SG11201408045UA - MACROCYCLIC INHIBITORS OF <i>FLAVIVIRIDAE</i> VIRUSES - Google Patents

MACROCYCLIC INHIBITORS OF <i>FLAVIVIRIDAE</i> VIRUSES

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Publication number
SG11201408045UA
SG11201408045UA SG11201408045UA SG11201408045UA SG11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA
Authority
SG
Singapore
Prior art keywords
california
foster city
gilead sciences
lakeside drive
lllll
Prior art date
Application number
SG11201408045UA
Inventor
Caroline Aciro
Victoria Alexandra Steadman
Simon Neil Pettit
Karine G Poullennec
Linos Lazarides
David Kenneth Dean
Neil Andrew Dunbar
Adrian John Highton
Andrew John Keats
Dustin Scott Siegel
Kapil Kumar Karki
Adam James Schrier
Petr Jansa
Richard Mackman
Original Assignee
Gilead Sciences Inc
Selcia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc, Selcia Ltd filed Critical Gilead Sciences Inc
Publication of SG11201408045UA publication Critical patent/SG11201408045UA/en

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/185090 A1 (51) International Patent Classification: C07K 5/062 (2006.01) C07D 498/18 (2006.01) C07D 487/08 (2006.01) A61P 31/14 (2006.01) C07D 498/08 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: PCT/US2013/044809 7 June 2013 (07.06.2013) English (26) Publication Language: (30) Priority Data: 61/657,553 8 June 2012 (08.06.2012) English US (71) Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive, Foster City, California 94404 (US). SEL- CIA LIMITED [GB/GB]; Fyfield Business & Research Park, Fyfield Road, Ongar Essex CM5 0GS (GB). (72) Inventors: ACIRO, Caroline; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). STEADMAN, Victoria Alexandra; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). PETTIT, Simon Neil; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). POULLENNEC, Karine G.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). LAZARIDES, Linos; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). DEAN, David Kenneth; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). DUN­ BAR, Neil Andrew; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). HIGHTON, Adrian John; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). KEATS, Andrew John; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). SIEGEL, Dustin Scott; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). KARKI, Kapil Kumar; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). SCHRIER, Adam James; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). JANSA, Petr; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). MACKMAN, Richard; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). (74) Agents: TANNER, Lorna L. et al.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Avenue, Palo Alto, CA 94301-1479 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, [Continued on next page] (54) Title: MACROCYCLIC INHIBITORS OF FLA VIVIR1DAE VIRUSES o 0\ © 00 (57) Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and esters thereof. The compounds, com­ positions, and methods provided are useful for the treatment of virus infections, particularly hepatitis infections. C i-H o CJ o & WO 2013/185090 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll llll lllll llll lllllll llll llll AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH,
SG11201408045UA 2012-06-08 2013-06-07 MACROCYCLIC INHIBITORS OF <i>FLAVIVIRIDAE</i> VIRUSES SG11201408045UA (en)

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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104703991B (en) * 2012-06-08 2018-03-23 吉利德科学公司 Macrocyclic Inhibitors of Flaviviridae Viruses
AR091279A1 (en) * 2012-06-08 2015-01-21 Gilead Sciences Inc MACROCICLIC INHIBITORS OF VIRUS FLAVIVIRIDAE
PT2859009T (en) 2012-06-08 2018-01-18 Gilead Sciences Inc Macrocyclic inhibitors of flaviviridae viruses
PH12017501029B1 (en) * 2014-12-24 2022-04-27 Lg Chemical Ltd Biaryl derivative as gpr120 agonist
AU2015370004B2 (en) 2014-12-26 2021-03-11 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
MD20170081A2 (en) 2015-03-04 2018-03-31 Gilead Sciences, Inc. Compounds 4,6-diamino-pyrido [3,2 D] pyrimidine modulators Toll-like receptors
MA42684A (en) 2015-08-26 2018-07-04 Gilead Sciences Inc TOLL RECEIVER DEUTERATED MODULATORS
CN109641874A (en) 2016-05-10 2019-04-16 C4医药公司 C for target protein degradation3The glutarimide degron body of carbon connection
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
CN109562113A (en) 2016-05-10 2019-04-02 C4医药公司 Loop coil degron body for target protein degradation
EP3454856B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
AU2017271990B2 (en) 2016-05-27 2019-12-19 Gilead Sciences, Inc. Methods for treating Hepatitis B virus infections using NS5A, NS5B or NS3 inhibitors
BR102017010009A2 (en) 2016-05-27 2017-12-12 Gilead Sciences, Inc. COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION
JOP20190024A1 (en) 2016-08-26 2019-02-19 Gilead Sciences Inc Substituted pyrrolizine compounds and uses thereof
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
CN109923106B (en) 2016-09-02 2022-09-13 吉利德科学公司 toll-like receptor modulator compounds
FI3526323T3 (en) 2016-10-14 2023-06-06 Prec Biosciences Inc Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome
TWI784370B (en) 2017-01-31 2022-11-21 美商基利科學股份有限公司 Crystalline forms of tenofovir alafenamide
JOP20180008A1 (en) 2017-02-02 2019-01-30 Gilead Sciences Inc Compounds for the treatment of hepatitis b virus infection
JOP20180040A1 (en) 2017-04-20 2019-01-30 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
EP3641762A4 (en) 2017-06-20 2021-03-10 C4 Therapeutics, Inc. N / O-LINKED DEGRONES AND DEGRONIMERS FOR PROTEIN DEGRADATION
WO2019040102A1 (en) 2017-08-22 2019-02-28 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
CA3082191C (en) 2017-12-07 2021-09-21 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
KR102492187B1 (en) 2017-12-20 2023-01-27 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. 3'3' cyclic dinucleotides with phosphonate linkages that activate STING adapter proteins
US11203610B2 (en) 2017-12-20 2021-12-21 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
IL300572A (en) 2018-02-13 2023-04-01 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2019165374A1 (en) 2018-02-26 2019-08-29 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors
EP3774883A1 (en) 2018-04-05 2021-02-17 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis b virus protein x
TWI833744B (en) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-cyclic dinucleotides
TWI818007B (en) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
TW202005654A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'2'-cyclic dinucleotides
TW201945388A (en) 2018-04-12 2019-12-01 美商精密生物科學公司 Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis B virus genome
WO2019204609A1 (en) 2018-04-19 2019-10-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US20190359645A1 (en) 2018-05-03 2019-11-28 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide
US11186579B2 (en) 2018-07-06 2021-11-30 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
KR102651420B1 (en) 2018-07-06 2024-03-28 길리애드 사이언시즈, 인코포레이티드 Therapeutic Heterocyclic Compounds
TWI809427B (en) 2018-07-13 2023-07-21 美商基利科學股份有限公司 Pd-1/pd-l1 inhibitors
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
PT3873903T (en) 2018-10-31 2024-05-16 Gilead Sciences Inc Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
KR102658602B1 (en) 2018-10-31 2024-04-19 길리애드 사이언시즈, 인코포레이티드 Substituted 6-azabenzimidazole compounds with HPK1 inhibitory activity
KR102808642B1 (en) 2019-03-07 2025-05-14 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. 3'3'-cyclic dinucleotide and prodrugs thereof
CN113543851B (en) 2019-03-07 2025-03-18 捷克共和国有机化学与生物化学研究所 2'3'-Cyclic dinucleotides and prodrugs thereof
EP3935065A1 (en) 2019-03-07 2022-01-12 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202210480A (en) 2019-04-17 2022-03-16 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
US20220305115A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
AU2020301161B2 (en) 2019-06-25 2023-10-26 Gilead Sciences, Inc. FLT3L-Fc fusion proteins and methods of use
WO2021011891A1 (en) 2019-07-18 2021-01-21 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
US20220296619A1 (en) 2019-08-19 2022-09-22 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
DK4037708T3 (en) 2019-09-30 2024-09-30 Gilead Sciences Inc HBV vaccines and methods of treating HBV
CN115873020B (en) 2019-11-04 2025-06-13 锐新医药公司 RAS inhibitors
US11566007B2 (en) 2019-11-04 2023-01-31 Revolution Medicines, Inc. Ras inhibitors
AU2020377925A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
DK4069729T3 (en) 2019-12-06 2025-04-07 Prec Biosciences Inc OPTIMIZED, MODIFIED MEGANUCLEASES WITH SPECIFICITY FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOME
KR20220156884A (en) 2020-03-20 2022-11-28 길리애드 사이언시즈, 인코포레이티드 Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
CA3186054A1 (en) 2020-08-07 2022-02-10 Daniel H. BYUN Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
TW202406932A (en) 2020-10-22 2024-02-16 美商基利科學股份有限公司 Interleukin-2-fc fusion proteins and methods of use
CN117616031A (en) 2021-05-05 2024-02-27 锐新医药公司 RAS inhibitors for cancer treatment
JP2024518558A (en) 2021-05-13 2024-05-01 ギリアード サイエンシーズ， インコーポレイテッド Combination of TLR8 Modulating Compounds with Anti-HBV siRNA Therapeutics
WO2022271650A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3220923A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222439A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271684A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
AR127308A1 (en) 2021-10-08 2024-01-10 Revolution Medicines Inc RAS INHIBITORS
GB202207348D0 (en) * 2022-05-19 2022-07-06 Cypralis Ltd Macrocyclic compounds and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR006514A1 (en) * 1995-07-04 1999-09-08 Sandoz Ag A MACROLID, ITS USES, A PROCESS TO PRODUCE IT, A BIOLOGICALLY PURE ISOLATE CAPABLE OF PRODUCING IT, AND A PHARMACEUTICAL COMPOSITION THAT IT INCLUDES
US6124453A (en) 1995-07-04 2000-09-26 Novartis Ag Macrolides
DE10239042A1 (en) 2002-08-21 2004-03-04 Schering Ag New fused macrocyclic pyrimidine derivatives, useful as e.g. cyclin-dependent kinase inhibitors for treating e.g. cancer, autoimmune, cardiovascular or neurodegenerative diseases or viral infections
US20050159345A1 (en) 2002-10-29 2005-07-21 Boehringer Ingelheim International Gmbh Composition for the treatment of infection by Flaviviridae viruses
WO2006138376A1 (en) 2005-06-16 2006-12-28 Cv Therapeutics, Inc. Prodrugs of a2b adenosine receptor antagonists
AR054778A1 (en) 2005-06-17 2007-07-18 Novartis Ag USE OF SANGLIFERINA IN HCV
EP2011786A1 (en) 2007-07-05 2009-01-07 Laboratorios del Dr. Esteve S.A. Indane-amine derivatives, their preparation and use as medicaments
CL2008003384A1 (en) * 2007-11-14 2009-12-11 Enanta Pharm Inc Macrocyclic quinoxaline derived compounds, serine protease inhibitors; pharmaceutical composition comprising them; and its use in the treatment of hepatitis c.
EP2241626B1 (en) 2008-01-09 2016-01-06 Konkuk University Industrial Cooperation Corp Baculovirus-based vaccines
US20100080770A1 (en) * 2008-09-29 2010-04-01 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
EP2382198B1 (en) * 2008-12-23 2013-07-10 Janssen Pharmaceuticals, Inc. Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
EP2504315A1 (en) 2009-11-23 2012-10-03 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
PT2523950T (en) 2010-01-15 2017-06-01 Gilead Sciences Inc Inhibitors of flaviviridae viruses
US9227971B2 (en) 2010-01-19 2016-01-05 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
GB201008123D0 (en) 2010-05-17 2010-06-30 Biotica Tech Ltd Novel compounds
US20130178413A1 (en) 2010-09-21 2013-07-11 John A. McCauley Hcv ns3 protease inhibitors
UY33775A (en) 2010-12-10 2012-07-31 Gilead Sciences Inc MACROCYCLIC INHIBITORS OF VIRUS FLAVIVIRIDAE, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND AND THEIR USES
CN104703991B (en) 2012-06-08 2018-03-23 吉利德科学公司 Macrocyclic Inhibitors of Flaviviridae Viruses
PT2859009T (en) 2012-06-08 2018-01-18 Gilead Sciences Inc Macrocyclic inhibitors of flaviviridae viruses
AR091279A1 (en) * 2012-06-08 2015-01-21 Gilead Sciences Inc MACROCICLIC INHIBITORS OF VIRUS FLAVIVIRIDAE

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