BR112018008339A2 - composições e métodos para ativar estimulador de sinalização dependente do gene de interferon - Google Patents

composições e métodos para ativar estimulador de sinalização dependente do gene de interferon

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Publication number
BR112018008339A2
BR112018008339A2 BR112018008339A BR112018008339A BR112018008339A2 BR 112018008339 A2 BR112018008339 A2 BR 112018008339A2 BR 112018008339 A BR112018008339 A BR 112018008339A BR 112018008339 A BR112018008339 A BR 112018008339A BR 112018008339 A2 BR112018008339 A2 BR 112018008339A2
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BR
Brazil
Prior art keywords
compositions
methods
present
cyclic
dependent signaling
Prior art date
Application number
BR112018008339A
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English (en)
Inventor
Obioma NDUBAKU Chudi
Kanne David
Edwin Katibah George
Mckenna Jeffrey
Leong Justin
Gauthier Kelsey
Hix Glickman Laura
Sung Leonard
M Mcwhirter Sarah
M Canham Stephen
W Dubensky Thomas Jr
Original Assignee
Aduro Biotech Inc
Novartis Ag
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Application filed by Aduro Biotech Inc, Novartis Ag filed Critical Aduro Biotech Inc
Publication of BR112018008339A2 publication Critical patent/BR112018008339A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

a presente invenção refere-se a estimuladores imunes de dinucleotídeo cíclico altamente ativos (cdn) que ativam dcs por meio de um receptor citoplasmático recentemente descoberto conhecido como sting (estimulator genes de interferon). em particular, os cdns da presente invenção são fornecidos na forma de uma composição compreendendo um ou mais dinucleotídeo(s) de purina cíclico(s) que induz(em) a produção de interferon tipo i dependente de sting humano, em que os dinucleotídeos de purina cíclicos presentes na composição são cdns de 2',5' - 3',5' de ligação mista substituídos por 2',3'-di-fluoro ou substituídos por 2'- ou 3'-mono-fluoro.
BR112018008339A 2015-10-28 2016-10-28 composições e métodos para ativar estimulador de sinalização dependente do gene de interferon BR112018008339A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562247658P 2015-10-28 2015-10-28
US201662379611P 2016-08-25 2016-08-25
PCT/US2016/059506 WO2017075477A1 (en) 2015-10-28 2016-10-28 Compositions and methods for activating "stimulator of interferon gene"-dependent signalling

Publications (1)

Publication Number Publication Date
BR112018008339A2 true BR112018008339A2 (pt) 2018-10-30

Family

ID=58631242

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018008339A BR112018008339A2 (pt) 2015-10-28 2016-10-28 composições e métodos para ativar estimulador de sinalização dependente do gene de interferon

Country Status (13)

Country Link
US (1) US10906930B2 (pt)
EP (1) EP3368072A4 (pt)
JP (1) JP2018534295A (pt)
KR (1) KR20180066241A (pt)
CN (1) CN108430503A (pt)
AU (1) AU2016343993A1 (pt)
BR (1) BR112018008339A2 (pt)
CA (1) CA3002236A1 (pt)
MX (1) MX2018005299A (pt)
RU (1) RU2018119306A (pt)
TW (1) TW201726700A (pt)
UY (1) UY36969A (pt)
WO (1) WO2017075477A1 (pt)

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