MX2019000933A - Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr). - Google Patents

Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr).

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Publication number
MX2019000933A
MX2019000933A MX2019000933A MX2019000933A MX2019000933A MX 2019000933 A MX2019000933 A MX 2019000933A MX 2019000933 A MX2019000933 A MX 2019000933A MX 2019000933 A MX2019000933 A MX 2019000933A MX 2019000933 A MX2019000933 A MX 2019000933A
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Mexico
Prior art keywords
rsv
mva
respiratory syncytial
virus
modified vaccinia
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MX2019000933A
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English (en)
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Paul Chaplin
Cédric Cheminay
Robin Steigerwald
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Bavarian Nordic As
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Publication of MX2019000933A publication Critical patent/MX2019000933A/es

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Abstract

La presente invención se refiere a cepas de virus vaccinia Ankara modificado (MVA) recombinan te como vacunas mejoradas contra la infección por el virus sincicial respiratorio (virus VSR) y a productos, métodos y usos relacionados. Específicamente, se proporcionan en la presente vectores de MVA recombinan te modificados genéticamente que comprenden al menos una secuencia de nucleótidos que codifica un determinante antigénico de una glicoproteína de membrana de VSR y al menos una secuencia de nucleótidos que codifica un determinante antigénico de una proteína de la nucleocápside de VSR. También se proporcionan en la presente productos, métodos y usos de éste, por ejemplo, apropiados para provocar una respuesta inmunológica en un sujeto o apropiados para diagnosticar una infección de VSR, así como también para determinar si un sujeto está en riesgo de una infección por VSR recurrente.
MX2019000933A 2012-08-01 2015-01-30 Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr). MX2019000933A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261678367P 2012-08-01 2012-08-01
EP12005594 2012-08-01

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MX2019000933A true MX2019000933A (es) 2022-06-27

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MX2015001479A MX362511B (es) 2012-08-01 2013-03-15 Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr).
MX2023003746A MX2023003746A (es) 2012-08-01 2015-01-30 Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr).
MX2019000933A MX2019000933A (es) 2012-08-01 2015-01-30 Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr).

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MX2015001479A MX362511B (es) 2012-08-01 2013-03-15 Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr).
MX2023003746A MX2023003746A (es) 2012-08-01 2015-01-30 Vacuna del virus vaccinia ankara modificado (mva) recombinante para virus sincicial respiratorio (vsr).

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US (6) US9480738B2 (es)
EP (2) EP3656396A1 (es)
JP (2) JP6523955B2 (es)
KR (3) KR20220119527A (es)
CN (2) CN109266622B (es)
AU (1) AU2013298915B2 (es)
BR (1) BR112015002131B1 (es)
CA (2) CA3158572A1 (es)
CY (1) CY1122717T1 (es)
EA (2) EA031453B1 (es)
HK (1) HK1205459A1 (es)
IL (1) IL236744B (es)
IN (1) IN2015DN01448A (es)
MX (3) MX362511B (es)
MY (1) MY171498A (es)
NZ (1) NZ704005A (es)
SG (1) SG11201500696VA (es)
SI (1) SI2879702T1 (es)
WO (1) WO2014019718A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2879702T3 (da) * 2012-08-01 2020-02-24 Bavarian Nordic As Rekombinant modificeret vacciniavirus ankara (mva)-vaccine mod respiratorisk syncytialvirus (rsv)
JP6480875B2 (ja) * 2013-03-15 2019-03-13 バヴァリアン・ノルディック・アクティーゼルスカブ 単一高用量のmvaは、新生児及び幼児において防御免疫応答を引き起こす
JP6664338B2 (ja) 2014-06-13 2020-03-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組合せ物
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
CA2988654A1 (en) 2015-06-12 2016-12-15 Glaxosmithkline Biologicals S.A. Adenovirus polynucleotides and polypeptides
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
BR112019020661A2 (pt) 2017-04-04 2020-05-05 University Of Washington nanoestruturas de proteína de auto-montagem que exibem proteínas f de paramixovírus e/ou pneumovírus e seu uso
EP3624851A1 (en) 2017-05-15 2020-03-25 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
WO2018211419A1 (en) 2017-05-15 2018-11-22 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
KR20200101394A (ko) 2017-12-20 2020-08-27 글락소스미스클라인 바이오로지칼즈 에스.에이. 엡스타인-바 바이러스 항원 구축물
AU2019228551A1 (en) 2018-02-28 2020-10-15 University Of Washington Self-assembling nanostructure vaccines
US20210187100A1 (en) * 2018-09-06 2021-06-24 Bavarian Nordic A/S Storage Improved Poxvirus Compositions
US20220195016A1 (en) * 2019-04-18 2022-06-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Biological and synthetic molecules inhibiting respiratory syncytial virus infection
CA3148026A1 (en) * 2019-08-13 2021-02-18 Vyjayanthi Krishnan Therapeutic agent effectiveness and its route of administration
KR20220153587A (ko) 2020-03-12 2022-11-18 버베리안 노딕 에이/에스 폭스바이러스 안정성을 개선하는 조성물
AU2022338199A1 (en) 2021-09-03 2024-03-14 Bavarian Nordic A/S Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva)

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US5110587A (en) 1981-12-24 1992-05-05 Health Research, Incorporated Immunogenic composition comprising synthetically modified vaccinia virus
US5149650A (en) 1986-01-14 1992-09-22 University Of North Carolina At Chapel Hill Vaccines for human respiratory virus
US5639853A (en) 1987-09-29 1997-06-17 Praxis Biologics, Inc. Respiratory syncytial virus vaccines
US5223254A (en) 1987-09-29 1993-06-29 Praxis Biologics, Inc. Respiratory syncytial virus: vaccines
JP2716503B2 (ja) 1987-12-23 1998-02-18 ジ・アップジョン・カンパニー ヒト呼吸系シンシチウムウイルスの糖蛋白類の免疫原性セグメントを含有するキメラ糖蛋白類
CA1341245C (en) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
JPH05509231A (ja) 1990-07-24 1993-12-22 ザ ユーエイビー リサーチ ファンデーション ウシrsウイルスの組換えdna、タンパク質ワクチン、抗体、および形質転換細胞の使用法
US6730305B1 (en) 2000-05-08 2004-05-04 The Uab Research Foundation Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins
GB9200117D0 (en) 1992-01-06 1992-02-26 Connaught Lab Production of recombinant chimeric proteins for vaccine use
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
FR2718452B1 (fr) 1994-04-06 1996-06-28 Pf Medicament Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation.
DE69509103T2 (de) 1994-08-25 1999-09-30 Pepscan Systems Bv Antigene peptide abgeleitet vom g-protein des rsv (respiratorisches synzytialvirus) für die typen- und subtypen spezifische diagnose einer rsv-infektionen
FR2726471B1 (fr) 1994-11-07 1997-01-31 Pf Medicament Procede pour ameliorer l'immunogenicite d'un compose immunogene ou d'un haptene et application a la preparation de vaccins
US6083925A (en) 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US6019980A (en) 1995-06-07 2000-02-01 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US6180398B1 (en) 1996-07-12 2001-01-30 Virogeneitics Corporation Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation
US6020182A (en) 1996-07-12 2000-02-01 Connaught Laboratories Limited Subunit respiratory syncytial virus vaccine preparation
FR2751229B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins
US6699478B1 (en) 1997-09-19 2004-03-02 Wyeth Holdings Corporation Enhanced immune response to attachment (G) protein of Respiratory Syncytial Virus
FR2798857B1 (fr) * 1999-09-23 2003-06-06 Pf Medicament Utilisation d'une proteine de membrane ompa d'enterobacterie associee a un peptide immunogene du vrs pour la preparation de vaccins administrables par voie nasale
US6651655B1 (en) 2000-01-18 2003-11-25 Quadrant Technologies Limited Inhaled vaccines
GB0024089D0 (en) * 2000-10-02 2000-11-15 Smithkline Beecham Biolog Novel compounds
SG106639A1 (en) 2000-10-10 2004-10-29 Gen Electric Apparatus and method for introducing small amounts of refractory elements into a vapor deposition coating
EP1334119B2 (en) 2000-10-18 2018-11-28 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Compositions and methods for modulating rsv infection and immunity
EE05680B1 (et) 2000-11-23 2013-10-15 Bavarian Nordic A/S Muundatud vaktsiiniaviirus, selle valmistamine ja kasutamine, seda sisaldav farmatseutiline kompositsioon ning vaktsiin
US6855493B2 (en) 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
FR2827605B1 (fr) 2001-07-20 2004-07-16 Pf Medicament Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin
EP1456230A2 (en) 2001-12-04 2004-09-15 Bavarian Nordic A/S Flavivirus ns1 subunit vaccine
JP4895505B2 (ja) 2002-05-16 2012-03-14 バヴァリアン・ノルディック・アクティーゼルスカブ 変異ワクシニアウイルスアンカラ(mva)ゲノム中の挿入部位としての遺伝子間領域
US7368537B2 (en) 2003-07-15 2008-05-06 Id Biomedical Corporation Of Quebec Subunit vaccine against respiratory syncytial virus infection
WO2006023029A2 (en) 2004-06-16 2006-03-02 The Johns Hopkins University The cysteine-rich region of respiratory syncytial virus and methods of use therefor
EP1793852A1 (en) * 2004-08-27 2007-06-13 Panacea Biotec Ltd. Inactivated poliomyelitis vaccine derived from sabin strain of polio virus
EP2062246A4 (en) * 2006-08-18 2010-09-29 Univ North Carolina CHIMERIC VIRAL VACCINES
EP2099486A2 (en) * 2006-11-30 2009-09-16 Government Of The United States Of America, As Represented by the Secretary Codon modified immunogenic compositions and methods of use
DE102006060799A1 (de) 2006-12-21 2008-06-26 RUHR-UNIVERSITäT BOCHUM RSV F-Protein und seine Verwendung
JP2010522540A (ja) * 2007-03-21 2010-07-08 アイディー バイオメディカル コーポレイション オブ ケベック キメラ抗原
KR100938105B1 (ko) * 2007-09-21 2010-01-21 이화여자대학교 산학협력단 호흡기 신시치아 바이러스 백신
AU2008340949A1 (en) 2007-12-24 2009-07-02 Glaxosmithkline Biologicals S.A. Recombinant RSV antigens
WO2010039224A2 (en) 2008-09-30 2010-04-08 University Of Massachusetts Medical School Respiratory syncytial virus (rsv) sequences for protein expression and vaccines
WO2010059689A2 (en) 2008-11-18 2010-05-27 Ligocyte Pharmaceuticals, Inc. Rsv f vlps and methods of manufacture and use thereof
CA2742247C (en) 2008-11-21 2017-07-04 Bavarian Nordic A/S Vector comprising multiple homologous nucleotide sequences
EP3718566B1 (en) * 2008-12-09 2024-06-12 Novavax, Inc. Modified rsv f proteins and methods of their use
US20110318376A1 (en) 2008-12-24 2011-12-29 University Of Rochester Recombinant expression of self-folding neutralizing epitope-bearing subdomains of the respiratory syncytial virus attachment and fusion proteins
US9492531B2 (en) 2009-06-24 2016-11-15 Glaxosmithkline Biologicals Sa Recombinant RSV vaccines
MX2012000036A (es) 2009-06-24 2012-02-28 Glaxosmithkline Biolog Sa Vacuna.
DK3178490T3 (da) * 2009-07-15 2022-06-20 Glaxosmithkline Biologicals Sa RSV F-proteinsammensætninger og fremgangsmåder til fremstilling af disse
CA2770304C (en) * 2009-08-04 2019-11-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Anti-rsv immunogens and methods of immunization
CN102695523A (zh) 2009-09-10 2012-09-26 诺华有限公司 针对呼吸道疾病的组合疫苗
WO2011046925A1 (en) 2009-10-12 2011-04-21 Technovax, Inc. Respiratory syncytial virus (rsv) virus-like particles (vlps)
US20120318376A1 (en) 2009-11-12 2012-12-20 Trojan Technologies Cleaning apparatus, radiation source module and fluid treatment system
NZ600629A (en) 2010-01-28 2014-12-24 Bavarian Nordic As Vaccinia virus mutants containing the major genomic deletions of mva
CN103037898B (zh) 2010-07-07 2016-06-29 人工细胞科技公司 呼吸道合胞病毒抗原组合物和方法
WO2012080477A1 (en) * 2010-12-17 2012-06-21 Philip Morris Products S.A. Container having interactive surface elements including design element
WO2012085936A2 (en) * 2010-12-20 2012-06-28 Panacea Biotech Ltd Recombinant respiratory syncytial virus plasmids and vaccines
WO2012089231A1 (en) 2010-12-30 2012-07-05 Okairòs Ag Paramyxovirus vaccines

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