gehirns |
| PL2578685T3 (pl) | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
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| HUE062459T2 (hu) | 2009-02-03 | 2023-11-28 | Koninklijke Nederlandse Akademie Van Wetenschappen | Tenyésztõközeg epiteliális õssejtek és az epiteliális õssejteket tartalmazó organoidok részére |
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| EP2305274A1 (en) | 2009-09-21 | 2011-04-06 | Centre National de la Recherche Scientifique (CNRS) | Use of WNT stimulators for treating demyelinating diseases |
| NZ600470A (en) | 2009-12-09 | 2015-02-27 | Bayer Pharma AG | Anti-c4.4a antibodies and uses thereof |
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