PE20191353A1 - Meganucleasas disenadas especificamente para el reconocimiento de secuencias en el genoma del virus de la hepatitis b - Google Patents

Meganucleasas disenadas especificamente para el reconocimiento de secuencias en el genoma del virus de la hepatitis b

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Publication number
PE20191353A1
PE20191353A1 PE2019000817A PE2019000817A PE20191353A1 PE 20191353 A1 PE20191353 A1 PE 20191353A1 PE 2019000817 A PE2019000817 A PE 2019000817A PE 2019000817 A PE2019000817 A PE 2019000817A PE 20191353 A1 PE20191353 A1 PE 20191353A1
Authority
PE
Peru
Prior art keywords
meganucleases
hepatitis
designer
specifically designed
hbv
Prior art date
Application number
PE2019000817A
Other languages
English (en)
Inventor
Derek Jantz
James Jefferson Smith
Original Assignee
Prec Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prec Biosciences Inc filed Critical Prec Biosciences Inc
Publication of PE20191353A1 publication Critical patent/PE20191353A1/es

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    • C12N9/22—Ribonucleases RNAses, DNAses
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2730/10011—Hepadnaviridae
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Abstract

La presente invencion abarca meganucleasas de diseno que reconocen y escinden una secuencia de reconocimiento dentro de un marco de lectura abierto (ORF) del genoma de al menos dos genotipos del virus de la hepatitis B (VHB). La presente invencion tambien abarca metodos para usar tales meganucleasas de diseno en una composicion farmaceutica y en metodos para tratar o reducir los sintomas de una infeccion por VHB, o para tratar el carcinoma hepatocelular (CHC). Ademas, la invencion abarca composiciones farmaceuticas que comprenden proteinas de meganucleasas modificadas por ingenieria genetica, acidos nucleicos que codifican meganucleasas de diseno y el uso de tales composiciones para tratar infecciones por VHB o CHC
PE2019000817A 2016-10-14 2017-10-13 Meganucleasas disenadas especificamente para el reconocimiento de secuencias en el genoma del virus de la hepatitis b PE20191353A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662408356P 2016-10-14 2016-10-14
US201762452506P 2017-01-31 2017-01-31
US201762527196P 2017-06-30 2017-06-30
US201762527159P 2017-06-30 2017-06-30
PCT/US2017/056638 WO2018071849A2 (en) 2016-10-14 2017-10-13 Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome

Publications (1)

Publication Number Publication Date
PE20191353A1 true PE20191353A1 (es) 2019-10-01

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PE2019000817A PE20191353A1 (es) 2016-10-14 2017-10-13 Meganucleasas disenadas especificamente para el reconocimiento de secuencias en el genoma del virus de la hepatitis b

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US (4) US10662416B2 (es)
EP (2) EP4234691A3 (es)
JP (4) JP6811857B2 (es)
KR (3) KR20210118240A (es)
CN (2) CN117402852A (es)
AU (2) AU2017342536A1 (es)
BR (1) BR112019007450A2 (es)
CA (1) CA3040143A1 (es)
CL (1) CL2019000993A1 (es)
CO (1) CO2019003675A2 (es)
CR (1) CR20190181A (es)
DK (1) DK3526323T3 (es)
DO (1) DOP2019000097A (es)
FI (1) FI3526323T3 (es)
IL (2) IL265921B2 (es)
MA (1) MA46535A (es)
MX (1) MX2019004349A (es)
PE (1) PE20191353A1 (es)
PH (1) PH12019500788A1 (es)
SG (2) SG11201903042VA (es)
WO (1) WO2018071849A2 (es)

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