JP2016520530A5 - - Google Patents

Info

Publication number

JP2016520530A5

JP2016520530A5 JP2016503192A JP2016503192A JP2016520530A5 JP 2016520530 A5 JP2016520530 A5 JP 2016520530A5 JP 2016503192 A JP2016503192 A JP 2016503192A JP 2016503192 A JP2016503192 A JP 2016503192A JP 2016520530 A5 JP2016520530 A5 JP 2016520530A5

Authority

JP

Japan

Prior art keywords

seq

vaccine

antigen

nucleic acid

nucleotide sequence

Prior art date

2014-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229960005486 vaccine Drugs 0.000 claims 25
• 239000000427 antigen Substances 0.000 claims 16
• 102000036639 antigens Human genes 0.000 claims 16
• 108091007433 antigens Proteins 0.000 claims 16
• 150000007523 nucleic acids Chemical class 0.000 claims 11
• 108020004707 nucleic acids Proteins 0.000 claims 9
• 102000039446 nucleic acids Human genes 0.000 claims 9
• 239000002773 nucleotide Substances 0.000 claims 8
• 125000003729 nucleotide group Chemical group 0.000 claims 8
• 230000028993 immune response Effects 0.000 claims 6
• 239000002671 adjuvant Substances 0.000 claims 5
• 241000701806 Human papillomavirus Species 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 241000223960 Plasmodium falciparum Species 0.000 claims 2
• 206010022000 influenza Diseases 0.000 claims 2
• 239000013612 plasmid Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• DLQPMEMYCIGJIM-UHFFFAOYSA-N Adjuvant peptide Natural products CC(NC(=O)CCOC1C(O)C(CO)OC(O)C1NC(=O)C)C(=O)NC(CCC(=O)O)C(=O)N DLQPMEMYCIGJIM-UHFFFAOYSA-N 0.000 claims 1
• 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 1
• 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 1
• 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 claims 1
• 101100540311 Human papillomavirus type 16 E6 gene Proteins 0.000 claims 1
• 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 claims 1
• 101100445364 Mus musculus Eomes gene Proteins 0.000 claims 1
• 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims 1
• 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims 1
• 102100036840 T-box transcription factor TBX21 Human genes 0.000 claims 1
• 102100024584 Tumor necrosis factor ligand superfamily member 12 Human genes 0.000 claims 1
• 101710097155 Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 1
• 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims 1
• 101100445365 Xenopus laevis eomes gene Proteins 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 230000000890 antigenic effect Effects 0.000 claims 1
• 238000004520 electroporation Methods 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• BSOQXXWZTUDTEL-QAQREVAFSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-QAQREVAFSA-N 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1