SG11201408045UA - MACROCYCLIC INHIBITORS OF <i>FLAVIVIRIDAE</i> VIRUSES - Google Patents

MACROCYCLIC INHIBITORS OF <i>FLAVIVIRIDAE</i> VIRUSES

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Publication number
SG11201408045UA
SG11201408045UA SG11201408045UA SG11201408045UA SG11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA SG 11201408045U A SG11201408045U A SG 11201408045UA
Authority
SG
Singapore
Prior art keywords
california
foster city
gilead sciences
lakeside drive
lllll
Prior art date
Application number
SG11201408045UA
Inventor
Caroline Aciro
Victoria Alexandra Steadman
Simon Neil Pettit
Karine G Poullennec
Linos Lazarides
David Kenneth Dean
Neil Andrew Dunbar
Adrian John Highton
Andrew John Keats
Dustin Scott Siegel
Kapil Kumar Karki
Adam James Schrier
Petr Jansa
Richard Mackman
Original Assignee
Gilead Sciences Inc
Selcia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc, Selcia Ltd filed Critical Gilead Sciences Inc
Publication of SG11201408045UA publication Critical patent/SG11201408045UA/en

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/185090 A1 (51) International Patent Classification: C07K 5/062 (2006.01) C07D 498/18 (2006.01) C07D 487/08 (2006.01) A61P 31/14 (2006.01) C07D 498/08 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: PCT/US2013/044809 7 June 2013 (07.06.2013) English (26) Publication Language: (30) Priority Data: 61/657,553 8 June 2012 (08.06.2012) English US (71) Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive, Foster City, California 94404 (US). SEL- CIA LIMITED [GB/GB]; Fyfield Business & Research Park, Fyfield Road, Ongar Essex CM5 0GS (GB). (72) Inventors: ACIRO, Caroline; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). STEADMAN, Victoria Alexandra; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). PETTIT, Simon Neil; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). POULLENNEC, Karine G.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). LAZARIDES, Linos; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). DEAN, David Kenneth; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). DUN­ BAR, Neil Andrew; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). HIGHTON, Adrian John; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). KEATS, Andrew John; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). SIEGEL, Dustin Scott; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). KARKI, Kapil Kumar; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). SCHRIER, Adam James; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). JANSA, Petr; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). MACKMAN, Richard; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404 (US). (74) Agents: TANNER, Lorna L. et al.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Avenue, Palo Alto, CA 94301-1479 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, [Continued on next page] (54) Title: MACROCYCLIC INHIBITORS OF FLA VIVIR1DAE VIRUSES o 0\ © 00 (57) Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and esters thereof. The compounds, com­ positions, and methods provided are useful for the treatment of virus infections, particularly hepatitis infections. C i-H o CJ o & WO 2013/185090 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll llll lllll llll lllllll llll llll AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH,
SG11201408045UA 2012-06-08 2013-06-07 MACROCYCLIC INHIBITORS OF <i>FLAVIVIRIDAE</i> VIRUSES SG11201408045UA (en)

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