TN2015000408A1 - Compositions and methods for activating "stimulator of interferon gene"-dependent signalling - Google Patents
Compositions and methods for activating "stimulator of interferon gene"-dependent signallingInfo
- Publication number
- TN2015000408A1 TN2015000408A1 TN2015000408A TN2015000408A TN2015000408A1 TN 2015000408 A1 TN2015000408 A1 TN 2015000408A1 TN 2015000408 A TN2015000408 A TN 2015000408A TN 2015000408 A TN2015000408 A TN 2015000408A TN 2015000408 A1 TN2015000408 A1 TN 2015000408A1
- Authority
- TN
- Tunisia
- Prior art keywords
- stimulator
- activating
- compositions
- methods
- present
- Prior art date
Links
Abstract
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2', 5', 2', 5' and 2', 5 ',3 ',5' CDNs, and prefereably Rp,Rp stereosiomers thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361825005P | 2013-05-18 | 2013-05-18 | |
PCT/US2014/038525 WO2014189805A1 (en) | 2013-05-18 | 2014-05-18 | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2015000408A1 true TN2015000408A1 (en) | 2017-01-03 |
Family
ID=57956460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TN2015000408A TN2015000408A1 (en) | 2013-05-18 | 2015-09-10 | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
Country Status (2)
Country | Link |
---|---|
MA (1) | MA38587B1 (en) |
TN (1) | TN2015000408A1 (en) |
-
2014
- 2014-05-18 MA MA38587A patent/MA38587B1/en unknown
-
2015
- 2015-09-10 TN TN2015000408A patent/TN2015000408A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
MA38587B1 (en) | 2018-11-30 |
MA38587A1 (en) | 2017-12-29 |
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