CN106661094B - 骨形态发生蛋白的治疗用途 - Google Patents

骨形态发生蛋白的治疗用途 Download PDF

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CN106661094B
CN106661094B CN201580036984.1A CN201580036984A CN106661094B CN 106661094 B CN106661094 B CN 106661094B CN 201580036984 A CN201580036984 A CN 201580036984A CN 106661094 B CN106661094 B CN 106661094B
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bmp9
amino acid
bmp10
acid sequence
polypeptide
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CN106661094A (zh
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尼古拉斯·W·莫雷尔
玮·李
保罗·D·厄普顿
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Cambridge Enterprise Ltd
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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CN201580036984.1A 2014-07-10 2015-07-09 骨形态发生蛋白的治疗用途 Active CN106661094B (zh)

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Application Number Priority Date Filing Date Title
GBGB1412290.7A GB201412290D0 (en) 2014-07-10 2014-07-10 Novel use
GB1412290.7 2014-07-10
PCT/GB2015/051989 WO2016005756A1 (en) 2014-07-10 2015-07-09 Therapeutic use of bone morphogenetic proteins

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CN106661094B true CN106661094B (zh) 2020-09-08

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CN111527106B (zh) * 2017-12-12 2024-10-25 协和麒麟株式会社 抗bmp10抗体和以该抗体为有效成分的对高血压和高血压性疾病的治疗剂
CN111939245B (zh) * 2019-05-16 2024-03-01 龚笑海 一种心脏治疗和保护的药物组合物
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KR20220021207A (ko) * 2020-08-13 2022-02-22 주식회사 나이벡 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물
WO2023012318A1 (en) * 2021-08-05 2023-02-09 Actelion Pharmaceuticals Ltd Bmp9 variant polypeptides and uses thereof
CN114317604B (zh) * 2022-03-04 2022-06-17 中国医学科学院阜外医院 一种自发性肺动脉高压模型及构建方法

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HUE054228T2 (hu) * 2016-07-15 2021-08-30 Acceleron Pharma Inc Használható actriia polipeptideket tartalmazó összetételek a pulmonalis hypertónia kezelésében történõ alkalmazásra
CN107760779B (zh) 2017-11-03 2020-10-16 中国医学科学院阜外医院 肺动脉高压相关的突变型bmp9基因及其应用
KR20220021207A (ko) 2020-08-13 2022-02-22 주식회사 나이벡 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물

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LT3166628T (lt) 2020-04-10
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GB201412290D0 (en) 2014-08-27
AU2015287397B2 (en) 2020-08-20
RU2017102381A (ru) 2018-08-10
KR102519869B1 (ko) 2023-04-07
CA2954221C (en) 2023-02-14
CN106661094A (zh) 2017-05-10
US20190359668A1 (en) 2019-11-28
EP3906936A1 (en) 2021-11-10
US10336800B2 (en) 2019-07-02
KR20170029576A (ko) 2017-03-15
JP2017521074A (ja) 2017-08-03
HUE054512T2 (hu) 2021-09-28
PT3166628T (pt) 2020-04-06
SMT202000171T1 (it) 2020-05-08
DK3166628T3 (da) 2020-03-09
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LT3669886T (lt) 2021-06-10
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US20240043485A1 (en) 2024-02-08
RU2017102381A3 (enExample) 2019-02-28
AU2015287397A1 (en) 2017-02-16
MX2017000448A (es) 2017-08-16
PT3669886T (pt) 2021-05-25
CA2954221A1 (en) 2016-01-14
RU2733318C2 (ru) 2020-10-01
EP3669886B1 (en) 2021-02-24
MX2020011333A (es) 2020-11-24
HRP20210734T1 (hr) 2021-06-11
US20170209540A1 (en) 2017-07-27

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