HK1244281B - 治療和預防乙型肝炎病毒感染的2-氧代-6，7-二氫苯並[a]喹嗪-3-甲酸衍生物 - Google Patents

治療和預防乙型肝炎病毒感染的2-氧代-6，7-二氫苯並[a]喹嗪-3-甲酸衍生物

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Publication number
HK1244281B
HK1244281B HK18103815.7A HK18103815A HK1244281B HK 1244281 B HK1244281 B HK 1244281B HK 18103815 A HK18103815 A HK 18103815A HK 1244281 B HK1244281 B HK 1244281B
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HK
Hong Kong
Prior art keywords
quinolizine
dihydrobenzo
prophylaxis
hepatitis
oxo
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HK18103815.7A
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English (en)
Inventor
Xingchun Han
Min Jiang
Song Yang
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Hoffmann La Roche
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Publication of HK1244281B publication Critical patent/HK1244281B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK18103815.7A 2015-02-11 2018-03-19 治療和預防乙型肝炎病毒感染的2-氧代-6，7-二氫苯並[a]喹嗪-3-甲酸衍生物 HK1244281B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2015072741 2015-02-11
PCT/EP2016/052585 WO2016128335A1 (en) 2015-02-11 2016-02-08 Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection

Publications (1)

Publication Number Publication Date
HK1244281B true HK1244281B (zh) 2020-02-07

Family

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Family Applications (1)

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HK18103815.7A HK1244281B (zh) 2015-02-11 2018-03-19 治療和預防乙型肝炎病毒感染的2-氧代-6，7-二氫苯並[a]喹嗪-3-甲酸衍生物

Country Status (6)

Country Link
US (1) US10093671B2 (zh)
EP (1) EP3256471B1 (zh)
JP (1) JP6435054B2 (zh)
CN (1) CN107207505B (zh)
HK (1) HK1244281B (zh)
WO (1) WO2016128335A1 (zh)

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