SG11201408186TA - Pyridinone and pyridazinone derivatives - Google Patents

Pyridinone and pyridazinone derivatives

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Publication number
SG11201408186TA
SG11201408186TA SG11201408186TA SG11201408186TA SG11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA SG 11201408186T A SG11201408186T A SG 11201408186TA
Authority
SG
Singapore
Prior art keywords
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international
road
north
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Prior art date
Application number
SG11201408186TA
Inventor
Robert D Hubbard
Le Wang
Chang H Park
Chaohong Sun
Keith F Mcdaniel
John K Pratt
Todd N Soltwedel
Michael D Wendt
John H Holms
Dachun Liu
George S Sheppard
Original Assignee
Abbvie Inc
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Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of SG11201408186TA publication Critical patent/SG11201408186TA/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/188381 A1 (51) International Patent Classification: C07D 403/12 C07D 401/14 C07D 213/74 C07D 213/81 C07D 401/02 C07D 401/04 C07D 401/10 C07D 401/12 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) C07D 403/04 C07D 237/14 C07D 403/10 C07D 407/04 C07D 407/12 C07D 409/04 C07D 413/10 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2013/045151 11 June 2013 (11.06.2013) (22) International Filing Date: (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2012/076748 12 June 2012 (12.06.2012) CN 13/796,437 12 March 2013 (12.03.2013) US (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, IL 60064 (US). (72) Inventors: HUBBARD, Robert, D.; 7684 Marker Road, San Diego, CA 92130 (US). WANG, Le; 338 East Coloni­ al Drive, Vernon Hills, IL 60061 (US). PARK, Chang, H.; 2871 N. Southern Hills Drive, Wadsworth, IL 60083 (US). SUN, Chaohong; 390 Churchill Lane, Gurnee, IL 60031 (US). MCDANIEL, Keith, F.; 26029 W. Laurel Court, Wauconda, IL 60084 (US). PRATT, John, K.; 8210 61st. Avenue, Kenosha, WI 53142 (US). SOLTWEDEL, Todd, N.; 4808 W. Strong Street, Chicago, IL 60646 (US). WENDT, Michael, D.; 1445 Maidstone Drive, Vernon Hills, IL 60061 (US). HOLMS, John, H.; 1239 Pine Grove Avenue, Gurnee, IL 60031 (US). LIU, Dachun; 1276 Georgetown Way, Vernon Hills, IL 60061 (US). SHEPPARD, George, S.; 807 Locust Road, Wilmette, IL 60091 (US). (74) Agents: BAUDE, Eric, J. et al.; AbbVie Inc., 1 North Waukegan Road, AP34-2/V377, North Chicago, IL 60064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, [Continued on next page] (54) Title: PYRIDINONE AND PYRIDAZINONE DERIVATIVES 00 m oo oo X 2a (Ha) (Kb) T-H o CJ (57) Abstract: The present invention provides for compounds of formula (I) Wherein J is a group of formula 11a or lib: A', A , 2 A3, A4, J, and X 3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are use - fill as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula 1. WO 2013/188381 Al I lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll lllll llll llll lllllll llll llll TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Published: KM, ML, MR, NE, SN, TD, TG). — internationa i searc h report (Art. 21(3))
SG11201408186TA 2012-06-12 2013-06-11 Pyridinone and pyridazinone derivatives SG11201408186TA (en)

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PCT/CN2012/076748 WO2013185284A1 (en) 2012-06-12 2012-06-12 Pyridinone and pyridazinone derivatives
US13/796,437 US9561231B2 (en) 2012-06-12 2013-03-12 Pyridinone and pyridazinone derivatives
PCT/US2013/045151 WO2013188381A1 (en) 2012-06-12 2013-06-11 Pyridinone and pyridazinone derivatives

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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013097052A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
CN104718201A (en) * 2012-06-12 2015-06-17 艾伯维公司 Pyridinone and pyridazinone derivatives
KR20150119926A (en) 2013-02-19 2015-10-26 바이엘 파마 악티엔게젤샤프트 Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines
JP2016513118A (en) 2013-02-22 2016-05-12 バイエル ファーマ アクチエンゲゼルシャフト 4-substituted pyrrolo- and pyrazolodiazepines
EP2958922A1 (en) 2013-02-22 2015-12-30 Bayer Pharma Aktiengesellschaft Pyrrolo- and pyrazolo-triazolodiazepines as bet-protein inhibitors for treating hyperproliferative diseases
CN105377851B (en) 2013-03-11 2018-07-20 密执安州立大学董事会 BET Bu Luomo structural domains inhibitor and the therapy for using these inhibitor
TWI719464B (en) 2013-03-15 2021-02-21 美商英塞特控股公司 Tricyclic heterocycles as bet protein inhibitors
EP3019502B1 (en) 2013-07-08 2017-05-17 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
RS60002B1 (en) 2013-10-18 2020-04-30 Celgene Quanticel Research Inc Bromodomain inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
AU2014363989A1 (en) 2013-12-09 2016-06-16 Abbvie Inc. Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors
WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
AU2015222887B2 (en) 2014-02-28 2019-06-27 The Regents Of The University Of Michigan 9H-pyrimido[4,5-b]indoles and related analogs as BET bromodomain inhibitors
DK3674302T3 (en) 2014-04-23 2023-04-03 Incyte Holdings Corp 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS
EA030946B1 (en) 2014-06-27 2018-10-31 Селджен Квонтисел Рисёрч, Инк. Inhibitors of lysine specific demethylase-1
US9527864B2 (en) 2014-09-15 2016-12-27 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
WO2016138332A1 (en) 2015-02-27 2016-09-01 The Regents Of The University Of Michigan 9h-pyrimido [4,5-b] indoles as bet bromodomain inhibitors
GB201504694D0 (en) 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Covalent conjugates
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
PL3319959T3 (en) 2015-07-06 2022-02-14 Alkermes, Inc. Hetero-halo inhibitors of histone deacetylase
GB201514015D0 (en) * 2015-08-07 2015-09-23 Arnér Elias S J And Dept Of Health And Human Services Novel pyridazinones and their use in the treatment of cancer
CN108290856A (en) 2015-08-11 2018-07-17 尼奥迈德研究所 The substituted dihydro-quinolone of aryl-, their preparation and their purposes as drug
US10836742B2 (en) 2015-08-11 2020-11-17 Neomed Institute N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
CA2994478C (en) 2015-08-12 2023-10-03 Neomed Institute Substituted benzimidazoles, their preparation and their use as pharmaceuticals
EA033679B1 (en) 2015-09-02 2019-11-15 Glaxosmithkline Ip No 2 Ltd Pyridinone dicarboxamide for use as bromodomain inhibitors
WO2017066876A1 (en) * 2015-10-21 2017-04-27 Neomed Institute Substituted imidazopyridines, their preparation and their use as pharmaceuticals
WO2017074992A1 (en) 2015-10-28 2017-05-04 E. I. Du Pont De Nemours And Company Novel pyrdazinone herbicides
WO2017075377A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
WO2017127930A1 (en) * 2016-01-28 2017-08-03 Neomed Institute Substituted [1,2,4]triazolo[4,3-a]pyridines, their preparation and their use as pharmaceuticals
ES2882066T3 (en) 2016-02-15 2021-12-01 Univ Michigan Regents Fused 1,4-oxazepines and related analogs as BET bromodomain inhibitors
CN113788818A (en) 2016-04-06 2021-12-14 密执安大学评议会 MDM2 protein degrading agent
US10759808B2 (en) 2016-04-06 2020-09-01 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
MX2018012379A (en) 2016-04-12 2019-07-04 Univ Michigan Regents Bet protein degraders.
TWI764237B (en) 2016-04-15 2022-05-11 美商艾伯維有限公司 Bromodomain inhibitors
KR102643344B1 (en) 2016-06-20 2024-03-07 인사이트 코포레이션 Crystalline solid forms of a bet inhibitor
US11466028B2 (en) 2016-09-13 2022-10-11 The Regents Of The University Of Michigan Fused 1,4-oxazepines as BET protein degraders
US10975093B2 (en) 2016-09-13 2021-04-13 The Regents Of The University Of Michigan Fused 1,4-diazepines as BET protein degraders
BR112019007631A2 (en) * 2016-10-14 2019-07-02 Abbvie Inc bromodomain inhibitors
BR112019007591A2 (en) * 2016-10-14 2019-07-02 Abbvie Inc bromodomain inhibitors
EP3539960A4 (en) 2016-11-10 2020-03-18 Luoxin Pharmaceutical (Shanghai) Co., Ltd. Nitrogenous macrocyclic compound, preparation method therefor, pharmaceutical composition and application thereof
EP3568135B1 (en) 2017-01-11 2021-04-07 Alkermes, Inc. Bicyclic inhibitors of histone deacetylase
EP3577120A1 (en) 2017-02-03 2019-12-11 The Regents of The University of Michigan Fused 1,4-diazepines as bet bromodomain inhibitors
TWI788343B (en) * 2017-04-18 2023-01-01 美商塞爾基因定量細胞研究公司 Therapeutic compounds
JP7152471B2 (en) 2017-08-07 2022-10-12 ロダン・セラピューティクス，インコーポレーテッド Bicyclic inhibitor of histone deacetylase
US11192865B2 (en) * 2017-08-21 2021-12-07 Vivace Therapeutics, Inc. Benzosulfonyl compounds
PL3672941T3 (en) * 2017-08-23 2022-06-13 Sprint Bioscience Ab Pyridylpyridone compounds
WO2019055444A1 (en) 2017-09-13 2019-03-21 The Regents Of The University Of Michigan Bet bromodomain protein degraders with cleavable linkers
KR102026243B1 (en) * 2018-01-19 2019-09-27 연세대학교 산학협력단 Pharmaceutical composition for treating leukemia
US11485729B2 (en) * 2018-01-23 2022-11-01 Shenzhen Targetrx, Inc. Substituted pyridazinone compound
US11661403B2 (en) 2018-05-16 2023-05-30 Vivace Therapeutics, Inc. Oxadiazole compounds
CN108929275B (en) * 2018-06-14 2021-08-24 沈阳药科大学 6- (3, 4-substituted phenyl) -3-oxo-2, 3-dihydropyridazine-4-hydrazide compound and application thereof
EP3852533B1 (en) * 2018-09-18 2024-02-28 Goldfinch Bio, Inc. Pyridazinones and methods of use thereof
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
WO2022115545A1 (en) 2020-11-25 2022-06-02 Deciphera Pharmaceuticals, Llc Pyridylpyridone derivatives as vsp34 inhibitors for use in the treatment of a viral infection
CN115477640A (en) * 2021-05-31 2022-12-16 由理生物医药（上海）有限公司 Pyridazinones as PARP7 inhibitors
WO2023146512A1 (en) * 2022-01-25 2023-08-03 Vivace Therapeutics, Inc. Compounds and methods of use thereof
WO2023215559A1 (en) * 2022-05-05 2023-11-09 Aria Pharmaceuticals, Inc. Compounds, compositions, and methods
CN116003315A (en) * 2023-01-09 2023-04-25 中国药科大学 Diaryl ether pyridone compound and preparation method and application thereof

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445510A1 (en) 1963-11-08 1969-03-13 Basf Ag Process for the preparation of 4-nitro-5-chloro- or -bromopyridazones
DE2845456A1 (en) 1978-10-19 1980-08-14 Merck Patent Gmbh 6-ARYLPYRIDAZIN-3-ONE AND METHOD FOR THE PRODUCTION THEREOF
JPS5795964A (en) 1980-12-04 1982-06-15 Morishita Seiyaku Kk Preparation of 2-substituted-3(2h)-pyridazinone derivative
US4404203A (en) 1981-05-14 1983-09-13 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4397854A (en) 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
EP0096517A3 (en) * 1982-06-05 1985-04-03 Smith Kline & French Laboratories Limited Aryl pyrazinones
US4657906A (en) 1982-06-05 1987-04-14 Smith Kline & French Laboratories Ltd. Heterocyclic compounds having inotropic activity
JPS591471A (en) * 1982-06-05 1984-01-06 スミス・クライン・アンド・フレンチ・ラポラトリ−ス・リミテツド Heterocyclic compound
US4734415A (en) 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
DE3433953A1 (en) * 1984-09-15 1986-03-27 A. Nattermann & Cie GmbH, 5000 Köln NEW, 3,4-DIHYDRO-2 (1H) -PYRIDONE AND 2 (1H) -PYRIDONE, INCLUDING AN IMIDAZOLE GROUP, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
DE68923527D1 (en) 1988-10-20 1995-08-24 Sandoz Ag Fiber reactive azo dyes.
DE4023369A1 (en) 1990-07-23 1992-01-30 Thomae Gmbh Dr K New 1-bi:phenylyl:methyl benzimidazole derivs.
JPH0578250A (en) 1991-09-18 1993-03-30 Fujisawa Pharmaceut Co Ltd Preventive/therapeutic agent for hepatitis or pancreatitis
JPH05148222A (en) 1991-11-29 1993-06-15 Fujirebio Inc Naphthoic acid derivative
US5664029A (en) 1992-05-13 1997-09-02 Apple Computer, Inc. Method of disregarding changes in data in a location of a data structure based upon changes in data in nearby locations
DE4237656A1 (en) 1992-06-13 1993-12-16 Merck Patent Gmbh benzimidazole derivatives
US5574030A (en) 1992-07-14 1996-11-12 Nippon Chemiphar Co., Ltd. N-aminoalkyl-substituted nitrogen-containing five membered heterocyclic compounds
US5814651A (en) 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
AU5891494A (en) 1993-01-29 1994-08-15 Nippon Soda Co., Ltd. Heterocyclic derivative
US5852006A (en) 1993-04-30 1998-12-22 Nippon Chemiphar Co., Ltd. N-aminoalkyl-substituted nitrogen-containing six membered heterocyclic compounds
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
CA2200981A1 (en) 1994-10-04 1996-04-11 Hisashi Takasugi Urea derivatives and their use as acat-inhibitors
IL115889A0 (en) 1994-11-14 1996-01-31 Rohm & Haas Pyridazinones and their use as fungicides
WO1996033994A1 (en) 1995-04-28 1996-10-31 Nippon Soda Co., Ltd. Amino-substituted derivatives, process for the preparation thereof, and herbicide
AU723064B2 (en) 1995-08-25 2000-08-17 Dow Agrosciences Llc Compositions having synergistic fungitoxic effects
JPH11512429A (en) 1995-09-15 1999-10-26 ファルマシア・アンド・アップジョン・カンパニー Aminoaryloxazolidinone N-oxide
WO1997020822A1 (en) 1995-12-01 1997-06-12 Novartis Ag Quinazolin-2,4-diazirines as npy receptor antagonist
JP3094453B2 (en) 1996-09-13 2000-10-03 ウェルファイド株式会社 Thienotriazolodiazepine compounds and their pharmaceutical uses
US5855654A (en) 1997-01-30 1999-01-05 Rohm And Haas Company Pyridazinones as marine antifouling agents
CN1258296A (en) 1997-04-01 2000-06-28 英国阿斯特拉药品有限公司 Pyridine derivatives and pharmaceutical compositions contg. them
GB9711753D0 (en) * 1997-06-06 1997-08-06 Merck Sharp & Dohme Therapeutic agents
JPH1149755A (en) 1997-07-30 1999-02-23 Nippon Kayaku Co Ltd New nitrogen containing heterocyclic derivative and acaricide composition using the same as active component
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
EP1086948A4 (en) 1998-02-25 2004-03-10 Sumitomo Pharma Pyridone derivatives and process for producing the same
JP2000178258A (en) 1998-10-09 2000-06-27 Nippon Nohyaku Co Ltd Phenylpyridazinone derivative
JP2000170870A (en) 1998-12-04 2000-06-23 Toyota Autom Loom Works Ltd Motive power transmission mechanism
US6284755B1 (en) 1998-12-08 2001-09-04 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6063781A (en) 1999-02-17 2000-05-16 Lai; Hoi Kiong Pesticidal phenylpyridazinone derivatives
DE19918294A1 (en) 1999-04-22 2000-10-26 Bayer Ag New 3-aryloxy-1,1-dioxo-1,4,2-dithiaza-heterocyclic compounds, used as pesticides, e.g. fungicides, bactericides, insecticides, acaricides or nematocides, for protection of plants or materials
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
CN1297916A (en) 1999-11-26 2001-06-06 上海博容基因开发有限公司 Human bromo structure domain-containing protein 95 as one new kind of polypeptide and polynucleotides encoding this polypeptide
DE10010429A1 (en) 2000-03-03 2001-09-06 Bayer Ag New 6-(4-sulfonamido-phenyl)-5-methyl-dihydropyridazinones, having erythropoietin sensitizing and erythropoiesis stimulating activity, useful for treating anemia
CN1315397A (en) 2000-03-28 2001-10-03 上海博德基因开发有限公司 Polypeptide-human bromo-structure domain 10 and polynucleotide for coding it
JP4251868B2 (en) * 2000-08-11 2009-04-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 2-Aminopyridine compound and pharmaceutical use
US20050070529A1 (en) 2001-02-12 2005-03-31 Merk Pantent Gmbh Use of type 4 phosphodiesterase inhibitors in myocardial diseases
MXPA04003668A (en) 2001-10-31 2004-07-22 Merck Patent Gmbh Type 4 phosphodiesterase inhibitors and uses thereof.
TW200406466A (en) 2001-11-13 2004-05-01 Ciba Sc Holding Ag Compositions comprising at least one oxonol dye and at least one metal complex
US20050043315A1 (en) 2002-01-02 2005-02-24 Hideo Tsutsumi Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
JP2003313169A (en) 2002-04-19 2003-11-06 Otsuka Chemical Holdings Co Ltd 4,4-difluoro-3-butenyl compound and insecticidal miticide for agricultural and horticultural use
ES2195785B1 (en) 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
DE10227269A1 (en) 2002-06-19 2004-01-08 Merck Patent Gmbh thiazole
GB0218630D0 (en) 2002-08-10 2002-09-18 Tanabe Seiyaku Co Novel compounds
WO2004022540A2 (en) * 2002-09-06 2004-03-18 Fujisawa Pharmaceutical Co., Ltd. Pyridazinone and pyridone derivatives as adenosine antagonists
AU2003274025A1 (en) 2002-10-17 2004-05-04 Syngenta Participations Ag Pyridine derivatives useful as herbicides
WO2004099192A2 (en) 2003-04-30 2004-11-18 The Institutes Of Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
ES2284054T3 (en) 2003-10-14 2007-11-01 Pharmacia Corporation PIRAZINONA COMPOUNDS SUBSTITUTED FOR THE TREATMENT OF INFLAMMATION.
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
ES2232306B1 (en) 2003-11-10 2006-08-01 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
SE0400014D0 (en) 2004-01-08 2004-01-08 Astrazeneca Ab Heterocyclic derivatives
JP2005255675A (en) 2004-02-09 2005-09-22 Tanabe Seiyaku Co Ltd Pharmaceutical composition
AU2005228894B9 (en) 2004-03-30 2011-10-13 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
PE20060285A1 (en) * 2004-03-30 2006-05-08 Aventis Pharma Inc PYRIDONES SUBSTITUTE AS POL (ADP-RIBOSA) -POLYMERASE (PARP) INHIBITORS
CN1739788A (en) 2004-03-31 2006-03-01 新加坡国立大学 Modulation of TRIP-BR function and method of treating proliferative disorders
DE602004009344T2 (en) 2004-04-19 2008-07-10 Symed Labs Ltd., Hyderabad A NEW METHOD FOR THE PRODUCTION OF LINEZOLID AND RELATED COMPOUNDS
US7087622B2 (en) 2004-05-07 2006-08-08 Janssen Pharmaceutica N.V. Pyridone compounds as inhibitors of bacterial type III protein secreation systems
ES2251867B1 (en) 2004-06-21 2007-06-16 Laboratorios Almirall S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
EP1768967B1 (en) 2004-07-20 2009-04-22 Symed Labs Limited Novel intermediates for linezolid and related compounds
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB0420970D0 (en) 2004-09-21 2004-10-20 Smithkline Beecham Corp Novel triazoloquinoline compounds
JP2008514702A (en) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド Novel cyclosporine analogues and their pharmaceutical use
US20080090827A1 (en) 2004-11-30 2008-04-17 Artesian Therapeutics, Inc. Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure
MX2007011041A (en) 2005-03-10 2008-02-22 Cgi Pharmaceuticals Inc Certain substituted amides, method of making, and method of use thereof.
WO2006119400A2 (en) 2005-05-03 2006-11-09 Dow Agrosciences Llc Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-trianzin-6-ones, and their use as fungicides
TWI447120B (en) 2005-05-30 2014-08-01 Mitsubishi Tanabe Pharma Corp Thienotriazolodiazepine compound and a medicinal use thereof
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
WO2007008144A1 (en) 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
ES2465666T3 (en) 2006-03-30 2014-06-06 Janssen R&D Ireland 5-amido-substituted pyrimidines HIV inhibitors
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
WO2008012622A2 (en) 2006-07-25 2008-01-31 Pfizer Products Inc. Azabenzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor
WO2008012623A1 (en) 2006-07-25 2008-01-31 Pfizer Products Inc. Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor
EP2492263A1 (en) 2006-07-25 2012-08-29 Cephalon, Inc. Pyridizinone Derivatives
US20100160292A1 (en) 2006-09-11 2010-06-24 Cgi Pharmaceuticals, Inc Kinase Inhibitors, and Methods of Using and Identifying Kinase Inhibitors
AR063706A1 (en) 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc CERTAIN AMIDAS REPLACED, THE USE OF THE SAME FOR THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE ACTIVITY OF BTK AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
EP2094662B1 (en) 2006-12-14 2012-04-11 Astellas Pharma Inc. Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents
JP2008156311A (en) 2006-12-26 2008-07-10 Institute Of Physical & Chemical Research Brd2 bromodomain binder
CA2676944C (en) 2007-02-15 2016-01-19 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
BRPI0810362A2 (en) 2007-04-19 2014-10-29 Concert Pharmaceuticals Inc DEFERRED MORPHOLINYL COMPOUNDS
DE102007025718A1 (en) 2007-06-01 2008-12-04 Merck Patent Gmbh pyridazinone derivatives
DE102007025717A1 (en) 2007-06-01 2008-12-11 Merck Patent Gmbh Aryl ether pyridazinone derivatives
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
US20090131485A1 (en) 2007-09-10 2009-05-21 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
EP2209774A1 (en) 2007-10-02 2010-07-28 Concert Pharmaceuticals Inc. Pyrimidinedione derivatives
GB0719751D0 (en) 2007-10-10 2007-11-21 Antoxis Ltd In vitro preservation of living animal cells and compounds suitable for use in the preservation of living animal cells
US8188080B2 (en) 2007-10-17 2012-05-29 Sanford-Burnham Medical Research Institute VHR protein tyrosine phosphatase inhibitors, compositions and methods of use
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
EP2212298B1 (en) 2007-10-18 2013-03-27 Concert Pharmaceuticals Inc. Deuterated etravirine
CA2703591C (en) 2007-10-26 2013-05-07 Concert Pharmaceuticals, Inc. Deuterated darunavir
JP5478262B2 (en) 2007-12-28 2014-04-23 田辺三菱製薬株式会社 Anticancer drug
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
CA2718264A1 (en) 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
KR20100126599A (en) 2008-04-08 2010-12-01 다우 아그로사이언시즈 엘엘씨 2-alkynyl-6-pyridin-2-yl-pyridazinones, 2-alkynyl-6-pyridin-2-yl-dihydropyridazinones, 2-alkynyl-6-pyrimidin-2-yl-pyridazinones and 2-alkynyl-6-pyrimidin-2-yl-dihydropyridazinones and their use as fungicides
CN102131801B (en) 2008-06-25 2015-04-08 福拉姆医药股份有限公司 1, 2 disubstituted heterocyclic compounds
PE20100087A1 (en) 2008-06-25 2010-02-08 Irm Llc COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS
WO2010029299A1 (en) 2008-09-12 2010-03-18 Biolipox Ab Pyrimidinone derivaties for use as medicaments
US20110230477A1 (en) 2008-12-08 2011-09-22 Euroscreen S.A. Compounds, pharmaceutical composition and methods for use in treating metabolic disorders
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
GEP20135992B (en) 2009-01-12 2013-12-25 Icagen Inc Sulfonamide derivatives
RU2531274C2 (en) 2009-05-07 2014-10-20 Энвиво Фармасьютикалз, Инк. Phenoxymethyl heterocyclic compounds
ME02360B (en) 2009-11-05 2016-06-20 Glaxosmithkline Llc Benzodiazepine bromodomain inhibitor
GB0919426D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
ES2539964T3 (en) 2009-11-05 2015-07-07 Glaxosmithkline Llc Novel procedure
GB0919434D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
KR20120097508A (en) 2009-11-05 2012-09-04 글락소스미스클라인 엘엘씨 Benzodiazepine bromodomain inhibitor
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB0919432D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Use
CN102933079B (en) 2010-03-04 2016-02-17 默沙东公司 Catechol-O-methyltransferase inhibitor and the purposes in treatment mental disorder thereof
WO2011143423A2 (en) * 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
AR084070A1 (en) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc BROMODOMINIUM INHIBITORS AND USES OF THE SAME
WO2012075456A1 (en) * 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
US9409916B2 (en) 2011-03-18 2016-08-09 Merck Sharp & Dohme Corp. Piperidinone carboxamide spirohydantoin CGRP receptor antagonists
EA029834B1 (en) * 2011-09-27 2018-05-31 Жанфит DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS Rev-Erb AGONISTS
CN104718201A (en) * 2012-06-12 2015-06-17 艾伯维公司 Pyridinone and pyridazinone derivatives

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