JP2017527558A5 - - Google Patents
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- JP2017527558A5 JP2017527558A5 JP2017511190A JP2017511190A JP2017527558A5 JP 2017527558 A5 JP2017527558 A5 JP 2017527558A5 JP 2017511190 A JP2017511190 A JP 2017511190A JP 2017511190 A JP2017511190 A JP 2017511190A JP 2017527558 A5 JP2017527558 A5 JP 2017527558A5
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- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 38
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 38
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims description 32
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims description 32
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 30
- 150000001413 amino acids Chemical class 0.000 claims description 30
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 29
- 230000000295 complement effect Effects 0.000 claims description 27
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- 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 claims description 20
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- 108090000623 proteins and genes Proteins 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 230000024203 complement activation Effects 0.000 claims description 11
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 208000002780 macular degeneration Diseases 0.000 claims description 8
- 239000013598 vector Substances 0.000 claims description 7
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 6
- 208000004451 Membranoproliferative Glomerulonephritis Diseases 0.000 claims description 6
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims description 6
- 206010025135 lupus erythematosus Diseases 0.000 claims description 6
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims description 6
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims 1
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- 102000004590 Peripherins Human genes 0.000 description 1
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- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
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- 239000003242 anti bacterial agent Substances 0.000 description 1
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- 239000003146 anticoagulant agent Substances 0.000 description 1
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- 239000003429 antifungal agent Substances 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043084P | 2014-08-28 | 2014-08-28 | |
| US62/043,084 | 2014-08-28 | ||
| PCT/US2015/047405 WO2016033444A1 (en) | 2014-08-28 | 2015-08-28 | Compositions, methods and kits for treating complement related disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019186857A Division JP6811821B2 (ja) | 2014-08-28 | 2019-10-10 | 補体関連障害を処置するための組成物、方法およびキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527558A JP2017527558A (ja) | 2017-09-21 |
| JP2017527558A5 true JP2017527558A5 (enExample) | 2018-10-04 |
| JP6651506B2 JP6651506B2 (ja) | 2020-02-19 |
Family
ID=55400647
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511190A Active JP6651506B2 (ja) | 2014-08-28 | 2015-08-28 | 補体関連障害を処置するための組成物、方法およびキット |
| JP2019186857A Active JP6811821B2 (ja) | 2014-08-28 | 2019-10-10 | 補体関連障害を処置するための組成物、方法およびキット |
| JP2020207487A Active JP7275095B2 (ja) | 2014-08-28 | 2020-12-15 | 補体関連障害を処置するための組成物、方法およびキット |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019186857A Active JP6811821B2 (ja) | 2014-08-28 | 2019-10-10 | 補体関連障害を処置するための組成物、方法およびキット |
| JP2020207487A Active JP7275095B2 (ja) | 2014-08-28 | 2020-12-15 | 補体関連障害を処置するための組成物、方法およびキット |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10813977B2 (enExample) |
| EP (2) | EP3892291A1 (enExample) |
| JP (3) | JP6651506B2 (enExample) |
| AU (1) | AU2015308773B2 (enExample) |
| ES (1) | ES2872537T3 (enExample) |
| WO (1) | WO2016033444A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012021891A2 (en) * | 2010-08-13 | 2012-02-16 | Tufts University | Compositions, kits and methods for treatment of complement-related disorders |
| EP3892291A1 (en) | 2014-08-28 | 2021-10-13 | Tufts University | Compositions, methods and kits for treating complement related disorders |
| GB201608046D0 (en) * | 2016-05-09 | 2016-06-22 | Cambridge Entpr Ltd And Syndey Children S Hospitals Network Randwick And Westmead Incorporating The | Treatment of complement-mediated disorders |
| JP2020505472A (ja) * | 2017-01-27 | 2020-02-20 | ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュアル アンド メカニカル カレッジ | 自己免疫性糖尿病のための二官能性低分子ペプチド |
| CN109331186B (zh) * | 2018-10-10 | 2022-04-05 | 华南师范大学 | 一种脂质体修饰的金纳米粒复合物及其在治疗帕金森氏症方面的应用 |
| JP7444968B2 (ja) * | 2019-04-13 | 2024-03-06 | ナショナル・センター・フォー・セル・サイエンス | Ｄａｆ－ｍｃｐキメラタンパク質、その製造方法及び補体系が関係する病的状態を処置するためのキメラタンパク質の使用 |
| IL309393A (en) * | 2021-06-18 | 2024-02-01 | Ikarovec Ltd | Retinal disorders |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
| US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
| WO1985005629A1 (en) | 1984-05-25 | 1985-12-19 | Dana-Farber Cancer Institute | Ltr vectors, methods of preparation and use |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| CA1315719C (en) | 1988-02-05 | 1993-04-06 | Arthur Bank | Retroviral packaging cell lines and processes of using same |
| US5112767A (en) | 1988-03-04 | 1992-05-12 | University Of Southern California | Vectors with enhancer domains |
| CA1339354C (en) | 1988-09-01 | 1997-08-26 | The Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
| AU4307589A (en) | 1988-09-15 | 1990-04-02 | North Carolina State University | Self-inactivating, replication defective, retroviral vectors and helper cells for producing the same |
| US5124263A (en) | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
| CA2055435A1 (en) | 1989-05-10 | 1990-11-11 | Eli Gilboa | Stably transformed eucaryotic cells comprising a foreign transcribable dna under the control of a pol iii promoter |
| EP0854193A1 (en) | 1990-09-21 | 1998-07-22 | Chiron Corporation | Human retroviral packaging cell line |
| ES2115662T3 (es) | 1990-10-31 | 1998-07-01 | Cell Genesys Inc | Modificacion genetica de celulas endoteliales. |
| US5122767A (en) | 1991-01-10 | 1992-06-16 | Northern Telecom Limited | Saw device tapped delay lines |
| EP0572401B2 (en) | 1991-02-19 | 2007-11-07 | The Regents of the University of California | Viral particles having altered host range |
| WO1993014188A1 (en) | 1992-01-17 | 1993-07-22 | The Regents Of The University Of Michigan | Targeted virus |
| US5627264A (en) | 1994-03-03 | 1997-05-06 | Alexion Pharmaceuticals, Inc. | Chimeric complement inhibitor proteins |
| US5851826A (en) | 1995-07-26 | 1998-12-22 | Children's Medical Center Corporation | Helper virus-free herpesvirus vector packaging system |
| US5843884A (en) | 1995-11-15 | 1998-12-01 | Oklahoma Medical Research Foundation | C9 complement inhibitor |
| US7166568B1 (en) | 1998-02-09 | 2007-01-23 | Oklahoma Medical Research Foundation | Compositions and methods to inhibit formation of the C5b-9 complex of complement |
| US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| WO2012016162A2 (en) * | 2010-07-29 | 2012-02-02 | Tufts University | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders |
| US8877896B2 (en) | 2008-02-15 | 2014-11-04 | Tufts University | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders |
| EP2252317B1 (en) | 2008-02-15 | 2014-04-09 | Tufts University | Treatment of macular degeneration |
| CA2899034A1 (en) * | 2013-01-23 | 2014-07-31 | Musc Foundation For Research Development | Targeting constructs based on natural antibodies and uses thereof |
| US9617940B2 (en) | 2014-08-14 | 2017-04-11 | General Electric Company | Engine diagnostic system and an associated method thereof |
| EP3892291A1 (en) | 2014-08-28 | 2021-10-13 | Tufts University | Compositions, methods and kits for treating complement related disorders |
-
2015
- 2015-08-28 EP EP21161633.9A patent/EP3892291A1/en active Pending
- 2015-08-28 ES ES15836880T patent/ES2872537T3/es active Active
- 2015-08-28 WO PCT/US2015/047405 patent/WO2016033444A1/en not_active Ceased
- 2015-08-28 JP JP2017511190A patent/JP6651506B2/ja active Active
- 2015-08-28 EP EP15836880.3A patent/EP3186269B1/en active Active
- 2015-08-28 AU AU2015308773A patent/AU2015308773B2/en active Active
-
2017
- 2017-02-28 US US15/444,500 patent/US10813977B2/en active Active
-
2019
- 2019-10-10 JP JP2019186857A patent/JP6811821B2/ja active Active
-
2020
- 2020-10-09 US US17/067,515 patent/US11654179B2/en active Active
- 2020-12-15 JP JP2020207487A patent/JP7275095B2/ja active Active
-
2023
- 2023-05-19 US US18/199,616 patent/US20230414714A1/en active Pending
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